Cancer stem cells werehave originally been identified in
leukemia and later in several solid tumor types. They have very
different properties from the bulk of the tumor, as they divide
much more slowly and have very efficient drug- resistance
mechanisms. Current treatments might largely spare cancer stem
cells, thus leading to tumor recurrence and metastasis. The recent
identification of growth and differentiation pathways responsible
for cancer stem cell proliferation and survival will help in the
discovery identification of novel therapeutic targets. Developing
selective drugs against cancer stem cells offers great therapeutic
opportunities but also provides for major challenges regarding
preclinical models, therapeutic windows, and clinical study end
points.
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