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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Genetics of Dyslipidemia (Hardcover)
Loot Price: R4,743
Discovery Miles 47 430
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Genetics of Dyslipidemia (Hardcover)
Series: Basic Science for the Cardiologist, 7
Expected to ship within 12 - 17 working days
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Profound mortality rates, due to cardiovascular disease, are a
worldwide problem. Cardiovascular disease results from
complications of a silent and chronic arterial disease:
atherosclerosis. The challenge for the practitioner is adapting
diagnostic and therapeutic responses to prevent this common and
complex disease. Dyslipidemia, are disorders of the metabolism of
soluble transporters of lipids in extracellular spaces of the human
body (including blood), called lipoproteins. They are major
cardiovascular risk factors, causally related with atherosclerosis
and are themselves multifactorial diseases, resulting from
interactions between genetic and environmental factors. The study
of genetic factors has recently taken a new path with the study of
DNA as an experimental object. More than fifty genes of lipoprotein
metabolism have been identified in both their physiological actions
and their contribution to the pathogenesis of human dyslipidemia.
The diversity of observations has refined our current knowledge of
the control of lipid metabolism and energy homeostasis in living
organisms beyond the limits of the cardiovascular system (e.g.,
brain, immune system, and development). These studies have given
way to a shake-up of former phenotypic classifications,
distinguishing new entities, defining targeted therapeutic
strategies, providing a basis for different patterns of disease
distribution in human populations.
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