The book presents a detailed assessment of the health science of
lead and the human health risk assessment models for lead s human
health impacts, followed by an account of various regulatory
efforts in the United States and elsewhere to eliminate or reduce
human toxic exposures to lead. The science of lead as presented
here covers releases of lead into the environment, lead s movement
through the environment to reach humans who are then exposed, and
the spectrum of toxic effects, particularly low-level toxic
effects, on the developing central nervous system of the very young
child. The section on human health risk assessment deals with
quantifying not only the dose-response relationships that underlie
toxic responses to lead in sensitive populations but also with the
likelihood of toxic responses vis-a-vis environmental lead at some
level of exposure. This section includes a treatment of computer
models of lead exposure, particularly those that use lead in whole
blood as a key measure. Various models convert lead intake via
various body compartments into measures of body lead burden. Such
measures are then directly related to severity of injury.
The final section of the book deals with past and present
regulatory efforts to control lead releases into the human
environment. Current control efforts present a mixed picture. The
most problematic issue is the continued presence of lead paint in
older housing and lead in soils of urban and mining industry
communities.
Comprehensive assessment of the three major facets of the public
health problem of lead: the voluminous science, the risk assessment
approaches, and approaches to controlling lead as a public health
problem.
Integration of the above three elements to provide a coherent
whole
Provides a single source of information that will be extremely
valuable to all professionals working in areas impacted by this
toxic substance"
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