This SpringerBrief on Spx reviews the investigations that led to
the discovery of Spx and its orthologs and ties together the
results of various studies that have explored the function and
control of spx in Gram-positive organisms. Spx of "Bacillus
subtilis" has been extensively studied, but very little has been
published about it. This book incorporates a number of studies that
have been conducted in other Gram positive bacteria, which examined
the role of Spx orthologs in stress response, bacterial development
and virulence.
The book contains an overview that will introduce the protein
and its orthologous forms, its association with RNA polymerase, the
species of Gram-positive bacteria in which it is found, and the
conditions in which it is abundant and active. Spx is a member of a
large group of proteins belonging to the ArsC/Spx protein family,
so the review touches upon the bioinformatic support for the
protein family composition and its meaning with regard to protein
structure/function.
General
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