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Novel Routes for the Synthesis of Thiazolidine-2,4-diones (Paperback)
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Novel Routes for the Synthesis of Thiazolidine-2,4-diones (Paperback)
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Diabetes mellitus is a complex, progressive lifestyle disease
resulting in chronic hyperglycemia, which in turn adversely affects
function of the kidneys, eyes, nervous and vascular systems. The
classical antidiabetic agent sulphonylurea, biguanides have lots of
side effects like mild to moderate hypoglycemia, lactic acidosis,
increased cardiovascular mortality, transient nausea, anorexia or
diarrhoea, abdominal discomfort, and metallic taste etc. Various
5-substituted thiazolidine-2,4-dione derivatives are also known to
potentially act on PPARs. There has been a surge of interest in the
development of novel antihyperglycemic agents that can reverse the
insulin resistance in non-insulin dependent diabetes mellitus (type
II) patients. The use of green technologies and novel catalysts and
green solvents have recently gained interest in an attempt to avoid
solvents like toluene, methylene chloride etc. used in organic
synthesis which are known to cause health and environmental
problems. Therefore to identify new routes of the synthesis of
thiazolidine-2,4-dione and its derivatives using metal
nanoparticles in green solvents is the main aim of the present
work.
General
Imprint: |
Lap Lambert Academic Publishing
|
Country of origin: |
Germany |
Release date: |
May 2012 |
First published: |
May 2012 |
Authors: |
Prashant Singh
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Dimensions: |
229 x 152 x 8mm (L x W x T) |
Format: |
Paperback - Trade
|
Pages: |
136 |
ISBN-13: |
978-3-8484-8671-7 |
Categories: |
Books >
Humanities >
Philosophy >
General
Books >
Philosophy >
General
|
LSN: |
3-8484-8671-7 |
Barcode: |
9783848486717 |
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