This book includes a review of the pathophysiology of acute colitis
in the adult horse and discussion of the more common etiologies for
this condition and treatment options available to the equine
clinician. The aim of the clinical study performed and documented
was to evaluate the use of a hyperimmunized plasma containing high
concentration of antibodies against Clostridium difficile,
Clostridium perfringens and Salmonella sp in a referral population
of equine colitis cases.Forty two horses were enrolled and 38
horses completed the study. At study admission clinical and
clinicopathological parameters, other than fecal frequency score
were comparable between the groups. Fecal frequency score was
significantly different between the treatment groups (p=0.003). The
mean duration of diarrhea was 40.79.8 hours (mean SEM), 119.256.1
hours and 72.024.5 hours for the hyperimmunized plasma, normal
plasma and control groups respectively. This data confirms the
hyperimmunized plasma used in this study decreased the time to
resolution of diarrhea.
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