From mRNA vaccines to gene therapies, the next frontier of medical
innovation is here. In Building Breakthroughs, Raju Prasad tells
the story of important advancements in biotechnology and medical
innovation from gene therapies to mRNA vaccines, providing
historical context and examining cutting-edge research. Based on
in-depth interviews with both the scientists who developed these
discoveries and the patients who have benefited from them, Building
Breakthroughs reveals the key players behind drug development and
the inner workings of this essential business. Through stories of
patients and their families, and of the researchers creating new
treatments, Prasad reveals how cell therapies are advancing to
treat childhood leukemia and a form of lymphoma, how a gene therapy
was established to treat the rare disease spinal muscular atrophy
type I, and potentially curative therapies that are being developed
for sickle cell disease. By examining the clinical trial and
regulatory paths each therapy took to reach approval, Prasad
uncovers the building blocks of biotechnology innovation and the
investments that must be made to catalyze the development of future
breakthroughs. He also explores issues of scientific communication
and misinformation, providing recommendations for improvements in
the future. For those seeking to understand the vitally important
processes that lead to new medicines and the surrounding ecosystem
that is enabling the next generation of innovative medicines with
the potential to transform patient outcomes, Building Breakthroughs
is essential reading.
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