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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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Neuroepigenomics in Aging and Disease (Hardcover, 1st ed. 2017)
Loot Price: R7,201
Discovery Miles 72 010
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Neuroepigenomics in Aging and Disease (Hardcover, 1st ed. 2017)
Series: Proteomics, Metabolomics, Interactomics and Systems Biology, 978
Expected to ship within 10 - 15 working days
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Epigenetic mechanisms (DNA modifications, histone alterations and
non-coding RNAs) are crucial for transcriptional regulation and
alterations of the "physiological epigenome" are increasingly
associated with human diseases. During the last decade the emerging
field of neuroepigenomics have started to impact tremendously in
areas such learning and memory, addiction or neurodegeneration.
This expert volume covers the role of epigenetic molecular
mechanism in regulation of central nervous system's function, one
of the most exciting areas of contemporary molecular neuroscience.
The book describes the current knowledge on the epigenetic basis of
human disease covering the complete lifespan: from
neurodevelopment/childhood (Rett Syndrome, Rubinstein-Taybi,
autism), adolescence (eating disorders, drug addiction, anxiety),
adulthood (depression, schizophrenia, amyotrophic lateral
sclerosis, Huntington's disease) and elderly (Alzheimer's disease,
Parkinson's disease). The book also covers the three major players
on neuroepigenomic mechanisms: histones alterations, DNA
modifications and non-coding RNAs, their roles at the molecular and
cellular level and the impact of their alterations on neuronal
function and behavior. Finally, a special chapter on
state-of-the-art technologies helps the reader not only to
understand epigenetic driven changes in human cognition and
diseases but also the methodology that will help to generate
paradigm shifts on our understanding of brain function and the role
of the neuroepigenome in human diseases.
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