This book covers all aspects of regulatory toxicology - test
methods and procedures required for generating data for submission
to regulatory authorities. The introductory chapter gives a brief
overview of various toxicity studies conducted as per Good
Laboratory practices. Important considerations in toxicology
testing have been outlined followed by a brief account of
fundamental aspects of toxicity testing, animal husbandry, animal
welfare and animal alternatives. The book also covers a wide range
of experimental procedures including clinical and morphological
studies, skin sensitization, teratogenicity, neurotoxicity and
carcinogenicity studies, clinical and target organ pathology,
inhalation toxicity, mutagenicity and statistical methods. Lastly,
there is a chapter on how to manage a GP facility making this book
useful for scientific and technical personnel involved in
generating data required for registration of products.
General
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