Genomics is majorly impacting therapeutics development in medicine.
This book contains up-to-date information on the use of genomics in
the design and analysis of therapeutic clinical trials with a focus
on novel approaches that provide a reliable basis for identifying
which patients are most likely to benefit from each treatment. It
is oriented to both clinical investigators and statisticians. For
clinical investigators, it includes background information on
clinical trial design and statistical analysis. For statisticians
and others who want to go deeper, it covers state-of-the-art
adaptive designs and the development and validation of
probabilistic classifiers. The author describes the development and
validation of prognostic and predictive biomarkers and their
integration into clinical trials that establish their clinical
utility for informing treatment decisions for future patients.
General
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