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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Stress and Mental Disorders: Insights from Animal Models (Hardcover)
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Stress and Mental Disorders: Insights from Animal Models (Hardcover)
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Stress has been recognized as an important factor in the
development or recurrence of various mental disorders, from major
depressive disorder to bipolar disorder to anxiety disorders.
Stressful stimuli also appear to exert their effects by acting upon
individuals with susceptible genotypes. Over the past 50 years,
animal models have been developed to study these dynamic
interactions between stressful stimuli and genetically susceptible
individuals during prenatal and postnatal development and into
adulthood. Stress and Mental Disorders: Insights from Animal Models
begins with a discussion of the history of psychiatric diagnosis
and the recent goal of moving toward precision psychiatry, followed
by a review of clinical research on connections between stressful
stimuli and the development of psychiatric disorders. Chapters are
also included on neuroendocrine, immune, and brain systems involved
in responses to stress. Additional chapters focus on the
development of animal models in psychiatry and the susceptibility
of the developing organism to stressful stimuli. Subsequent
chapters are devoted to animal models of specific stress-sensitive
psychiatric disorders, including schizophrenia, autism spectrum
disorders, bipolar disorder, anxiety disorders, depression, and
post-traumatic stress disorder. These chapters also focus on
identification of promising molecular targets for development of
new drug therapies. The section concludes with a chapter on animal
models of resilience to stress-induced behavioral alterations as a
newer approach to understanding why some animals are susceptible to
stress and others are resilient, even though they are essentially
genetically identical. The final chapter discusses how these basic
laboratory studies are providing promising leads for future
breakthroughs in the diagnosis, treatment, and prevention of mental
disorders.
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