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Books > Medicine > Clinical & internal medicine > Paediatric medicine
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Early Pregnancy Loss - Mechanisms and Treatment (Paperback, Softcover reprint of the original 1st ed. 1988)
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Early Pregnancy Loss - Mechanisms and Treatment (Paperback, Softcover reprint of the original 1st ed. 1988)
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The first few months of any pregnancy are of supreme importance to
the success of that pregnancy. This statement is so obvious as to
be almost a platitude, yet it must be said that no aspect of
pregnancy has been more neglected in the human than the first three
months. Little is known of the morphological changes that occur at
that time and our knowledge of the mechanisms that control this
vital stage of pregnancy is almost non-existent. The explanation
for this neglect of what is an obvious area for study is the
difficulty of obtaining normal material. It is rare to have
material to study from a healthy first trimester pregnancy and the
study by Hertig and Rock!l) of early conception found by chance in
hysterectomy speci mens must be unique. The information that we do
have about early pregnancy is mostly gained from animal studies or
single miscarriages in humans. Chromosomal defects are common but
are not an explanation for the majority of recurrent miscarriages.
Obstetricians have hypothesised many causes for this condition and
have deve loped numerous metQods for treating it, but the studies
have been poorly con trolled so that our understanding of the
cause(s) has not advanced. Treatment of women with a history of
recurrent miscarriage by paternal leuco cyte infusion
(immunotherapy) may be yet another form of treatment that is hailed
as a new advance only to be rejected when subject to rigorous
testing.
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