Asymmetric Synthesis of Bioactive Lactones and the Development of a Catalytic Asymmetric Synthesis of -Aryl Ketones (Paperback, Softcover reprint of the original 1st ed. 2015)

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereo control, which is significant because it allows the configuration of a new stereo centre to be controlled by a simple change of proton source.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	October 2016
First published:	2015
Authors:	Robert Doran
Dimensions:	235 x 155 x 12mm (L x W x T)
Format:	Paperback
Pages:	202
Edition:	Softcover reprint of the original 1st ed. 2015
ISBN-13:	978-3-319-37034-7
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Chemistry > Physical chemistry > Catalysis Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-319-37034-0
Barcode:	9783319370347

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