In the past few years, the number of applications of tracers for in
vivo biomedical studies has greatly increased. New analytical tools
at the genetic and protein levels have spurred this growth, opening
the door for a deeper understanding of metabolic events. This in
turn promises to yield significant advances in the understanding
and treatment of human disease.
Now fully revised and expanded, "Isotope Tracers in Metabolic
Research," Second Edition is the established definitive text on
stable and radioactive isotope tracers. In unique,
multidisciplinary fashion, it presents comprehensive coverage of
new methodological, mathematical, and theoretical approaches.
This new Second Edition includes: All-new chapters on nuclear
magnetic resonance, mass isotopomer analysis, and methods of
protein metabolism analysis
A completely updated categorized list of over 750 references
Major advances in the development of mass isotopomer and
positional isotopomer techniques, noninvasive isotope techniques
for studying metabolic pathways, hyphenated techniques, and new
tracer techniques
The latest developments in quantification of DNA synthesis and
mass spectrometry spurred by genome sequencing and proteomics
New coverage of mathematical modeling
Expanded coverage of microdialysis probes, laboratory procedures,
and regulatory issues related to human studies
In this complete guide to performing tracer studies, the
authors systematically cover tracer selection, modeling
considerations, sample derivitization, mass spectrometry analysis,
and data interpretation. Problems and discussion questions
highlight key points in each chapter. Isotope "Tracers in Metabolic
Research,"Second Edition offers students and researchers a
comprehensive, practical resource for utilizing the latest tracer
methodologies.
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