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This book provides biomedical engineers with the premiere reference on medical instrumentation as well as a comprehensive overview of the basic concepts. The revised edition features new material on infant apnea monitors, impedance pneumography, the design of cardiac pacemakers, and disposable defibrillator electrodes and their standards. Each chapter includes new problems and updated reference material that cover the latest medical technologies. The chapters have also been revised with new material in medical imaging, providing biomedical engineers with the most current techniques in the field.
How new biomedical technologies-from prenatal testing to gene-editing techniques-require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities-especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich-an award-winning poet and memoirist, and the father of a young woman with Down syndrome-delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on "three-parent IVF," a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.
This practical text provides an overview of the adverse consequences of health information technology (HIT) and its impact on patient safety. Specific cases of errors and risks related to various types of HIT are featured along with best practices for patient safety, workflows and organizational standards. The full impact of these challenges with meaningful solutions are openly examined. Written from a clinical perspective, healthcare professionals within multiple settings will find this timely book an invaluable resource to this essential and bourgeoning technology.
MATLAB: A Practical Introduction to Programming and Problem Solving, winner of TAA's 2017 Textbook Excellence Award ("Texty"), guides the reader through both programming and built-in functions to easily exploit MATLAB's extensive capabilities for tackling engineering and scientific problems. Assuming no knowledge of programming, this book starts with programming concepts, such as variables, assignments, and selection statements, moves on to loops, and then solves problems using both the programming concept and the power of MATLAB. The fifth edition has been updated to reflect the functionality of the current version of MATLAB (R2018a), including the addition of local functions in scripts, the new string type, coverage of recently introduced functions to import data from web sites, and updates to the Live Editor and App Designer.
* A step-by-step look at a growing and difficult to understand
A midwife is responsible for recording the progress of labour on a partograph or partogram. The partograph helps caregivers detect whether labour is progressing normally or not, indicates when augmentation of labour is appropriate and assists in recognising potential problems before they occur. Each title covers one important topic, and has been written by a specialist in that field. The series follows a consistent format and covers issues such as key ethical and legal considerations, relevant legislation, case studies, and practical applications. These concise, accessible texts will be suitable for accreditation when continuing professional development becomes a requirement
This book provides an up-to-date overview of the clinical applications, methods, and technologies of teleophthalmology within the field of preventive medicine. The ability of novel methods to detect the initial signs of neurodegenerative diseases on the basis of alterations in the retina is reviewed, and detailed attention is paid to the role of teleophthalmology in screening for vision-threatening diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. A major part of the book is devoted to novel imaging methods and the latest information technologies, including advanced mobile communication and Web 2.0 applications in teleophthalmology. In addition, the initial projects of an interdisciplinary cooperation in preventive medicine are described. All of the authors are experienced in the scientific and practical aspects of teleophthalmology, including e-learning, and have produced a book that will meet the needs of all medical care providers interested in using teleophthalmology.
This book covers ACS and Heart Failure, the chapters represent the most current, up to date and knowledgeable content on the topic available. It is written by the worlds most respected leaders in biomarkers, with a majority emphasis on what clinicians need to know. The Editors and their contributors have provided algorithms, annotated case discussions and caveats. They cover biomarkers to predict risk of heart disease, biomarkers of cardiorenal disease , and conclude with a section on new and emerging biomarkers. It be genuinely helpful and practical to those in the field, including not just people working in the field, but nurses, doctors, etc who practice medicine in the clinic, the emergency department and the hospital.
This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.
Regenerative medicine is a highly interdisciplinary field, with contributions from medicine, engineering, and chemistry. Chemical biology plays a key role - small molecules are involved in differentiating, reprogramming and manipulating stem cells and in enabling transplantation.
In "Chemical Biology in Regenerative Medicine, "an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. It also includes an overview of the current regulatory climate and discusses the future of these therapies. Topics covered include: Wnt Signaling in Regulation of Stem CellsDirected Cardiomyogenesis of Pluripotent Stem CellsChemical Genetics in Cardiomyocyte Generation" "Challenges and New Directions for Cardiac ReprogrammingComparative Analysis of Adult Stem Cell NichesChemicals and Stem Cells for Promoting RegenerationChemically Induced Pluripotent Stem Cells (CiPSC): A Potential Chemical Biological Breakthrough in Reprogramming?An Introduction to Cellular Reprogramming: The Plasticity of Cell Fates and IdentitiesChemicals Facilitating ReprogrammingChemicals Facilitating Reprogramming: Targeting the SAM Binding Site to Identify Novel Methyltransferase InhibitorsBiomaterials for Directed differentiation
"Chemical Biology in Regenerative Medicine" is an essential overview of this emerging technology for researchers in academia, industry and clinical settings working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering.
Pocket-sized quick reference emphasizes importance of ECG diagnostics in primary care medicine. This edition includes information on antibradycardia pacemakers, numerous 12-lead ECGs, standardized ECG evaluation sheet, and more. For students, residents, nurses and clinicians.
This open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book's promise is "no math, no code"and will explain the topics in a style that is optimized for a healthcare audience.
As a general introduction to the SNOMED CT clinical terminology code system, the book explains in simple terms a wealth of key aspects, including the fundamentals of SNOMED CT, the various ways in which it can be used, and the methods by which it may quickly be deployed for use within an electronic documentation system that deals with clinical and clinics-related data. Further considerations include how end users can employ the system, how healthcare IT designers and developers can build highly ergonomic systems, and how health informatics experts and clinical analysts can successfully harness the various features that the clinical terminology code system provides in order to unleash the hidden potentials of clinical data. The book brings together material from various sources, presenting it in an easy-to-follow manner and supplemented by analyses of a number of different (imaginary) scenarios including case summaries from the author's experience and knowledge. The book will greatly benefit all stakeholders involved: clinicians, nurses, paramedics, dentists, public health professionals, health informatics professionals and healthcare IT engineers involved in the design and development of information systems for healthcare. Students at both the undergraduate and postgraduate levels seeking a practical introduction to SNOMED CT will find this book to be a valuable guide.
An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies Now in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed. This revised fourth edition: Offers the only text available to include sample size software for use in designing and planning clinical studies Presents new and extended chapters with many additional and refreshed examples Includes clear explanations of the principles and methodologies involved with relevant practical examples Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results Contains guidance from an internationally recognised team of medical statistics experts Written for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and EpidemiologyStudies offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.
Learn need-to-know information on more than 300 dental instruments! Dental Instruments: A Pocket Guide, 6th Edition, makes it quick and easy for dental assistants and hygienists to master the identification and use of instruments and equipment used in everyday practice. It includes nearly 700 photographs and illustrations along with monographs describing each instrument's use, characteristics, practice considerations, and sterilization. It's also easy to review and to assess your knowledge, thanks to the flashcard-style, flip-book format. This spiral-bound guide is ideal both for study and for chairside reference. Clear, consistent format includes a photo of each instrument along with its name, functions, characteristics, practice notes, and sterilization, with chapters progressing from basic instruments to more specialized instruments. Nearly 700 high-quality photographs and illustrations include both full and close-up views to help you quickly and accurately identify and differentiate dental instruments. Flashcard format makes it easy to quiz yourself and assess your knowledge of dental instruments. Pocket size, spiral binding, and Velcro closure makes the book ideal for on-the-go study and ease of use. Interactive review activities on the Evolve companion website include chapter quizzes as well as tray setup exercises and questions. NEW content includes modern sickle scalers, Invisalign, CAD/CAM for orthodontics, magnified cameras for endodontics, temporary anchorage devices, cordless prophy handpieces, and more. NEW images of instruments include modern professional photographs, specifically many close-up views of instrument tips, and high-quality drawings of details that cannot be shown in a photograph. EXPANDED! In-use photos and illustrations show instruments or equipment within the context of dental care.
This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.
Over the past decade, Big Data have become ubiquitous in all economic sectors, scientific disciplines, and human activities. They have led to striking technological advances, affecting all human experiences. Our ability to manage, understand, interrogate, and interpret such extremely large, multisource, heterogeneous, incomplete, multiscale, and incongruent data has not kept pace with the rapid increase of the volume, complexity and proliferation of the deluge of digital information. There are three reasons for this shortfall. First, the volume of data is increasing much faster than the corresponding rise of our computational processing power (Kryder's law > Moore's law). Second, traditional discipline-bounds inhibit expeditious progress. Third, our education and training activities have fallen behind the accelerated trend of scientific, information, and communication advances. There are very few rigorous instructional resources, interactive learning materials, and dynamic training environments that support active data science learning. The textbook balances the mathematical foundations with dexterous demonstrations and examples of data, tools, modules and workflows that serve as pillars for the urgently needed bridge to close that supply and demand predictive analytic skills gap. Exposing the enormous opportunities presented by the tsunami of Big data, this textbook aims to identify specific knowledge gaps, educational barriers, and workforce readiness deficiencies. Specifically, it focuses on the development of a transdisciplinary curriculum integrating modern computational methods, advanced data science techniques, innovative biomedical applications, and impactful health analytics. The content of this graduate-level textbook fills a substantial gap in integrating modern engineering concepts, computational algorithms, mathematical optimization, statistical computing and biomedical inference. Big data analytic techniques and predictive scientific methods demand broad transdisciplinary knowledge, appeal to an extremely wide spectrum of readers/learners, and provide incredible opportunities for engagement throughout the academy, industry, regulatory and funding agencies. The two examples below demonstrate the powerful need for scientific knowledge, computational abilities, interdisciplinary expertise, and modern technologies necessary to achieve desired outcomes (improving human health and optimizing future return on investment). This can only be achieved by appropriately trained teams of researchers who can develop robust decision support systems using modern techniques and effective end-to-end protocols, like the ones described in this textbook. * A geriatric neurologist is examining a patient complaining of gait imbalance and posture instability. To determine if the patient may suffer from Parkinson's disease, the physician acquires clinical, cognitive, phenotypic, imaging, and genetics data (Big Data). Most clinics and healthcare centers are not equipped with skilled data analytic teams that can wrangle, harmonize and interpret such complex datasets. A learner that completes a course of study using this textbook will have the competency and ability to manage the data, generate a protocol for deriving biomarkers, and provide an actionable decision support system. The results of this protocol will help the physician understand the entire patient dataset and assist in making a holistic evidence-based, data-driven, clinical diagnosis. * To improve the return on investment for their shareholders, a healthcare manufacturer needs to forecast the demand for their product subject to environmental, demographic, economic, and bio-social sentiment data (Big Data). The organization's data-analytics team is tasked with developing a protocol that identifies, aggregates, harmonizes, models and analyzes these heterogeneous data elements to generate a trend forecast. This system needs to provide an automated, adaptive, scalable, and reliable prediction of the optimal investment, e.g., R&D allocation, that maximizes the company's bottom line. A reader that complete a course of study using this textbook will be able to ingest the observed structured and unstructured data, mathematically represent the data as a computable object, apply appropriate model-based and model-free prediction techniques. The results of these techniques may be used to forecast the expected relation between the company's investment, product supply, general demand of healthcare (providers and patients), and estimate the return on initial investments.
Adopting a proactive approach and focusing on emerging radiation-generating technologies, "Health Physics in the 21st Century" meets the growing need for a presentation of the relevant radiological characteristics and hazards. As such, this monograph discusses those technologies that will affect the health physics and radiation protection profession over the decades to come.
After an introductory overview, the second part of this book looks at fission and fusion energy, followed by a section devoted to accelerators, while the final main section deals with radiation on manned space missions. Throughout, the author summarizes the relevant technology and scientific basis, while providing over 200 problems plus solutions to illustrate and amplify the text.
Twelve appendices add further background material to support and enrich the topics addressed in the text, making this invaluable reading for students and lecturers in physics, biophysicists, clinical, nuclear and radiation physicists, as well as physicists in industry.
Technological innovation is deeply woven into the fabric of American culture, and is no less a basic feature of American health care. Medical technology saves lives and relieves suffering, and is enormously popular with the public, profitable for doctors, and a source of great wealth for industry. Yet its costs are rising at a dangerously unsustainable rate. The control of technology costs poses a terrible ethical and policy dilemma. How can we deny people what they may need to live and flourish? Yet is it not also harmful to let rising costs strangle our health care system, eventually harming everyone? In Taming the Beloved Beast, esteemed medical ethicist Daniel Callahan confronts this dilemma head-on. He argues that we can't escape it by organizational changes alone. Nothing less than a fundamental transformation of our thinking about health care is needed to achieve lasting and economically sustainable reform. The technology bubble, he contends, is beginning to burst. Callahan weighs the ethical arguments for and against limiting the use of medical technologies, and he argues that reining in health care costs requires us to change entrenched values about progress and technological innovation. Taming the Beloved Beast shows that the cost crisis is as great as that of the uninsured. Only a government-regulated universal health care system can offer the hope of managing technology and making it affordable for all.
Colloidal systems occur everywhere in soils, seawater, foodstuff, pharmaceuticals, paints, blood, biological cells, and microorganisms. Colloids and Interfaces in Life Sciences and Bionanotechnology, Second Edition, gives a concise treatment of physicochemical principles determining interrelated colloidal and interfacial phenomena.
New in the Second Edition
Focusing on physicochemical concepts that form the basis of understanding colloidal and interfacial phenomena rather than on experimental methods and techniques this book is an excellent primer for students and scientists interested in colloidal and interfacial phenomena, their mutual relations and connections, and the fascinating role they play in natural and man-made systems.
By the year 2050, the world's population is expected to reach nine billion. To feed and sustain this projected population, world food production must increase by at least 50 percent on much of the same land that we farm today. To meet this staggering challenge, scientists must develop the technology required to achieve an "evergreen" revolution -- one that increases crop productivity without degrading natural resources. With 30 percent new material, the updated and revised third edition of Growth and Mineral Nutrition of Field Crops covers all aspects of crop growth and mineral nutrition that contribute to sustainable, high-yield agriculture. Bringing together international scientific knowledge of crop production and the impacts of agriculture on the environment, this book: * Includes two new chapters on remediation of heavy-metal contaminated soils and cover crops * Covers theoretical and practical aspects of mineral nutrition of field crops * Provides recommendations for judicious use of fertilizers, which will reduce cost of crop production and enhance high crop yields without risking environmental pollution * Provides growth patterns for annual crops and forages * Includes a handful of color pictures of nutrient deficiencies for easy diagnostic purposes To make the book as practical as possible, each chapter is supported by experimental results and extensive references. A large number of figures and tables are also included to save readers time when researching. The overall emphasis of this reference is on the soil's ability to sustain high crop yields and a healthy human population.
This book outlines the principle and display methods of stereopsis, the biological effects of image viewing, and the effects on the human body, as well as its clinical significance. The authors also present the latest research findings and future prospects for stereopsis methods. In the field of medical care, the technique is useful for the 3-dimensional identification of lesions and affected regions; however, stereoscopic images can cause unpleasant symptoms including motion sickness, headache, and visual fatigue. With increasing opportunities for using the stereoscopic viewing technique in various other fields outside medicine, it is important to resolve the underlying issues of stereoscopic viewing and improve the diagnostic accuracy, safety of surgery and reduce the stress for physicians. Written by pioneering authors, Cutting Edge in Information Displays and Hygiene is a valuable resource for both new and established researchers and students seeking comprehensive information on stereoscopic imaging methods as well as professionals working in environmental/occupational health and health promotion.
Advances in medicine have brought us the stethoscope, artificial kidneys, and computerized health records. They have also changed the doctor-patient relationship. This book explores how the technologies of medicine are created and how we respond to the problems and successes of their use. Stanley Joel Reiser, MD, walks us through the ways medical innovations exert their influence by discussing a number of selected technologies, including the X-ray, ultrasound, and respirator. Reiser creates a new understanding of thinking about how health care is practiced in the United States and thereby suggests new methods to effectively meet the challenges of living with technological medicine. As healthcare reform continues to be an intensely debated topic in America, Technological Medicine shows us the pros and cons of applying technological solutions health and illness.
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