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This book provides biomedical engineers with the premiere reference on medical instrumentation as well as a comprehensive overview of the basic concepts. The revised edition features new material on infant apnea monitors, impedance pneumography, the design of cardiac pacemakers, and disposable defibrillator electrodes and their standards. Each chapter includes new problems and updated reference material that cover the latest medical technologies. The chapters have also been revised with new material in medical imaging, providing biomedical engineers with the most current techniques in the field.
The Pacific Symposium on Biocomputing (PSB) 2015 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2015 will be held from January 4 - 8, 2015 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2015 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
How new biomedical technologies-from prenatal testing to gene-editing techniques-require us to imagine who counts as human and what it means to belong. From next-generation prenatal tests, to virtual children, to the genome-editing tool CRISPR-Cas9, new biotechnologies grant us unprecedented power to predict and shape future people. That power implies a question about belonging: which people, which variations, will we welcome? How will we square new biotech advances with the real but fragile gains for people with disabilities-especially when their voices are all but absent from the conversation? This book explores that conversation, the troubled territory where biotechnology and disability meet. In it, George Estreich-an award-winning poet and memoirist, and the father of a young woman with Down syndrome-delves into popular representations of cutting-edge biotech: websites advertising next-generation prenatal tests, feature articles on "three-parent IVF," a scientist's memoir of constructing a semisynthetic cell, and more. As Estreich shows, each new application of biotechnology is accompanied by a persuasive story, one that minimizes downsides and promises enormous benefits. In this story, people with disabilities are both invisible and essential: a key promise of new technologies is that disability will be repaired or prevented. In chapters that blend personal narrative and scholarship, Estreich restores disability to our narratives of technology. He also considers broader themes: the place of people with disabilities in a world built for the able; the echoes of eugenic history in the genomic present; and the equation of intellect and human value. Examining the stories we tell ourselves, the fables already creating our futures, Estreich argues that, given biotech that can select and shape who we are, we need to imagine, as broadly as possible, what it means to belong.
The bright colour of haemoglobin has, from the very beginning,
played a significant role in both the investigation of this
compound as well as in the study of blood oxygen transport.
Numerous optical methods have been developed for measuring
haemoglobin concentration, oxygen saturation, and the principal
dyshaemoglobins in vitro as well as in vivo. Modern applications
include pulse oximeters, fibre optic oximeters, multiwavelength
haemoglobin photometers ('co-oximeters') and instruments for near
infrared spectroscopy in vivo. Knowledge of the light absorption
spectra of the common haemoglobin derivatives is a prerequisite for
the development and understanding of these techniques.
The Pacific Symposium on Biocomputing (PSB) 2017 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2017 will be held on January 4 - 8, 2017 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2017 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
* A step-by-step look at a growing and difficult to understand
This practical text provides an overview of the adverse consequences of health information technology (HIT) and its impact on patient safety. Specific cases of errors and risks related to various types of HIT are featured along with best practices for patient safety, workflows and organizational standards. The full impact of these challenges with meaningful solutions are openly examined. Written from a clinical perspective, healthcare professionals within multiple settings will find this timely book an invaluable resource to this essential and bourgeoning technology.
Massage, aromatherapy, reflexology and a variety of relaxation techniques are frequently used in hospices, supportive care settings and some hospitals. However, there are still gaps and limitations in the choices offered to patients. HEARTS (Hands-on, Empathy, Aromas, Relaxation, Textures, Sound) was devised to bridge this gap for complementary therapists, patients, carers and health care professionals. HEARTS can be used either on its own, or integrated with a conventional complementary therapy. It can also be used easily by health care workers (and carers) who are not qualified in any therapies. By discussing principles which may influence the effectiveness of touch and relaxation therapies, the book emphasises that there are 'easy' approaches that can be utilised when working with distressed and vulnerable patients. By developing an understanding of touch, aromas and the sound of the human voice, Combining Touch and Relaxation Skills for Cancer Care guides practitioners in helping their patients achieve a state of relaxation and calm as quickly and easily as possible.
A midwife is responsible for recording the progress of labour on a partograph or partogram. The partograph helps caregivers detect whether labour is progressing normally or not, indicates when augmentation of labour is appropriate and assists in recognising potential problems before they occur. Each title covers one important topic, and has been written by a specialist in that field. The series follows a consistent format and covers issues such as key ethical and legal considerations, relevant legislation, case studies, and practical applications. These concise, accessible texts will be suitable for accreditation when continuing professional development becomes a requirement
This book provides an up-to-date overview of the clinical applications, methods, and technologies of teleophthalmology within the field of preventive medicine. The ability of novel methods to detect the initial signs of neurodegenerative diseases on the basis of alterations in the retina is reviewed, and detailed attention is paid to the role of teleophthalmology in screening for vision-threatening diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. A major part of the book is devoted to novel imaging methods and the latest information technologies, including advanced mobile communication and Web 2.0 applications in teleophthalmology. In addition, the initial projects of an interdisciplinary cooperation in preventive medicine are described. All of the authors are experienced in the scientific and practical aspects of teleophthalmology, including e-learning, and have produced a book that will meet the needs of all medical care providers interested in using teleophthalmology.
This scholarly set of well-harmonized volumes provides indispensable and complete coverage of the exciting and evolving subject of medical imaging systems. Leading experts on the international scene tackle the latest cutting-edge techniques and technologies in an in-depth but eminently clear and readable approach. Complementing and intersecting one another, each volume offers a comprehensive treatment of substantive importance to the subject areas. The chapters, in turn, address topics in a self-contained manner with authoritative introductions, useful summaries, and detailed reference lists. Extensively well-illustrated with figures throughout, the five volumes as a whole achieve a unique depth and breath of coverage. As a cohesive whole or independent of one another, the volumes may be acquired as a set or individually.
An authoritative resource that offers the statistical tools and software needed to design and plan valid clinical studies Now in its fourth and extended edition, Sample Sizes for Clinical, Laboratory and Epidemiology Studiesincludes the sample size software (SSS) and formulae and numerical tables needed to design valid clinical studies. The text covers clinical as well as laboratory and epidemiology studies and contains the information needed to ensure a study will form a valid contribution to medical research. The authors, noted experts in the field, explain step by step and explore the wide range of considerations necessary to assist investigational teams when deriving an appropriate sample size for their when planned study. The book contains sets of sample size tables with companion explanations and clear worked out examples based on real data. In addition, the text offers bibliography and references sections that are designed to be helpful with guidance on the principles discussed. This revised fourth edition: Offers the only text available to include sample size software for use in designing and planning clinical studies Presents new and extended chapters with many additional and refreshed examples Includes clear explanations of the principles and methodologies involved with relevant practical examples Makes clear a complex but vital topic that is designed to ensure valid methodology and publishable results Contains guidance from an internationally recognised team of medical statistics experts Written for medical researchers from all specialities and medical statisticians, Sample Sizes for Clinical, Laboratory and EpidemiologyStudies offers an updated fourth edition of the important guide for designing and planning reliable and evidence based clinical studies.
Biologists are stepping up their efforts in understanding the biological processes that underlie disease pathways in the clinical contexts. This has resulted in a flood of biological and clinical data from genomic and protein sequences, DNA microarrays, protein interactions, biomedical images, to disease pathways and electronic health records. To exploit these data for discovering new knowledge that can be translated into clinical applications, there are fundamental data analysis difficulties that have to be overcome. Practical issues such as handling noisy and incomplete data, processing compute-intensive tasks, and integrating various data sources, are new challenges faced by biologists in the post-genome era. This book will cover the fundamentals of state-of-the-art data mining techniques which have been designed to handle such challenging data analysis problems, and demonstrate with real applications how biologists and clinical scientists can employ data mining to enable them to make meaningful observations and discoveries from a wide array of heterogeneous data from molecular biology to pharmaceutical and clinical domains.
This book provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response. Common ways to modify implant surfaces are described, and methods for the evaluation of surface properties are presented in an easy-to-read style. Experimental results that have contributed to surface modifications relevant for commercial available implants are presented, with emphasis on in vivo and clinical studies. While the focus is primarily on surface modifications at the micrometer and nanometer levels, alterations at the millimeter level are also covered, including thread designs and their possible influence on stress distribution. In addition, it is analyzed how surface alterations have changed the clinical long-term results for certain groups of patients.
"Clinical Engineering" is intended for professionals and students in the clinical engineering field who need to successfully deploy medical technologies. The book provides a broad reference to the core elements of the subject and draws from the expertise of a range of experienced authors.
In addition to engineering skills, clinical engineers must be
able to work with patients and with a range of professional staff,
including technicians and clinicians, and with equipment
manufacturers. They have to keep up-to-date with fast-moving
scientific and medical research in the field and be able to develop
laboratory, design, workshop, and management skills. This book is
the ideal companion in such studies, covering fundamentals such as
IT and software engineering as well as topics in rehabilitation and
Learn need-to-know information on more than 300 dental instruments! Dental Instruments: A Pocket Guide, 6th Edition, makes it quick and easy for dental assistants and hygienists to master the identification and use of instruments and equipment used in everyday practice. It includes nearly 700 photographs and illustrations along with monographs describing each instrument's use, characteristics, practice considerations, and sterilization. It's also easy to review and to assess your knowledge, thanks to the flashcard-style, flip-book format. This spiral-bound guide is ideal both for study and for chairside reference. Clear, consistent format includes a photo of each instrument along with its name, functions, characteristics, practice notes, and sterilization, with chapters progressing from basic instruments to more specialized instruments. Nearly 700 high-quality photographs and illustrations include both full and close-up views to help you quickly and accurately identify and differentiate dental instruments. Flashcard format makes it easy to quiz yourself and assess your knowledge of dental instruments. Pocket size, spiral binding, and Velcro closure makes the book ideal for on-the-go study and ease of use. Interactive review activities on the Evolve companion website include chapter quizzes as well as tray setup exercises and questions. NEW content includes modern sickle scalers, Invisalign, CAD/CAM for orthodontics, magnified cameras for endodontics, temporary anchorage devices, cordless prophy handpieces, and more. NEW images of instruments include modern professional photographs, specifically many close-up views of instrument tips, and high-quality drawings of details that cannot be shown in a photograph. EXPANDED! In-use photos and illustrations show instruments or equipment within the context of dental care.
Over the past decade, Big Data have become ubiquitous in all economic sectors, scientific disciplines, and human activities. They have led to striking technological advances, affecting all human experiences. Our ability to manage, understand, interrogate, and interpret such extremely large, multisource, heterogeneous, incomplete, multiscale, and incongruent data has not kept pace with the rapid increase of the volume, complexity and proliferation of the deluge of digital information. There are three reasons for this shortfall. First, the volume of data is increasing much faster than the corresponding rise of our computational processing power (Kryder's law > Moore's law). Second, traditional discipline-bounds inhibit expeditious progress. Third, our education and training activities have fallen behind the accelerated trend of scientific, information, and communication advances. There are very few rigorous instructional resources, interactive learning materials, and dynamic training environments that support active data science learning. The textbook balances the mathematical foundations with dexterous demonstrations and examples of data, tools, modules and workflows that serve as pillars for the urgently needed bridge to close that supply and demand predictive analytic skills gap. Exposing the enormous opportunities presented by the tsunami of Big data, this textbook aims to identify specific knowledge gaps, educational barriers, and workforce readiness deficiencies. Specifically, it focuses on the development of a transdisciplinary curriculum integrating modern computational methods, advanced data science techniques, innovative biomedical applications, and impactful health analytics. The content of this graduate-level textbook fills a substantial gap in integrating modern engineering concepts, computational algorithms, mathematical optimization, statistical computing and biomedical inference. Big data analytic techniques and predictive scientific methods demand broad transdisciplinary knowledge, appeal to an extremely wide spectrum of readers/learners, and provide incredible opportunities for engagement throughout the academy, industry, regulatory and funding agencies. The two examples below demonstrate the powerful need for scientific knowledge, computational abilities, interdisciplinary expertise, and modern technologies necessary to achieve desired outcomes (improving human health and optimizing future return on investment). This can only be achieved by appropriately trained teams of researchers who can develop robust decision support systems using modern techniques and effective end-to-end protocols, like the ones described in this textbook. * A geriatric neurologist is examining a patient complaining of gait imbalance and posture instability. To determine if the patient may suffer from Parkinson's disease, the physician acquires clinical, cognitive, phenotypic, imaging, and genetics data (Big Data). Most clinics and healthcare centers are not equipped with skilled data analytic teams that can wrangle, harmonize and interpret such complex datasets. A learner that completes a course of study using this textbook will have the competency and ability to manage the data, generate a protocol for deriving biomarkers, and provide an actionable decision support system. The results of this protocol will help the physician understand the entire patient dataset and assist in making a holistic evidence-based, data-driven, clinical diagnosis. * To improve the return on investment for their shareholders, a healthcare manufacturer needs to forecast the demand for their product subject to environmental, demographic, economic, and bio-social sentiment data (Big Data). The organization's data-analytics team is tasked with developing a protocol that identifies, aggregates, harmonizes, models and analyzes these heterogeneous data elements to generate a trend forecast. This system needs to provide an automated, adaptive, scalable, and reliable prediction of the optimal investment, e.g., R&D allocation, that maximizes the company's bottom line. A reader that complete a course of study using this textbook will be able to ingest the observed structured and unstructured data, mathematically represent the data as a computable object, apply appropriate model-based and model-free prediction techniques. The results of these techniques may be used to forecast the expected relation between the company's investment, product supply, general demand of healthcare (providers and patients), and estimate the return on initial investments.
Regenerative medicine is a highly interdisciplinary field, with contributions from medicine, engineering, and chemistry. Chemical biology plays a key role - small molecules are involved in differentiating, reprogramming and manipulating stem cells and in enabling transplantation.
In "Chemical Biology in Regenerative Medicine, "an international team of experts provides an overview of progress towards clinical application in the areas of transplantation (allogenic and autologous), manipulation of niche environment and homing, and cell reprogramming (trans-differentiation and de-differentiation). The book highlights the interdisciplinary approaches undertaken to resolve current technical problems in regenerative medicine, with special attention paid to small molecules and biomaterials engineering. It also includes an overview of the current regulatory climate and discusses the future of these therapies. Topics covered include: Wnt Signaling in Regulation of Stem CellsDirected Cardiomyogenesis of Pluripotent Stem CellsChemical Genetics in Cardiomyocyte Generation" "Challenges and New Directions for Cardiac ReprogrammingComparative Analysis of Adult Stem Cell NichesChemicals and Stem Cells for Promoting RegenerationChemically Induced Pluripotent Stem Cells (CiPSC): A Potential Chemical Biological Breakthrough in Reprogramming?An Introduction to Cellular Reprogramming: The Plasticity of Cell Fates and IdentitiesChemicals Facilitating ReprogrammingChemicals Facilitating Reprogramming: Targeting the SAM Binding Site to Identify Novel Methyltransferase InhibitorsBiomaterials for Directed differentiation
"Chemical Biology in Regenerative Medicine" is an essential overview of this emerging technology for researchers in academia, industry and clinical settings working in regenerative medicine, chemical biology, biochemistry, cell biology, biomaterials and bioengineering.
As a general introduction to the SNOMED CT clinical terminology code system, the book explains in simple terms a wealth of key aspects, including the fundamentals of SNOMED CT, the various ways in which it can be used, and the methods by which it may quickly be deployed for use within an electronic documentation system that deals with clinical and clinics-related data. Further considerations include how end users can employ the system, how healthcare IT designers and developers can build highly ergonomic systems, and how health informatics experts and clinical analysts can successfully harness the various features that the clinical terminology code system provides in order to unleash the hidden potentials of clinical data. The book brings together material from various sources, presenting it in an easy-to-follow manner and supplemented by analyses of a number of different (imaginary) scenarios including case summaries from the author's experience and knowledge. The book will greatly benefit all stakeholders involved: clinicians, nurses, paramedics, dentists, public health professionals, health informatics professionals and healthcare IT engineers involved in the design and development of information systems for healthcare. Students at both the undergraduate and postgraduate levels seeking a practical introduction to SNOMED CT will find this book to be a valuable guide.
The field of forensic arts therapies is dynamic and diverse, and so this unique volume covers a fascinating range of work. It brings together a collection of presentations given at FATAG conferences, case studies, research, new developments in theory, and explorations in the peculiarities of forensic arts therapies: art, music, drama, and dance. Therapists work with male and female offenders in detained in prisons or secure health care units, or sometimes with patients involved in probation or counselling services, victim support, and other services and institutions concerned with understanding the causes and effects of crime. The experiences described are often difficult, but also very rewarding for all involved. Arts therapy (in any of its forms) regularly has a profound and beneficial effect on the life of an offender. This thought-provoking and enlightening work gives an insight into how these skilled professionals have been a necessary part of UK forensic services for more than four decades.The Forensic Arts Therapies Advisory Group (FATAG) is a voluntary organisation which aims to provide support, advice and opportunities for continuing professional development for arts therapists working in forensic or secure settings and trainee arts therapists on clinical placement in forensics. FATAG provides a safe space to share difficult, complex and, at times, painful work not easily shared amongst a non-forensic audience.
This text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.
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