The journal Biomaterials was launched in 1980. The subject of biomaterials science was then in its infancy, being largely cofined to the study of the characteristics of materials used for medical devices. Twenty-five years on, we can truly say that biomaterials science has matured at an incredible rate and now represents a formidable sector that bridges the materials sciences, advanced medical therapies, and molecular and cell sciences. This Silver Jubilee Compendium consists of reprinted versions of the top 25 papers, published during these 25 years, as judged by an international panel of biomaterials scientists. This book is published as a landmark in biomaterials science and it is to be hoped that it will serve as a stimulus to young biomaterials scientists of the early twenty-first century for their pioneering work of the future.

Over the past decade, there has been rapid growth in bioengineering applications in the field of spine implants. This book explains the technical foundation for understanding and expanding the field of spine implants, reviews the major established technologies related to spine implants, and provides reference material for developing and commercializing new spine implants. The editors, who have a track record of collaboration and editing technical books, provide a unified approach to this topic in the most comprehensive and useful book to date.
-Related website provides the latest information on spine technology including articles and research papers on the latest technology and development.
-Major technologies reviewed include devices used for fusion (screws, plates, rods, and cages), disc repair and augmentation, total disc replacement, and vertebral body repair and augmentation.
-Technology landscape, review of published/public domain data currently available, and safety and efficacy of technology discussed in detail.

The field of statistics not only affects all areas of scientific activity, but also many other matters such aspublic policy. It is branching rapidly into so many different subjects that a series of handbooks is the only way of comprehensively presenting the various aspects of statistical methodology, applications, and recent developments.

The Handbook of Statistics, a series of self-contained reference books. Each volume is devoted to a particular topic in statistics with Volume 28 dealing with bioinformatics. Every chapter is written by prominent workers in the area to which the volume is devoted. The series is addressed to the entire community of statisticians and scientists in various disciplines who use statistical methodology in their work. At the same time, special emphasis is placed on applications-oriented techniques, with the applied statistician in mind as the primary audience.
Comprehensively presents the various aspects of statistical methodologyDiscusses a wide variety of diverse applications and recent developmentsContributors are internationally renowned experts in their respective areas"

SAS Data Management for Public Health: An Introduction equips readers with the tools and knowledge they need to prepare public health data in SAS Data Management software for use in analysis. Highly accessible in nature, the book is specifically designed to help students who are new to SAS learn and master the system. The book is organized into 20 lessons. The opening lessons introduce SAS and provide tips and best practices for exploring data. Students are introduced to PROC MEANS, FREQ, UNIVARIATE, and PROC SGPLOT. They learn how to import data; merge, concatenate, and manage variables; perform data cleanup; and recode categorical and continuous variables. Specific lessons address comments, labels, and titles, formatting variables, conditional recoding, DO groups, arrays for recoding, and categorical data analysis. Closing lessons introduce stratified and subpopulation analysis, as well as logistic regression. The book includes an appendix to help students navigate and use SAS Studio. SAS Data Management for Public Health is an ideal resource for standalone courses in which SAS is taught or to complement any biostatistics or epidemiology course where students need to use SAS to analyze their data.

This book presents a variety of perspectives on vision-based applications. These contributions are focused on optoelectronic sensors, 3D & 2D machine vision technologies, robot navigation, control schemes, motion controllers, intelligent algorithms and vision systems. The authors focus on applications of unmanned aerial vehicles, autonomous and mobile robots, industrial inspection applications and structural health monitoring. Recent advanced research in measurement and others areas where 3D & 2D machine vision and machine control play an important role, as well as surveys and reviews about vision-based applications. These topics are of interest to readers from diverse areas, including electrical, electronics and computer engineering, technologists, students and non-specialist readers. * Presents current research in image and signal sensors, methods, and 3D & 2D technologies in vision-based theories and applications; * Discusses applications such as daily use devices including robotics, detection, tracking and stereoscopic vision systems, pose estimation, avoidance of objects, control and data exchange for navigation, and aerial imagery processing; * Includes research contributions in scientific, industrial, and civil applications.

The healthcare industry is starting to adopt digital twins to improve personalized medicine, healthcare organization performance, and new medicine and devices. These digital twins can create useful models based on information from wearable devices, omics, and patient records to connect the dots across processes that span patients, doctors, and healthcare organizations as well as drug and device manufacturers. Digital twins are digital representations of human physiology built on computer models. The use of digital twins in healthcare is revolutionizing clinical processes and hospital management by enhancing medical care with digital tracking and advancing modelling of the human body. These tools are of great help to researchers in studying diseases, new drugs, and medical devices. Digital Twins and Healthcare: Trends, Techniques, and Challenges facilitates the advancement and knowledge dissemination in methodologies and applications of digital twins in the healthcare and medicine fields. This book raises interest and awareness of the uses of digital twins in healthcare in the research community. Covering topics such as deep neural network, edge computing, and transfer learning method, this premier reference source is an essential resource for hospital administrators, pharmacists, medical professionals, IT consultants, students and educators of higher education, librarians, and researchers.

Progress in ubiquitous computing, social networking, medical informatics and IT technologies has resulted in a new generation of healthcare systems. Ubiquitous Health and Medical Informatics: The Ubiquity 2.0 Trend and Beyond provides insight into the various trends, innovations, and organizational challenges of contemporary ubiquitous health and medical informatics. Contributions highlight changes to healthcare distribution that will significantly revolutionize the exchange between healthcare providers and consumers.

The application of biosensors is expanding in different areas. These are portable and convenient devices that permit the rapid, accurate, and reliable detection of analytes of interest present either in the atmosphere or in aqueous or in liquid phases. The detection of glucose levels in blood for the effective management of diabetes is one. Though different biosensors have been designed for an increasing number of applications, the kinetics of binding (and dissociation) of analytes by the receptors on the biosensor surfaces has not been given enough attention in the open literature. This is a very important area of investigation since it significantly impacts biosensor performance parameters such as stability, sensitivity, selectivity, response time, regenerability, etc. Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals addresses this critical need besides helping to correct or demonstrate the need to modify the present software available with commercial biosensors that determines the kinetics of analyte-receptor reactions on biosensor surfaces.
* first book to provide detailed kinetic analysis of the binding and dissociation reactions that are occuring on the biosensor surface
* addresses the area of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces
* provides physical insights into reactions occuring on biosensor surfaces

Women's health comprises a large range of activities including fertility and reproductive health and screening and treatment for gynecological conditions, with computer systems providing vital support. Medical Informatics in Obstetrics and Gynecology provides industry knowledge and insight to challenges in the areas of informatics that are important to women's health. Covering topics such as ethical and legal issues, imaging and communication systems, and electronic health records, this Medical Information Science Reference publication provides medical libraries and researchers, as well as medical students, health technology specialists, and practicing physicians and nurses with unrivaled data on the role of technology in obstetrics and gynecology.

No longer confined to medical devices, medical software has become a pervasive technology giving healthcare operators access to clinical information stored in electronic health records and clinical decision support systems, supporting robot-assisted telesurgery, and providing the technology behind ambient assisted living. These systems and software must be designed, built and maintained according to strict regulations and standards to ensure that they are safe, reliable and secure. Engineering High Quality Medical Software illustrates how to exploit techniques, methodologies, development processes and existing standards to realize high-confidence medical software. After an introductory survey of the topic the book covers global regulations and standards (including EU MDD 93/42/EEC, FDA Title 21 of US CFR, ISO 13485, ISO 14971, IEC 52304, IEEE 1012 and ISO/IEC 29119), verification and validation techniques and techniques, and methodologies and engineering tasks for the development, configuration and maintenance of medical software.

Interest in Information and Communication Technologies for human monitoring, smart health and assisted living is growing due to the significant impact that these technologies are expected to have on improving the quality of life of ageing populations around the world. This book brings together chapters written by a range of researchers working in these topics, providing an overview of the areas and covering current research, developments and applications for a readership of researchers and research-led engineering practitioners. It discusses the promises and the possible advantages of these technologies, and also indicates the challenges for the future. Topics covered include: personal monitoring and health data acquisition in smart homes; contactless monitoring of respiratory activity; technology-based assistance of people with dementia; wearable sensors for gesture analysis; design and prototyping of home automation systems for the monitoring of elderly people; multi-sensor platform for circadian rhythm analysis; smart multi-sensor solutions for activity detection; human monitoring based on heterogeneous sensor networks; mobile health for vital signs and gait monitoring systems; and smartphone-based blood pressure monitoring for falls risk assessment.

The Handbook of Research on Informatics in Healthcare and Biomedicine is the single authoritative reference source for information on the newest trends and breakthroughs in computer applications applied to healthcare and biomedicine. Innovative technologies in health information systems, medicine, health services, and other areas in biomedicine are explored. The comprehensive chapters contained in this handbook of research have been written by 99 international experts from the field of healthcare and IT. More than 900 references to existing publications and a wide-ranging compendium of over 450 key terms and definitions have been included to provide readers with the ultimate research tool.

The new edition of this practical text presents a clear anatomic approach to locating the needle insertion site for EMG. Succinct descriptions are provided for 71 routinely tested muscles, and each is accompanied by a full-page drawing of the muscle and related anatomy. Many new cross-sectional drawings have been added to further delineate the anatomy. Guidelines have been expanded throughout to include more detail. There are also more pearls, additional tips on avoiding pitfalls, and anatomical and clinical descriptions. Teaching points have been expanded and replace the previous "notes" from the first edition. The text is in outline format and indicates peripheral and nerve root innervations and patient positioning.

Aging, Health and Technology takes a problem-centered approach to examine how older adults use technology for health. It examines the many ways in which technology is being used by older adults, focusing on challenges, solutions and perspectives of the older user. Using aging-health technology as a lens, the book examines issues of technology adoption, basic human factors, cognitive aging, mental health, aging and usability, privacy, trust and automation. Each chapter takes a case study approach to summarize lessons learned from unique examples that can be applied to similar projects, while also providing general information about older adults and technology.

This book focuses on the state-of-the-art of biosensor research and development for specialists and non-specialists. It introduces the fundamentals of the subject with relevant characteristics of transducer elements, as well as biochemical recognition molecules. This book is ideal for researchers of nanotechnology, materials science and biophysics.

Biomedical Texture Analysis: Fundamentals, Applications, Tools and Challenges describes the fundamentals and applications of biomedical texture analysis (BTA) for precision medicine. It defines what biomedical textures (BTs) are and why they require specific image analysis design approaches when compared to more classical computer vision applications. The fundamental properties of BTs are given to highlight key aspects of texture operator design, providing a foundation for biomedical engineers to build the next generation of biomedical texture operators. Examples of novel texture operators are described and their ability to characterize BTs are demonstrated in a variety of applications in radiology and digital histopathology. Recent open-source software frameworks which enable the extraction, exploration and analysis of 2D and 3D texture-based imaging biomarkers are also presented. This book provides a thorough background on texture analysis for graduate students and biomedical engineers from both industry and academia who have basic image processing knowledge. Medical doctors and biologists with no background in image processing will also find available methods and software tools for analyzing textures in medical images.

Microdialysis is currently one of the most important in vivo sampling methods in physiology and pharmacology. It is used to determine the chemical components of the fluid in the extracellular space of tissues. The technique is now well established in neuroscience research and is used excessively in behavioral neuroscience to determine the concentrations and identities of molecules in brain tissues, and their change due to behavior, hormonal and transmitter changes in the nervous system. The book provides a detailed comprehensive overview of the technology and its applications, including application in pathology, drug development, and the application in the clinic. The authors are all well known researchers in Neuroscience and experts in the use of Microdialysis.
Organized into two parts of seven sections, the Handbook of Microdialysis critically examines recent developments in the field through a variety of chapters written by an internationally acclaimed group of authors. It is the first comprehensive handbook covering the technology of Microdialysis and its applications in Neuroscience.
* Presents microdialysis methods and interpretation including the technical aspects of microdialysis as a sampling technique followed by the analytical chemical methods
* Discusses the role of microdialysis in pharmacology, drug development and models of CNS
pathology
* Includes clinical applications of microdialysis