Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included.

Wound Healing Biomaterials: Volume Two, Functional Biomaterials discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal wounds opening up a new area of research in biomaterials and the ways they can be applied to the challenges associated with wound care. Much research is now concerned with new therapies, regeneration methods, and the use of biomaterials that can assist in wound healing and alter healing responses. This book provides readers with a thorough review of the functional biomaterials used for wound healing, with chapters discussing the fundamentals of wound healing biomaterials, films for wound healing applications, polymer-based dressing for wound healing applications, and functional dressings for wound care.

Wound Healing Biomaterials: Volume One, Therapies and Regeneration discusses the types of wounds associated with trauma, illness, or surgery that can sometimes be extremely complex and difficult to heal. Consequently, there is a prominent drive for scientists and clinicians to find methods to heal these types of wounds, with science increasingly turning towards biomaterials to address these challenges. Much research is now concerned with new therapies, regeneration methods, and biomaterials to assist in wound healing and healing response. This book provides readers with a comprehensive review of the fundamentals and advances in the field of wound healing with regard to therapies and tissue regeneration. Chapters in Part One discuss fundamentals and strategies of wound healing, while Part Two reviews gene, stem cell, and drug delivery therapies for wound healing. Final chapters look at tissue regeneration strategies, making this an all-encompassing book on the topic of wound care and biomaterials.

The journal Biomaterials was launched in 1980. The subject of biomaterials science was then in its infancy, being largely cofined to the study of the characteristics of materials used for medical devices. Twenty-five years on, we can truly say that biomaterials science has matured at an incredible rate and now represents a formidable sector that bridges the materials sciences, advanced medical therapies, and molecular and cell sciences. This Silver Jubilee Compendium consists of reprinted versions of the top 25 papers, published during these 25 years, as judged by an international panel of biomaterials scientists. This book is published as a landmark in biomaterials science and it is to be hoped that it will serve as a stimulus to young biomaterials scientists of the early twenty-first century for their pioneering work of the future.

Informed and Healthy: Theoretical and Applied Perspectives on the Value of Information to Health Care focuses on two major issues: the value attributed to information by users and its effect on health care; and, a new model of information behavior in which the value of information drives various information activities (unlike many information models which tend to give prominence to information needs). The inductive development of the model is explained, with associated implications for theory and transferability or applicability elsewhere. The book uses a case study of the health information system in Uganda and expands the analysis by comparing it to other systems utilized by different countries in diverse levels of development. Topics such as access and use of information; value attribution and effect on health outcomes; and modelling information behavior and its implications on health informatics are discussed in detail. This book is a valuable resource for health professionals, planners, and policy makers, as well as researchers interested in health information systems and their applicability in different environments.

Sensors for Health Monitoring discusses the characteristics of U-Healthcare systems in different domains, providing a foundation for working professionals and undergraduate and postgraduate students. The book provides information and advice on how to choose the best sensors for a U-Healthcare system, advises and guides readers on how to overcome challenges relating to data acquisition and signal processing, and presents comprehensive coverage of up-to-date requirements in hardware, communication and calculation for next-generation uHealth systems. It then compares new technological and technical trends and discusses how they address expected u-Health requirements. In addition, detailed information on system operations is presented and challenges in ubiquitous computing are highlighted. The book not only helps beginners with a holistic approach toward understanding u-Health systems, but also presents researchers with the technological trends and design challenges they may face when designing such systems.

Biomedical research data sets are becoming larger and more complex, and computing capabilities are expanding to enable transformative scientific results. The National Institutes of Health's (NIH's) National Library of Medicine (NLM) has the unique role of ensuring that biomedical research data are findable, accessible, interoperable, and reusable in an ethical manner. Tools that forecast the costs of long-term data preservation could be useful as the cost to curate and manage these data in meaningful ways continues to increase, as could stewardship to assess and maintain data that have future value. The National Academies of Sciences, Engineering, and Medicine convened a workshop on July 11-12, 2019 to gather insight and information in order to develop and demonstrate a framework for forecasting long-term costs for preserving, archiving, and accessing biomedical data. Presenters and attendees discussed tools and practices that NLM could use to help researchers and funders better integrate risk management practices and considerations into data preservation, archiving, and accessing decisions; methods to encourage NIH-funded researchers to consider, update, and track lifetime data; and burdens on the academic researchers and industry staff to implement these tools, methods, and practices. This publication summarizes the presentations and discussion of the workshop. Table of Contents Front Matter 1 Introduction 2 Data Sharing and Data Preservation 3 Data Risks and Costs 4 Tools and Practices for Risk Management, Data Preservation, and Accessing Decisions 5 Lifetime Data Costs 6 Reflections and Next Steps References Appendixes Appendix A: Workshop Agenda Appendix B: Biographical Sketches of Committee Appendix C: Registered In-Person Workshop Participants

This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

* A step-by-step look at a growing and difficult to understand area
* Covers important aspects of ICD therapy with full-page illustrations, accompanying text and representative ICD recordings
* An accompanying CD is also available
* Useful for all health care workers involved with ICD patients

This book reviews the convergence technologies like cloud computing, artificial intelligence (AI) and Internet of Things (IoT) in healthcare and how they can help all stakeholders in the healthcare sector. The book is a proficient guide on the relationship between AI, IoT and healthcare and gives examples into how IoT is changing all aspects of the healthcare industry. Topics include remote patient monitoring, the telemedicine ecosystem, pattern imaging analytics using AI, disease identification and diagnosis using AI, robotic surgery, prediction of epidemic outbreaks, and more. The contributors include applications and case studies across all areas of computational intelligence in healthcare data. The authors also include workflow in IoT-enabled healthcare technologies and explore privacy and security issues in healthcare-based IoT.

Virtual Reality (VR) is the use of computer technology to construct an environment that is simulated. VR places the user inside and in the center of the experience, unlike conventional user interfaces. Users are immersed and able to connect with 3D environments instead of seeing a screen in front of them. The computer has to role to provide the experiences of the user in this artificial environment by simulating as many senses as possible, such as sight, hearing, touch and smell. In Augmented Reality (AR) we have an enhanced version of the real physical world that is achieved through the use of digital visual elements, sound, or other sensory stimuli delivered via technology. It can be seen as VR imposed into real life. In both VR and AR the experience is composed of a virtual or extended world, an immersion technology, sensory feedback and interactivity. These elements use a multitude of technologies that must work together and presented to the user seamlessly integrated and synchronized. This book is dedicated to applications, new technologies and emerging trends in the fields of virtual reality and augmented reality in healthcare. It is intended to cover technical areas as well as areas of applied intervention. It is expected to cover hardware and software technologies while encompassing all components of the virtual experience. The main goal of this book is to show how to put Virtual Reality in action by linking academic and informatics researchers with professionals who use and need VR in their day-a-day work, with a special focus on healthcare professionals and related areas. The idea is to disseminate and exchange the knowledge, information and technology provided by the international communities in the area of VR, AR and XR throughout the 21st century. Another important goal is to synthesize all the trends, best practices, methodologies, languages and tools which are used to implement VR. In order to shape the future of VR, new paradigms and technologies should be discussed, not forgetting aspects related to regulation and certification of VR technologies, especially in the healthcare area. These last topics are crucial for the standardization of VR. This book will present important achievements and will show how to use VR technologies in a full range of settings able to provide decision support anywhere and anytime using this new approach.

Ein fundiertes Referenzwerk zu den statistischen Instrumenten und Softwareprogrammen, die fur das Design und die Planung klinischer Studien erforderlich sind. Die erweiterte 4. Auflage von Sample Sizes for Clinical, Laboratory and Epidemiology Studies beinhaltet eine Sample-Size-Software (SSS), Formeln und nummerische Tabellen fur die Gestaltung valider klinischer Studien. Das Fachbuch behandelt ebenfalls Labor- und epidemiologische Studien und stellt die Informationen zur Verfugung, damit Studien einen wesentlichen Beitrag zur medizinischen Forschung leisten. Die Autoren, allesamt anerkannte Experten des Fachgebiets, erlautern und untersuchen Schritt fur Schritt die vielfaltigen UEberlegungen bei der Festlegung geeigneter Stichprobengroessen und helfen so bei der Planung von Studien. Bereitgestellt werden ebenfalls Stichprobentabellen mit Erlauterungen und aussagekraftige Beispiele auf der Basis von Echtdaten. Daruber hinaus enthalt das Fachbuch ein Literaturverweise und Angaben zu weiterfuhrenden Referenzen zur Unterstutzung der vorgestellten Prinzipien. Diese uberarbeitete 4. Auflage - ist das bislang einzige Referenzwerk mit einem Softwareprogramm fur die Gestaltung und Planung klinischer Studien. - enthalt neue und erweiterte Kapitel mit einer Vielzahl neuer und aktualisierter Beispiele. - erlautert verstandlich die angewandten Prinzipien und Methoden anhand von Beispielen aus der Praxis. - prasentiert auf nachvollziehbare Weise ein komplexes und dennoch wichtiges Thema, damit die richtigen Methoden verwendet werden und fundierte Ergebnisse veroeffentlicht werden koennen. - bietet Hilfestellung von einem Team international anerkannter Statistikexperten im medizinischen Bereich. Sample Sizes for Clinical, Laboratory and Epidemiology Studies richtet sich an medizinische Forscher aller Disziplinen sowie an Medizinstatistiker. Die aktualisierte 4. Auflage ist ein wichtiges Referenzwerk fur die Gestaltung und Planung verlasslicher, evidenzbasierter klinischer Studien.

The updated edition of the second of three volumes on Medical Physics presents modern physical methods for medical diagnostics. It provides a solid background on imaging techniques that use non-ionizing probes (ultrasound, endoscopy including CLE and OCT, MRI) and imaging techniques that use ionizing radiation (X-ray radiography, CT, SPECT, PET). Radiation sources, interactions of radiation with matter and radiation protection for x-rays, -rays, protons and neutrons are presented. Some of these topics are also relevant to the therapeutic applications presented in Volume 3. NEW: highlighted boxes emphasize specifi c topics; math boxes explain more advanced mathematical issues; each chapter concludes with a summary of the key concepts, questions, a self-assessment of the acquired competence and exercises. The appendix provides answers to questions and solutions to exercises.

The updated edition of the first of three volumes on Medical Physics focuses even more on body systems related to physical principles such as body mechanics, energy balance, and action potentials. Thanks to numerous newly incorporated didactic features, the introductory text into the broad fi eld of medical physics is easy to understand and supports self-study. New: highlighted boxes emphasize special topics; math boxes explain more advanced mathematical issues; each chapter concludes with a summary of the key concepts, questions, a self-assessment of the acquired competence, and exercises. The appendix contains answers to questions and solutions to exercises.

This monograph offers a fundamentally new approach to facilitate the study of metabolic networks in cells. It aims to overcome the limitations of either just a single FBA solution, or an overwhelming number of extreme pathways in a realistic network. Instead it focusses on the FBA solution space and describes it in a simplified way by extracting just a bounded subspace: the Solution Space Kernel or SSK. This reduces the relevant number of flux space dimensions by orders of magnitude, and allows its location, size and shape to be characterised. It is a multi-stage process, requiring many new concepts and algorithms for manipulating polytopes in high dimensional spaces.The book introduces and develops these concepts in a pragmatic way that takes into account the difficulties of performing analyses in a flux space with dimensions counting in the hundreds or thousands. It emphasizes the details of implementation in computational code and applications to realistic models are demonstrated. For many cases, the number of constraints and flux variables that fully specify the SSK polytope is only a single or double-digit number. This allows the range of metabolic states accessible to a cell to be further interpreted geometrically in terms of a manageable set of orthogonal diameters and aspect ratios. In addition, explicit representative fluxes, giving the centre and periphery of the solution space kernel, become available for further exploration.

This new edition of the classic textbook on health informatics provides readers in healthcare practice and educational settings with an unparalleled depth of information on using informatics methods and tools. However, this new text speaks to nurses and - in a departure from earlier editions of this title - to all health professionals in direct patient care, regardless of their specialty, extending its usefulness as a textbook. This includes physicians, therapists, pharmacists, dieticians and many others. In recognition of the evolving digital environments in all healthcare settings and of interprofessional teams, the book is designed for a wide spectrum of healthcare professions including quality officers, health information managers, administrators and executives, as well as health information technology professionals such as engineers and computer scientists in health care. The book is of special interest to those who bridge the technical and caring domain, particularly nurse and medical informaticians and other informaticians working in the health sciences. Nursing Informatics: An Interprofessional and Global Perspective contains real-life case studies and other didactic features to illustrate the theories and principles discussed, making it an ideal resource for use within health and nursing informatics curricula at both undergraduate and graduate level, as well as for workforce development. It honors the format established by the previous editions by including a content array and questions to guide the reader. Readers are invited to look out of the box through a dedicated global perspective covering health informatics applications in different regions, countries and continents.

Use technology and agile methodologies such as DevOps and micro-enterprises to find your solution space to design, form and provide sustainable healthcare Key Features * Distinguish different pace and timing of change for healthcare systems and recognize constraints * Apply shared mental models for common understanding between digital, medical and enterprise * Integrate new technology to accelerate digital transformation based on practical examples Book Description Technology is an important driver for change, but in essence we should design and plan for personalized health and not focus on the tech. Healthcare transformation requires more than just technology: medical staff, supporting staff, and patients including their community need to embrace it. We need a methodology to bring it all together: people, organizations, and technology by creating common understanding. This book presents ways to build understanding between the stakeholders and agree jointly on the way forward. Every chapter of this book has a specific theme, providing a comprehensive overview of the challenges, the opportunities and the approaches to deal with them in architecture and transformation. You will be able to guide the digital transformation of global healthcare. It includes the impact of new technologies, but addresses primarily a methodology or framework for common understanding in the first place. The framework is referred to as TISH: transformation in sustainable healthcare. In addition, you will also apply OODA principles (Observe, Orient, Decide, Act) and DevOps4Care in real practice, step-by-step. By the end of this book, you will not only understand the issues and challenges, but also possess a workable, actionable solution in the form of a roadmap. What you will learn * Understand the need for transformation of healthcare * Accelerate transformation through common understanding in manageable steps * Learn about networked, stepped, integrated, and directed care * Handle complexity through System of Systems * Learn about Journey Interaction Mapping (JIM) * Add value to healthcare by applying DevOps methodologies Who This Book Is For This book is written for anyone interested in designing, building, and providing data driven healthcare. Architects, consultants, engineers, and especially healthcare practitioners who want to embrace the complexity of the digital transformation of healthcare can benefit from this book. The book will be interesting for digital leaders (including C-suite) and for anyone who is on a learning path to understand the world of technological innovation combined with healthcare and wants to be a part of it.