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This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005.
The 15 revised full papers and 10 revised extended abstracts presented together with 3 invited papers were carefully reviewed and selected from 55 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.
With the ever-growing power to generate, transmit and collect huge amounts of data, information overload is now an imminent problem to mankind. The overwhelming demand for information processing is not just about a better - derstanding of data, but also a better usage of data in a timely fashion. Data mining, or knowledge discovery from databases, is proposed to gain insight into aspects of dataand to help peoplemakeinformed, sensible, andbetter decisions. At present, growing attention has been paid to the study, development and - plication of data mining. As a result there is an urgent need for sophisticated techniques and tools that can handle new ?elds of data mining, e.g., spatialdata mining, biomedical data mining, and mining on high-speed and time-variant data streams. The knowledge of data mining should also be expanded to new applications. The1stInternationalConferenceonAdvancedDataMiningandApplications (ADMA 2005) aimed to bring together the experts on data mining throughout the world. It provided a leading international forum for the dissemination of original research results in advanced data mining techniques, applications, al- rithms, software and systems, and di?erent applied disciplines. The conference attracted 539 online submissions and 63 mailing submissions from 25 di?erent countriesandareas.Allfullpaperswerepeer reviewedbyatleastthreemembers of the Program Committee composed of international experts in data mining ?elds. A total number of 100 papers were accepted for the conference. Amongst them 25 papers were selected as regular papers and 75 papers were selected as short papers, yielding a combined acceptance rate of 17%
The explosion in the number and size of life science data resources, and the rapid growth in the variety and volume of laboratory data has been fueled by world-wide research activity and the emergence of new technologies. The m- eling, management and analysis of this data often requires a comprehensive - tegration of heterogeneous and typically semistructured data, distributed across many possibly data sources. Recent interoperability standards such as XML and WSDL solve some (easy) problems, but data and process integration often - main time-consuming and error-pone manual tasks. The di?culty of these tasks is compounded by the high degree of semantic heterogeneity across data sources, varying data quality, and other domain-speci?c application requirements. DILS 2005 was the 2nd International Workshop on Data Integration in the Life Sciences, following a successful ?rst DILS workshop, March 2004 in Leipzig, Germany. For a specialized workshop, the DILS 2005 call for papers created a largeinterest(over50abstractsandeventually42papersubmissions;anincrease ofover20%overDILS2004), outofwhichtheinternationalProgramCommittee selected 15 full papers, as well as 5 short papers, and 8 posters/demonstrations, which are all included in this volume. They cover a wide spectrum of theoretical and practical issues including scienti?c/clinical work?ows, ontologies, tools and systems, and integration techniques. DILS 2005 also featured keynotes by Dr. PeterBuneman, ProfessorattheSchoolofInformatics, UniversityofEdinburgh, and Dr. Shankar Subramaniam, Professor at the Department of Bioengineering andChemistry, UCSanDiego.Theprogramalsoincluded6invitedpresentations and reports on ongoing research activities in academia and industry and a panel organized by the AMIA Geomics Working Gr
This volume contains the papers selected for presentation at the 2nd Inter- tional Workshop on Active Mining (AM 2003) which was organized in conju- tion with the 14th International Symposium on Methodologies for Intelligent Systems (ISMIS 2003), held in Maebashi City, Japan, 28-31 October, 2003. The workshop was organized by the Maebashi Institute of Technology in - operation with the Japanese Society for Arti?cial Intelligence. It was sponsored by the Maebashi Institute of Technology, the Maebashi Convention Bureau, the Maebashi City Government, the Gunma Prefecture Government, JSAI SIGKBS (Japanese Arti?cial Intelligence Society, Special Interest Group on Knowledge- Based Systems), a Grant-in-Aid for Scienti?c Research on Priority Areas (No. 759) "Implementation of Active Mining in the Era of Information Flood," US AFOSR/AOARD, the Web Intelligence Consortium (Japan), the Gunma Inf- mation Service Industry Association, and Ryomo Systems Co., Ltd. ISMIS is a conference series that was started in 1986 in Knoxville, Tennessee. SincethenithasbeenheldinCharlotte(NorthCarolina), Knoxville(Tennessee), Torin (Italy), Trondheim (Norway), Warsaw (Poland), Zakopane (Poland), and Lyon (France). The objective of this workshop was to gather researchers as well as prac- tioners who are working on various research ?elds of active mining, share ha- learned experiences, and shed light on the future development of active mining.
Probabilistic Modelling in Bioinformatics and Medical Informatics has been written for researchers and students in statistics, machine learning, and the biological sciences. The first part of this book provides a self-contained introduction to the methodology of Bayesian networks. The following parts demonstrate how these methods are applied in bioinformatics and medical informatics. All three fields - the methodology of probabilistic modeling, bioinformatics, and medical informatics - are evolving very quickly. The text should therefore be seen as an introduction, offering both elementary tutorials as well as more advanced applications and case studies.
As the biomedical engineering field expands throughout the world,
clinical engineers play an evermore-important role as translators
between the medical, engineering, and business professions. They
influence procedure and policy at research facilities,
universities, as well as private and government agencies including
the Food and Drug Administration and the World Health Organization.
The profession of clinical engineering continues to seek its place
amidst the myriad of professionals that comprise the health care
Global Health Informatics: How Information Technology Can Change Our Lives in a Globalized World discusses the critical role of information and communication technologies in health practice, health systems management and research in increasingly interconnected societies. In a global interconnected world the old standalone institutional information systems have proved to be inadequate for patient-centered care provided by multiple providers, for the early detection and response to emerging and re-emerging diseases, and to guide population-oriented public health interventions. The book reviews pertinent aspects and successful current experiences related to standards for health information systems; digital systems as a support for decision making, diagnosis and therapy; professional and client education and training; health systems operation; and intergovernmental collaboration.
Each year this series provides a unique, timely, and readable look at the world of Rorschach: surveys of the most recent clinical research results, discussions of the instrument's usefulness, how the Rorschach is used in various countries around the world and in different problem areas, as well as new insights from seasoned practitioners and theoreticians. It is a vital and thought-provoking source of up-to-date information for experts, and also makes fascinating reading for those learning Rorschach techniques, such as graduate students in clinical programs. Rorschachiana, now under the Editorship of Prof. Anne Andronikof-Sanglade, is the official publication of the International Rorschach Society, now consisting of some 1,700 members throughout the world, which for half a century has played an important role in supporting the use of the instrument, as well as helping to develop extensive empirical research on its effectiveness in specific clinical situations. Thought-provoking contributions from the world of the Rorschach and similar tests.
The European Society for Arti?cial Intelligence in Medicine (AIME) was - tablished in 1986 with two main goals: 1) to foster fundamental and applied research in the application of Arti?cial Intelligence (AI) techniques to medical care and medical research, and 2) to provide a forum for reporting signi?cant results achieved at biennial conferences. Additionally, AIME assists medical - dustrials to identify new AI techniques with high potential for integration into new products. A major activity of this society has been a series of international conferences, fromMarseille(FR)in1987toCascais(PT)in2001, heldbiennially over the last 16 years. The AIME conference provides a unique opportunity to present and improve the international state of the art of AI in medicine from both a research and an applicationsperspective.Forthispurpose, theAIMEconferenceincludesinvited lectures, contributed papers, system demonstrations, tutorials and workshops. The present volume contains the proceedings of the AIME 2003 conference, the ninthconferenceonArti?cialIntelligenceinMedicineinEurope, heldinCyprus, October 18-22, 2003. In the AIME 2003 conference announcement, we encouraged authors to s- mit original contributions to the development of theory, techniques, and - plications of AI in medicine, including the evaluation of health care programs. Theoretical papers should include a prospective part about possible applications to medical problems solving. Technical papers should describe the novelty of the proposed approach, its assumptions and pros and cons compared to other alt- native techniques. Application papers should present su?cient information to allow the evaluation of the practical bene?ts of the proposed system or meth- ol
With the dramatic evolution of shoulder arthroscopy techniques over the past five years, practitioners must search through numerous educational resources to learn about specific indications and definitive techniques. The field of orthopaedics lacks an all-encompassing text that is strictly and exclusively devoted to shoulder arthroscopy. Drs. James Tibone, Felix Savoie III, and Benjamin Shaffer have assembled the leading authorities in shoulder arthroscopy to provide the practitioner with invaluable information on the most cutting edge procedures to treat impingement problems, frozen shoulder, calcific tendonitis, and shoulder instability. This comprehensive, practical volume is enhanced with striking illustrations, detailing the surgical technique from positioning to closure. The chapter format gives introductory comments about disease/disorder, clinical presentation, surgical indications/patient selection, contraindications, surgical techniques, results, complications and pitfalls. There are also selected references and recommended readings at the end of each chapter. Shoulder Arthroscopy will be essential for all practicing orthopaedic surgeons, sports medicine and shoulder specialists who want to expand their expertise in this area.
Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends. Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas: Nanobiomaterials and scaffolds-including nanocomposites and electrospun nanofibers Tissue mechanics Stem cells and nanobiomaterials Oral and cranial implants and regeneration of bone Cartilage tissue engineering Controlled release-DNA, RNA, and protein delivery Animal science and clinical medicine The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.
This book constitutes the refereed proceedings of the International Symposium on Surgery Simulation and Soft Tissue Modeling, IS4TM 2003, held in Juan-Les-Pins, France in June 2003. The 33 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 45 submissions. The papers are organized in topical sections on soft tissue models, haptic rendering, cardiac modeling, and patient specific simulators.
This book offers a comprehensive report on the technological aspects of Mobile Health (mHealth) and discusses the main challenges and future directions in the field. It is divided into eight parts: (1) preventive and curative medicine; (2) remote health monitoring; (3) interoperability; (4) framework, architecture, and software/hardware systems; (5) cloud applications; (6) radio technologies and applications; (7) communication networks and systems; and (8) security and privacy mechanisms. The first two parts cover sensor-based and bedside systems for remotely monitoring patients' health condition, which aim at preventing the development of health problems and managing the prognosis of acute and chronic diseases. The related chapters discuss how new sensing and wireless technologies can offer accurate and cost-effective means for monitoring and evaluating behavior of individuals with dementia and psychiatric disorders, such as wandering behavior and sleep impairments. The following two parts focus on architectures and higher level systems, and on the challenges associated with their interoperability and scalability, two important aspects that stand in the way of the widespread deployment of mHealth systems. The remaining parts focus on telecommunication support systems for mHealth, including radio technologies, communication and cloud networks, and secure health-related applications and systems. All in all, the book offers a snapshot of the state-of-art in mHealth systems, and addresses the needs of a multidisciplinary audience, including engineers, computer scientists, healthcare providers, and medical professionals, working in both academia and the industry, as well as stakeholders at government agencies and non-profit organizations.
This book highlights the responsibility of medical device designers and engineers to eliminate sites of failure and to test devices to demonstrate their ultimate safety and efficacy. It also evaluates biomaterials and their properties as related to the design and reliability of medical devices. The principles that are described are readily applicable to the biomaterial scaffolds used for generating tissue-engineered constructs.
The cross-disciplinary pursuits between modern technology, their computations and applications to the human body have exploded because of rapid developments in computer technology and mathematical computational techniques.
This four-volume set, Computational Methods in Biophysics,
Biomaterials, Biotechnology and Medical Systems, represents the
first multi-volume treatment of this significant subject on the
international scene. The work is an indispensable reference source
by leading researchers, and is essential reference work for
academics, practitioners, students and researchers working
The three-volume set LNCS 9900, 9901, and 9902 constitutes the refereed proceedings of the 19th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2016, held in Athens, Greece, in October 2016. Based on rigorous peer reviews, the program committee carefully selected 228 revised regular papers from 756 submissions for presentation in three volumes. The papers have been organized in the following topical sections: Part I: brain analysis, brain analysis - connectivity; brain analysis - cortical morphology; Alzheimer disease; surgical guidance and tracking; computer aided interventions; ultrasound image analysis; cancer image analysis; Part II: machine learning and feature selection; deep learning in medical imaging; applications of machine learning; segmentation; cell image analysis; Part III: registration and deformation estimation; shape modeling; cardiac and vascular image analysis; image reconstruction; and MR image analysis.
Implants into the human body, such as hip joints, heart valves and dental crowns, have been increasingly used over the last 40 years or so, and many patients have benefited from their use. But how much is known about the metals, ceramics and polymers that are used in these repairs? This book provides a state-of-the-art account of the chemistry of the synthetic materials used in medicine and dentistry. It looks at the properties and interactions of these materials within the body at a molecular level, and includes discussion of bioengineering and cell biology. In addition, there is an account of the surgical procedures used, as well as extensive coverage of the possible biological reactions to the presence of foreign materials in the body. A brief look at the emerging field of tissue engineering completes the text. Fully referenced, with detailed reviews of the current literature, The Chemistry of Medical and Dental Materials will be an essential starting-point for all those in academia and industry who are involved in the development of new and improved repair materials.
A careful review of the literature covering various aspects of applications of lasers in science and technology reveals that lasers are being applied very widely throughout the entire gamut of physical medicine. After surveying the current developments taking place in the field of medical applications of lasers, it was considered appropriate to bring together these efforts of international research scientists and experts into one volume. It is with this aim that the editors have prepared this volume which brings current research and recent developments to the attention of a wide spectrum of readership associated with hospitals, medical institutions and universities world wide, including also the medical instrument industry. Both teachers and students in the medical faculties will especially find this compendium quite useful. This book is comprised of eleven chapters. All of the important medical applications of lasers are featured. The editors have made every effort that individual chapters are self-contained and written by experts. Emphasis has been placed on straight and simple presentation of the subject matter so that even the new entrants into the field will find the book of value.
This textbook consists of ten chapters, and is a must-read to all medical and health professionals, who already have basic knowledge of how to analyze their clinical data, but still, wonder, after having done so, why procedures were performed the way they were. The book is also a must-read to those who tend to submerge in the flood of novel statistical methodologies, as communicated in current clinical reports, and scientific meetings. In the past few years, the HOW-SO of current statistical tests has been made much more simple than it was in the past, thanks to the abundance of statistical software programs of an excellent quality. However, the WHY-SO may have been somewhat under-emphasized. For example, why do statistical tests constantly use unfamiliar terms, like probability distributions, hypothesis testing, randomness, normality, scientific rigor, and why are Gaussian curves so hard, and do they make non-mathematicians getting lost all the time? The book will cover the WHY-SOs.
Lo sviluppo di nuove tecnologie nell'era digitale e di sistemi informativi di condivisione, gestione e archiviazione dei dati, ha contribuito alla nascita di un nuovo modo di intendere l'attivita del medico: la telemedicina. Esperti della Unione Europea la definirono come "l'integrazione, il monitoraggio e la gestione dei pazienti, nonche l'educazione dei medesimi e del personale, usando sistemi che consentano un pronto accesso alla consulenza di esperti e alle informazioni del paziente, indipendentemente da dove esso o le informazioni risiedano." Con i nuovi metodi di raccolta e trasmissione di dati, non e quindi piu il paziente a spostarsi ma le informazioni che lo riguardano. Il volume introduce il lettore alla Information and Communication Technology (ICT) applicata alla medicina e ne illustra l'impatto sulla diagnostica e sulla terapia medica. Nell'ambito dello sviluppo di applicazioni software e fondamentale "parlare la stessa lingua"; gli autori di questo volume hanno pertanto voluto dare ampio spazio, da una parte alla descrizione degli standard utilizzati in informatica sanitaria, dall'altra alle norme attualmente esistenti e alla rappresentazione delle informazioni sui vari media. Per le sue caratteristiche, questo volume rappresenta uno strumento molto valido sia per quelle figure professionali (medici, amministratori di aziende sanitarie, tecnici di laboratorio, informatici e ingegneri) coinvolte nell'applicazione e nello sviluppo delle procedure della telemedicina, che per la didattica universitaria di quelle discipline rivolte a formare tali figure professionali.
Big Data Analytics for Intelligent Healthcare Management covers both the theory and application of hardware platforms and architectures, the development of software methods, techniques and tools, applications and governance, and adoption strategies for the use of big data in healthcare and clinical research. The book provides the latest research findings on the use of big data analytics with statistical and machine learning techniques that analyze huge amounts of real-time healthcare data.
The Pacific Symposium on Biocomputing (PSB) 2014 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2014 will be held from January 3 - 7, 2014 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2014 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's "hot topics." In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
This text for students and researchers, takes an interdisciplinary approach to describing the chemistry and physics of materials, their biocompatibility, and the consequences of implantation of devices made of these materials into the human body. The reader is introduced to the principles of polymer science and the study of metals, ceramics and composites, and also to the basic biology required to understand the nature of the host-transplant interface. Topics covered in this book include the macromolecular components of cells and tissues, self-assembly processes, biological cascade systems, microscopic structure of cells and tissues, immunology, transplantation biology, and the pathobiology of wound healing. Topics covered in the materials science chapters include the structures and properties of polymers, metals, ceramics and composites, and the processes for forming materials as well as the pathobiology of devices. The final two chapters deal with tissue engineering and the relations between the biology of cells and tissue transplantation, and the engineering of tissue replacements using passaged cells.
The third edition of "Current Techniques in Arthroscopy" brings you up-to-date on the latest advances in this important and rapidly growing specialty. Featuring nearly 300 color illustrations and contributions from recognized experts, the book provides complete information on twenty new procedures including meniscal and rotator cuff repair, advanced hip and elbow surgery, ligament reconstruction, and arthroscopy in joint replacement.
Each chapter covers an important new procedure in detail, beginning with indications, pathology, and instrumentation and progressing to surgical technique, complications, and postoperative care.
Among this work's special features you'll find: Step-by-step coverage of the most important recent advances in arthroscopic surgery of the hip, knee, ankle, shoulder, elbow, and wrist An efficient, easy-to-use format and more than 250 outstanding color drawings and photographs that lead you through each procedure from start to finish Contributions from recognized authorities in the field A complete list of references and additional readings for each procedure
Concise, up-to-date, and superbly illustrated, "Current Techniques in Arthroscopy" is essential for orthopedic surgeons who wish to stay at the leading edge of the profession.
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