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The Evolution from Protein Chemistry to Proteomics - Basic Science to Clinical Application (Paperback)
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The Evolution from Protein Chemistry to Proteomics - Basic Science to Clinical Application (Paperback)
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Largely driven by major improvements in the analytical capability
of mass spectrometry, proteomics is being applied to broader areas
of experimental biology, ranging from oncology research to plant
biology to environmental health. However, while it has already
eclipsed solution protein chemistry as a discipline, it is still
essentially an extension of classical protein chemistry, owing much
of its maturation to prior contributions. Unfortunately, this debt
is not always evident in current literature. The Evolution from
Protein Chemistry to Proteomics: Basic Science to Clinical
Application, in providing a different perspective than other
reviews, strengthens the connection between solution protein
chemistry and proteomic technology. Towards this end, Roger
Lundblad, a long-time leader in protein chemistry and a scientist
who has worked in both academics and industry, brings together some
seemingly disparate areas into a single volume. Discussing
analytical proteomics, expression proteomics, and clinical
proteomics (biomarker identification), he provides coverage that is
uniquely rich in detail. Lundblad applies this detail to sample
preparation for proteomic analysis, including preparation from
blood and tissues. He also presents specifics on the
prefractionation of samples used to identify specific subproteomes
such as phosphoproteomes and glycoproteomes. Comprehensive reviews
are provided covering the chemical modification of proteins,
including its use for chemical proteomics. Special attention is
given to challenges that impede the identification, validation, and
development of biomarkers into clinically useful diagnostic
analytes. A bestselling author, Lundblad utilizes classical protein
chemistry literature in providing an intellectual basis for
proteomics that merges current concepts with the existing
literature, while providing the technical detail necessary for the
effective commercialization of proteomics.
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