Cross-over trials are an important class of design used in the pharmaceutical industry and medical research, and their use continues to grow. Cross-over Trials in Clinical Research, Second Edition has been fully updated to include the latest methodology used in the design and analysis of cross-over trials. It includes more background material, greater coverage of important statistical techniques, including Bayesian methods, and discussion of analysis using a number of statistical software packages.

• Comprehensive coverage of the design and analysis of cross-over trials.

• Each technique is carefully explained and the mathematics is kept to a minimum.

• Features many real and original examples, taken from the author's vast experience.

• Includes discussion of analysis using SAS, S-Plus and, GenStat, StatXact and Excel.

• Written in a style suitable for statisticians and physicians alike.

This book provides a comprehensive overview of advances in the field of medical data science, presenting carefully selected articles by leading information technology experts. Information technology, as a rapidly evolving discipline in medical data science, with significant potential in future healthcare, and multimodal acquisition systems, mobile devices, sensors, and AI-powered applications has redefined the optimization of clinical processes. This book features an interdisciplinary collection of papers that have both theoretical and applied dimensions, and includes the following sections: Medical Data Science Quantitative Data Analysis in Medical Diagnosis Data Mining Tools and Methods in Medical Applications Image Analysis Analytics in Action on SAS Platform Biocybernetics in Physiotherapy Signal Processing and Analysis Medical Tools & Interfaces Biomechanics and Biomaterials. As such, it is a valuable reference tool for scientists designing and implementing information processing tools used in systems that assist clinicians in patient care. It is also useful for students interested in innovations in quantitative medical data analysis, data mining, and artificial intelligence.

This open access volume focuses on the development of a P5 eHealth, or better, a methodological resource for developing the health technologies of the future, based on patients' personal characteristics and needs as the fundamental guidelines for design. It provides practical guidelines and evidence based examples on how to design, implement, use and elevate new technologies for healthcare to support the management of incurable, chronic conditions. The volume further discusses the criticalities of eHealth, why it is difficult to employ eHealth from an organizational point of view or why patients do not always accept the technology, and how eHealth interventions can be improved in the future. By dealing with the state-of-the-art in eHealth technologies, this volume is of great interest to researchers in the field of physical and mental healthcare, psychologists, stakeholders and policymakers as well as technology developers working in the healthcare sector.

This book is written in a very easy-to-follow format, and explains the key concepts of biomedical statistics in a lucid yet straightforward manner. It explains how mathematical and statistical tools can be used to find answers to common research questions. In addition, the main text is supplemented by a wealth of solved exercises and illustrative examples to aid in comprehension. Given its content, the book offers an invaluable quick reference guide for graduating students and can be very helpful in their examination process. At the same time, it represents a handy guide for medical and paramedical teachers, post-graduate medical students, research personnel, biomedical scientists and epidemiologists.

ITiB'2018 is the 6th Conference on Information Technology in Biomedicine, hosted every two years by the Department of Informatics & Medical Devices, Faculty of Biomedical Engineering, Silesian University of Technology. The Conference is organized under the auspices of the Committee on Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences. The meeting has become an established event that helps to address the demand for fast and reliable technologies capable of processing data and delivering results in a user-friendly, timely and mobile manner. Many of these areas are recognized as research and development frontiers in employing new technology in the clinical setting. Technological assistance can be found in prevention, diagnosis, treatment, and rehabilitation alike. Homecare support for any type of disability may improve standard of living and make people's lives safer and more comfortable. The book includes the following sections: O Image Processing O Multimodal Imaging and Computer-aided Surgery O Computer-aided Diagnosis O Signal Processing and Medical Devices O Bioinformatics O Modelling & Simulation O Analytics in Action on the SAS Platform O Assistive Technologies and Affective Computing (ATAC)

This two-volume set LNBI 10813 and LNBI 10814 constitutes the proceedings of the 6th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2018, held in Granada, Spain, in April 2018.The 88 regular papers presented were carefully reviewed and selected from 273 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and diseases; bioinformatics tools to integrate omics dataset and address biological question; challenges and advances in measurement and self-parametrization of complex biological systems; computational genomics; computational proteomics; computational systems for modelling biological processes; drug delivery system design aided by mathematical modelling and experiments; generation, management and biological insights from big data; high-throughput bioinformatic tools for medical genomics; next generation sequencing and sequence analysis; interpretable models in biomedicine and bioinformatics; little-big data. Reducing the complexity and facing uncertainty of highly underdetermined phenotype prediction problems; biomedical engineering; biomedical image analysis; biomedical signal analysis; challenges in smart and wearable sensor design for mobile health; and healthcare and diseases.

Single-Use Technology (SUT) is the first comprehensive publication of practical considerations for each stage of the implementation process of SUT, and covers the selection, specification, design and qualification of systems to meet end-user requirements. Having become readily available for all processing operations within the biopharmaceutical industry, SUT has the potential to reduce capital costs, improve plant throughput and reduce the risk of cross-contamination. However, there are no clear guidelines to aid the end-user on implementation of these technologies into a validated, good manufacturing practice (GMP) environment. This book presents approaches for the implementation within various end-user facilities and systems, SUT within regulatory frameworks (ICH Q8, Q9, Q10 and GMP), standardisation and assessment strategies, specifation of user requirements and SUT design, risk assessment and evaluation as well as qualification for different SUT types.

Engineering Innovation is an overview of the interconnected business and product development techniques needed to nurture the development of raw, emerging technologies into commercially viable products. This book relates Funding Strategies, Business Development, and Product Development to one another as an idea is refined to a validated concept, iteratively developed into a product, then produced for commercialization. Engineering Innovation also provides an introduction to business strategies and manufacturing techniques on a technical level designed to encourage passionate clinicians, academics, engineers and savvy entrepreneurs. Offers a comprehensive overview of the process of bringing new technology to market. Identifies a variety of technology management skill sets and management tools. Explores concept generation in conjunction with intellectual property development for early-stage companies. Explores Quality and Transfer-to-Manufacturing.

Point of care ultrasound is a critical tool required for assessing all patients, providing rapid answers to clinical questions and facilitating high quality care for patients. This essential guide caters for all generalist clinicians beginning their ultrasound journey and extends to more advanced assessments for those with established ultrasound experience wishing to advance their knowledge and skills. It covers a wide range of ultrasound topics from echocardiography, thoracic and COVID-19 to emerging areas such as palliative care, hospital at home and remote and austere medicine. An extensive collection of colour images, videos and examples of clinical applications will inspire readers to acquire the skills of point of care ultrasound quickly, safely and systematically. The printed code on the inside of the cover provides access to an online version on Cambridge Core. An essential aid for acute clinicians, paramedics, general practitioners as well as remote medical providers, medical educators and students.

This book constitutes the thoroughly refereed post-conference proceedings of the International Conference for Smart Health, ICSH 2018, held in Wuhan, China, in July 2018.The 14 full papers and 21 short papers presented were carefully reviewed and selected from 49 submissions. They focus on studies on the principles, approaches, models, frameworks, new applications, and effects of using novel information technology to address healthcare problems and improve social welfare. The selected papers are organized into the following topics: smart hospital; online health community; mobile health; medical big data and healthcare machine learning; chronic disease management; and health informatics.

Rapid advancement of telecommunications and information technology has created the potential for high-quality expert healthcare to be delivered when and where it is needed. This text charts the development of the telemedicine industry, defines its current scope and reveals the potential of new methodologies.

• Explains the main features of telemedicine and telecare
• Reviews the technology needed for telemedicine
• Describes how to develop, deliver and evaluate telemedicine services
• Considers the associated ethical and legal issues
• Includes an in-depth survey of the literature with over 300 references to research articles and hyperlinks to associated websites

This book offers a practical introduction to healthcare analytics that does not require a background in data science or statistics. It presents the basics of data, analytics and tools and includes multiple examples of their applications in the field. The book also identifies practical challenges that fuel the need for analytics in healthcare as well as the solutions to address these problems. In the healthcare field, professionals have access to vast amount of data in the form of staff records, electronic patient record, clinical findings, diagnosis, prescription drug, medical imaging procedure, mobile health, resources available, etc. Managing the data and analyzing it to properly understand it and use it to make well-informed decisions can be a challenge for managers and health care professionals. A new generation of applications, sometimes referred to as end-user analytics or self-serve analytics, are specifically designed for non-technical users such as managers and business professionals. The ability to use these increasingly accessible tools with the abundant data requires a basic understanding of the core concepts of data, analytics, and interpretation of outcomes. This book is a resource for such individuals to demystify and learn the basics of data management and analytics for healthcare, while also looking towards future directions in the field.

Cross-sectoral interaction and cooperation in the communication of nutritional health risks represents a strategic research area among national governments and international health authorities. The key research question this book addresses is whether and how different industrial sectors interact with each other in the communication and industrial utilisation of health research findings. Through the introduction and exploration of large-scale industry news and digital media resources, this book systematically analyses a range of digital news genres and identifies new and growing trends of inter-sectoral interaction around the communication of nutritional health in the Chinese language at both international and national levels. This book argues that cross-sectoral interaction can be explored to identify areas that require policy intervention to increase the efficiency and effectiveness of current health communication and promotion. Inter-sectoral interaction can also provide incentives to develop new social programmes and business models to innovate and transform traditional industrial sectors.

This book constitutes the refereed post-conference proceedings of the 7th International Conference on Mobile Communication and Healthcare, MobiHealth 2017, held in Vienna, Austria, in November 2017. The 34 revised full papers were reviewed and selected from more than 50 submissions and are organized in topical sections covering data analysis, systems, work-in-process, pervasive and wearable health monitoring, advances in healthcare services, design for healthcare, advances in soft wearable technology for mobile-health, sensors and circuits.

This book introduces medical imaging, its security requirements, and various security mechanisms using data hiding approaches. The book in particular provides medical data hiding techniques using various advanced image transforms and encryption methods. The book focuses on two types of data hiding techniques: steganography and watermarking for medical images. The authors show how these techniques are used for security and integrity verification of medical images and designed for various types of medical images such as grayscale image and color image. The implementation of techniques are done using discrete cosine transform (DCT), discrete wavelet transform (DWT), singular value decomposition (SVD), redundant DWT (RDWT), fast discrete curvelet transform (FDCuT), finite ridgelet transform (FRT) and non-subsampled contourlet transform (NSCT). The results of these techniques are also demonstrated after description of each technique. Finally, some future research directions are provided for security of medical images in telemedicine application.

The application of bioinformatics approaches in drug design involves an interdisciplinary array of sophisticated techniques and software tools to elucidate hidden or complex biological data. This work reviews the latest bioinformatics approaches used for drug discovery. The text covers ligand-based and structure-based approaches for computer-aided drug design, 3D pharmacophore modeling, molecular dynamics simulation, the thermodynamics of ligand receptor and ligand enzyme association, thermodynamic characterization and optimization, and techniques for computational genomics and proteomics.

Volumetric, or three-dimensional, digital imaging now plays a vital role in many areas of research such as medicine and geology. Medical images acquired by tomographic scanners for instance are often given as a stack of cross-sectional image slices. Such images are called ‘volumetric’ because they depict objects in their entire three-dimensional extent rather than just as a projection onto a two-dimensional image plane. Since huge amounts of volumetric data are continually being produced in many places around the world, techniques for their automatic analysis become ever more important. Written by a computer vision specialist, this clear, detailed account of volumetric image analysis techniques provides a practical approach to the field including the following topics:

• preprocessing of volumetric images
• obtaining quantitative measurements in volumetric images
• detection and modelling of objects in volumetric images

This book describes recent radiotherapy technologies including tools for measuring target position during radiotherapy and tracking-based delivery systems.  This book presents a customized prediction of respiratory motion with clustering from multiple patient interactions. The proposed method contributes to the improvement of patient treatments by considering breathing pattern for the accurate dose calculation in radiotherapy systems. Real-time tumor-tracking, where the prediction of irregularities becomes relevant, has yet to be clinically established. The statistical quantitative modeling for irregular breathing classification, in which commercial respiration traces are retrospectively categorized into several classes based on breathing pattern are discussed as well. The proposed statistical classification may provide clinical advantages to adjust the dose rate before and during the external beam radiotherapy for minimizing the safety margin. In the first chapter following the Introduction  to this book, we review three prediction approaches of respiratory motion: model-based methods, model-free heuristic learning algorithms, and hybrid methods. In the following chapter, we present a phantom study—prediction of human motion with distributed body sensors—using a Polhemus Liberty AC magnetic tracker. Next we describe respiratory motion estimation with hybrid implementation of extended Kalman filter. The given method assigns the recurrent neural network the role of the predictor and the extended Kalman filter the role of the corrector. After that, we present customized prediction of respiratory motion with clustering from multiple patient interactions. For the customized prediction, we construct the clustering based on breathing patterns of multiple patients using the feature selection metrics that are composed of a variety of breathing features. We have evaluated the new algorithm by comparing the prediction overshoot and the tracking estimation value. The experimental results of 448 patients’ breathing patterns validated the proposed irregular breathing classifier in the last chapter.

This book focuses on the most recent advances in the application of visualization and simulation methods to understand the flow behavior of complex fluids used in biomedical engineering and other related fields. It shows the physiological flow behavior in large arteries, microcirculation, respiratory systems and in biomedical microdevices.

Monika Futschik introduces an evaluation model that allows a holistic assessment of the advantages and disadvantages of electronic batch recording solutions versus traditional paper batch ticket solutions. In comparison to former studies, this newly developed evaluation model considers the change management efforts and the financial investments required for system deployment. The model proves the overall performance value through the implementation of electronic batch recording solutions and supports decision-makers in finding the most effective solution. The development and effectiveness of this model is based on various surveys, expert interviews, a Delphi study as well as a case study with a real-life pharmaceutical company. The outcome of her research can be easily applied to other industries as well.

During the last years computational methods lead to new approaches that can be applied within medical practice. Based on the tremendous advances in medical imaging and high-performance computing, virtual testing is able to help in medical decision processes or implant designs. Current challenges in medicine and engineering are related to the application of computational methods to clinical medicine and the study of biological systems at different scales. Additionally manufacturers will be able to use computational tools and methods to predict the performance of their medical devices in virtual patients. The physical and animal testing procedures could be reduced by virtual prototyping of medical devices. Here simulations can enhance the performance of alternate device designs for a range of virtual patients. This will lead to a refinement of designs and to safer products. This book summarizes different aspects of approaches to enhance function, production, initialization and complications of different types of implants and related topics.

This book constitutes the refereed proceedings of the 6th International Conference on Well-Being in the Information Society, WIS 2016, held in Tampere, Finland, in September 2016. The 21 revised full papers presented were carefully reviewed and selected from 42 submissions. With the core topic "Building Sustainable Health Ecosystems" WIS 2016 focused on innovations and fresh ideas in the cross-section of urban living, information society and health as understood in a wide sense. The papers presented in this volume are organized along the following seven broad topics: 1. Macro level considerations of e-health and welfare, 2.Welfare issues of children, youth, young elderly and seniors, 3. Analytics issues of eHealth and welfare, 4. National/regional initiatives in eHealth and welfare, and 5. Specific topics of eHealth. The papers in these topics span qualitative and quantitative analysis, empirical surveys, case studies as well as conceptual work.

Covering both physical as well as mathematical and algorithmic foundations, this graduate textbook provides the reader with an introduction into modern biomedical imaging and image processing and reconstruction. These techniques are not only based on advanced instrumentation for image acquisition, but equally on new developments in image processing and reconstruction to extract relevant information from recorded data. To this end, the present book offers a quantitative treatise of radiography, computed tomography, and medical physics. Contents Introduction Digital image processing Essentials of medical x-ray physics Tomography Radiobiology, radiotherapy, and radiation protection Phase contrast radiography Object reconstruction under nonideal conditions

A biomedical engineering perspective on the theory, methods, and applications of signal processing This book provides a unique framework for understanding signal processing of biomedical signals and what it tells us about signal sources and their behavior in response to perturbation. Using a modeling-based approach, the author shows how to perform signal processing by developing and manipulating a model of the signal source, providing a logical, coherent basis for recognizing signal types and for tackling the special challenges posed by biomedical signals–including the effects of noise on the signal, changes in basic properties, or the fact that these signals contain large stochastic components and may even be fractal or chaotic. Each chapter begins with a detailed biomedical example, illustrating the methods under discussion and highlighting the interconnection between the theoretical concepts and applications. The author has enlisted experts from numerous subspecialties in biomedical engineering to help develop these examples and has made most examples available as Matlab or Simulink files via anonymous ftp. Without the need for a background in electrical engineering, readers will become acquainted with proven techniques for analyzing biomedical signals and learn how to choose the appropriate method for a given application.