This book constitutes the refereed proceedings of the 13th Conference on Artificial Intelligence in Medicine, AIME 2011, held in Bled, Slovenia, in July 2011.

The 42 revised full and short papers presented together with 2 invited talks were carefully reviewed and selected from 113 submissions. The papers are organized in topical sections on knowledge-based systems; data mining; special session on AI applications; probabilistic modeling and reasoning; terminologies and ontologies; temporal reasoning and temporal data mining; therapy planning, scheduling and guideline-based care; and natural language processing.

Understanding the importance of nanosciences in diabetes is problematic as some texts can be too technical for the novice. This book uses a reader friendly format suitable not only for practitioners but newcomers as well. It begins with general aspects of nanotechnology and nanomedicine in diabetes. It then discusses glucose and glucose sensors based on functional nanocomposites before moving on to a discussion of insulin and the use of nanoprobes to monitor cell processes in the pancreas. Finally, it explores drugs and other treatments, including second-generation sulfonylurea glipizide loaded biodegradable nanoparticles and nanoparticle-mediated delivery of angiogenic inhibitors in diabetic retinopathy."

Like the previous editions, this book is a primer for those new to nursing informatics. It provides a thorough introduction to basic terms and concepts, as well as an in-depth exploration of the most prevalent applications in nursing practice, education, administration, and research. Expanded and updated to reflect the remarkable technical advances achieved in health care in recent years, this new edition offers the reader illustrative examples and valuable information resources. Topics include: Telecommunications and Informatics; Nursing Aspects of Health Information Systems; Clinical Practice Applications of Nursing Informatics; Infrastructure Elements of the Health Informatics Environment; and Future Opportunities for Nurses in Health Informatics. This primer guides reader who want basic information on how to select and use information systems and information management in all aspects of nursing practice, education, management, and research.

With the ever-increasing volume of information in clinical medicine, researchers and health professionals need computer-based storage, processing and dissemination. In this book, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. This book is the perfect guide for researchers and clinical scientists working in this emerging "omics" era.

The recent accumulation of information from genomes, including their sequences, has resultednotonlyinnewattemptstoansweroldquestionsandsolvelongstandingissues inbiology,butalsointheformulationofnovelhypothesesthatarisepreciselyfromthis wealth of data. The storage, processing, description, transmission, connection, and analysis of these data has prompted bioinformatics to become one the most relevant applied sciences for this new century, walking hand-in-hand with modern molecular biology and clearly impacting areas like biotechnology and biomedicine. Bioinformatics skills have now become essential for many scientists working with DNA sequences. With this idea in mind, this book aims to provide practical guidance andtroubleshootingadviceforthecomputationalanalysisofDNAsequences,covering a range of issues and methods that unveil the multitude of applications and relevance that Bioinformatics has today. The analysis of protein sequences has been purposely excludedtogainfocus.Individualbookchaptersareorientedtowardthedescriptionof theuseofspecificbioinformaticstools,accompaniedbypracticalexamples,adiscussion on the interpretation of results, and specific comments on strengths and limitations of the methods and tools. In a sense, chapters could be seen as enriched task-oriented manuals that will direct the reader in completing specific bioinformatics analyses. The target audience for this book is biochemists, and molecular and evolutionary biologiststhatwanttolearnhowtoanalyzeDNAsequencesinasimplebutmeaningful fashion. Readers do not need a special background in statistics, mathematics, or computer science, just a basic knowledge of molecular biology and genetics. All the tools described in the book are free and all of them can be downloaded or accessed throughtheweb.Mostchapterscouldbeusedforpracticaladvancedundergraduateor graduate-level courses in bioinformatics and molecular evolution.

Pervasive healthcare is the conceptual system of providing healthcare to anyone, at anytime, and anywhere by removing restraints of time and location while increasing both the coverage and the quality of healthcare. Pervasive Healthcare Computing is at the forefront of this research, and presents the ways in which mobile and wireless technologies can be used to implement the vision of pervasive healthcare.

This vision includes prevention, healthcare maintenance and checkups; short-term monitoring (home healthcare), long-term monitoring (nursing home), and personalized healthcare monitoring; and incidence detection and management, emergency intervention, transportation and treatment. The pervasive healthcare applications include intelligent emergency management system, pervasive healthcare data access, and ubiquitous mobile telemedicine.

Pervasive Healthcare Computing includes the treatment of several new wireless technologies and the ways in which they will implement the vision of pervasive healthcare.

Here is a book that aggregates five years of experience of three successive R and D projects (ELCH, GetTogether, GROPIS) covering technical and organizational issues of eProcurement. The projects, which were funded partly by the government and partly by industry and hospitals, looked at the characteristics of procurement processes and at standard technologies. Two of the projects included case studies (ELCH, GROPIS), the third project focused on the development of standard business objects for eProcurement in healthcare (GetTogether). Together they form a rich source of information worth communicating to a large audience of experts and newcomers alike.

This book constitutes the proceedings of the KR4HC 2010 workshop held at ECAI in Lisbon, Portugal, in August 2010. The 11 extended papers presented were carefully reviewed and selected from 19 submissions. The papers cover topics like ontologies, patient data, records, and guidelines, and clinical practice guidelines.

The book provides a comprehensive overview for the latest WBAN systems, technologies, and applications. The chapters of the book have been written by various specialists who are experts in their areas of research and practice. The book starts with the basic techniques involved in designing and building WBAN systems. It explains the deployment issues and then moves into the application areas of WBAN. The remaining chapters focus on the development of hardware, signal processing algorithms, and wireless communication and network design for wearable and implantable body sensors used in WBAN applications. The book also deals with the antenna design, propagation in and around the body, channel modeling, coexistence and power management issues, which are other critical design components for WBAN systems to achieve a successful hospital deployment.

A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.

Health institutions are investing in and fielding information technology solutions at an unprecedented pace. With the recommendations from the Institute of Medicine around information technology solutions for patient safety, mandates from industry groups such as Leapfrog about using infor mation systems to improve health care, and the move toward evidence based practice, health institutions cannot afford to retain manual practices. The installation of multi-million dollar computerized health systems repre sents the very life blood of contemporary clinical operations and a crucial link to the financial viability of institutions. Yet, the implementation of health information systems is exceptionally complex, expensive and often just plain messy. The need for improvement in the art and science of systems implemen tation is clear: up to 70-80% of information technology installations fail. The reasons are multi-faceted, ranging from the complexity of the diverse workflows being computerized, the intricate nature of health organizations, the knowledge and skills of users to other reasons such as strategies for obtaining key executive support, weaving through the politics peculiar to the institution, and technical facets including the usability of systems. Thus, the art and science of successfully implementing systems remains deeply layered in elusiveness. Still, given the pervasiveness of system implementa tions and the importance of the outcomes, this is a critical topic, especially for nurses and informatics nurse specialists."

This series is directed to healthcare professionals who are leading the trans formation of health care by using information and knowledge. Launched in 1988 as Computers in Health Care, the series offers a broad range of titles: some addressed to specific professions such as nursing, medicine, and health administration; others to special areas of practice such as trauma and radiol ogy. Still other books in the series focus on interdisciplinary issues, such as the computer-based patient record, electronic health records, and networked healthcare systems. Renamed Health Informatics in 1998 to reflect the rapid evolution in the discipline now known as health informatics, the series will continue to add titles that contribute to the evolution of the field. In the series, eminent ex perts, serving as editors or authors, offer their accounts of innovations in health informatics. Increasingly, these accounts go beyond hardware and soft ware to address the role of information in influencing the transformation of healthcare deli very systems around the world. The series also increasingly focuses on "peopleware" and the organizational, behavioral, and societal changes that accompany the diffusion of information technology in health services environments."

The European Society for Arti?cial Intelligence in Medicine (AIME) was - tablished in 1986 following a very successful workshop held in Pavia, Italy, the year before. The principal aims of AIME are to foster fundamental and applied research in the application of arti?cial intelligence (AI) techniques to medical care and medical research, and to provide a forum at biennial conferences for discussing any progress made. For this reason the main activity of the society wastheorganizationofaseriesofbiennialconferences, heldinMarseilles, France (1987), London, UK (1989), Maastricht, The Netherlands (1991), Munich, G- many (1993), Pavia, Italy (1995), Grenoble, France (1997), Aalborg, Denmark (1999), Cascais, Portugal(2001), Protaras, Cyprus(2003), Aberdeen, UK(2005), and Amsterdam, The Netherlands (2007). This volume contains the proceedings of AIME 2009, the 12th Conference on Articial Intelligence in Medicine, held in Verona, Italy, July 18-22, 2009. The AIME 2009 goalswereto present and consolidate the internationalstate of the art of AI in biomedical research from the perspectives of theory, meth- ology, and application. The conference included two invited lectures, full and short papers, tutorials, workshops, and a doctoral consortium. In the conference announcement, authors were solicited to submit originalcontributions regarding the developmentoftheory, techniques, andapplications ofAI in biomedicine, - cluding the exploitation of AI approaches to molecular medicine and biomedical informaticsandto healthcareorganizationalaspects. Authorsofpapersaddre- ing theory were requested to describe the properties of novel AI methodologies potentially useful for solving biomedical

This book contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. It contains detailed description of the procedures, discussion of potential difficulties and failures. All protocols follow the successful Methods in Molecular Biology series format.

The nanosciences are a rapidly expanding field of research with a wide applicability to all areas of health and disease prevention. This book, covers the regulation of nanomedicine, nanotubes, topical applications of nanoparticles, nanocrystals, antioxidant nanoparticles, lipid nanocapsules, nanotheragnostic colloids, nanotechnology in the control of infectious disease, virus-based nanoparticles and the safety of nanoparticles. It also covers nanomedicine in relation to pulmonary drug delivery, the control of infectious disease, radiation protection, arthritis, cancer nanomedicine, blood diseases, neurodegenerative disorders, and tissue and implant engineering.

Medical science and practice have undergone fundamental changes in the last 5 years, as large-scale genome projects have resulted in the sequencing of a number of important microbial, plant and animal genomes. This book aims to combine industry standard software engineering and design principles with genomics, bioinformatics and cancer research. Rather than an exercise in learning a programming platform, the text focuses on useful analytical tools for the scientific community.

Why some patients wait longer than others remains an important question. This book is a reference for health services researchers looking for statistical tools with which to study waiting times. The book offers detailed coverage of statistical concepts and methods for the analysis and interpretation of waiting-time data. It provides analysis from health services research perspective, rather than operations management, and contains a collection of examples.

This book provides a timely and first-of-its-kind collection of papers on anatomy ontologies. It is interdisciplinary in its approach, bringing together the relevant expertise from computing and biomedical studies. The book aims to provide readers with a comprehensive understanding of the foundations of anatomical ontologies and the-state-of-the-art in terms of existing tools and applications. It also highlights challenges that remain today.

According to a statement of Gordon Moore computer performance doubles every 18 months. So it is not surprising that the "half-time" of modern computers is rapidly decreasing. Increasing demands of public health for radiology together with a rapid development of information technology and innovations result in a digital environment, where thorough guidance is necessary. This book is such a solid guidance for radiologists and other medical staff working in this field. The second edition has been brought up-to-date, revised and new aspects have been incorporated that focus on the synergy that results from the integration of digital systems used in radiology such as image fusion, "functional" imaging, electronic patient records and health networks, etc. It is intended for radiologists and all other physicians, as well as technicians, scientists, IT-experts, health care providers and health maintenance organisations. The IT-market now has changed so much that Integrated Health Care Enterprise becomes reality.

This bookis the resultof merging two workshopsseries, namely, oneon comp- erized guidelines and protocols and the other one on knowledge management for healthcareprocedures. Themergeresultedinthe KR4HCworkshop: Knowledge Representationfor HealthCare: Data, Processes, andGuidelines. This workshop was held in conjunction with the 12th Conference on Arti?cial Intelligence in Medicine (AIME 2009), in Verona, Italy. The book included, in addition to the full-length workshop papers, invited peer-reviewed advanced papers on lessons learned in these ?elds. The KR4HC workshop continued a line of successful guideline workshops held in 2000, 2004, 2006, 2007, and 2008. Following the success of the ?rst - ropean Workshop on Computerized Guidelines and Protocols held in Leipzig, Germany, in 2000, the Symposium on Computerized Guidelines and Protocols (CGP 2004) was organized in Prague, Czech Republic in 2004 to identify use cases for guideline-based applications in health care, computerized methods for supportingtheguidelinedevelopmentprocess, andpressingissuesandpromising approachesfordevelopingusableandmaintainablevehiclesforguidelinedelivery. In 2006 an ECAI 2006 workshop at Riva del Garda, Italy, entitled "AI Te- niques in Health Care: Evidence-BasedGuidelinesand Protocols"wasorganized to bring together researchers from di?erent branches of arti?cial intelligence to examine cutting-edge approaches to guideline modeling and development and to consider how di?erent communities can cooperate to address the challenges of computer-based guideline development.

Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While most mathematicians are well-versed in the distinctive features and empirical performance of SVMs, many chemists and biologists are not as familiar with what they are and how they work. Presenting a clear bridge between theory and application, Support Vector Machines and Their Application in Chemistry and Biotechnology provides a thorough description of the mechanism of SVMs from the point of view of chemists and biologists, enabling them to solve difficult problems with the help of these powerful tools. Topics discussed include: Background and key elements of support vector machines and applications in chemistry and biotechnology Elements and algorithms of support vector classification (SVC) and support vector regression (SVR) machines, along with discussion of simulated datasets The kernel function for solving nonlinear problems by using a simple linear transformation method Ensemble learning of support vector machines Applications of support vector machines to near-infrared data Support vector machines and quantitative structure-activity/property relationship (QSAR/QSPR) Quality control of traditional Chinese medicine by means of the chromatography fingerprint technique The use of support vector machines in exploring the biological data produced in OMICS study Beneficial for chemical data analysis and the modeling of complex physic-chemical and biological systems, support vector machines show promise in a myriad of areas. This book enables non-mathematicians to understand the potential of SVMs and utilize them in a host of applications.

eHealth 2008, the First International Conference on Electronic healthcare for the twenty-first century, was held in City University, London, during September 8-9, 2008. The conference was organized as a meeting point for telecare product vendors, policy makers, government ministers, academics, clinicians and all those involved in electronic and mobile health, to examine and to share ideas contributing to the - vancement of electronic healthcare into the twenty-first century. The conference had a huge success with a large number of paper submissions. Ninety-seven papers were submitted, of which 32 were selected for presentation. Each paper was carefully reviewed blindly by a minimum of three referees from the resp- tive field. A special thanks should go to the Technical Program Committee for their hard and efficient work in the review process. In addition to the submitted contributions, the conference included a business pres- tation track with 12 invited talks by key people in the world of eHealth. The business presentation track was chaired by Sir Jonathan Michael (Deputy Director, BT Health). The success of this conference is to be credited to the contribution of many people.

In den letzten Jahren hat sich der Workshop Bildverarbeitung fur die Medizin durch erfolgreiche Veranstaltungen etabliert. Ziel ist auch 2009 wieder die Darstellung aktueller Forschungsergebnisse und die Vertiefung der Gesprache zwischen Wissenschaftlern, Industrie und Anwendern. Die Beitrage dieses Bandes - einige in englischer Sprache - behandeln alle Bereiche der medizinischen Bildverarbeitung, insbesondere Bildgebung, CAD, Segmentierung, Bildanalyse, Visualisierung und Animation, Roboter und Manipulatoren, Chirurgische Simulatoren, Diagnose, Therapieplanung sowie deren klinische Anwendungen."

Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines. Edited by Gavin Gordon, Bioinformatics in Cancer and Cancer Therapy, the focus of this book is to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, to show how a bioinformatics approach has been used to characterize various cancer-related processes, and to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.

The Workgroup Human-Computer Interaction & Usability Engineering (HCI&UE) of the Austrian Computer Society (OCG) serves as a platform for interdisciplinary - change, research and development. While human-computer interaction (HCI) tra- tionally brings together psychologists and computer scientists, usability engineering (UE) is a software engineering discipline and ensures the appropriate implementation of applications. Our 2008 topic was Human-Computer Interaction for Education and Work (HCI4EDU), culminating in the 4th annual Usability Symposium USAB 2008 held during November 20-21, 2008 in Graz, Austria (http: //usab-symposium.tugraz.at). As with the field of Human-Computer Interaction in Medicine and Health Care (HCI4MED), which was our annual topic in 2007, technological performance also increases exponentially in the area of education and work. Learners, teachers and knowledge workers are ubiquitously confronted with new technologies, which are available at constantly lower costs. However, it is obvious that within our e-Society the knowledge acquired at schools and universities - while being an absolutely necessary basis for learning - may prove insufficient to last a whole life time. Working and learning can be viewed as parallel processes, with the result that li- long learning (LLL) must be considered as more than just a catch phrase within our society, it is an undisputed necessity. Today, we are facing a tremendous increase in educational technologies of all kinds and, although the influence of these new te- nologies is enormous, we must never forget that learning is both a basic cognitive and a social process - and cannot be replaced by technology.