Das Buch richtet sich vor allem an junge Anasthesiologen und Assistenzarzte auf Intensivstationen, die die Technik der transoesophageale Echokardiographie erlernen moechten, aber ebenso an Kardiologen und Internisten, die Patienten kardiologisch betreuen.

These eight volumes, which developed out of the international congress "Update and Future Trends in Fibrin Sealing in Surgical and Nonsurgical Fields" held in November 1992, present the state of the art in fibrin sealing. Initially, fibrin sealant played an important role in surgery. During the past few years, it has been increasingly applied nonsurgically and we can now say that it has become an integral component of medical treatment. The doubts which have been raised by nonusers about the efficacy of fibrin sealant are no longer valid. The correct indication and technique continue to be basic prerequisites for effective treatment. Even today - 20 years after fibrin sealant was first used - the three most prominent effects of fibrin sealant are still hemostasis, sealing of the wound, and support of wound healing. The problems posed by the transmission of viral infections have gained substantially in importance because of the potential transmission of AIDS via fibrin sealant. Fortunately, this is so unlikely today that it no longer represents a cause for concern, which does not mean, however, that research in this field can be discontinued.

This 3rd edition of a classic textbook examines the context and background of public health informatics, explores the technology and science underlying the field, discusses challenges and emerging solutions, reviews many key public health information systems, and includes practical, case-based studies to guide the reader through the topic. The editors have expanded the text into new areas that have become important since publication of the previous two editions due to changing technologies and needs in the field, as well as updating and augmenting much of the core content. The book contains learning objectives, overviews, future directions, and review questions to assist readers to engage with this vast topic. The Editors and their team of well-known contributors have built upon the foundation established by the previous editions to provide the reader with a comprehensive and forward-looking review of public health informatics. The breadth of material in Public Health Informatics and Information Systems, 3rd edition makes it suitable for both undergraduate and graduate coursework in public health informatics, enabling instructors to select chapters that best fit their students' needs.

'Clinical epidemiology' is now widely promoted and taught as a 'basic science' of Evidence-Based Medicine, of clinical EBM to be specific. This book, however, is mostly about that which Miettinen takes to be the necessary substitute for this now-so-fashionable subject - namely, Theory of Clinical Medicine together with its subordinate Theory of Clinical Research. The leit motif in all of this is Miettinen's perception of the need, and opportunity, to bring major improvements into clinical medicine in this Information Age, now that theoretical progress has made feasible the development of practice-guiding Expert Systems for it. Parts of this text constitute essential reading for whoever is expected, or otherwise inclined, to study - or teach - 'clinical epidemiology,' and the same is true of those who set policy for the education of future clinicians; but practically all of it is essential reading for future - and current - academics in the various disciplines of clinical medicine. After all, the text is the result of a concentrated effort, over a half-century no less, to really understand both clinical and community medicine and the research to advance the knowledge-base of these. Research epidemiologists, too, will find this text interesting and instructive.

The last volume in the series Fibrin Sealing in Surgical and Nonsurgical Fields discusses various uses of fibrin glue in endoscopic surgery. During the last years fibrin sealant has been established in the treatment of gastrointestinal ulcers and esophageal fistulae.

Fibrin sealant is used for numerous indications in gynecology, especially for the McIndoe Operation and Cohn biopsy, the Marshall-Marchetti-Krantz-Hirsch-Stoll-Operation, urethrocysopexy, or in vitro fertilization for embryo transfer. The use of fibrin sealant in urology has also been extended, especially in operations of the spermatic cord, reconstruction of the urethra and closing of nephrotomies.

"Advances in Neurosurgery 22" is devoted to three main topics, the first one being Cerebellar Infarcts. Following the introduction with the microsurgical anatomy and the neuropathology of cerebellar infarction, the indication for operative treatment and its results are then discussed. The neuroradiological treatment with local and antifibrinolytic therapy for vertebrobasilar occlusion completes this section. The management and surgical approaches to the various forms of midline lesions are then presented. Special interest is centred on minimal invasive endoscopic neurosurgery (MIEN), (intraventricular tumors, optic pathway gliomas, endoscopic brainstem tumors and vascular malformations). Furthermore the special equipment and fields of indications are extensively discussed.

These eight volumes, which developed out of the international congress "Update and Future Trends in Fibrin Sealing in Surgical and Nonsurgical Fields" held in November 1992, present the state of the art in fibrin sealing. In itially, fibrin sealant played an important role in surgery. During the past few years, it has been increasingly applied nonsurgically, and we can now say that it has become an integral component of medical treatment. The doubts which have been raised by nonusers about the efficacy of fibrin sealant are no longer valid. The correct indication and technique continue to be basic prerequisites for effective treatment. Even today - 20 years after fibrin sealant was first used - the three most prominent effects of fibrin sealant are still hemostasis, sealing of the wound, and support of wound healing. The problems posed by the transmission of viral infections have gained sub stantially in importance because of the potential transmission of AIDS via fi brin sealant. Fortunately, this is so unlikely today that it no longer represents a cause for concern, which does not mean, however, that research in this field can be discontinued.

.".". this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues--making the book enticing and useful, all at once..."" Human Vaccines, 2010

.".". This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..."" -Virology Journal, 2009

Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health.

Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers.

This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development byintroducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinologyputting it into a historical and societal context, and exploring the scope of its methods and applications.

"Bioinformatics for Vaccinology" is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

In the field of orthopedic surgery, additional areas of application and new indications have been discovered for fibrin glue treatment, for example, hemostasis in pseudotumors in hemophilic patients or in torn ligaments, and in spongiosa transplantation, primarily when nonautologous bone material is being used, or to fill large defects. In maxillofacial surgery fibrin glue is mainly used for osseous contouring of the facial and frontal bones, for alveolar ridge augmentations in preprosthetic surgery, and for soft tissue reconstructions.

A timely, practical, and concise resource for advanced practice registered nursing (APRN) students, faculty, and providers, Telehealth Essentials for Advanced Practice Nursing provides readers with an understanding of and tools to embrace the emerging field of telehealth and optimize its application in clinical practice.  Telehealth offers a unique solution to many health-care challenges, such as provider shortages, chronic disease management, an aging population, and limited access to care.  As telehealth is being incorporated into health care and health care delivery at an ever-increasing rate, APRNs that can navigate the telehealth arena are uniquely positioned to serve as leaders in the health care of the future. Using Telehealth Essentials for Advanced Practice Nursing, readers will learn how to utilize telehealth to provide new and innovative methods of care. Authors Patty A. Schweickert and Carolyn M. Rutledge present a multi-modal approach to telehealth education that layers telehealth onto nurses' existing knowledge of nursing practice. The text begins with the history and basics of telehealth before moving on to critical content that a provider must understand in order to maximize its use in the health care arena, covering topics including: The process of integrating telehealth in practice Laws, policies, and regulations governing telehealth practice Barriers to implementation and strategies for overcoming them Telehealth etiquette and ethics Using telehealth for effective interprofessional collaboration Each chapter includes group exercises, prompts for reflection, questions for discussion, and case studies. With Telehealth Essentials for Advanced Practice Nursing, APRN students, faculty, and practicing providers will learn to advocate for telehealth implementation, establish telehealth programs, and utilize telehealth to overcome barriers to care in order to optimize access and quality of care.

A portable study guide for MLS & MLT exams! Use these handy cards to review course content for classroom exams now...and certification exam-prep later. More than 600 cards concisely summarize common procedures and disorders, critical knowledge for entry-level practice, and cover topics that are frequently included on MLS and MLT certification exams. The enclosed ring lets you organize and carry the sections you need for studying on the go. Updated! Hematology and microbiology sections reflect the major reclassifications in these fields Expanded! More illustrations, especially in the hematology section New! Printed on heavier paper to improve durability Revised! Section on "Molecular Diagnostics" focuses on general principles of testing (testing applications now covered in the core lab sections). Revised! Combines laboratory operations content with management and education to reflect latest certification exam outlines New! A Q&A card with 10 multiple-choice questions in each section New & Updated! Thoroughly reviewed to incorporate the latest scientific information and changes in practice

Healthcare transformation requires us to continually look at new and better ways to manage insights - both within and outside the organization today. Increasingly, the ability to glean and operationalize new insights efficiently as a byproduct of an organization's day-to-day operations is becoming vital to hospitals and health systems ability to survive and prosper. One of the long-standing challenges in healthcare informatics has been the ability to deal with the sheer variety and volume of disparate healthcare data and the increasing need to derive veracity and value out of it. Demystifying Big Data and Machine Learning for Healthcare investigates how healthcare organizations can leverage this tapestry of big data to discover new business value, use cases, and knowledge as well as how big data can be woven into pre-existing business intelligence and analytics efforts. This book focuses on teaching you how to: Develop skills needed to identify and demolish big-data myths Become an expert in separating hype from reality Understand the V's that matter in healthcare and why Harmonize the 4 C's across little and big data Choose data fi delity over data quality Learn how to apply the NRF Framework Master applied machine learning for healthcare Conduct a guided tour of learning algorithms Recognize and be prepared for the future of artificial intelligence in healthcare via best practices, feedback loops, and contextually intelligent agents (CIAs) The variety of data in healthcare spans multiple business workflows, formats (structured, un-, and semi-structured), integration at point of care/need, and integration with existing knowledge. In order to deal with these realities, the authors propose new approaches to creating a knowledge-driven learning organization-based on new and existing strategies, methods and technologies. This book will address the long-standing challenges in healthcare informatics and provide pragmatic recommendations on how to deal with them.

The Fourth International "Nursing Informatics '91" Preconference sessions held in Melbourne Australia on the 12th and 13th April 1991 hosted by the Nursing Computer Group, Victoria Inc. (N.C.G.V.) and I.M.I.A. Working Group 8. The aims of both the International Committee and the N.C.G.V.are to provide our Nursing Colleagues nationally and internationally with access to a wide range of information about computers awareness literacy, and, the sharing of experiences. As technology advances and nurses understand their particular practice setting needs, progress in the area of nursing informatics will be an expanding arena for Industry and knowledge. Papers such as those presented here will contribute greatly to the dissemination of todays knowledge base and hopefully assist in our expansion as we move toward the year 2000. The vision and subsequent motivation of hosting an International Informatics Meeting is that a few very dedicated nurses can encourage their colleagues to approach this newly defined specialty with openness and enthusiasm. If nurses are not able to attend these sessions the papers presented here demonstrate care and commitment to the learning opportunities afforded nurses in Australia and Internationally.

This welcome addition to the series Update in Intensive Care and Emergency Medicine emerges from the most recent of a series of meetings organized by Alvar Net and Salvador Benito of Barcelona. This gathering provided a forum for European intensive care specialists to exchange ideas, knowledge and experience on, the measurements feasible in mechanically ventilated patients. The scope was ambitious, ranging from basics like the measurement of airway pressure and blood gases to topics such as CT, MRI and the multiple inert gas elimination technique. The success of the meeting made publication a logical consequence. The book is unique in its breadth. The contributors, from numerous centers in Europe and North America, cover all tech niques employed in intensive care units, describing indications, contraindications, procedures, biases and complications. This volume will be an invaluable source for intensive care specialists and other clinicians. Alongside practical descriptions of procedures they employ routinely (spirometry, measurement of sys temic vascular oxygen pressure, Swan-Ganz catheterization, BOPA etc.), they will find accounts of such sophisticated techniques as on line measurement offunctional residual capacity, isotope determina tion of ventilation/perfusion ratios, diaphragmatic metabolism and peripheral oxygen exchange. I am especially happy to see the book published by Springer-Verlag, which has distinguished itself in the field of intensive care medicine.

This book is an up-to-date textbook for biologists and biomedical scientists covering the basics of radioisotope methodology and safety. Radioisotopes are widely used in biological and medical research, particularly in biochemistry. Graduate students and technicians usually learn how to use radioisotopes through short training courses or as part of laboratory courses in biology and biochemistry. This text was written for use in courses on the theoretical aspects of radioisotopic methods or for self-study and reference; it assumes little knowledge of radioactive materials and develops mathematical discussions slowly and clearly. The focus of the book is on the topics listed on the U.S. Nuclear Regulatory Commission's license application: principles and practices of radiation protection; radioactivity measurement, standardization and monitoring techniques and instruments; mathematics and calculations basic to the use and measurement of radioactivity; and biological effects of radiation.

This book presents a comprehensive survey in which internationally recognized experts discuss specific topics. Physiological and biophysical foundations of hemodynamics are reviewed and clinical tools to evaluate these newer parameters are described. Monitoring strategies integrating theoretical and practical aspects of hemodynamics in commonly encountered ICU conditions are presented. This "Update" represents the series' continuous effort to combine the most recent developments in one reference source for all those involved in cardiology, internal medicine, pediatrics, anesthesia, intensive care and emergency medicine.

With the increasing availability of omics data and mounting evidence of the usefulness of computational approaches to tackle multi-level data problems in bioinformatics and biomedical research in this post-genomics era, computational biology has been playing an increasingly important role in paving the way as basis for patient-centric healthcare.Two such areas are: (i) implementing AI algorithms supported by biomedical data would deliver significant benefits/improvements towards the goals of precision medicine (ii) blockchain technology will enable medical doctors to securely and privately build personal healthcare records, and identify the right therapeutic treatments and predict the progression of the diseases.A follow-up in the publication of our book Computation Methods with Applications in Bioinformatics Analysis (2017), topics in this volume include: clinical bioinformatics, omics-based data analysis, Artificial Intelligence (AI), blockchain, big data analytics, drug discovery, RNA-seq analysis, tensor decomposition and Boolean network.

The Second European Conference on Artificial Intelligence in Medicine followed the successful meeting in Marseilles in 1987. As for AIME 87, the goal of AIME 89 was to promote scientific interchange within and between all subfields of AI in medicine, among researchers from all over the world, and especially from Europe. There were sessions on: knowledge elicidation and acquisition, architectures for medical knowledge-based systems, clinical applications, methodology, reasoning based on physiological models, and uncertainty. It is clear form the quality of papers presented, that the rate of development which took place between the Pavia meeting of 1985 and AIME 87 has been well maintained. With the launch of the European Community's exploratory programme in Advanced Informatics in Medicine in Europe, 1989 is clearly a very important year for this discipline. AIME 89 provided an important forum which demonstrated progress in some of the more difficult methodological problems, and advances in the application of these techniques to real-world medicine. This volume should be consulted by anyone who wishes to appreciate the state of the art in Medical AI in Europe.

Der vorliegende Band fasst die Ergebnisse eines zweitagigen Symposions "Multiple Hypothesenprufung" am 6. und 7. November 1987 in Gerolstein/ Eifel zusammen. Das Problem der multiplen Hypothesenprufung stellt sich immer dann, wenn aufgrund eines statistischen Experimentes mehrere Fragestellungen beantwortet werden sollen. Insbesondere innerhalb biologisch-medizi- nischer Studien sind haufig mehrere Behandlungen, mehrere Zielgrossen oder Messungen zu mehreren Zeitpunkten zu beurteilen. In der Vergangenheit wurde dem Problem der Multiplizitat der Fragestel- lungen nicht genugend Beachtung geschenkt. Im deutschsprachigen Raum erschien dieses Thema etwa ab Ende der 70er Jahre vermehrt auf Kongres- sen sowie in Veroffentlichungen, ausgelost durch die Arbeiten von MARCUS, PERITZ und GABRIEL (1976) und HOLM (1979). Besonders durch das Schwerpunkuhema "Simultane Hypothesenprufung" und die gemein- same Publikation der Referate im Rahmen des Biometrischen Seminars im Jahre 1981 in Bad Ischl, Osterreich, wurde die Aufmerksamkeit vieler Biometriker auf neuere Entwicklungen in diesem fur die Anwendung so wichtigen Bereich gelenkt. In der Folge kam es zu einer intensiven For- schungstatigkeit an den verschiedensten Stellen, vorwiegend von Biometr- kern und von Statistikern mit engem Verhaltnis zur Biometrie. Es war daher naheliegend zu versuchen, die in diesem Bereich methodisch tatigen Biometriker und Statistiker zu einem intensiven Meinungsaus- tausch zusammenzubringen. Dabei sollte eine Bestandsaufnahme vorge- nommen und uber die Richtung weiterer Entwicklungen diskutiert werden. Schon wahrend des Symposions wurde von emlgen Teilnehmern der Vor- schlag gemacht, den Tagungsband in englischer Sprache abzufassen, um IV den Ergebnissen international eine grossere Verbreitung zu ermoglichen.

This third edition presents and dissects a wide variety of HIT failures so that the reader can understand in each case what went wrong and why and how to avoid such problems, without focusing on the involvement of specific people, organizations, or vendors. The lessons may be applied to future and existing projects, or used to understand why a previous project failed. The reader also learns how common causes of failure affect different kinds of HIT projects and with different results. Cases are organized by the type of focus (hospital care, ambulatory care, and community). Each case provides analysis by an author who was involved in the project plus the insight of an HIT expert. This book presents a model to discuss HIT failures in a safe and protected manner, providing an opportunity to focus on the lessons offered by a failed initiative as opposed to worrying about potential retribution for exposing a project as having failed. Access expert insight into key obstacles that must be overcome to leverage IT and transform healthcare. Each de-identified case study includes an analysis by a group of industry experts along with a counter analysis. Cases include a list of key words and are categorized by project (e.g. CPOE, business intelligence). Each case study concludes with a lesson learned section. Thought provoking commentary chapters add additional context to the challenges faced during HIT projects, from social and organizational to legal and contractual.

This book presents a collection of invited contributions, each reflecting an area of biomedicine in which simulation techniques have been successfully applied. Thus, it provides a state-of-the-art survey of simulation techniques in a variety of biomedical applications. Chapter one presents the conceptual framework for advanced simulations such as parallel processing in biological systems. Chapter two focuses on structured biological modeling based on the bond graph method. This is followed by an up-to-date account of advanced simulation of a variety of sophisticated biomedical processes. The authors provide many insights into how computer simulation techniques and tools can be applied to research problems in biomedicine. The idea for this book arose out of the daily work by experts in their field and reflects developing areas. Therefore, I think the material is timely and hope that the work described will be an encouragement for others. It is the objective of this book to present advanced simulation techniques in biomedicine and outline current research, as well as to point out open problems, in this dynamic field. Finally, I wish to express my thanks to those colleagues who have made this book possible with their contributions.

This textbook provides a detailed resource introducing the subdiscipline of mental health informatics. It systematically reviews the methods, paradigms, tools and knowledge base in both clinical and bioinformatics and across the spectrum from research to clinical care. Key foundational technologies, such as terminologies, ontologies and data exchange standards are presented and given context within the complex landscape of mental health conditions, research and care. The learning health system model is utilized to emphasize the bi-directional nature of the translational science associated with mental health processes. Descriptions of the data, technologies, paradigms and products that are generated by and used in each process and their limitations are discussed. Mental Health Informatics: Enabling a Learning Mental Healthcare System is a comprehensive introductory resource for students, educators and researchers in mental health informatics and related behavioral sciences. It is an ideal resource for use in a survey course for both pre- and post-doctoral training programs, as well as for healthcare administrators, funding entities, vendors and product developers working to make mental healthcare more evidence-based.

About the Book The book provides details of applying intelligent mining techniques for extracting and pre-processing medical data from various sources, for application-based healthcare research. Moreover, different datasets are used, thereby exploring real-world case studies related to medical informatics. This book would provide insight to the learners about Machine Learning, Data Analytics, and Sustainable Computing. Salient Features of the Book Exhaustive coverage of Data Analysis using R Real-life healthcare models for: Visually Impaired Disease Diagnosis and Treatment options Applications of Big Data and Deep Learning in Healthcare Drug Discovery Complete guide to learn the knowledge discovery process, build versatile real life healthcare applications Compare and analyze recent healthcare technologies and trends Target Audience This book is mainly targeted at researchers, undergraduate, postgraduate students, academicians, and scholars working in the area of data science and its application to health sciences. Also, the book is beneficial for engineers who are engaged in developing actual healthcare solutions.