Chapter 1 offers an overview of the basic computer technology. Each succeeding chapter, describes the problems in medicine, followed by a review in chronological sequence of why and how computers were applied to try to meet these problems. Only the technical aspects of computer hardware, software, and communications are discussed as they are necessary to explain how the technology was applied. This approach generally led to defining the objectives for applications of medical informatics. At the end of each chapter, the author summarizes his personal views and interpretations of the chapter contents. Although the concurrent evolution of medical informatics in Canada, Europe, and Japan certainly influenced workers in the United States, the scope of this historical review is limited to the development of medical informatics within the United States. Furthermore, this review is limited to electronic digital computers; it excludes mechanical, analog, and hybrid computers.

Myocardial tissue engineering (MTE), a concept that intends to prolong patients life after cardiac damage by supporting or restoring heart function, is continuously improving. Common MTE strategies include an engineered vehicle, which may be a porous scaffold or a dense substrate or patch, made of either natural or synthetic polymeric materials. The function of the substrate is to aid transportation of cells into the diseased region of the heart and support their integration. This book, which contains chapters written by leading experts in MTE, gives a complete analysis of the area and presents the latest advances in the field. The chapters cover all relevant aspects of MTE strategies, including cell sources, specific TE techniques and biomaterials used. Many different cell types have been suggested for cell therapy in the framework of MTE, including autologous bone marrow-derived or cardiac progenitors, as well as embryonic or induced pluripotent stem cells, each having their particular advantages and disadvantages. The book covers a complete range of biomaterials, examining different aspects of their application in MTE, such as biocompatibility with cardiac cells, mechanical capability and compatibility with the mechanical properties of the native myocardium as well as degradation behaviour in vivo and in vitro. Although a great deal of research is being carried out in the field, this book also addresses many questions that still remain unanswered and highlights those areas in which further research efforts are required. The book will also give an insight into clinical trials and possible novel cell sources for cell therapy in MTE."

In his treatment of activity measurement in the fields of medicine and psychology, Tryon gives us a book that clearly accomplishes the three purposes set out in its preface. The reader is definitely encouraged to wrestle with the concepts ofbehavior and activity in terms of "dynamic physical quantities." Moreover, the reader cannot help but become familiarized with the technology available for performing activity measurements. Motivation to use some of this technology is enhanced by the very extensive summary of other people's uses of it provided throughout the book. Readers may find the book provocative on a number of Ievels. It is concep tually provocative to those of us struggling with understanding basic issues in the assessment and measurement of behavior. It is practically provocative to those of us working with various forms of behavioral difference, especially in clinical popula tions. The book provokes because it is essentially an unfinished exploration, open ing us to numerous pathways that, when traveled, reveal still more paths to explore. In this sense the book should be heuristically useful both in the more traditional empirical sense, and in terms of its Stimulation of conceptual discussion."

The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 100 papers included in the first volume have been organized in the following topical sections: microstructure imaging; image reconstruction and enhancement; registration; segmentation; intervention planning and guidance; oncology; and optical imaging.

Swamy Laxminarayan was an outstanding researcher active in many diverse fields of science and technology. He was one of the most prominent biomedical scientists and his ideas influenced the Biomedical Technology substantially. This book tries to provide an overview on the multiple achievements of Swamy Laxminarayan. It presents a collection of his most outstanding publications and an overview on his outstanding life. This Volume is the second part of the liber amicorum in Memory of Swamy Laxminarayan.

This is an introduction to the patient monitoring technologies that are used in today's acute care environments, including the operating room, recovery room, emergency department, intensive care unit, and telemetry floor. To a significant extent, day-to-day medical decision-making relies on the information provided by these technologies, yet how they actually work is not always addressed during education and training. The editors and contributors are world-renowned experts who specialize in developing, refining, and testing the technology that makes modern-day clinical monitoring possible. Their aim in creating the book is to bridge the gap between clinical training and clinical practice with an easy to use and up-to-date guide. * How monitoring works in a variety of acute care settings * For any healthcare professional working in an acute care environment * How to apply theoretical knowledge to real patient situations * Hemodynamic, respiratory, neuro-, metabolic, and other forms of monitoring * Information technologies in the acute care setting * New and future technologies

The three-volume set LNCS 8673, 8674, and 8675 constitutes the refereed proceedings of the 17th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2014, held in Boston, MA, USA, in September 2014. Based on rigorous peer reviews, the program committee carefully selected 253 revised papers from 862 submissions for presentation in three volumes. The 53 papers included in the third volume have been organized in the following topical sections: shape and population analysis; brain; diffusion MRI; and machine learning.

This publication identifies and discusses important challenges affecting eHealth in the EU and North America in the three areas of law, ethics and governance. It makes meaningful contributions to the eHealth discourse by suggesting solutions and making recommendations for good practice and potential ways forward. Legal challenges discussed include issues related to electronic medical records, telemedicine, the Internet and pharmaceutical drugs, healthcare information systems and medical liability. Ethical challenges focus on telehealth and service delivery in the home, Web 2.0 and the Internet, patient perceptions and ethical frameworks. Governance challenges focus on IT governance in healthcare, governance and decision-making in acute care hospitals, and different models of eHealth governance. The publication provides useful support materials and readings for persons active in developing current understandings of the legal, ethical and governance challenges involved in the eHealth context.

Since the publication of Hospital Computer Systems, edited by Morris F. Collen in 1974, many reviews have appeared presenting sound analyses and evaluations of the of hospital information systems (HIS). Many of latest developments and design them were published within the IMIA Working Group 10 which is devoted to HIS but still an updated and critical overview was lacking which reviews what has been achieved since then and which also takes a inspired glance into the future. As the quotation from Romain Rolland introducing this latest work by Rudi van de Velde states "/ love and admire the past but I would like the future to be even better. " Hence, it is noteworthy to point out that this book includes topics ranging from "Trends in Medical Informatics, Setting the Scene" to "HIS in the Years Ahead" and dealing separately with hospital management concerns and medical applications. Hospital management is the field wholly supported by the HIS, since it deals with transactions issued by the team of patient care professionals about the patients and, as such, handles computer communications between the more or less autonomous substructures of the hospital, including central and costly resources such as laboratories, radiology departments and pharmacies, and links medical and administrative services (as Marion J. Ball already pointed out when she undertook to categorize the HIS).

The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 81 papers included in the third volume have been organized in the following topical sections: image reconstruction and motion modeling; machine learning in medical image computing; imaging, reconstruction, and enhancement; segmentation; physiological modeling, simulation, and planning; intraoperative guidance and robotics; microscope, optical imaging, and histology; diffusion MRI; brain segmentation and atlases; and functional MRI and neuroscience applications.

The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 86 papers included in the second volume have been organized in the following topical sections: registration and atlas construction; microscopy, histology, and computer-aided diagnosis; motion modeling and compensation; segmentation; machine learning, statistical modeling, and atlases; computer-aided diagnosis and imaging biomarkers; physiological modeling, simulation, and planning; microscope, optical imaging, and histology; cardiology; vasculatures and tubular structures; brain segmentation and atlases; and functional MRI and neuroscience applications.

Bernhard Gleich introduces Magnetic Particle Imaging (MPI) including all aspects that are necessary for a complete understanding. MPI is a new imaging modality invented by Bernhard Gleich and Jurgen Weizenecker. The method is capable of imaging the distribution of superparamagnetic iron oxide particles (SPIOs) with high sensitivity, high spatial resolution, and high imaging speed. The author summarizes the results of a number of original papers and countless innovations he has elaborated in the young discipline of magnetic particle imaging."

New computerized approaches to various problems have become critically important in healthcare. Computer assisted diagnosis has been extended towards a support of the clinical treatment. Mathematical information analysis, computer applications together with medical equipment and instruments have become standard tools underpinning the current rapid progress with developing Computational Intelligence. We are witnessing a radical change as technologies have been integrated into systems that address the core of medicine, including patient care in ambulatory and in-patient setting, disease prevention, health promotion, rehabilitation and home care. Computer aided diagnosis and treatment systems increase the objectivity of the analysis and speed up the response to pathological changes.

This book presents a variety of state-of-the-art information technology and its applications to the networked environment to allow robust computerized approaches to be introduced throughout the healthcare enterprise. Patient's safety and shortening of the rehabilitation time requires a more rapid development of minimally invasive surgery supported by image navigation techniques. Home care, remote rehabilitation assistance, safety of the elderly requires new areas to be explored in telemedicine and telegeriatrics.

This book is a great reference tool for scientists who deal with problems of designing and implementing processing tools employed in systems that assist clinicians in patient diagnosis and treatment."

This book constitutes the thoroughly refereed post-conference proceedings of the Second International Symposium on Foundations of Health Information Engineering and Systems, FHIES 2012, held in Paris, France, in August 2012. The 11 revised full papers presented together with 3 short papers in this volume were carefully reviewed and selected from 26 submissions. Topics of interest covered in this volume are such as software engineering; systems engineering; data engineering; applied mathematics; and psychology.

In nowadays aging society, many people require mobility assistance. Sometimes, assistive devices need a certain degree of autonomy when users' disabilities difficult manual control. However, clinicians report that excessive assistance may lead to loss of residual skills and frustration. Shared control focuses on deciding when users need help and providing it. Collaborative control aims at giving just the right amount of help in a transparent, seamless way. This book presents the collaborative control paradigm. User performance may be indicative of physical/cognitive condition, so it is used to decide how much help is needed. Besides, collaborative control integrates machine and user commands so that people contribute to self-motion at all times. Collaborative control was extensively tested for 3 years using a robotized wheelchair at a rehabilitation hospital in Rome with volunteer inpatients presenting different disabilities, ranging from mild to severe. We also present a taxonomy of common metrics for wheelchair navigation and tests are evaluated accordingly. Obtained results are coherent both from a quantitative and qualitative point of view.

This book constitutes the refereed proceedings of the 8th IAPR International Conference on Pattern Recognition in Bioinformatics, PRIB 2013, held in Nice, France, in June 2013. The 25 revised full papers presented were carefully reviewed and selected from 43 submissions. The papers are organized in topical sections on bio-molecular networks and pathway analysis; learning, classification, and clustering; data mining and knowledge discovery; protein: structure, function, and interaction; motifs, sites, and sequence analysis.

The "information explosion" in recent decades has made it impossible for practicing physicians (even specialists) to keep up with all the information potentially at their disposal. As a result, it is not surprising that empirical studies have shown that physicians do not always make optimal decisions. Thus, medical expert systems are now available to support - not replace - physicians and healthcare providers in their goal of providing the best possible healthcare to every patient. Knowledge Engineering in Health Informatics is a guide to the creation of such systems. Presenting the core material for courses such as Medical Knowledge Engineering and Expert System Development, it allows non-experts to make diagnostic decisions with the precision and accuracy of medical experts thanks to the help of the computer.

This book constitutes the refereed proceedings of the First International Conference on Human Factors in Computing and Informatics, SouthCHI 2013, held in Maribor, Slovenia, in July 2013. SouthCHI is the successor of the USAB Conference series and promotes all aspects of human-computer interaction. The 38 revised full papers presented together with 12 short papers, 4 posters and 3 doctoral thesis papers were carefully reviewed and selected from 169 submissions. The papers are organized in the following topical sections: measurement and usability evaluation; usability evaluation - medical environments; accessibility methodologies; game-based methodologies; Web-based systems and attribution research; virtual environments; design culture for ageing well: designing for "situated elderliness"; input devices; adaptive systems and intelligent agents; and assessing the state of HCI research and practice in South-Eastern Europe.

Responding to demographic changes among physicians and six years of new experiences since the first edition, Dr. Myers has revamped his well received work. He includes new information on older physicians, gay and lesbian physicians, medical student abuse, economic strain on interns, depression, malpractice, ethical violations, and other stressors which may cause marital difficulties. Therapists seeking to council symptomatic physicians, as well physicians themselves, will find this a humane, readable, and useful book.

The book uses STELLA software to develop simulation models, thus allowing readers to convert their understanding of a phenomenon to a computer model, and then run it to yield the inevitable dynamic consequences built into the structure. Part I provides an introduction to modeling dynamic systems, while Part II offers general modeling methods. Parts III through VIII then apply these methods to model real-world phenomena from chemistry, genetics, ecology, economics, and engineering. A clear, approachable introduction to the modeling process, of interest in any field where real problems can be illuminated by computer simulation.

This book provides a theoretical foundation for the analysis of discrete data such as count and binary data in the longitudinal setup. Unlike the existing books, this book uses a class of auto-correlation structures to model the longitudinal correlations for the repeated discrete data that accommodates all possible Gaussian type auto-correlation models as special cases including the equi-correlation models. This new dynamic modelling approach is utilized to develop theoretically sound inference techniques such as the generalized quasi-likelihood (GQL) technique for consistent and efficient estimation of the underlying regression effects involved in the model, whereas the existing 'working' correlations based GEE (generalized estimating equations) approach has serious theoretical limitations both for consistent and efficient estimation, and the existing random effects based correlations approach is not suitable to model the longitudinal correlations. The book has exploited the random effects carefully only to model the correlations of the familial data. Subsequently, this book has modelled the correlations of the longitudinal data collected from the members of a large number of independent families by using the class of auto-correlation structures conditional on the random effects. The book also provides models and inferences for discrete longitudinal data in the adaptive clinical trial set up. The book is mathematically rigorous and provides details for the development of estimation approaches under selected familial and longitudinal models. Further, while the book provides special cares for mathematics behind the correlation models, it also presents the illustrations of the statistical analysis of various real life data. This book will be of interest to the researchers including graduate students in biostatistics and econometrics, among other applied statistics research areas. Brajendra Sutradhar is a University Research Professor at Memorial University in St. John's, Canada. He is an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He has published about 110 papers in statistics journals in the area of multivariate analysis, time series analysis including forecasting, sampling, survival analysis for correlated failure times, robust inferences in generalized linear mixed models with outliers, and generalized linear longitudinal mixed models with bio-statistical and econometric applications. He has served as an associate editor for six years for Canadian Journal of Statistics and for four years for the Journal of Environmental and Ecological Statistics. He has served for 3 years as a member of the advisory committee on statistical methods in Statistics Canada. Professor Sutradhar was awarded 2007 distinguished service award of Statistics Society of Canada for his many years of services to the society including his special services for society's annual meetings.

This user-friendly, comprehensive guide places evaluation in the context of HIV to give all health care professionals the necessary tools for developing and implementing successful HIV interventions. Every aspect of evaluation is discussed, including: * the social and political context of evaluation * coding and inter-rater reliability procedures * barriers to evaluation and solution * the dissemination of results * the application of theory to HIV interventions. Case studies and examples from both the US and abroad to illustrate practical issues, and numerous tables and figures complement the text.

Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.

Methodological problems have hampered researchers' efforts to understand and control AIDS since the beginning of the epidemic. This practical book addresses these problems by using actual health research case studies to develop strategies regarding design and sampling, measurement, and analysis and modeling issues. Researchers working on both biological and behavioral aspects of the disease will find this work a singularly effective tool to improve their study designs.

"Clinical Laboratory Blood Banking and Transfusion Medicine: Principles and Practices" provides readers with the didactic foundation, background, and tools to successfully function in a typical transfusion medicine laboratory. The text's teaching and learning package includes an Instructor's Manual, lecture slides, and test bank. Teaching and Learning Experience:

• Presents detailed technical information and real-life case studies that help learners envision themselves as members of the health care team
• Mixes theoretical and practical information that allows learners to analyze and synthesize the concepts
• Complemented by a variety of ancillary materials designed to help instructors be more effective and students more successful