Medical imaging is a very important area in diagnostic (and increasingly therapeutic) medicine. Many new techniques are being developed or extended which depend on digital methods. Although conventional x-radiographs still comprise the bulk of the medical images acquired in a hospital, digital methods such as computerized tomography and magnetic resonance imaging are now often claimed to have a more significant clinical impact. This book is concerned with three aspects of such digital images: their formation, or how they can be acquired; their handling, or how they may be manipulated to increase their clinical value; and their evaluation, or how their impact and value may be assessed. The book is divided into three parts. Part 1 comprises a series of reviews in the general subject area written by authorities in the field. Part 2 includes papers on theoretical aspects: 3D images, reconstruction, perception, and image processing. Part 3includes papers on applications in nuclear medicine, magnetic resonance, andradiology.

The three-volume set LNCS 7510, 7511, and 7512 constitutes the refereed proceedings of the 15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012, held in Nice, France, in October 2012. Based on rigorous peer reviews, the program committee carefully selected 252 revised papers from 781 submissions for presentation in three volumes. The third volume includes 79 papers organized in topical sections on diffusion imaging: from acquisition to tractography; image acquisition, segmentation and recognition; image registration; neuroimage analysis; analysis of microscopic and optical images; image segmentation; diffusion weighted imaging; computer-aided diagnosis and planning; and microscopic image analysis.

The continuing growth of computed tomography (CT) and other imaging techniques motivated us to bring together a comprehensive review of the state of the art in diagnostic imaging. Twelve years after the first appearance of x-ray CT, computerized diagnostic imaging has grown so rapidly in sophistication that it is difficult to follow current developments in this diversified field. In this book, we have attempted to cover the basic developments in several areas. The first part includes some of the fundamental aspects of computerized diagnostic imaging such as algorithms and detectors. Specific applications in emission tomography, digital radiography, ultrasound and nuclear magnetic resonance imaging are dealt with in the secondpart. The contributed papers are by experts currently in the field, whom we feel would certainly enlighten the subject matter and possibly suggest directions for future development. We would like to express our sincere thanks to those who have contributed to this volume. We are sure that their original papers will be beneficial for readers and will also remain as an important reference for researchers in the years to come. We would also like to thank Betty Trent for her expert and patient typing of the entire book. Finally, special thanks are due to Mrs. Ingeborg Mayer of Springer-Verlag for her encouragements, support and patience throughout the preparation of this book.

The three-volume set LNCS 7510, 7511, and 7512 constitutes the refereed proceedings of the 15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012, held in Nice, France, in October 2012. Based on rigorous peer reviews, the program committee carefully selected 252 revised papers from 781 submissions for presentation in three volumes. The second volume includes 82 papers organized in topical sections on cardiovascular imaging: planning, intervention and simulation; image registration; neuroimage analysis; diffusion weighted imaging; image segmentation; computer-assisted interventions and robotics; and image registration: new methods and results.

Ziel des Workshops "Bildverarbeitung fur die Medizin" ist die Prasentation aktueller Forschungsergebnisse und die Vertiefung des Gesprachs zwischen Wissenschaftlern, Industrie und Anwendern. Die Beitrage dieses Bandes behandeln alle Bereiche der medizinischen Bildverarbeitung, darunter insbesondere die Themen molekulare Bildgebung, Animation, patientenindividuelle Simulation und Planung, computerunterstutzte Diagnose, biomechanische Modellierung, Bildverarbeitung in der Telemedizin, bildgestutzte Roboter und chirurgische Simulatoren.

Allen I. Laskin Biosciences Research Exxon Research and Engineering Company Linden, New Jersey I was contacted in the Fall of 1981 by Professors Martin Dworkin and Palmer Rogers, of the University of Minnesota and asked to participate in the orgnization of the 1983 conference in the series, "Interface Between Biology and Medicine." They and the other members of the advisory committee had the vision to realize that this was a time to depart somewhat from the traditional theme, since one of the major areas of interest in the biological and related sciences these days is that of biotechnology in a broader sense than its impact on medicine alone. In designing the format of the Conference, we considered another factor. There has been a plethora of conferences, symposia, and meetings on biotechnology over the past few years, and the faces and topics have become rather familiar. There has been a strong emphasis on the development of the technology and the "biotechnology industry"; less attention has been paid to the science behind it. One might get the impression from some of these meetings and from the popular press that biotechnology has just recently sprung up, apparently full blown; the very fundamental scientific discoveries and the great body of 1 ALLEN I. LASKIN 2 continuing research that forms that basis for the technology is often obscured.

This book constitutes the thoroughly refereed post-conference proceedings of the 4th International Conference, eHealth 2011, held in Malaga, Spain, in November 2011. The 20 revised full papers presented along with 8 short papers were carefully reviewed and selected from numerous submissions in total and cover a wide range of topics including social media analysis, knowledge integration and EPR, personalisation and patient support systems, early warning systems and mobile monitoring, games and learning, security, privacy and prevention, online support for professionals and patients, agents in eHealth, online communities of practice, eHealth solutions, social media surveillance, and communication and data integration.

This book constitutes the refereed proceedings of the 6th International Conference on Pattern Recognition in Bioinformatics, PRIB 2011, held in Delft, The Netherlands, in November 2011. The 29 revised full papers presented were carefully reviewed and selected from 35 submissions. The papers cover the wide range of possible applications of bioinformatics in pattern recognition: novel algorithms to handle traditional pattern recognition problems such as (bi)clustering, classification and feature selection; applications of (novel) pattern recognition techniques to infer and analyze biological networks and studies on specific problems such as biological image analysis and the relation between sequence and structure. They are organized in the following topical sections: clustering, biomarker selection and classification, network inference and analysis, image analysis, and sequence, structure, and interactions.

Computer technology has impacted the practice of medicine in dramatic ways. Imaging techniques provide noninvasive tools which alter the di agnostic process. Sophisticated monitoring equipment presents new levels of detail for both patient management and research. In most of these tech nology applications, the computer is embedded in the device; its presence is transparent to the user. There is also a growing number of applications in which the health care provider directly interacts with a computer. In many cases, these appli cations are limited to administrative functions, e.g., office practice man agement, location of hospital patients, appointments, and scheduling. Nevertheless, there also are instances of patient care functions such as results reporting, decision support, surveillance, and reminders. This series, Computers and Medicine, will focus upon the direct use of information systems as it relates to the medical community. After twenty-five years of experimentation and experience, there are many tested applications which can be implemented economically using the current generation of computers. Moreover, the falling cost of computers suggests that there will be even more extensive use in the near future. Yet there is a gap between current practice and the state-of-the-art."

Hospital information systems (HIS) have become integral tools in the management of a hospital's medical and administrative information. With illustrated case studies, this book emphasizes clinical information systems (CIS) and their use in the direct management of the patient. Topics include the medical record, security, resource amangement, and imopaging integration.

With the exception of some additions in Section 3.1 and minor changes, the English edition of the "Medizinische Informatik" is a translation of the German edition. Because there is frequently no one-to-one correspondence between the Ger man and the English terminology, misinterpretations are possible. I have tried to avoid this situation as far as possible. The main problem re mains within the academic setting. In recent years, the term 1 for.atics has become popular in Europe, but is widely unknown in the United States. The field covers mostly what is understood as computer science and in formation science. The corresponding term medical inforaatics, now used in the name of international societies such as the "International Medical Informatics Association," covers "medical computer science," "medical information science," as well as "biomedical engineering" and has no de finite boundary to "biomathematics." The book has not been translated on a professional basis in order to keep my own style, although there has been assistance by Dr. S. Raymond, for which I am very grateful. Dipl.-Phys. N. Osada has been of great help both by proof-reading and by excellent support during preparation of the camera-ready manuscript. Further valuable advice has been given by: A.W. Pratt, M.D.; M. Ebstein, Ph.D.; M. Pacak, Ph.D.; G.S. Dunham; L.D. Nadel, Ph.D.; P.O. Miller."

Biology education, like science education in general, is in the midst of a revolution that is worldwide in scope. The changes in the ways science education researchers think about learning and understanding represent a major paradigm shift. In this book, international leaders in the field of biology education research give summaries of problems and solutions in biology learning and teaching at various grade levels. Based on a NATO workshop in the Special Programme on Advanced Educational Technology, it provides practical information for teachers, especially in using new interactive, constructivist teaching methods. For science education researchers, it offers a concise summary of a number of research issues in biology education.

Healthcare Information Management Systems, Third edition, will be a comprehensive volume addressing the technical, organizational, and management issues confronted by healthcare professionals in the selection, implementation, and management of healthcare information systems. With contributions from experts in the field, this book focuses on topics such as strategic planning, turning a plan into reality, implementation, patient-centered technologies, privacy, the new culture of patient safety, and the future of technologies in progress. With the addition of 28 new chapters, the Third Edition is also richly peppered with case studies of implementation, both in the United States and abroad. The case studies are evidence that information technology can be implemented efficiently to yield results, yet they do not overlook pitfalls, hurdles, and other challenges that are encountered. Designed for use by physicians, nurses, nursing and medical directors, department heads, CEOs, CFOs, CIOs, COOs, and healthcare informaticians, the book aims to be a indispensible reference."

In this book, research and development trends of physics, engineering, mathematics and computer sciences in biomedical engineering are presented. Contributions from industry, clinics, universities and research labs with foci on medical imaging (CT, MRT, US, PET, SPECT etc.), medical image processing (segmentation, registration, visualization etc.), computer-assisted surgery (medical robotics, navigation), biomechanics (motion analysis, accident research, computer in sports, ergonomics etc.), biomedical optics (OCT, soft-tissue optics, optical monitoring etc.) and laser medicine (tissue ablation, gas analytics, topometry etc.) give insight to recent engineering, clinical and mathematical studies.

Cognitive science is a multidisciplinary science concerned with understanding and utilizing models of cognition. It has spawned a great dealof research on applications such as expert systems and intelligent tutoring systems, and has interacted closely with psychological research. However, it is generally accepted that it is difficult to apply cognitive-scientific models to medical training and practice. This book is based on a NATO Advanced Research Workshop held in Italy in 1991, the purpose of which was to examine the impact ofmodels of cognition on medical training and practice and to outline future research programmes relating cognition and education, and in particular to consider the potential impact of cognitive science on medical training and practice. A major discovery presented in the book is that the research areas related to artificial intelligence, cognitive psychology, and medical decision making are considerably closer, both conceptually and theoretically, than many of the workshop participants originally thought.

Health Information Management: What Strategies? contains the Proceedings of the Fifth European Conference on Medical and Health Libraries and gives a full account of the state-of-the-art of European medical librarianship. This book is the fifth in a well-received series of proceedings of the European conferences and together the volumes form a valuable source for medical librarians in Europe. The quality of papers reflects the growth of the European Association for Health Information and Libraries (EAHIL) towards maturity and the ongoing professional development of its members. The field of medical and health information has no geographical borders, therefore medical librarianship needs to be an international and multinational cooperation. The book reflects the important developments ongoing in medical informatics and medical information management. These subjects are touched upon as they have a close connection to medical librarianship. The future of medical libraries will be dominated by strong alliances with computer departments and health and hospital management departments. Many contributions deal with the strategies medical librarians can or will develop in order to incorporate the many tools of modern information technology into library policy and practice.

"Progress in Medical Imaging" contains a collection of interdisciplinary reviews of subtopics in medical imaging written by internationally known experts. Topics contained in the book include automatic recognition of cells and tissue types in light microscopy, computerized manipulation and assembly of two-dimensional scans of an organ into images of the three-dimensional organ which can be rotated in space, techniques for reducing the image degradation produced by scattering radiation in chest radiography, recent advances in instrumentation, and principles of positron-emission tomography. The final chapters of this book describe the advantages of pseudo-random codes as transmitted signals for ultrasonic flow measurement, imaging, and medium characterization. The primary audience for "Progress in Medical Imaging" includes engineers, physicists, and students engaged in research, development, or applications of medical imaging.

This book is the result of several years of enthusiastic planning and effort. Much of this enthusiasm came from the experience of devel{)ping Critical Care Consultant, a large BASIC program for critical care applications (St. Louis, C. V. Mosby, 1985). Working with clinicians showed me that many were interested in learning about clinical applications of computers (and even programming in small doses) but were faced with a paucity of clinical application software. Few had the time or training to develop any such software on their own. After a search through the existing medical literature unearthed relatively little in the way of usable programs, I decided that a series of small clinical applications programs would be of use to the medical community. At the onset a number of strategic decisions were made: (1) the programs would be written in BASIC, in view of its universal popularity, (2) the units used for clinical laboratory tests would be those in common use in the United States, (3) the programs would be simple and easily understood and employ no exotic tricks that were not easily transported across computers, (4) references to the literature would be provided to allow the clinician to critically assess the algorithm or method used himself or to follow up on subsequent criticisms that may have been published, and (5) the programs would demonstrate reasonable standards of software engineering in terms of clarity, trans portability, documentation, and ease of modification."

This is a resource book on clinical decision support systems for informatics specialists, a textbook for teachers or students in health informatics and a comprehensive introduction for clinicians. It has become obvious that, in addition to physicians, other health professionals have need of decision support. Therefore, the issues raised in this book apply to a broad range of clinicians. The book includes chapters written by internationally recognized experts on the design, evaluation and application of these systems, who examine the impact of computer-based diagnostic tools both from the practitioner 's perspective and that of the patient.

Emergent Computation emphasizes the interrelationship of the different classes of languages studied in mathematical linguistics (regular, context-free, context-sensitive, and type 0) with aspects to the biochemistry of DNA, RNA, and proteins. In addition, aspects of sequential machines such as parity checking and semi-groups are extended to the study of the Biochemistry of DNA, RNA, and proteins. Mention is also made of the relationship of algebraic topology, knot theory, complex fields, quaternions, and universal turing machines and the biochemistry of DNA, RNA, and proteins.

Emergent Computation tries to avoid an emphasis upon mathematical abstraction ("elegance") at the expense of ignoring scientific facts known to Biochemists. Emergent Computation is based entirely upon papers published by scientists in well-known and respected professional journals. These papers are based upon current research. A few examples of what is not ignored to gain "elegance":

- DNA exists as triple and quadruple strands

- Watson-Crick complementary bases have mismatches

- There can be more than four bases in DNA

- There are more than sixty-four codons

- There may be more that twenty amino acids in proteins

While Emergent Computation emphasizes bioinformatics applications, the last chapter studies mathematical linguistics applied to areas such as languages found in birds, insects, medical applications, anthropology, etc.

Emergent Computation tries to avoid unnecessary mathematical abstraction while still being rigorous. The demands made upon the knowledge of chemistry or mathematics is minimized as well. The collected technical references are valuable in itself for additional reading.

Nursing and Computers: An Anthology 1987-1996 is a compilation of both landmark historic and contemporary papers, illustrating the inception and evolution of nursing informatics. The editors have collected these newly-published independent papers, and assembled them into an invaluable source book providing a framework for future developments in the field of Nursing Informatics. It will be an essential tool for nurses seeking to attain credentials as Nursing Informatics Specialists. The articles demonstrate representative experiences and philosophies in the field, attempting to maintain and expand upon the current knowledge base of computer technology in nursing. Examining the relationship between nursing and information systems, practical applications include: administration, practice, research, education, critical care, and community health.

Modern critical care is characterized by the collection of large volumes of data and the making of urgent patient care decisions. The two do not necessarily go together easily. For many years the hope has been that ICU data management systems could play a meaningful role in ICU decision support. These hopes now have a basis in fact, and this book details the history, methodology, current status, and future prospects for critical care decision support systems. By focusing on real and operational systems, the book demonstrates the importance of integrating data from diverse clinical data sources; the keys to implementing clinically usable systems; the pitfalls to avoid in implementation; and the development of effective evaluation methods.

This book brings together the best thinking from both sides of the Atlantic to explore the issues surrounding soaring health care costs. It employs disciplinary perspectives from economics, ethics, philosophy, psychology, clinical practice, and epidemiology to explore various ways that value for patients have and can be determined. A major section of the book discusses problems that can reduce the value to patients of medical care. The volume is must read for practitioners, policy makers, and researchers who want to find in one place the state-of-the-art thinking and future directions of valuing medical care from the patient 's perspective.

Nanotechnologies are among the fastest growing areas of scientific research, and this is expected to have a substantial impact on human health care, especially in biomedical applications and nanomedicine now and in the near future. In the present scenario, nanotechnology is spreading its wings to address the key problems in the field of nanomedicine and human health care by improving diagnosis, prevention, treatment, and tissue engineering. This book provides an in-depth investigation of nanotechnology-based therapy and recent advancements in this field for revolutionizing the treatments for various fatal diseases, including cardiovascular and infectious diseases.

Arguably medicine is either an arts-based science or a science-based art. In medieval times, clinical decisions were based on simple measures, such as the temperature of the body, the rhythm of the pulse, the consistency of the stool and the colour of the urine. Nowadays, thanks partly to modern technology, medical science has improved in many ways, as has healthcare. In particular, approaches which have their origins in Artificial Intelligence and Operational Research have a significant contribution to make in terms of improving not only diagnosis and treatment of patients, but also providing ways of managing patients in a more effective, more efficient, and more patient-friendly manner. This book focuses on the use of such Intelligent Patient Management to the benefit of clinicians, other healthcare and community practitioners and managers, patients and carers.