In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.

This book constitutes the refereed proceedings of the 8th Conference on Artificial Intelligence in Medicine in Europe, AIME 2001, held in Cascais, Portugal in July 2001. The 31 revised full papers presented together with 30 posters and two invited papers were carefully reviewed and selected from 79 submissions. Among the topics addressed in their context on medical information processing are knowledge management, machine learning, data mining, decision support systems, temporal reasoning, case-based reasoning, planning and scheduling, natural language processing, computer vision, image and signal interpretation, intelligent agents, telemedicine, careflow systems, and cognitive modeling.

The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models

Preface This book describes problems and results of research in the gap between two fields: Human genetics, and clinical neurophysiology. Whenever I talked about my research on the genetics of the EEG, the answer of human geneticists was: "Very interesting, but I do not understand anything about the EEG. " On the other hand, EEG specialists usually remark: "Very interesting, but I do not understand anything about human genetics. " This is why I wrote this book. It tries to summarize results my own and from some others - and to point to problems. In the from researc- light of the recent progress especially in human molecular genetics, this field of research promises deep insights into biological mechanisms of brain function, as well as genetic variation involved in mental performance, and personality of humans. However, the logistic problems of such studies are not easy to overcome: It is necessary to study carefully ascertained population samples either of "normal" persons, or of persons selected for phenotypic characteristics that are not easy to diagnose. Moreover, EEG diagnosis and classification must be very specific, and is not trivial at all. All these problems require careful preparations at various levels, long-lasting efforts, and patience. Of this I am sure, however: The results would justify the efforts. I am too old to plan such a program myself; moreover, as an emeritus professor, I do not have the means for such studies.

Physics and Instrumentation of Diagnostic Medical Ultrasound Peter Fish. University of Wales -- Bangor, School of Electronic Engineering Science, and Gwynedd and Clwyd Health Authorities, Department of Medical Physics. The field of diagnostic medical ultrasound is constantly changing as new equipment and techniques are developed and refined. The use of ultrasound is increasing rapidly throughout the world and consequently a knowledge of the underlying scientific principles and instrument operation has become an essential part of medical ultrasound courses. This book provides a concise, highly illustrated description of physics and instrumentation of diagnostic medical ultrasound and includes substantial coverage of Doppler techniques and real-time instruments. It will be of great value to sonographers, radiographers, radiologists, medical physicists and technicians as an aid to the study of the clinical use of diagnostic ultrasound, and as an excellent introduction for those intending to investigate the subject in greater depth. Other Wiley Books of Related Interest Include: Doppler Ultrasound: Physics, Instrumentation, and Clinical Applications D. H. Evans, W. N. McDicken, R. Skidmore, J. P. Woodcock 1989 Clinical Magnetic Resonance: Imaging and Spectroscopy R. Andrew, G. Bydder, J. R. Griffiths, R. A. Iles, P. Styles 1990 Ultrasound Teaching Cases Volume 1 H. B. Meire, K. C. Dewbury, D. O. Cosgrove 1988 Ultrasound Teaching Cases Volume 2 K. C. Dewbury, H. B. Meire, D. O. Cosgrove 1988

The European Societies for Arti cial Intelligence in Medicine (AIME) and M- ical Decision Making (ESMDM) were both established in 1986.A major activity of both these societies has been a series of international conferences, held bi- nially over the last 13 years. In the year 1999 the two societies organized a joint conference for the r st time. It took place from June 20{24th, 1999 in Aalborg, Denmark. This \Joint European Conference on Arti cial Intelligence in Medicine and Medical Decision Making (AIMDM'99)" was the seventh conference for each of thetwosocieties.ThisconferencefollowstheAIMEconferencesheldinMarseilles (1987), London (1989), Maastricht (1991), Munich (1993), Pavia (1995), and Grenoble(1997).PreviousESMDMconferenceshavebeenheldinLeiden(1986), Copenhagen (1988), Glasgow (1990), Marburg (1992), Lille (1994), and Torino (1996). The AIMDM conference is the major forum for the presentation and d- cussion of new ideas in the areas of Arti cial Intelligence and Medical Decision Making in Medicine. This ful lls the aims of both societies. The aims of AIME are to foster fundamental and applied researchin the applicationof Arti cial - telligence (AI) techniques to medicalcareandmedicalresearch, andto providea forum for reporting signi cant results achieved. ESMDM's aims are to promote research and training in medical decision-making, and to provide a forum for circulating ideas and programs of related interest. In the AIMDM'99 conference announcement, authors were encouraged to submit original contributions to the development of theory, techniques, and - plications of both AI in medicine (AIM) and medical decision making (MDM).

A master practitioner teaches, with 200 sample electrocardiograms, a simple but powerfully enlightening scientific approach to the art of EKG interpretation. Moving beyond the traditional practice of many books that stress technical skill and pattern recognition, Dr. Blake demonstrates in detail how tracings may be interpreted with consistency and confidence. By examining each tracing much like a patient in a physical examination, the author provides a full description of its findings and a detailed clinical explanation of how to interpret it. Drawing on a lifetime of teaching and practicing EKG interpretation, Dr. Blake demonstrates in An Annotated Atlas of Electrocardiography: A Guide to Confident Interpretation an orderly, confidence-inspiring method for arriving at a clinically useful interpretation.

Artificial Intelligence (AI) in Healthcare is more than a comprehensive introduction to artificial intelligence as a tool in the generation and analysis of healthcare data. The book is split into two sections where the first section describes the current healthcare challenges and the rise of AI in this arena. The ten following chapters are written by specialists in each area, covering the whole healthcare ecosystem. First, the AI applications in drug design and drug development are presented followed by its applications in the field of cancer diagnostics, treatment and medical imaging. Subsequently, the application of AI in medical devices and surgery are covered as well as remote patient monitoring. Finally, the book dives into the topics of security, privacy, information sharing, health insurances and legal aspects of AI in healthcare.

Organized to serve as a resource for those just beginning to learn EEG as well as those who are already experienced, it contains concise presentations of the fundamentals of EEG technology and interpretation as well as an up-to-date review of the latest digital EEG technology and EEG clinical correlations. Unlike other EEG textbooks, the second half of this book is uniquely organized according to EEG findings rather than individual disorders. This is the best practical approach to learning interpretation because it mirrors the actual practice of EEG, the EEGer is confronted by EEG patterns, not diagnoses. All other textbooks organize findings according to clinical disorder. The book contains sufficient information to serve as a laboratory manual. The appendices contain the American Clinical Neurophysiology Society guidelines for EEG and the International Federation of Clinical Neurophysiology glossary. Each chapter begins with a summary of major concepts. An overview of EEG can be quickly obtained by those beginning the study of EEG by simply reading the introductory summaries of all chapters before reading the contents of the chapters.

This book constitutes the refereed proceedings of the 6th Conference on Artificial Intelligence in Medicine Europe, AIME'97, held in Grenoble, France, in March 1997.
The volume presents 33 revised full papers selected from a total of 82 submissions; also included are three invited presentations and 25 posters. The papers are organized in topical sections on protocols and guidelines, knowledge acquisition and learning, decision-support theories, diagnostic problem solving, probabilistic models and fuzzy logic, temporal reasoning and planning, natural language and terminology, image and signal processing, and hybrid and cooperative systems.

A timely, practical, and concise resource for advanced practice registered nursing (APRN) students, faculty, and providers, Telehealth Essentials for Advanced Practice Nursing provides readers with an understanding of and tools to embrace the emerging field of telehealth and optimize its application in clinical practice.  Telehealth offers a unique solution to many health-care challenges, such as provider shortages, chronic disease management, an aging population, and limited access to care.  As telehealth is being incorporated into health care and health care delivery at an ever-increasing rate, APRNs that can navigate the telehealth arena are uniquely positioned to serve as leaders in the health care of the future. Using Telehealth Essentials for Advanced Practice Nursing, readers will learn how to utilize telehealth to provide new and innovative methods of care. Authors Patty A. Schweickert and Carolyn M. Rutledge present a multi-modal approach to telehealth education that layers telehealth onto nurses' existing knowledge of nursing practice. The text begins with the history and basics of telehealth before moving on to critical content that a provider must understand in order to maximize its use in the health care arena, covering topics including: The process of integrating telehealth in practice Laws, policies, and regulations governing telehealth practice Barriers to implementation and strategies for overcoming them Telehealth etiquette and ethics Using telehealth for effective interprofessional collaboration Each chapter includes group exercises, prompts for reflection, questions for discussion, and case studies. With Telehealth Essentials for Advanced Practice Nursing, APRN students, faculty, and practicing providers will learn to advocate for telehealth implementation, establish telehealth programs, and utilize telehealth to overcome barriers to care in order to optimize access and quality of care.

This book constitutes the refereed proceedings of the 4th International Conference on Visualization in Biomedical Computing, VBC '96, held in Hamburg, Germany, in September 1996.
The 73 revised full papers presented were selected from a total of 232 submissions. The book reports the state of the art in the field of computer based visualization in medicine and biology. The papers are organized in sections on visualization; image processing; segmentation; registration; brain: description of shape; brain: characterization of pathology; brain: visualization of function; simulation of surgery and endoscopy; image guided surgery and endoscopy.

This volume presents the proceedings of the 5th Conference on Artificial Intelligence in Medicine Europe, AIME '95, held in Pavia, Italy in June 1995.
The volume contains 32 full refereed selected papers contributed by researchers and professionals coming from computer science departments, medical informatics departments, and hospitals; in addition there are the keynote address and 28 poster presentations. The volume is organized in topical sections on medical records, temporal reasoning and simulation, probabilistic models, patient management and therapy planning, evaluation of knowledge-based systems, diagnostic support systems, models for clinical information systems, and neural networks and image interpretation.

These eight volumes, which developed out of the international congress "Update and Future Trends in Fibrin Sealing in Surgical and Nonsurgical Fields" held in November 1992, present the state of the art in fibrin sealing. Initially, fibrin sealant played an important role in surgery. During the past few years, it has been increasingly applied nonsurgically and we can now say that it has become an integral component of medical treatment. The doubts which have been raised by nonusers about the efficacy of fibrin sealant are no longer valid. The correct indication and technique continue to be basic prerequisites for effective treatment. Even today - 20 years after fibrin sealant was first used - the three most prominent effects of fibrin sealant are still hemostasis, sealing of the wound, and support of wound healing. The problems posed by the transmission of viral infections have gained substantially in importance because of the potential transmission of AIDS via fibrin sealant. Fortunately, this is so unlikely today that it no longer represents a cause for concern, which does not mean, however, that research in this field can be discontinued.

Das Buch richtet sich vor allem an junge Anasthesiologen und Assistenzarzte auf Intensivstationen, die die Technik der transoesophageale Echokardiographie erlernen moechten, aber ebenso an Kardiologen und Internisten, die Patienten kardiologisch betreuen.

'Clinical epidemiology' is now widely promoted and taught as a 'basic science' of Evidence-Based Medicine, of clinical EBM to be specific. This book, however, is mostly about that which Miettinen takes to be the necessary substitute for this now-so-fashionable subject - namely, Theory of Clinical Medicine together with its subordinate Theory of Clinical Research. The leit motif in all of this is Miettinen's perception of the need, and opportunity, to bring major improvements into clinical medicine in this Information Age, now that theoretical progress has made feasible the development of practice-guiding Expert Systems for it. Parts of this text constitute essential reading for whoever is expected, or otherwise inclined, to study - or teach - 'clinical epidemiology,' and the same is true of those who set policy for the education of future clinicians; but practically all of it is essential reading for future - and current - academics in the various disciplines of clinical medicine. After all, the text is the result of a concentrated effort, over a half-century no less, to really understand both clinical and community medicine and the research to advance the knowledge-base of these. Research epidemiologists, too, will find this text interesting and instructive.

The last volume in the series Fibrin Sealing in Surgical and Nonsurgical Fields discusses various uses of fibrin glue in endoscopic surgery. During the last years fibrin sealant has been established in the treatment of gastrointestinal ulcers and esophageal fistulae.

Fibrin sealant is used for numerous indications in gynecology, especially for the McIndoe Operation and Cohn biopsy, the Marshall-Marchetti-Krantz-Hirsch-Stoll-Operation, urethrocysopexy, or in vitro fertilization for embryo transfer. The use of fibrin sealant in urology has also been extended, especially in operations of the spermatic cord, reconstruction of the urethra and closing of nephrotomies.

This textbook provides a detailed resource introducing the subdiscipline of mental health informatics. It systematically reviews the methods, paradigms, tools and knowledge base in both clinical and bioinformatics and across the spectrum from research to clinical care. Key foundational technologies, such as terminologies, ontologies and data exchange standards are presented and given context within the complex landscape of mental health conditions, research and care. The learning health system model is utilized to emphasize the bi-directional nature of the translational science associated with mental health processes. Descriptions of the data, technologies, paradigms and products that are generated by and used in each process and their limitations are discussed. Mental Health Informatics: Enabling a Learning Mental Healthcare System is a comprehensive introductory resource for students, educators and researchers in mental health informatics and related behavioral sciences. It is an ideal resource for use in a survey course for both pre- and post-doctoral training programs, as well as for healthcare administrators, funding entities, vendors and product developers working to make mental healthcare more evidence-based.

"Advances in Neurosurgery 22" is devoted to three main topics, the first one being Cerebellar Infarcts. Following the introduction with the microsurgical anatomy and the neuropathology of cerebellar infarction, the indication for operative treatment and its results are then discussed. The neuroradiological treatment with local and antifibrinolytic therapy for vertebrobasilar occlusion completes this section. The management and surgical approaches to the various forms of midline lesions are then presented. Special interest is centred on minimal invasive endoscopic neurosurgery (MIEN), (intraventricular tumors, optic pathway gliomas, endoscopic brainstem tumors and vascular malformations). Furthermore the special equipment and fields of indications are extensively discussed.

These eight volumes, which developed out of the international congress "Update and Future Trends in Fibrin Sealing in Surgical and Nonsurgical Fields" held in November 1992, present the state of the art in fibrin sealing. In itially, fibrin sealant played an important role in surgery. During the past few years, it has been increasingly applied nonsurgically, and we can now say that it has become an integral component of medical treatment. The doubts which have been raised by nonusers about the efficacy of fibrin sealant are no longer valid. The correct indication and technique continue to be basic prerequisites for effective treatment. Even today - 20 years after fibrin sealant was first used - the three most prominent effects of fibrin sealant are still hemostasis, sealing of the wound, and support of wound healing. The problems posed by the transmission of viral infections have gained sub stantially in importance because of the potential transmission of AIDS via fi brin sealant. Fortunately, this is so unlikely today that it no longer represents a cause for concern, which does not mean, however, that research in this field can be discontinued.

.".". this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues--making the book enticing and useful, all at once..."" Human Vaccines, 2010

.".". This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..."" -Virology Journal, 2009

Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health.

Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers.

This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development byintroducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinologyputting it into a historical and societal context, and exploring the scope of its methods and applications.

"Bioinformatics for Vaccinology" is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.

In the field of orthopedic surgery, additional areas of application and new indications have been discovered for fibrin glue treatment, for example, hemostasis in pseudotumors in hemophilic patients or in torn ligaments, and in spongiosa transplantation, primarily when nonautologous bone material is being used, or to fill large defects. In maxillofacial surgery fibrin glue is mainly used for osseous contouring of the facial and frontal bones, for alveolar ridge augmentations in preprosthetic surgery, and for soft tissue reconstructions.

This third edition presents and dissects a wide variety of HIT failures so that the reader can understand in each case what went wrong and why and how to avoid such problems, without focusing on the involvement of specific people, organizations, or vendors. The lessons may be applied to future and existing projects, or used to understand why a previous project failed. The reader also learns how common causes of failure affect different kinds of HIT projects and with different results. Cases are organized by the type of focus (hospital care, ambulatory care, and community). Each case provides analysis by an author who was involved in the project plus the insight of an HIT expert. This book presents a model to discuss HIT failures in a safe and protected manner, providing an opportunity to focus on the lessons offered by a failed initiative as opposed to worrying about potential retribution for exposing a project as having failed. Access expert insight into key obstacles that must be overcome to leverage IT and transform healthcare. Each de-identified case study includes an analysis by a group of industry experts along with a counter analysis. Cases include a list of key words and are categorized by project (e.g. CPOE, business intelligence). Each case study concludes with a lesson learned section. Thought provoking commentary chapters add additional context to the challenges faced during HIT projects, from social and organizational to legal and contractual.