This Brief highlights Informatics and related techniques to Computer Science Professionals, Engineers, Medical Doctors, Bioinformatics researchers and other interdisciplinary researchers. Chapters include the Bioinformatics of Diabetes and several computational algorithms and statistical analysis approach to effectively study the disorders and possible causes along with medical applications.

Valuation is a hot topic among life sciences professionals. There is no clear understanding on how to use the different valuation approaches and how to determine input parameters. Some do not value at all, arguing that it is not possible to get realistic and objective numbers out of it. Some claim it to be an art. In the following chapters we will provide the user with a concise val- tion manual, providing transparency and practical insight for all dealing with valuation in life sciences: project and portfolio managers, licensing executives, business developers, technology transfer managers, entrep- neurs, investors, and analysts. The purpose of the book is to explain how to apply discounted cash flow and real options valuation to life sciences p- jects, i.e. to license contracts, patents, and firms. We explain the fun- mentals and the pitfalls with case studies so that the reader is capable of performing the valuations on his own and repeat the theory in the exercises and case studies. The book is structured in five parts: In the first part, the introduction, we discuss the role of the players in the life sciences industry and their p- ticular interests. We describe why valuation is important to them, where they need it, and the current problems to it. The second part deals with the input parameters required for valuation in life sciences, i.e. success rates, costs, peak sales, and timelines.

An accessible guide that introduces students in all areas of life sciences to bioinformatics Basic Applied Bioinformatics provides a practical guidance in bioinformatics and helps students to optimize parameters for data analysis and then to draw accurate conclusions from the results. In addition to parameter optimization, the text will also familiarize students with relevant terminology. Basic Applied Bioinformatics is written as an accessible guide for graduate students studying bioinformatics, biotechnology, and other related sub-disciplines of the life sciences. This accessible text outlines the basics of bioinformatics, including pertinent information such as downloading molecular sequences (nucleotide and protein) from databases; BLAST analyses; primer designing and its quality checking, multiple sequence alignment (global and local using freely available software); phylogenetic tree construction (using UPGMA, NJ, MP, ME, FM algorithm and MEGA7 suite), prediction of protein structures and genome annotation, RNASeq data analyses and identification of differentially expressed genes and similar advanced bioinformatics analyses. The authors Chandra Sekhar Mukhopadhyay, Ratan Kumar Choudhary, and Mir Asif Iquebal are noted experts in the field and have come together to provide an updated information on bioinformatics. Salient features of this book includes: * Accessible and updated information on bioinformatics tools * A practical step-by-step approach to molecular-data analyses * Information pertinent to study a variety of disciplines including biotechnology, zoology, bioinformatics and other related fields * Worked examples, glossary terms, problems and solutions Basic Applied Bioinformatics gives students studying bioinformatics, agricultural biotechnology, animal biotechnology, medical biotechnology, microbial biotechnology, and zoology an updated introduction to the growing field of bioinformatics.

More than one in six men will develop prostate cancer in their lifetime. In recent years there has been an explosion of information regarding PSA screening and biomarkers for the disease. In Prostate Cancer Screening, Second Edition, the world's leading experts on prostate cancer detection update the first edition with the latest findings. The book incorporates a series of thoughtful and cutting-edge works from the world's experts in prostate cancer screening, ranging from the current status quo of prostate cancer screening across the globe to consensus on optimal utilization of the traditional PSA and DRE tests, to cutting-edge research in new biomarkers, biomeasures, and extended risk algorithms for prostate cancer. An additional chapter covers family-based linkage analysis as well as possible pitfalls in prostate cancer biomarker evaluation studies. Timely and authoritative, Prostate Cancer Screening, Second Edition, is an essential text for urologists, oncologists and family physicians, as well as researchers in the biomarker industry who seek methods to better develop and support markers and measures of prostate cancer.

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies of parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. The 2013 impact factor is 4.36.

Despite all the jokes about the poor quality of physician handwriting, physician adoption of computerized provider order entry (CPOE) in hospitals still lags behind other industries' use of technology. As of the end of 2010, less than 22% of hospitals had deployed CPOE. Yet experts claim that this technology reduces over 80% of medication errors and could prevent an estimated 522,000 serious medication errors annually in the US. Even though the federal government has offered $20 billion dollars in incentives to hospitals and health systems through the 2009 stimulus (the ARRA HITECH section of the American Recovery and Reinvestment Act of 2009), many organizations are struggling to implement advanced clinical information systems including CPOE. In addition, industry experts estimate that the healthcare industry is lacking as many as 40,000 persons with expertise in clinical informatics necessary to make it all happen by the 2016 deadline for these incentives. While the scientific literature contains numerous studies and stories about CPOE, no one has written a comprehensive, practical guide like Making CPOE Work. While early adopters of CPOE were mainly academic hospitals, community hospitals are now proceeding with CPOE projects and need a comprehensive guide. Making CPOE Work is a book that will provide a concise guide to help both new and experienced health informatics teams successfully plan and implement CPOE. The book, in a narrative style, draws on the author's decade-long experiences of implementing CPOE at a variety of academic, pediatric and community hospitals across the United States.

'Clinical epidemiology' is now widely promoted and taught as a 'basic science' of Evidence-Based Medicine, of clinical EBM to be specific. This book, however, is mostly about that which Miettinen takes to be the necessary substitute for this now-so-fashionable subject - namely, Theory of Clinical Medicine together with its subordinate Theory of Clinical Research. The leit motif in all of this is Miettinen's perception of the need, and opportunity, to bring major improvements into clinical medicine in this Information Age, now that theoretical progress has made feasible the development of practice-guiding Expert Systems for it. Parts of this text constitute essential reading for whoever is expected, or otherwise inclined, to study - or teach - 'clinical epidemiology,' and the same is true of those who set policy for the education of future clinicians; but practically all of it is essential reading for future - and current - academics in the various disciplines of clinical medicine. After all, the text is the result of a concentrated effort, over a half-century no less, to really understand both clinical and community medicine and the research to advance the knowledge-base of these. Research epidemiologists, too, will find this text interesting and instructive.

Over the next few years, the Connecting for Health IT programme for the NHS in England is due to implement electronic prescribing systems at all hospitals in England. Furthermore, the other UK countries are likely to follow suit with clinical IT implementation programmes, and these developments will generate interest in electronic prescribing at European and international level. There is therefore likely to be an exponential growth in the significance of electronic prescribing over the next ten years. Principles of Electronic Prescribing discusses the basic principles of design and implementation of secondary care electronic medicines management systems, and how their design and configuration can impact on benefits realization, hospital workflow and clinical practice.

This book focuses on the innovative and more critical management approach adopted in the PA (Public Administration) in order to identify and describe the main models and instruments to economically evaluate the decision making process in accordance to the specific conditions such as efficiency, effectiveness, cost and equity. The manuscript pays special attention to this sector by identifying, investigating and applying the main evaluation models (logic and methods) of the decision making process, in particular in terms of investment decisions. In the recent decades, with reference to PA, several managerial approaches have been developed from a business management perspective. These managerial approaches differ in terms of variables analyzed, such as the role of governance or the specific logics and mechanisms applied, but all of them have a common goal, which is the improvement of efficiency, effectiveness, economic and equitable decision making and operations in the PA. This book investigates the different mentioned frameworks adopting a wider and integrated analysis perspective on the evaluation of investments in the health care system.

This book constitutes the thoroughly refereed post-conference proceedings of the Third International Symposium on Foundations of Health Information Engineering and Systems, FHIES 2013, held in Macau, China, in August 2013. The 19 revised full papers presented together with 1 invited talk in this volume were carefully reviewed and selected from 22 submissions. The papers are organized in following subjects: panel position statements, pathways, generation and certification, interoperability, patient safety, device safety, formal methods and HIV/AIDS and privacy.

Advances in medicine have brought us the stethoscope, artificial kidneys, and computerized health records. They have also changed the doctor-patient relationship. This book explores how the technologies of medicine are created and how we respond to the problems and successes of their use. Stanley Joel Reiser, MD, walks us through the ways medical innovations exert their influence by discussing a number of selected technologies, including the X-ray, ultrasound, and respirator. Reiser creates a new understanding of thinking about how health care is practiced in the United States and thereby suggests new methods to effectively meet the challenges of living with technological medicine. As healthcare reform continues to be an intensely debated topic in America, Technological Medicine shows us the pros and cons of applying technological solutions health and illness.

AIDS is the fourth leading cause of death among women of childbearing age and is increasing by about 8% a year in this group. * And yet, our understanding of the impact of HIV and AIDS on women's lives remains fragmented and incomplete. After a decade of struggling with mounting surveys of risk behavior, clinical trials, and behavioral interventions that were based primarily on experience with gay communities in large cities and, subsequently, on the needs of injection drug users, we have not given programs for women the attention they require if they are to be meaningful, effective, and gender appropriate. This book will introduce the reader to the range of complex issues of HIV and AIDS in women's lives. Ann O'Leary and Loretta Sweet Jemmott have assembled an impres sive list of authors who have contributed chapters from different disciplinary viewpoints. The reader will find information on prevention programs that have been effective for adolescent girls, on culturally specific strategies for African American and Latina women, and on the multiple issues of sub stance use and HIV that need to be faced by any outreach and intervention programs for drug-using women.

This text provides a foundation for the initiation of advocacy efforts and for the evaluation of their success and includes topics such as: specific strategies, grassroots advocacy efforts, formation and development of coalitions, advocacy efforts in legislatures, administrative agencies, court, and the media. It is of interest to public and urban health workers, social workers, community organizers, and legislators.

Following both a patient and an employee through a physician visit, this is a "how-to" manual for implementing practice management solutions. The first section provides information and examples prior to the patient visit, and includes examples of physicians who utilize email and Web sites to attract patients, electronic scheduling systems to decrease wait time, and registration systems which can verify insurance information. The second section focuses on electronic medical records, electronic referral systems, billing and collection systems, and follow-up patient education and discharge information, thus portraying the "future physician office visit." The third section centres on the physician practice manager's daily operations and how technology can achieve efficacy.

This volume is for students and practitioners interested in improving their understanding and skills in the area of needs assessment. The text follows the typical sequence of an actual needs assessment process. Case studies are used to illustrate conceptualization of the task through the application of needs-based data to effective public health solutions. Examples are drawn from myriad public health efforts, recognizing that not all public health sector agencies bear direct responsibility for all activities that could be considered part of public health.

Information technology constantly changes and quickly becomes obsolete. The methodology of planning and implementing a health care information system, however, is more constant. Through practical, step-by-step guidelines, the author demonstrates how to establish the strategy and architecture against which vendor and system decisions must be made. Both management and technical perspectives are discussed. Thus, regardless of the technology used, the health care administrator and systems manager learn to implement information systems successfully and to link those systems with business strategy to achieve higher quality and more cost-effective patient care.

Many of the changes occurring within medicine are being catalyzed by the proliferation of professional and social activity with the internet and mobile technology. Understanding of the way in which healthcare is being transformed by IT is key in the improvement of medical standards and reduction of cost. This book presents the current and future trends in the transformation of healthcare services in the Information Society Era.

The synergy between computer technology and medical services has opened fascinating new possibilities for benefit in areas such as continuing care, chronic disease treatment and old people home monitoring, bringing with it the promise of essential changes in existing models of care delivery and system performance. This book addresses the priorities within international informatics and presents a complete and thorough survey of the most promising e-health technologies. This is illustrated with the inclusion of case reports indentifying real applications of the techniques, with the focus on providing an integrated overview of e-health, and the medical, sociological and technical aspects.

The authors primary objective has been to provide an in-depth study of internet-enhanced healthcare services, while mobile technology is also reviewed in the context of modern wireless technologies. The authors have provided a unique analysis of the evolution of healthcare services. The book is illustrated by numerous examples and comes together to provide a valuable set of tele-care solutions available to modern informatics practice."

In this volume, Steven Evans reports on a quarter century of work-work that resulted in a commercial product known as the PACE System. An advanced clinical management system, PACE links all care delivery set tings and reaches across multiple episodes. It offers capabilities critical to managed care, including care planning and clinical pathways, the critical pathway analyzer and clinical repository central to outcomes-based care, and more. The pages that follow describe the PACE project, focusing on its knowl edge base and semantic network. They offer insights into system implemen tation and address the synthesis of principles within the PACE System. From this project in nursing informatics, Steven Evans relates both suc cesses and failures, sharing the strategies and techniques to adopt and pitfalls to avoid in a project that followed five years of preliminary theo retical work. With clarity and candor, he gives us the benefit of two decades of project development, first in academia and then in the commercial sector. Over the course of the project, many tens of millions of dollars and close to 500 person-years of effort were invested. Building on the strong conceptual base developed at Creigton University's School of Nursing, the project has seen exponential growth in its clinical capabilities since entering the commercial sector in 1989.

In this thoroughly revised second edition of the frequently downloaded manual, The SAGES Manual of Quality, Outcomes, and Patient Safety. A panel of experts update and expand their survey of the many factors that influence quality in the world of surgery, surgical outcomes, and threats to patient safety. Among the highlights include a section devoted to threats to quality and outcomes and safety, such as surgeon wellness and burnout, disruptive behavior, second victims, the surgeon with declining skills, and maintaining quality in the setting of a crisis. Another all-new section focuses on surgical controversies, such as whether or not to use robotic surgical technology and whether or not it influences surgical outcomes; whether or not routine cholangiography reduces the common bile duct injury rate; whether or not having a consistent operating room team influences surgical outcomes, and whether a conflict of interest truly influences surgical quality. Further, this manual updates chapters on surgical simulation, teamwork and team training, teleproctoring, mentoring, and error analysis. State-of-the-art and readily accessible, The SAGES Manual of Quality, Outcomes, and Patient Safety, Second Edition will offer physicians strategies to maintain surgical quality in a rapidly changing practice environment the tools they require to succeed.

Critical Appraisal of Medical Literature provides a step-by-step approach to help the reader reach a good level of proficiency in systematic critical appraisal of medical information. To this end, the book covers all the elements that are necessary to develop these skills and is a comprehensive guide to the subject. The book is written in three parts. The first part focuses on the logical justification and the validity of medical information. Its chapters present basic working definitions and discussions on relevant basic topics of statistics and epidemiology. The second part focuses on the complementary aspects of critique, common study designs and articles whose main topics are treatment, diagnosis, prognosis, aetiology, reviews, medical guidelines, audit, and qualitative research. The third part presents some statistical techniques that are commonly used in published articles. Critical Appraisal of Medical Literature is intended for those interested in developing critical appraisal skills such as psychiatric trainees preparing for the Critical Review Paper of the MRCPsych Examination in the UK, other practitioners as part of their preparation for examinations, and medical professionals and students as part of their introduction to aspects of systematic critical appraisal of medical information.

Performance Improvement through Information Management highlights performance improvement and business strategies throughout various health care settings, focusing on business drivers and management mechanisms, explaining when, how, and why information technology solutions are of value. Structured on three levels: Market Environment, Transformational Processes, and Enabling Technologies, the text describes the current state of the art of health care and the shape of things to come, and provides practical solutions and strategies for implementing applications of technology within the current context of health care and its transformation. This text will be an invaluable reference to the chief executive officers, chief information officers, senior executives, and board members who are shaping health care today and into the 21st century. Likewise, it will appeal to healthcare administrators and managers, healthcare systems specialists, and students in advanced healthcare professional and academic programs.

Cancer Informatics chronicles the development of the National Cancer Institute's new Cancer Informatics Infrastructure (CII) - an information management system infrastructure designed to faciliate clinical trials, provide for reliable, secure information exchange, and improve patient care. The book details the challenges involved in creating and managing such a knowledge base, including technologies, standards, and current, state-of-the-art applications. The ultimate goal of CII is to function as an enabler of clinical trials, expediting the clinical trials lifecycle, faciliating faster and safer drug development and more appropriate treatment choices for cancer patients. Contributors address the role the CII must play in converting the growing knowledge of genes, proteins, and pathways into appropriate preventative, diagnostic, and therapeutic measures. Presented in four sections, the first provides an overview of the processes involved in moving the infrastructure for cancer from theory into practice. Sections two through four offer the latest work done in the areas of technology, cancer-specific and national standards, and applications to faciliate clinical trials.

Information and the technology to rapidly transmit, analyze, document, and disperse this information are increasing arithmetically, if not logarithmi cally. Arguably, no discipline better exemplifies this trend than medicine. It can be further argued that care of the trauma patient is one of the better examples of informatics and the potential benefit to the health profession als who care for these patients. Maull and Augenstein have provided us with a primer on informatics and its use in trauma care. The subject matter is timely and covers the gamut of trauma care from prehospital to rehabilitation. Who will benefit from trauma informatics? A simple answer would be anyone who takes care of trauma patients. From a broader perspective, however, at least three examples illustrate how trauma informatics can be used today to exert a positive effect on patient outcome. The first example is care of combat casualties, including battlefield resuscitation, evacuation, acute care, and ultimate return to the continental United States. Current technology is such that via global positioning satellite, a corpsman could transmit to a remote area the vital signs and pertinent physical findings of a combat casualty. Furthermore, the location of the corpsman and the casu alty would be precisely known, and consultation and destination disposition would be possible. The injured person, when admitted to a combat support hospital, could be continuously monitored and additional remote consulta tion obtained.

Fundamentals of Clinical Practice is an introductory textbook focusing on the patient physician relationship. Formerly closeted behind closed doors, this most intimate of healing relationships is coming under increasing scientific scrutiny. Physicians and other healthcare providers are beginning to understand the critical importance of this relation ship to the health of patients, as well as to larger societal relationships, systems, and values. To facilitate the reader's exploration of the patient-physician relationship, all chap ters include numerous illustrative cases and conclude with cases for discussion that allow small groups of learners to tackle these difficult issues. Our hypothesis is that through discussion a deeper understanding of the dynamics of the patient-physician relationship will allow medical students and other future healthcare providers to form more effective therapeutic relationships with their patients. Part I of this textbook, "The Patient," explores the relationship through the patient's perspective, with chapters on human health and disease and individual and family devel opment. Understanding the patient's perspective is critical to establishing a sound thera peutic relationship. The day when a physician could maintain solely a disease or techno logical perspective is fading fast under the weight of patient criticism, particularly in primary care fields. Patients judge such a disease or technological perspective as less humane and frequently vote with their feet, finding other physicians who are much better able to balance the caring aspects of medicine with the curing.