Computational Modelling of Biomechanics and Biotribology in the Musculoskeletal System: Biomaterials and Tissues, Second Edition reviews how a wide range of materials are modeled and applied. Chapters cover basic concepts for modeling of biomechanics and biotribology, the fundamentals of computational modeling of biomechanics in the musculoskeletal system, finite element modeling in the musculoskeletal system, computational modeling from a cells and tissues perspective, and computational modeling of the biomechanics and biotribology interactions, looking at complex joint structures. This book is a comprehensive resource for professionals in the biomedical market, materials scientists and biomechanical engineers, and academics in related fields. This important new edition provides an up-to-date overview of the most recent research and developments involving hydroxyapatite as a key material in medicine and its application, including new content on novel technologies, biomorphic hydroxyapatite and more.

The EHRA Book of Interventional Electrophysiology is the second official textbook of European Heart Rhythm Association (EHRA). Using clinical cases to encourage practical learning, this book assists electrophysiologists and device specialists in tackling both common and unusual situations that they may encounter during daily practice. Richly illustrated, and covering electrophysiological procedures for supra-ventricular and ventricular arrhythmias, the book enables specialists to deepen their understanding of complex concepts and techniques. Tracings, covering supra-ventricular and ventricular arrhythmias, are presented with multiple-choice questions to allow readers to hone their skills for interpreting challenging cases and to prepare for the EHRA certification exam in electrophysiology. Cases include Orthodromic AVRT, PV Isolation, VT ablation, and Atypical left atrial flutter to name a few. The EHRA Book of Interventional Electrophysiology is a wide-ranging, practical case-book, written by leading experts in the field and edited by members of the EHRA education committee: an essential companion for electrophysiologists and trainees alike.

This paperback, full-color book is ideally suited for anesthesiologists, residents, and nurse anesthetists who need a concise, practical, easily accessible reference on anesthesia equipment. Written by the authors of the definitive text Understanding Anesthesia Equipment, A Practical Approach to Anesthesia Equipment covers the most commonly used machines and devices and addresses common problems and pitfalls that affect clinical situations. The book is written in outline format and thoroughly illustrated with full-color photographs and line drawings.

As the human lifespan increases, New York Times best-selling author Michael Roizen, M.D. offers an inspiring look into the future of longevity--and reveals how to prepare for a longer, healthier future. Believe it or not, living to 100, 120, or even 130 years old will become increasingly common over the next decade--and life past 100 may not be what you think. In this groundbreaking narrative, best-selling author Michael Roizen explains how cutting-edge science and technology will revolutionize your ability to live longer, younger, and better. As evidenced in the global press, today's breakthroughs in longevity research are unprecedented. This provocative yet practical book will help you prepare for the next major social disruptor by making the best decisions for your brain, your body, and your bank account. Dr. Roizen, along with acclaimed economists Peter Linneman and Albert Ratner, unpacks a wide swath of medical phenomena--from reengineering aging cells to DNA manipulation to bionic bodies--and shows how increased longevity will change our lives and our culture. They also provide a concrete action plan for good health, a youthful appearance, mental vigor, and strong finances in this brave new world. The most comprehensive and forward-looking take on aging to date, this indispensable book illuminates the prevention, treatment, and technology that will reshape how we think about old age--and help us plan for an audacious future.

Distributional cost-effectiveness analysis aims to help health care and public health organisations make fairer decisions with better outcomes. Whereas standard cost-effectiveness analysis provides information about total costs and effects, distributional cost-effectiveness analysis provides additional information about fairness in the distribution of costs and effects - who gains, who loses, and by how much. It can also provide information about the trade-offs that sometimes occur between efficiency objectives, such as improving total health, and equity objectives, such as reducing unfair inequality in health. This is a practical guide to a flexible suite of economic methods for quantifying the equity consequences of health programmes in high-, middle- and low-income countries. The methods can be tailored and combined in various ways to provide useful information to different decision-makers in different countries with different distributional equity concerns. The handbook is primarily aimed at postgraduate students and analysts specialising in cost-effectiveness analysis but is also accessible to a broader audience of health sector academics, practitioners, managers, policymakers and stakeholders. As well as offering an overview for research commissioners, users, and producers, the book includes systematic technical guidance on how to simulate and evaluate distributions, with accompanying hands-on spreadsheet training exercises, and discussions about how to handle uncertainty about facts and disagreement about values, and the future challenges facing this young and rapidly evolving field of study.

Advanced manufacturing technologies (AMTs) combine novel manufacturing techniques and machines with the application of information technology, microelectronics and new organizational practices within the manufacturing sector. They include 'hard' technologies such as rapid prototyping, and 'soft' technologies such as scanned point cloud data manipulation. AMTs contribute significantly to medical and biomedical engineering. The number of applications is rapidly increasing, with many important new products now under development. "Advanced Manufacturing Technology for Medical Applications" outlines the state of the art in advanced manufacturing technology and points to the future development of this exciting field. Early chapters look at actual medical applications already employing AMT, and progress to how reverse engineering allows users to create system solutions to medical problems. The authors also investigate how hard and soft systems are used to create these solutions ready for building. Applications follow where models are created using a variety of different techniques to suit different medical problems. One of the first texts to be dedicated to the use of rapid prototyping, reverse engineering and associated software for medical applications, this title ties together the two distinct disciplines of engineering and medicine. It features contributions from experts who are recognised pioneers in the use of these technologies for medical applications. It includes work carried out in both a research and a commercial capacity, with representatives from 3 companies that are established as world leaders in the field - Medical Modelling, Materialise, & Anatomics. It covers a comprehensive range of medical applications, from dentistry and surgery to neurosurgery and prosthetic design. Medical practitioners interested in implementing new advanced methods will find "Advanced Manufacturing Technology for Medical Applications" invaluable as will engineers developing applications for the medical industry. Academics and researchers also now have a vital resource at their disposal.

Simulation-based training (SBT) has long been an important tool for students and trainees in multiple medical specialties given its usefulness in building cognitive and technical skills as well as improving team functional dynamics. Medical educators have recently recognized the need for SBT incorporation in the subspecialty service areas of radiology. Edited and contributed to by leaders of radiology simulation-based training at Louisiana State University School of Medicine, this book is the first of its kind to thoroughly cover such training and education. Concise yet comprehensive, chapters are organized into three sections focusing on key aspects of SBT in radiology, providing a blueprint for radiology educators, program directors, and administrators in designing and implementing an SBT program. The first section provides general considerations of using simulation in training; the second discusses educational principles and testing; and the third presents a summary review of the scientific literature and current work being done in SBT in radiology. For more information on the LSUHSC Radiology Department simulation program, including simulation procedure videos,

Fully updated and revised for its second edition, the Oxford Handbook of Clinical Examination and Practical Skills is the only truly comprehensive pocket guide to all aspects of history taking, physical examination, practical procedures, data interpretation, and communication skills. Packed with expert knowledge and practical guidance it gives realistic advice on coping with common situations. The handbook is structured to allow rapid reference of key information, and to aid understanding with concise and practical clinical guidance. Full colour throughout, it includes over 140 detailed photographs and diagrams of all common examination skills to show you exactly what you need to do and the theory, practice and complications for each. More photos have been included, with over half completely new and specially produced for this edition. Each system chapter covers applied anatomy, history, examination, and the presentation of common and important disorders. Data interpretation covers the basics of x-rays, ECGs and other key areas. A new chapter on the eyes is included along with the sections on body language and non-verbal communication, and the section on practical procedures has been expanded. This handbook will help to ensure you have the confidence and skill to carry out an 'A' grade examination every time.

The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019. The total of 97 papers presented in the proceedings, was carefully reviewed and selected from 301 submissions. The papers are organized in topical sections as follows: Part I: High-throughput genomics: bioinformatics tools and medical applications; omics data acquisition, processing, and analysis; bioinformatics approaches for analyzing cancer sequencing data; next generation sequencing and sequence analysis; structural bioinformatics and function; telemedicine for smart homes and remote monitoring; clustering and analysis of biological sequences with optimization algorithms; and computational approaches for drug repurposing and personalized medicine. Part II: Bioinformatics for healthcare and diseases; computational genomics/proteomics; computational systems for modelling biological processes; biomedical engineering; biomedical image analysis; and biomedicine and e-health.

This volume presents the proceedings of the International Conference on Biomedical and Health Informatics (ICBHI). The conference was a new special topic conference and a common initiative by the International Federation of Medical and Biological Engineering (IFMBE) and IEEE Engineering in Medicine and Biology Society (IEEE- EMBS). BHI2015 was held in Haikou, China, 8-10 October 2015. The main theme of the BHI2015 is "The Convergence: Integrating Information and Communication Technologies with Biomedicine for Global Health". The ICBHI2015 proceedings examine enabling technologies of sensors, devices and systems that optimize the acquisition, transmission, processing, storage, retrieval, use of biomedical and health information as well as to report novel clinical applications of health information systems and the deployment of m-Health, e-Health, u-Health, p-Health and Telemedicine.

In diesem essential wird erlautert, was die Lichtblattmikroskopie von gewoehnlicher Lichtmikroskopie unterscheidet. Der Autor beleuchtet kurz die Historie solcher Verfahren, wobei der Schwerpunkt auf den technischen Konzepten liegt. Schliesslich werden aktuelle Erscheinungsformen vorgestellt, ohne in die Tiefen der Ingenieurskunst hinabzusteigen. Die Ungewoehnlichkeit der Lichtblattmikroskopie besteht nicht nur darin, dass Betrachtung und Beleuchtung unter einem rechten Winkel stattfinden, vielmehr gewinnt diese Art der Mikroskopie vor allem dadurch, dass durch die Art der Beleuchtung nur ein ganz kleiner Teil des Praparates durchstrahlt wird. Die geeignete Auswahl der optischen Elemente sorgt dafur, dass das beobachtete Bild keine unscharfen Anteile mehr enthalt.

This book provides a comprehensive overview of the state of the art in signal quality assessment techniques for physiological signals, and chiefly focuses on ECG (electrocardiography) and PPG (photoplethysmography) signals obtained from wearable sensors in ambulatory clinical settings. It presents the techniques currently proposed by leading researchers, as well as examples using data from clinical trials on wearable sensors for inpatient and outpatient settings. In addition, the book assesses current approaches through a practical lens by discussing the implications of deploying the various proposed systems for clinical practices and health outcomes. As such, it will be of considerable interest to both graduate students and researchers working to develop personalized healthcare applications, as well as physiological sensor software and hardware developers.

This book presents high-quality peer-reviewed papers from the International Conference on Electronics, Biomedical Engineering, and Health Informatics (ICEBEHI) 2021 held at Surabaya, Indonesia, virtually. The contents are broadly divided into three parts: (i) electronics, (ii) biomedical engineering, and (iii) health informatics. The major focus is on emerging technologies and their applications in the domain of biomedical engineering. It includes papers based on original theoretical, practical, and experimental simulations, development, applications, measurements, and testing. Featuring the latest advances in the field of biomedical engineering applications, this book serves as a definitive reference resource for researchers, professors, and practitioners interested in exploring advanced techniques in the field of electronics, biomedical engineering, and health informatics. The applications and solutions discussed here provide excellent reference material for future product development.

This book examines the potential to deploy low-cost, three-dimensional printers known as RepRaps in developing countries to fabricate surgical instruments and medical supplies to combat the "global surgical burden of disease." Approximately two billion people in developing countries around the world lack access to essential surgical services, resulting in the avoidable deaths of millions of individuals each year. A fundamental barrier that inhibits access to surgical care in these locations is the lack of basic surgical instruments and supplies in healthcare facilities. RepRap printers are highly versatile 3D printers assembled from basic, domestically sourced materials that can fabricate low-cost surgical instruments on-site, ultimately enhancing the interventional capacity of healthcare facilities to treat patients. Rather than focusing on one specific field of interest, this book takes an integrative approach that incorporates topics and methods from multiple disciplines ranging from global health and development economics to materials science and applied engineering. These topics include the feasibility of using bio-based plastics to fabricate surgical instruments via 3D printing sustainably, the application of "frugal innovation and engineering" in resource-poor settings, and analyses related to the social returns on investment, barriers to entry, and current and future medical device supply-chain paradigms. In taking a multi-disciplinary approach, the reader can gain a holistic understanding of the multiple facets related to implementing medical device innovations in developing countries.

This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2014, held in Cambridge, UK, in June 2014. The 25 revised full papers presented were carefully reviewed and selected from 44 submissions. The papers focus problems concerning computational techniques in bioinformatics, systems biology, medical informatics and biostatistics.

Rene Theophile Hyacinthe Laennec (1781-1826) is best known for his invention of the stethoscope, one of medicine's most powerful symbols. Histories, novels, and films have cloaked his life in hagiography and legend. Jacalyn Duffin's fascinating new biography relies on a vastly expanded foundation of primary source material, including thousands of pages of handwritten patient records, lecture notes, unpublished essays, and letters. She situates Laennec, the scientist and teacher, within the broader social and intellectual currents of post-Revolutionary France. Her work uncovers a complex character who participated actively in the dramatic changes of his time. Laennec's famous Treatise on Mediate Auscultation was his only published book, but two lesser known works were left in manuscript: an early treatise on pathological anatomy and a later set of lectures on disease. The three parts of Duffin's biography correspond to these books. First, she examines Laennec's student research on the emerging science of pathological anatomy, the background for his major achievement. Second, she uses his clinical records to trace the discovery and development of "mediate auscultation" (listening through an instrument, or mediator, to sounds within the human body). The stethoscope allowed clinicians to "see" the organic alterations inside their living patients' bodies. Finally, she explores the impact of auscultation on diagnostic practice and on concepts of disease. Analyzed here for the first time in their entirety, Laennec's College de France lectures reveal his criticism of over-enthusiastic extrapolations of his own method at the expense of the patient's story. Originally published in 1998. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Die rasante Entwicklung der Informationstechnologien forciert den Wandel im Gesundheitswesen und damit die neuen Rollenverstandnisse von Patient, Arzt, Gesundheitsdienstleister und Life-Science-Industrie. Die sich anbahnenden Chancen und Risiken im Gesundheitswesen sind so vielseitig, wie das Verstandnis des Begriffes e-Health. In kompakter und verstandlicher Form werden sowohl fundierte Basiskenntnisse vermittelt als auch Praxis-Perspektiven mit Fallbeispielen fur e-Health aufgezeigt.

Many people in developing countries lack access to health technologies, even basic ones. Why do these problems in access persist? What can be done to improve access to good health technologies, especially for poor people in poor countries?

This book answers those questions by developing a comprehensive analytical framework for access and examining six case studies to explain why some health technologies achieved more access than others. The technologies include praziquantel (for the treatment of schistosomiasis), hepatitis B vaccine, malaria rapid diagnostic tests, vaccine vial monitors for temperature exposure, the Norplant implant contraceptive, and female condoms. Based on research studies commissioned by the Bill & Melinda Gates Foundation to better understand the development, adoption, and uptake of health technologies in poor countries, the book concludes with specific lessons on strategies to improve access. These lessons will be of keen interest to students of health and development, public health professionals, and health technology developers all who seek to improve access to health technologies in poor countries.

This Brief highlights Informatics and related techniques to Computer Science Professionals, Engineers, Medical Doctors, Bioinformatics researchers and other interdisciplinary researchers. Chapters include the Bioinformatics of Diabetes and several computational algorithms and statistical analysis approach to effectively study the disorders and possible causes along with medical applications.

In recent years, important technological innovations have made it possible to evaluate the small bowel endoscopically. Thus, traditional diagnostic methods such as imaging techniques are flanked by enteroscopy. The aim of this book is to present the results of enteroscopy as a method to diagnose small bowel disease, correlating it to the other investigative methods and above all to clinical findings. The book is a unique selected collection of images deriving from the results of documented experience and also including a brief clinical presentation, tables and diagrams of diagnostic algorithms. Renowned and accredited experts in gastroenterology, enteroscopy and researchers in the sector of small bowel disease have contributed to this volume.

Los incentivos para la innovacion son especialmente relevantes en el sector farmaceutico, en el que no todas las necesidades sociales proporcionan las mismas oportunidades de beneficio y en el que la mayoria de los paises de la OCDE intentan aplicar diferentes medidas que fomenten la investigacion en estos campos que generan menos beneficios. La falta de incentivos para la innovacion resulta especialmente dramatica si tenemos en cuenta las enfermedades que afectan principalmente a paises de renta baja, y tambien las enfermedades que afectan a grupos pequenos de pacientes."

Diese praktische Anleitung stellt die Physiologie und Pathologie der Tube mit allen operativen Korrekturmoglichkeiten dar.
- Mikrochirurgie und operative Endoskopie, Lasertechniken
- Behandlung der Extrauteringraviditat, Endometriose und tubaren Sterilitat, Reanastomosierung
- Praoperative Abklarung und postoperative Betreuung
Alle Operationstechniken sind prazise und verstandlich beschrieben. Speziell fur Anfanger enthalt das Buch ein Trainingsprogramm, das sie in den chirurgischen Techniken schnell fit macht."

Using bioinformatics methods to generate a systems-level view of the immune system; description of the main biological concepts and the new data-driven algorithms. Despite the fact that advanced bioinformatics methodologies have not been used as extensively in immunology as in other subdisciplines within biology, research in immunological bioinformatics has already developed models of components of the immune system that can be combined and that may help develop therapies, vaccines, and diagnostic tools for such diseases as AIDS, malaria, and cancer. In a broader perspective, specialized bioinformatics methods in immunology make possible for the first time a systems-level understanding of the immune system. The traditional approaches to immunology are reductionist, avoiding complexity but providing detailed knowledge of a single event, cell, or molecular entity. Today, a variety of experimental bioinformatics techniques connected to the sequencing of the human genome provides a sound scientific basis for a comprehensive description of the complex immunological processes. This book offers a description of bioinformatics techniques as they are applied to immunology, including a succinct account of the main biological concepts for students and researchers with backgrounds in mathematics, statistics, and computer science as well as explanations of the new data-driven algorithms in the context of biological data that will be useful for immunologists, biologists, and biochemists working on vaccine design. In each chapter the authors show interesting biological insights gained from the bioinformatics approach. The book concludes by explaining how all the methods presented in the book can be integrated to identify immunogenic regions in microorganisms and host genomes.