"

Respiratory Support in Intensive Care" is a clear and didactic guide to the methods used to provide respiratory support in the patient with respiratory failure. It outlines the evolution of different techniques, explains the physiological principles, and evaluates their role in clinical practice.

The new edition has been thoroughly updated to take into account the increasingly sophisticated techniques used in this rapidly advancing field. It includes information on:
The increasing use of non-invasive techniques
Semi-automated techniques of mechanical ventilation
A simplified description of the most commonly used ventilators."

Respiratory Support in Intensive Care" will be invaluable as a sound introduction to the subject for trainee anaesthetists, intensivists, and all those who are responsible for the care of patients requiring respiratory support.

This volume contains the papers selected for presentation at the 2nd Inter- tional Workshop on Active Mining (AM 2003) which was organized in conju- tion with the 14th International Symposium on Methodologies for Intelligent Systems (ISMIS 2003), held in Maebashi City, Japan, 28-31 October, 2003. The workshop was organized by the Maebashi Institute of Technology in - operation with the Japanese Society for Arti?cial Intelligence. It was sponsored by the Maebashi Institute of Technology, the Maebashi Convention Bureau, the Maebashi City Government, the Gunma Prefecture Government, JSAI SIGKBS (Japanese Arti?cial Intelligence Society, Special Interest Group on Knowledge- Based Systems), a Grant-in-Aid for Scienti?c Research on Priority Areas (No. 759) "Implementation of Active Mining in the Era of Information Flood," US AFOSR/AOARD, the Web Intelligence Consortium (Japan), the Gunma Inf- mation Service Industry Association, and Ryomo Systems Co., Ltd. ISMIS is a conference series that was started in 1986 in Knoxville, Tennessee. SincethenithasbeenheldinCharlotte(NorthCarolina), Knoxville(Tennessee), Torin (Italy), Trondheim (Norway), Warsaw (Poland), Zakopane (Poland), and Lyon (France). The objective of this workshop was to gather researchers as well as prac- tioners who are working on various research ?elds of active mining, share ha- learned experiences, and shed light on the future development of active mining.

This book constitutes the refereed proceedings of the Third International Symposium on Biomedical Simulation, ISBMS 2006, held in Zurich, Switzerland in July 2006. The 12 revised full papers and 11 poster papers presented were carefully reviewed and selected from 37 submissions. The papers are organized in topical sections on simulation of biophysical processes, systems and applications, and anatomical modeling and tissue properties.

This book constitutes the refereed proceedings of the Third International Workshop on Data Integration in the Life Sciences, DILS 2006, held in Hinxton, UK in July 2006. Presents 19 revised full papers and 4 revised short papers together with 2 keynote talks, addressing current issues in data integration from the life science point of view. The papers are organized in topical sections on data integration, text mining, systems, and workflow.

This book constitutes the refereed proceedings of the International Workshop on Knowledge Discovery in Life Science Literature, KDLL 2006, held in conjunction with the 10th Pacific-Asia Conference on Knowledge Discovery and Data Mining (PAKDD 2006). The 12 revised full papers presented together with two invited talks were carefully reviewed and selected for inclusion in the book. The papers cover all topics of knowledge discovery in life science data.

The explosion in the number and size of life science data resources, and the rapid growth in the variety and volume of laboratory data has been fueled by world-wide research activity and the emergence of new technologies. The m- eling, management and analysis of this data often requires a comprehensive - tegration of heterogeneous and typically semistructured data, distributed across many possibly data sources. Recent interoperability standards such as XML and WSDL solve some (easy) problems, but data and process integration often - main time-consuming and error-pone manual tasks. The di?culty of these tasks is compounded by the high degree of semantic heterogeneity across data sources, varying data quality, and other domain-speci?c application requirements. DILS 2005 was the 2nd International Workshop on Data Integration in the Life Sciences, following a successful ?rst DILS workshop, March 2004 in Leipzig, Germany. For a specialized workshop, the DILS 2005 call for papers created a largeinterest(over50abstractsandeventually42papersubmissions;anincrease ofover20%overDILS2004), outofwhichtheinternationalProgramCommittee selected 15 full papers, as well as 5 short papers, and 8 posters/demonstrations, which are all included in this volume. They cover a wide spectrum of theoretical and practical issues including scienti?c/clinical work?ows, ontologies, tools and systems, and integration techniques. DILS 2005 also featured keynotes by Dr. PeterBuneman, ProfessorattheSchoolofInformatics, UniversityofEdinburgh, and Dr. Shankar Subramaniam, Professor at the Department of Bioengineering andChemistry, UCSanDiego.Theprogramalsoincluded6invitedpresentations and reports on ongoing research activities in academia and industry and a panel organized by the AMIA Geomics Working Gr

The Information Society is bringing about radical changes in the way people work and interact with each other and with information. In contrast to previous information processing paradigms, where the vast majority of computer-mediated tasks were business-oriented and executed by office workers using the personal computer in its various forms (i. e. , initially alphanumeric terminals and later on graphical user interfaces), the Information Society signifies a growth not only in the range and scope of the tasks, but also in the way in which they are carried out and experienced. To address the resulting dimensions of diversity, the notion of universal access is critically important. Universal access implies the accessibility and usability of Information Society technologies by anyone, anywhere, anytime. Universal access aims to enable equitable access and active participation of potentially all citizens in existing and emerging computer-mediated human activities by developing universally accessible and usable products and services, which are capable of accommodating individual user requirements in different contexts of use and independently of location, target machine, or run-time environment. In the context of the emerging Information Society, universal access becomes predominantly an issue of design, pointing to the compelling need for devising systematic and cost-effective approaches to designing systems that accommodate the requirements of the widest possible range of end-users. Recent developments have emphasized the need to consolidate progress by means of establishing a common vocabulary and a code of design practice, which addresses the specific challenges posed by universal access.

With the rapid increase in the variety and quantity of biomedical images in recent years, we see a steadily growing number of computer vision technologies applied to biomedical applications. The time is ripe for us to take a closer look at the accomplishments and experiences gained in this research subdomain, and to strategically plan the directions of our future research. The scientific goal of our workshop, "Computer Vision for Biomedical Image Applications: Current Techniques and Future Trends" (CVBIA), is to examine the diverse applications of computer vision to biomedical image applications, considering both current methods and promising new trends. An additional goal is to provide the opportunity for direct interactions between (1) prominent senior researchers and young scientists, including students, postdoctoral associates and junior faculty; (2) local researchers and international leaders in biomedical image analysis; and (3) computer scientists and medical practitioners. Our CVBIA workshop had two novel characteristics: each contributed paper was authored primarily by a young scientist, and the workshop attracted an unusually large number of well-respected invited speakers (and their papers). We had the good fortune of having Dr. Ayache of INRIA, France to talk about "Computational Anatomy and Computational Physiology," Prof. Grimson of MIT to discuss "Analyzing Anatomical Structures: Leveraging Multiple Sources of Knowledge," Dr. Jiang of the Chinese Academy of Sciences to present their work on "Computational Neuroanatomy and Brain Connectivity," Prof.

Master the skills you'll need to perform accurate clinical laboratory calculations! Mathematics for the Clinical Laboratory, 4th Edition demonstrates the calculations used in the analysis of test specimens. It begins by explaining basic mathematical principles and then covers the types of calculations needed in specific areas of the clinical lab including urinalysis, hematology, and microbiology. Finally, it focuses on the statistical calculations used in quality assurance and quality control. Step-by-step examples reinforce your understanding, and calculation templates and practice problems ensure that you make correct calculations every time. Step-by-step examples explain basic mathematical principles and show you exactly how to perform each type of calculation. Sample problems with answers can also be used as templates for solving laboratory calculations. Practice problems at the end of each chapter provide a self-assessment tool, helping you determine what you need to review. Summaries of important formulas are included at the end of the text's major sections. Coverage of statistical calculations includes standard deviation, as well as calculations associated with quality assurance and quality control. Quick tips and notes make it easier to understand and remember pertinent information. Learning objectives at the beginning of each chapter provide measurable outcomes to achieve by completing the chapter material. Full-color design includes 100 illustrations. Useful appendix of Greek symbols provides a quick reference to turn to when studying. Glossary at the back of the textbook includes definitions of important mathematical terms. New! Updated content and calculations reflect the latest procedures used in today's laboratories.

The nineteenth biennial International Conference on Information Processing in Medical Imaging (IPMI) was held July 11-15, 2005 in Glenwood Springs, CO, USA on the Spring Valley campus of the Colorado Mountain College. Following the successful meeting in beautiful Ambleside in England, this year's conference addressed important recent developments in a broad range of topics related to the acquisition, analysis and application of biomedical images. Interest in IPMI has been steadily growing over the last decade. This is p- tially due to the increased number of researchers entering the ?eld of medical imagingasaresultoftheWhitakerFoundationandtherecentlyformedNational Institute of Biomedical Imaging and Bioengineering. This year, there were 245 full manuscripts submitted to the conference which was twice the number s- mitted in 2003 and almost four times the number of submissions in 2001. Of these papers, 27 were accepted as oral presentations, and 36 excellent subm- sions that could not be accommodated as oral presentations were presented as posters. Selection of the papers for presentation was a di?cult task as we were unable to accommodate many of the excellent papers submitted this year. All accepted manuscripts were allocated 12 pages in these proceedings.

This book constitutes the refereed proceedings of the 4th International Symposium on Medical Data Analysis, ISMDA 2003, held in Berlin, Germany in October 2003.

The 15 revised full papers presented were carefully reviewed and selected for inclusion in the book. The papers are organized in topical sections on medical models and learning, integration of intelligent analysis methods into medical databases, medical signal processing and image analysis, and applications of medical diagnostic support systems.

The European Society for Arti?cial Intelligence in Medicine (AIME) was - tablished in 1986 with two main goals: 1) to foster fundamental and applied research in the application of Arti?cial Intelligence (AI) techniques to medical care and medical research, and 2) to provide a forum for reporting signi?cant results achieved at biennial conferences. Additionally, AIME assists medical - dustrials to identify new AI techniques with high potential for integration into new products. A major activity of this society has been a series of international conferences, fromMarseille(FR)in1987toCascais(PT)in2001, heldbiennially over the last 16 years. The AIME conference provides a unique opportunity to present and improve the international state of the art of AI in medicine from both a research and an applicationsperspective.Forthispurpose, theAIMEconferenceincludesinvited lectures, contributed papers, system demonstrations, tutorials and workshops. The present volume contains the proceedings of the AIME 2003 conference, the ninthconferenceonArti?cialIntelligenceinMedicineinEurope, heldinCyprus, October 18-22, 2003. In the AIME 2003 conference announcement, we encouraged authors to s- mit original contributions to the development of theory, techniques, and - plications of AI in medicine, including the evaluation of health care programs. Theoretical papers should include a prospective part about possible applications to medical problems solving. Technical papers should describe the novelty of the proposed approach, its assumptions and pros and cons compared to other alt- native techniques. Application papers should present su?cient information to allow the evaluation of the practical bene?ts of the proposed system or meth- ol

Organ regeneration, once unknown in adult mammals, is at the threshold of maturity as a clinical method for restoration of organ function in humans. Several laboratories around the world are engaged in the development of new tools such as stem cells and biologically active scaffolds. Others are taking fresh looks at well-known clinical problems of replacement of a large variety of organs: Bone, skin, the spinal cord, peripheral nerves, articular cartilage, the conjunctiva, heart valves and urologic organs. Still other investigators are working out the mechanistic pathways of regeneration and the theoretical implications of growing back organs in an adult. The time has come to present a collection of these efforts from leading practitioners in the field of organ regeneration.

  This book constitutes the refereed proceedings of the International Symposium on Surgery Simulation and Soft Tissue Modeling, IS4TM 2003, held in Juan-Les-Pins, France in June 2003. The 33 revised full papers presented together with 3 invited papers were carefully reviewed and selected from 45 submissions. The papers are organized in topical sections on soft tissue models, haptic rendering, cardiac modeling, and patient specific simulators.

The EU Physical Agents Directive on Noise, which will be implemented into UK law in February 2006, will reduce noise action levels drastically. Under the new regulations, many more industries, which have so far not been associated with high noise levels such as restaurants and call centres, will have to assess the noise levels in their businesses and monitor their employees' hearing according to HSE guidelines.
This practical guide gives occupational health nurses everything they need to know about setting up and managing hearing conservation programmes, as well as how to carry out the audiometric tests. The text fully covers the syllabus of BSA accredited courses for the certificate of competence in Industrial Audiometry and includes practical examples, case studies, sample audiograms and questionnaires for setting up case histories. As the BSA syllabus is based on the HSE's guidelines, the book will be a useful training manual and up-to-date reference for Health and Safety professionals, Occupational Health professionals, and HSE inspectors.
Dr Maryanne Maltby is an Audiological Scientist and Principal Lecturer on the Amplivox courses in Industrial Audiometry. She has previously taught Audiology and related subjects at Manchester University (Course Leader) and at Oxford Brookes University. She is a committee member of the Hearing Aid Council and a member of the British Society of Audiology. She also has wide consultancy experience in workplace training and advice on hearing conservation issues, fitting hearing protection, management of hearing and tinnitus problems at work.
* Fully covers the syllabus of BSA accredited courses in Industrial Audiometry
* Simple butaccurate instructions for testing hearing and for undertaking otoscopic examination
* Includes a brief explanation of background science: anatomy, physiology, medical aspects, acoustics

This book is a step-by-step guide to procedures and analysis of infant lung function testing. Each test description is preceded by a brief resume of the theoretical background. A troubleshooting section compiles the problems most frequently encountered during measurement and analysis. This book will provide those training in pediatric pulmonary with a sound grasp of the fundamental principles and practical issues involved in measuring infant lung function.

About this book— In recent years, a number of different spectroscopic techniques have been applied to the study of a wide range of biomedical topics. Biomedical investigations in fields as diverse as eye lens research, the study of cardiovascular and inflammatory diseases, and the study of oxidative stress in disease can now be carried out by spectroscopic means. The nine chapters in Biomedical Applications of Spectroscopy present an authoritative overview of the current status of the field, with each chapter written by acknowledged experts. A wide range of techniques is considered, including optical microspectroscopy, Raman spectroscopy, FTIR spectroscopy, NMR and EPR spectroscopy and mass spectrometry. This highly topical volume will stimulate interest in this expanding field, and point the way towards future directions in research. The major objectives of this established series are to integrate theory and practice and to bring together different branches of both academic and industrial research through the presentation of critical review articles in fundamental and applied spectroscopy. The policy of the editors is to commission authoritative reviews by acknowledged leaders in the various fields of spectroscopy. Thus each volume presents a carefully composed picture of the ‘state of the art’ for a particular area. For each volume the subject matter is presented in a manner which is Comprehensible to the non-expert, for whom the series will continue to provide a valuable introduction, and a timely overview of topics in spectroscopy which are of current interest and importance. At the same time the involved expert will find much to engage his or her attention. The series is of interest to research scientists and technologists, to teachers and both graduate and undergraduate students.

Statistics for the Health Sciences is a highly readable and accessible textbook on understanding statistics for the health sciences, both conceptually and via the SPSS programme. The authors give clear explanations of the concepts underlying statistical analyses and descriptions of how these analyses are applied in health science research without complex maths formulae. The textbook takes students from the basics of research design, hypothesis testing and descriptive statistical techniques through to more advanced inferential statistical tests that health science students are likely to encounter. The strengths and weaknesses of different techniques are critically appraised throughout, and the authors emphasise how they may be used both in research and to inform best practice care in health settings. Exercises and tips throughout the book allow students to practice using SPSS. The companion website provides further practical experience of conducting statistical analyses. Features include: * multiple choice questions for both student and lecturer use * full Powerpoint slides for lecturers * practical exercises using SPSS * additional practical exercises using SAS and R This is an essential textbook for students studying beginner and intermediate level statistics across the health sciences.

This book constitutes the refeered proceedings of the 18th Interational Conference on Information Processing in Medical Imaging, IPMI 2003, held in UK, in July 2003. The 57 revised full papers presented were carefully reviewed and selected from submissions. The papers are organized in topical sections shape modeling, shape analysis, segmentation, color, performance characterization, registration and modeling similarity, registration and modeling deformation, cardiac motion, fMRI analysis, and diffusion imaging and tractography.

In this revised and expanded second edition, seasoned experts describe in step-by-step detail their best state-of-the-art techniques for studying neuronal cell death. These readily reproducible methods solve a wide variety of research problems, including the detection of the key proteins involved in neuronal apoptosis (Bax protein, cytochrome c, and caspases), the direct assessment of the role of pro-apoptotic proteins in neurons by viral infections and microinjections, and the detection of pro-apoptotic proteins in situ. There are also hands-on methods for the study of apoptosis mechanisms in neuronal compartments, for studying synaptosis, and for establishing gene expression profiles in neurodegenerative brain tissues by using DNA microarrays.

This book constitutes the refereed proceedings of the 8th Conference on Artificial Intelligence in Medicine in Europe, AIME 2001, held in Cascais, Portugal in July 2001. The 31 revised full papers presented together with 30 posters and two invited papers were carefully reviewed and selected from 79 submissions. Among the topics addressed in their context on medical information processing are knowledge management, machine learning, data mining, decision support systems, temporal reasoning, case-based reasoning, planning and scheduling, natural language processing, computer vision, image and signal interpretation, intelligent agents, telemedicine, careflow systems, and cognitive modeling.

Physics and Instrumentation of Diagnostic Medical Ultrasound Peter Fish. University of Wales -- Bangor, School of Electronic Engineering Science, and Gwynedd and Clwyd Health Authorities, Department of Medical Physics. The field of diagnostic medical ultrasound is constantly changing as new equipment and techniques are developed and refined. The use of ultrasound is increasing rapidly throughout the world and consequently a knowledge of the underlying scientific principles and instrument operation has become an essential part of medical ultrasound courses. This book provides a concise, highly illustrated description of physics and instrumentation of diagnostic medical ultrasound and includes substantial coverage of Doppler techniques and real-time instruments. It will be of great value to sonographers, radiographers, radiologists, medical physicists and technicians as an aid to the study of the clinical use of diagnostic ultrasound, and as an excellent introduction for those intending to investigate the subject in greater depth. Other Wiley Books of Related Interest Include: Doppler Ultrasound: Physics, Instrumentation, and Clinical Applications D. H. Evans, W. N. McDicken, R. Skidmore, J. P. Woodcock 1989 Clinical Magnetic Resonance: Imaging and Spectroscopy R. Andrew, G. Bydder, J. R. Griffiths, R. A. Iles, P. Styles 1990 Ultrasound Teaching Cases Volume 1 H. B. Meire, K. C. Dewbury, D. O. Cosgrove 1988 Ultrasound Teaching Cases Volume 2 K. C. Dewbury, H. B. Meire, D. O. Cosgrove 1988

The European Societies for Arti cial Intelligence in Medicine (AIME) and M- ical Decision Making (ESMDM) were both established in 1986.A major activity of both these societies has been a series of international conferences, held bi- nially over the last 13 years. In the year 1999 the two societies organized a joint conference for the r st time. It took place from June 20{24th, 1999 in Aalborg, Denmark. This \Joint European Conference on Arti cial Intelligence in Medicine and Medical Decision Making (AIMDM'99)" was the seventh conference for each of thetwosocieties.ThisconferencefollowstheAIMEconferencesheldinMarseilles (1987), London (1989), Maastricht (1991), Munich (1993), Pavia (1995), and Grenoble(1997).PreviousESMDMconferenceshavebeenheldinLeiden(1986), Copenhagen (1988), Glasgow (1990), Marburg (1992), Lille (1994), and Torino (1996). The AIMDM conference is the major forum for the presentation and d- cussion of new ideas in the areas of Arti cial Intelligence and Medical Decision Making in Medicine. This ful lls the aims of both societies. The aims of AIME are to foster fundamental and applied researchin the applicationof Arti cial - telligence (AI) techniques to medicalcareandmedicalresearch, andto providea forum for reporting signi cant results achieved. ESMDM's aims are to promote research and training in medical decision-making, and to provide a forum for circulating ideas and programs of related interest. In the AIMDM'99 conference announcement, authors were encouraged to submit original contributions to the development of theory, techniques, and - plications of both AI in medicine (AIM) and medical decision making (MDM).

The majority of patients in need of organ transplants do not survive long enough for a suitable human organ to become available. Xenotransplantation, the transplant of animal organs into humans, has attracted substantial media attention. If, as appears likely, it proves possible to "humanize" animal organs and evade the problems of rejection, in the coming few years there will be a tremendous increase in this procedure, mostly using organs from animals specifically for their harvestable organs. This book will lay out the potential and promise of the technique, the history of organ transplantation, the technical problems and breakthroughs in overcoming immune rejection, and typing and humanizing donor organs for transplantation. The ethical question of growing animals specifically for organ harvest, and the substantial public health concern from the certainty that animal viruses will pass into humans with the donated organs, will be fully discussed. The authors are among the leaders in the field of Xenotransplantation.