The rapidly evolving field of protein science has now come to realize the ubiquity and importance of protein-protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of high throughput proteomics to monitor protein-protein interactions at an organism level, we can now safely state that protein-protein interactions are the norm and not the exception. Thus, protein function must be understood in the larger context of the various binding complexes that each protein may form with interacting partners at a given time in the life cycle of a cell. Proteins are now seen as forming sophisticated interaction networks subject to remarkable regulation. The study of these interaction networks and regulatory mechanism, which I would like to term "systems proteomics," is one of the thriving fields of proteomics.

The bird-eye view that systems proteomics offers should not however mask the fact that proteins are each characterized by a unique set of physical and chemical properties. In other words, no protein looks and behaves like another. This complicates enormously the design of high-throughput proteomics methods. Unlike genes, which, by and large, display similar physico-chemical behaviors and thus can be easily used in a high throughput mode, proteins are not easily amenable to the same treatment. It is thus important to remind researchers active in the proteomics field the fundamental basis of protein chemistry. This book attempts to bridge the two extreme ends of protein science: on one end, systems proteomics, whichdescribes, at a system level, the intricate connection network that proteins form in a cell, and on the other end, protein chemistry and biophysics, which describe the molecular properties of individual proteins and the structural and thermodynamic basis of their interactions within the network.

Bridging the two ends of the spectrum is bioinformatics and computational chemistry. Large data sets created by systems proteomics need to be mined for meaningful information, methods need to be designed and implemented to improve experimental designs, extract signal over noise, and reject artifacts, and predictive methods need to be worked out and put to the test. Computational chemistry faces similar challenges. The prediction of binding thermodynamics of protein-protein interaction is still in its infancy. Proteins are large objects, and simplifying assumptions and shortcuts still need to be applied to make simulations manageable, and this despite exponential progress in computer technology.

Finally, the study of proteins impacts directly on human health. It is an obvious statement to say that, for decades, enzymes, receptors, and key regulator proteins have been targeted for drug discovery. However, a recent and exciting development is the exploitation of our knowledge of protein-protein interaction for the design of new pharmaceuticals. This presents particular challenges because protein-protein interfaces are generally shallow and interactions are weak. However, progress is clearly being made and the book seeks to provide examples of successes in this area.

Healthcare is noted for using leading-edge technologies and embracing new scientific discoveries to enable better cures for diseases and better means to enable early detection of most life-threatening diseases. However, the healthcare industry globally, and in the US specifically, has been extremely slow to adopt technologies that focus on better practice management and administrative needs. Presently, healthcare is grappling with many challenges both nationally and globally, including escalating costs, a move to a preventative care environment, and a technologically savvy patient with high expectations. The Handbook of Research on Optimizing Healthcare Management Techniques is a pivotal reference source that provides an extensive and rich compilation of various ICT initiatives and examines the role that ICT plays and will play in the future of healthcare delivery. It represents ways in which healthcare delivery can be made superior and the healthcare industry can begin to address the major challenges it faces in the 21st century so that ultimately the most important person in the web of healthcare players, the patient, can be confident about receiving high-quality, cost-effective healthcare. While highlighting topics such as e-health, medical informatics, and patient value, this publication explores the role of supportive technologies as well as the methods of focused, patient-centric outcomes. This book is ideally designed for doctors, nurses, hospital administrators, medical staff, hospital directors, medical boards, IT consultants, health practitioners, academicians, researchers, and students.

e-Health Systems: Theory, Advances and Technical Applications offers a global vision of all the parties involved with e-health system deployment and its operation process, presenting the state of the art in major trends for improving healthcare quality and efficiency of healthcare management. The authors focus on ICT technologies and solutions for health management and healthcare applications, specifically emerging ICT to help reduce costs and improve healthcare quality, and healthcare trends in consumer empowerment and information-rich "Smart Care", with ubiquitous care access from anywhere, at any time, by any authorized person(s) when needed. Split into two parts, this book provides a comprehensive introduction to the concepts of e-health and delves into the processes carried out to store information, as well as the standards that are used; the authors explore applications and implementation of e-health systems, explaining in depth the types of wireless networks and security protocols employed to convert these systems into robust solutions avoiding any kind of data corruption and vulnerabilities.

This book focuses on the materials, synthetic methods, tools and techniques being developed in the nanoregime towards the life sciences -- in particular biology, biotechnology and medicine.
Readers from materials science, engineering, chemistry, biology and medical backgrounds will find detailed accounts of the design and synthesis of nanomaterials and the tools and techniques involved in their production for applications in biology, biotechnology and medicine.

Shirt Pocket Companion To The Complete Guide To Ecgs The ECG Criteria Book Provides ECG Criteria For 125 ECG Diagnoses, Including Arrhythmias And Conduction Disturbances; Chamber Enlargement And Hypertrophy; Ischemic Syndromes; Pacemakers; And Drug, Electrolyte And Medical Disorders. Also Includes Sections On Approach To ECG Interpretation, Differential Diagnosis Of ECG Abnormalities, And ACLS Algorithms.

Leading researchers have contributed state-of-the-art chapters to this overview of high-performance computing in biomedical research. The book includes over 30 pages of color illustrations. Some of the important topics featured in the book include the following:

Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. Significant progress has been made leading from pre-clinical studies through phase 3 clinical trials for some therapies. This volume provides a state-of-the-art report on tissue engineering toward the goals of tissue and organ restoration and regeneration. Examples from different organ systems illustrate progress with growth factors to assist in tissue remodeling; the capacity of stem cells for restoring damaged tissues; novel synthetic biomaterials to facilitate cell therapy; transplantable tissue patches that preserve three-dimensional structure; synthetic organs generated in culture; aspects of the immune response to transplanted cells and materials; and, suitable animal models for non-human clinical trials. The chapters of this book are organized into six sections: Stem Cells, Biomaterials and the Extracellular Environment, Engineered Tissue, Synthetic Organs, Immune Response, and Animal Models. Each section is intended to build upon information presented in the previous chapters, and set the stage for subsequent sections. Throughout the chapters, the reader will observe a common theme of basic discovery informing clinical translation, and clinical studies in animals and humans guiding subsequent experiments at the bench.

"True wellness innovation requires the recruitment of multi-disciplinary participants. This book breaks the mold with examples from healthcare experts and other professionals who have leveraged informatics to better the lives of their constituents." - Jason Helgerson, Founder & CEO, Helgerson Solutions Group LLC Developed for those training in academic centers as well as for those already "out in the field," this book looks at how attorneys, behavioral health experts, business development experts, chief information officers, chief medical officers, chief nursing information officers, consumer advocates, cryptographic experts, futurists, geneticists, informaticists, managed care executives, nurses, pharmacists, physicians, public health professionals, software developers, systems security officers, and workforce experts are collaborating on a "team-based," IT-enabled approach to improve healthcare.

In Sight is a memoir about how a love of science and discovery drove Julia Levy, a celebrated scholar and biotech CEO, to work her way through gender bias in order to achieve academic and professional recognition. Her story traces the unconventional invention of a breakthrough drug treatment from its development from laboratory research to its application as a medical treatment for vision loss. Told from a female perspective, In Sight is a unique and personal story covering Levy's early years as a refugee, her university training in the UK, and her appointment as professor at the University of British Columbia. Years spent as an academic led the author to unexpected exposure to the biotechnology industry and a chance meeting with colleagues that led to the formation of a lucrative biotechnology company, known today as QLT Inc. The bulk of the book covers the years spent building the company, and Levy's surprising transition from chief scientific officer to CEO. In Sight is an honest description of the trials of drug development, the tensions inherent in the commercialization of health innovations, and the truly remarkable hurdles faced by women in the scientific community.

This special volume contributes to the rapidly growing body of eHealth research, presenting a selection of multidisciplinary studies on the role and impacts of technology and the Internet in health communication, healthcare delivery, and patient self-management. The use of the Internet and new communication technologies have impacted nearly every aspect of life in recent years. These technologies hold tremendous promise to improve systems of healthcare and enable people to better understand their health and manage their healthcare. However, there are also risks to the use of eHealth technologies. Empirical evidence is urgently needed to examine the use and impacts of eHealth technologies and to inform targeted health communication interventions. Chapters explore both old and new challenges associated with technology-enabled care. These include the persistence of social determinants in shaping Digital Divides in access and use of eHealth technologies, the unintended consequences associated with electronic medical records and pagers on healthcare professionals' ability to control their work time, and how self-tracking and quantification may exacerbate gendered norms of the body and health. Other chapters provide updated information on trends in and predictors of people's trust of health information channels, how people make credibility assessments of online health information, the role of personality traits in perceived benefits in online support group participation, and how online health resources impact people's sense of empowerment and the use of healthcare services. Finally, chapters explore the future potential of eHealth in addressing the needs of underserved communities and guide the creation of new technology-enabled intervention strategies.

"Software Tools and Algorithms for Biological Systems" is composed of a collection of papers received in response to an announcement that was widely distributed to academicians and practitioners in the broad area of computational biology and software tools. Also, selected authors of accepted papers of BIOCOMP'09 proceedings (International Conference on Bioinformatics and Computational Biology: July 13-16, 2009; Las Vegas, Nevada, USA) were invited to submit the extended versions of their papers for evaluation.

Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.

Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.

This book explores the benefits of deploying Machine Learning (ML) and Artificial Intelligence (AI) in the health care environment. The authors study different research directions that are working to serve challenges faced in building strong healthcare infrastructure with respect to the pandemic crisis. The authors take note of obstacles faced in the rush to develop and alter technologies during the Covid crisis. They study what can be learned from them and what can be leveraged efficiently. The authors aim to show how healthcare providers can use technology to exploit advances in machine learning and deep learning in their own applications. Topics include remote patient monitoring, data analysis of human behavioral patterns, and machine learning for decision making in real-time.

This book provides readers with a detailed orientation to healthcare simulation research, aiming to provide descriptive and illustrative accounts of healthcare simulation research (HSR). Written by leaders in the field, chapter discussions draw on the experiences of the editors and their international network of research colleagues. This seven-section practical guide begins with an introduction to the field by relaying the key components of HSR. Sections two, three, four, and five then cover various topics relating to research literature, methods for data integration, and qualitative and quantitative approaches. Finally, the book closes with discussions of professional practices in HSR, as well as helpful tips and case studies.Healthcare Simulation Research: A Practical Guide is an indispensable reference for scholars, medical professionals and anyone interested in undertaking HSR.

Modern cancer research is a high-tech undertaking, overlapping with many fields in the physical sciences. These include nanotechnology, engineering, immunology, and bioinformatics. This book focuses on the science and technology underlying the diagnosis and treatement of cancer. The authors offer insights into technologies including radiotherapy, modelling, and drug encapsulation.

The book defines the differences between synthetic and natural superabsorbent polymers. It describes polymerization techniques, processing strategies and the use and importance of smart SAPs. It also includes SAP design to aid in selection of the best SAP for a specific application. The book is an indispensible resource for any academics and industrials interested in SAPs.

This book gives an introduction to the highly interdisciplinary field of biomaterials. It concisely summarizes properties, synthesis and modification of materials such as metals, ceramics, polymers or composites. Characterization, in vitro and in vivo testing as well as a selection of various applications are also part of this inevitable guide.

In today's hospitals, the gap between technology and medicine constantly needs to be bridged, both by physicians and engineers. By taking a unique clinical neuroengineering approach, From Neurology to Methodology and Back offers a translational study of neurology and technology from both sides. The fundamental topics covered range from basic concepts such as sampling and simple statistical measures via Fourier analysis to source localization. Providing clinically relevant context and introduce technical concepts, the neurological diseases presented range from epilepsy, brain tumors and cerebrovascular diseases to tremor, MS and neuromuscular diseases. All topics are presented in a true clinical neuroengineering approach. Each chapter begins with one or more patient cases for inspiration. Each case is then presented to illustrate a working example of a distinct neurodiagnostic technique, and the mathematical and physical principles underlying these techniques are explained. Finally, the author returns to the patient, and examines how the presented technology can help provide a diagnosis for each case. From Neurology to Methodology and Back serves as an upper-undergraduate/graduate level guide for those interested in a translational approach between the fields of medicine and technology in neuroengineering. Neurologists and residents in neurology, medical engineers, medical students, biomedical engineers and students, technical medicine students or students of other interdisciplinary fields will therefore all find this book useful. Each chapter begins with one or more patient cases for inspiration. Each case is then presented to illustrate a working example of a distinct neurodiagnostic technique, and the mathematical and physical principles underlying these techniques are explained. Finally, the author returns to the patient, and examines how the presented technology can help provide a diagnosis for each case. From Neurology to Methodology and Back serves as an upper-undergraduate/graduate level guide for those interested in a translational approach between the fields of medicine and technology in neuroengineering. Neurologists and residents in neurology, medical engineers, medical students, biomedical engineers and students, technical medicine students or students of other interdisciplinary fields will therefore all find this book useful.