Translational Medicine: Tools and Techniques provides a standardized path from basic research to the clinic and brings together various policy and practice issues to simplify the broad interdisciplinary field. With discussions from academic and industry leaders at international institutions who have successfully implemented translational medicine techniques and tools in various settings, readers will be guided through implementation strategies relevant to their own needs and institutions. The book also addresses regulatory processes in USA, EU, Japan and China. By providing details on omics sciences techniques, biomarkers, data mining and management approaches, case reports from industry, and tools to assess the value of different technologies and techniques, this book is the first to provide a user-friendly go-to guide for key opinion leaders (KOLs), industry administrators, faculty members, clinicians, researchers, and students interested in translational medicine.

In today's hospitals, the gap between technology and medicine constantly needs to be bridged, both by physicians and engineers. By taking a unique clinical neuroengineering approach, From Neurology to Methodology and Back offers a translational study of neurology and technology from both sides. The fundamental topics covered range from basic concepts such as sampling and simple statistical measures via Fourier analysis to source localization. Providing clinically relevant context and introduce technical concepts, the neurological diseases presented range from epilepsy, brain tumors and cerebrovascular diseases to tremor, MS and neuromuscular diseases. All topics are presented in a true clinical neuroengineering approach. Each chapter begins with one or more patient cases for inspiration. Each case is then presented to illustrate a working example of a distinct neurodiagnostic technique, and the mathematical and physical principles underlying these techniques are explained. Finally, the author returns to the patient, and examines how the presented technology can help provide a diagnosis for each case. From Neurology to Methodology and Back serves as an upper-undergraduate/graduate level guide for those interested in a translational approach between the fields of medicine and technology in neuroengineering. Neurologists and residents in neurology, medical engineers, medical students, biomedical engineers and students, technical medicine students or students of other interdisciplinary fields will therefore all find this book useful. Each chapter begins with one or more patient cases for inspiration. Each case is then presented to illustrate a working example of a distinct neurodiagnostic technique, and the mathematical and physical principles underlying these techniques are explained. Finally, the author returns to the patient, and examines how the presented technology can help provide a diagnosis for each case. From Neurology to Methodology and Back serves as an upper-undergraduate/graduate level guide for those interested in a translational approach between the fields of medicine and technology in neuroengineering. Neurologists and residents in neurology, medical engineers, medical students, biomedical engineers and students, technical medicine students or students of other interdisciplinary fields will therefore all find this book useful.

This comprehensive book focuses on better big-data security for healthcare organizations. Following an extensive introduction to the Internet of Things (IoT) in healthcare including challenging topics and scenarios, it offers an in-depth analysis of medical body area networks with the 5th generation of IoT communication technology along with its nanotechnology. It also describes a novel strategic framework and computationally intelligent model to measure possible security vulnerabilities in the context of e-health. Moreover, the book addresses healthcare systems that handle large volumes of data driven by patients' records and health/personal information, including big-data-based knowledge management systems to support clinical decisions. Several of the issues faced in storing/processing big data are presented along with the available tools, technologies and algorithms to deal with those problems as well as a case study in healthcare analytics. Addressing trust, privacy, and security issues as well as the IoT and big-data challenges, the book highlights the advances in the field to guide engineers developing different IoT devices and evaluating the performance of different IoT techniques. Additionally, it explores the impact of such technologies on public, private, community, and hybrid scenarios in healthcare. This book offers professionals, scientists and engineers the latest technologies, techniques, and strategies for IoT and big data.

This is an essential guide for doctors wishing to maximise the potential of their PDA or smartphones and is the only book available to address the specific needs of doctors in relation to PDAs and smartphones. Handheld computers, or PDAs, are computers small enough to hold in your hand or fit into your pocket. Smartphones are PDAs which also allow the user to make and receive phone calls. For doctors, PDAs are possibly the most clinically appropriate of all the computer devices created. The Doctor's PDA and Smartphone Handbook aims to introduce readers to the basics of PDAs. Comprehensive in its approach and easily accessible to those with no technical knowledge, the first few chapters demonstrate how the devices are used and how effective they can be in day-to-day clinical care and in training activities. Communication and sharing data and clinical information is enhanced if the full team is equipped with PDAs, and later chapters discuss more advanced uses and issues that should be considered if planning to equip the whole team. The text is accompanied by invaluable teaching videos and vignettes illustrating how teaching points covered in each chapter can be applied to realistic scenarios. Written by one of the world's leading experts on the clinical uses of mobile computing, Dr Mohammad Al-Ubaydli is now a researcher in the USA. The online videos are by Dr Chris Paton, Director of New Media New Medicine and creator of some of the world's leading websites for clinical education. Together, they have combined their expertise and have created a highly informative and effective text.

Searching for an objective and specific in vivo biomarker for normal physiology and early disease diagnosis has always been a major goal, but also one of the most challenging aspects in brain research. Possible earlier identification of the key pathological signature of diseases (for instance, Alzheimers disease (AD)) is critical for efficient treatment and disease prevention. The concept of combined imaging features is based on the recent accumulating evidence that neither PET nor MRI alone is enough for characterising the earliest AD pathology. The results of this book will, for the first time, highlight in vivo the possibility to describe the early detection and multiple biomarkers based on combined imaging features using PET-MRI, which is the most ideal model for such studies. The newly-developed hybrid imaging technology combining PET and MRI (PET/MRI) for the past few years is emerging, and has drawn much attention in technical developments and clinical applications. PET-MRI opens new horizons in multi-parametric neuroimaging for clinical research that allows simultaneous imaging of multiple parametric changes, such as blood flow and metabolism at the same time. This integration significantly decreases the potential errors in image registration, the difficulty of interpreting underlying coexisting pathophysiological events, and most importantly, patient discomfort. This book will provide the most up-to-date and current status of multiple neuroimaging techniques. The most intriguing application of multi-modality neuroimaging lies in simultaneous interpretation and unique information that each modality can offer. Therefore, this book will present some forefront and interesting examples for the first time in this field of research. This will hopefully trigger the interest of colleagues in this challenging field and help facilitate the applications of the neuroimaging techniques described.

This book focuses on the development and use of interoperability standards related to healthcare information technology (HIT) and provides in-depth discussion of the associated essential aspects. The book explains the principles of conformance, examining how to improve the content of healthcare data exchange standards (including HL7 v2.x, V3/CDA, FHIR, CTS2, DICOM, EDIFACT, and ebXML), the rigor of conformance testing, and the interoperability capabilities of healthcare applications for the benefit of healthcare professionals who use HIT, developers of HIT applications, and healthcare consumers who aspire to be recipients of safe and effective health services facilitated through meaningful use of well-designed HIT. Readers will understand the common terms interoperability, conformance, compliance and compatibility, and be prepared to design and implement their own complex interoperable healthcare information system. Chapters address the practical aspects of the subject matter to enable application of previously theoretical concepts. The book provides real-world, concrete examples to explain how to apply the information, and includes many diagrams to illustrate relationships of entities and concepts described in the text. Designed for professionals and practitioners, this book is appropriate for implementers and developers of HIT, technical staff of information technology vendors participating in the development of standards and profiling initiatives, informatics professionals who design conformance testing tools, staff of information technology departments in healthcare institutions, and experts involved in standards development. Healthcare providers and leadership of provider organizations seeking a better understanding of conformance, interoperability, and IT certification processes will benefit from this book, as will students studying healthcare information technology.

In celebration of Allan Hoffman's 70th birthday, a symposium entitled Gels, Genes, Grafts and Giants was held in Maui in December 2002. This symposium, organized by The University of Washington Engineered Biomaterials (UWEB) NSF Engineering Research Center, was a great success, with many excellent papers presented by scientists from all over the world.
All those who made oral or poster presentations at the symposium, but also those who worked with Allan Hoffman in the past or worked in similar research areas were invited to submit articles for special issues of the Journal of Biomaterials Science, Polymer Edition. The special issues of the journal will also be published in one hardcover book (expected beginning 2005).

This volume explores a broad range of different genotyping techniques. Genotyping: Methods and Protocols consists of chapters that cover numerous topics such as: an overview of multiplexed microsatellite analysis; High Resolution Melt analysis and TaqMan-based assays; in situ analysis of variants in single RNA molecules; the MassARRAY system and Molecular Inversion Probes; Pulsed Field Gel Electrophoresis, Paralogue Ratio Test, and Multiplex Ligation-Dependent Probe Amplification; long-range PCR combined with PacBio sequencing; Targeted Locus Amplification; Multilocus Sequence Typing and rapid SNP detection with pyrosequencing; and genotyping-by-sequencing for plant analysis. Finally, the volume concludes with a summary of pertinent points to describe genetic variation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Genotyping: Methods and Protocols is a valuable resource for anyone interested in learning more about the diverse field of genotyping.

The Human-Computer Interaction & Usability Engineering Workgroup (Ar- .. beitskreis HCI&UE) of the Austrian Computer Society (Osterreichische C- puter Gesellschaft, OCG) has been serving as an international platform for interdisciplinaryexchange,researchanddevelopmentsinceFebruary2005. While human-computer interaction (HCI) traditionally brings psychologists and c- puter scientists together, the inclusion of usability engineering (UE), a software engineering discipline ensuring the appropriate implementation of applications, has become indispensable. Because of the fast developments in information and communication technologies (ICT), the ?elds of application of HCI and UE are broader than ever. Therefore, USAB 2010 had, in comparison to past USAB conferences, quite a broad focus on all potential aspects of HCI in work - vironments, learning, private life and leisure activities. Each of these areas of application includes various challenges for HCI and UE, which go far beyond the classical desktop interface as well as usability norms and de?nitions pos- lated in the late twentieth century. The contributions for USAB 2010 provide important insights on the actual researchactivities in the ?eld and support the interested audience by presenting the state of the art in HCI researchas well as giving valuable input on questions arising when planning or designing research projects. Because of the increasing propagation of the ?eld of HCI research, it is not possible to address all areas within a smallconference;however,this is not the goalofUSAB 2010-itshould be seen as a metaphorical counterpart of a wholesale, an HCI delicatessen shop providinga tasting menuwith di?erent courses(hopefully) cateringto alltastes.

In this volume, scientists and practitioners write about new methods and technologies for improving the operation of health care organizations. Statistical analyses play an important role in these methods with the implications of simulation and modeling applied to the future of health care. Papers are based on work presented at the Second International Conference on Health Care Systems Engineering (HCSE2015) in Lyon, France. The conference was a rare opportunity for scientists and practitioners to share work directly with each other. Each resulting paper received a double blind review. Paper topics include: hospital drug logistics, emergency care, simulation in patient care, and models for home care services.

Recent, rapid advances in mathematical engineering and applied mathematics have opened the door to solving complex problems in angiography imaging. For the first time, this book presents the different medical imaging modalities - MR, CT, x-ray, and ultrasound - for performing angiography and its analysis.

Pioneers from a variety of relevant disciplines address state-of-the-art issues related to angiography, pre- and post angiography imaging, and their applications, such as intravascular ultrasound and x-ray fusion, plaque imaging, and morphology analysis. Their presentations cover most of the segmentation algorithms for anatomic blood vessels of the body, such as the brain, aorta, and retina.

The art of angiography imaging has penetrated several fields of medicine, such as ophthalmology, neurology, cardiology, and pulmonary medicine. Angiography and Plaque Imaging: Advanced Segmentation Techniques presents current information beneficial to all researchers and physicians interested in the effective diagnosis and treatment of various vascular diseases.

With the advent of recombinant DNA technology, monoclonal antibody technology, and new technologies for studying and handling cells and tissues, the field of biotechnology has undergone a tremendous resurgence in a wide range of applications pertinent to industry, medicine, and science in general. A volume in the Principles and Applications in Engineering series, Biotechnology for Biomedical Engineers covers the topics in biotechnology of interest to the practicing biomedical engineer. Topics include protein engineering, monoclonal antibody production, applications of nucleic acid chemistry, antisense technology, applied virology, cell structure and function, and more.

This paperback, full-color book is ideally suited for anesthesiologists, residents, and nurse anesthetists who need a concise, practical, easily accessible reference on anesthesia equipment. Written by the authors of the definitive text Understanding Anesthesia Equipment, A Practical Approach to Anesthesia Equipment covers the most commonly used machines and devices and addresses common problems and pitfalls that affect clinical situations. The book is written in outline format and thoroughly illustrated with full-color photographs and line drawings.

A comprehensive introduction to ICA for students and practitioners

Independent Component Analysis (ICA) is one of the most exciting new topics in fields such as neural networks, advanced statistics, and signal processing. This is the first book to provide a comprehensive introduction to this new technique complete with the fundamental mathematical background needed to understand and utilize it. It offers a general overview of the basics of ICA, important solutions and algorithms, and in-depth coverage of new applications in image processing, telecommunications, audio signal processing, and more.

Independent Component Analysis is divided into four sections that cover:

• General mathematical concepts utilized in the book
• The basic ICA model and its solution
• Various extensions of the basic ICA model
• Real-world applications for ICA models

Authors Hyvärinen, Karhunen, and Oja are well known for their contributions to the development of ICA and here cover all the relevant theory, new algorithms, and applications in various fields. Researchers, students, and practitioners from a variety of disciplines will find this accessible volume both helpful and informative.