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Septic Shock Methods and Protocols (Hardcover, 2000 ed.)
Loot Price: R4,085
Discovery Miles 40 850
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Septic Shock Methods and Protocols (Hardcover, 2000 ed.)
Series: Methods in Molecular Medicine, 36
Expected to ship within 12 - 17 working days
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Septic shock remains a serious medical condition with high
mortality. Despite many advances in intensive care medicine and
antibiotic devel- ment, this has not changed appreciably in the
last 20 years. Frustratingly, over the same period of time,
enormous advances have been made in understa- ing the underlying
pathogenic mechanisms of this condition. This has resulted in the
development of several novel therapies for septic shock, which,
despite excellent theoretical grounds for their efficacy, have
failed in altering mort- ity attributable to sepsis. The reasons
for these failures are multiple, but it is clear that further
research is required aimed at increasing our understanding of the
basic pat- physiological processes that occur following infection.
Research into septic shock draws upon a number of different
disciplines, ranging from molecular and cellular biology to
physiological measurements on whole animals. Septic Shock Methods
and Protocols is an attempt to draw together into one volume a
number of protocols that are of use in the investigation of the
mechanisms of septic shock. I have divided the book into five
sections. The first deals with endotoxin, the lipopolysaccharide
component of the Gram-negative cell m- brane that can mimic many of
the features of septic shock. Gram-positive organisms are found
increasingly as causes of septic shock, and several - pects of
toxins produced from these bacteria are considered in the second s-
tion.
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