The gripping and shocking story of three generations of the Sackler family and their roles in the stories of Valium and Oxycontin, by the prize-winning, bestselling author of Say Nothing.

The Sackler name adorns the walls of many storied institutions – Harvard; the Metropolitan Museum of Art; Oxford; the Louvre. They are one of the richest families in the world, known for their lavish donations in the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing Oxycontin, a blockbuster painkiller that was a catalyst for the opioid crisis-an international epidemic of drug addiction which has killed nearly half a million people.

In this masterpiece of narrative reporting and writing, Patrick Radden Keefe exhaustively documents the jaw-dropping and ferociously compelling reality. Empire of Pain is the story of a dynasty: a parable of 21st century greed.

Now in its third edition, Pharmacology in Clinical Practice has been updated to ensure it remains up-to-date and relevant.

Particular care has been taken to simplify and clarify difficult concepts by explaining the links between pharmacology and physiology by providing definitions of new concepts, and using plain language for ease of understanding. Fundamental concepts, such as pharmacodynamics and pharmacokinetics, are well covered in a matter that is accessible and clear. Individual chapters cover the various systems of the body.

Updates include:

• A colour plate to illustrate the links between pharmacology and physiology
• Additional information on side-effects, contra-indications and patient education for groups of drugs
• A guide on how to access this information, to assist with exam preparation and nursing practice
• An updated chapter on nursing management of drug preparations and treatment
• An updated chapter on clinical applications
• A chapter on the legal framework for dispensing and prescribing.

The OSCEs have become a part of most examinations in Critical Care Medicine. This book will be of great help to the examinees. The contents have been divided into two sections one is Questions and the second is Answers. It contains chapters on Respiratory Medicine, Neurology, Nephrology, Microbiology and Infection Control, Hemodynamics, Drugs, Biochemistry, Miscellaneous, and Case Scenarios. Contains nearly 330 questions with model answers. Questions range from the old tests, new techniques and devices, and results of laboratory and other investigations. Also covers questions on all organ systems and different ways these systems may be affected by the disease. The answers are structured from examination point-of-view. These will help the examinees in developing the skills to face the objective structured clinical examinations (OSCEs) in their examination.

There are 41 chapters in the manual under different section heads dealing with physiology, clinical applications, use in different types of respiratory failure, including end of life situations, and limitations, challenges as well as its use in pediatrics. This flagship book of ISCCM one of the first of its kind in India. Covers all aspects of noninvasive ventilation from initiation to disease specific conditions. Evidence-based and updated protocols have been used in easy to read format with flowcharts and diagrams. Stalwarts in this field have contributed to this book. This book will be helpful to all postgraduates, intensivists and physicians.

This book on and signs and symptoms, which is indexed in alphabetical order from which the physician will be able to weave a clinical narrative, anatomically and pathophysiologically explicit, to form the accurate diagnostic hypotheses. It is compact, handy and bedside clinical companion book for all dedicated healthcare professionals who are committed to evaluate the patient accurately on the basis of signs and the symptoms. Consists of 91 chapters, enriched with knowledge of about more than 100 contributors. Covers almost all the possible signs and the symptoms, commonly seen in the day-to-day clinical practice. Useful in evaluating the patients in early stages of the complaints and also helpful in initial treatment and management. This book is helpful for undergraduates, postgraduates, residents, and emergency physicians.

This book focuses on improving decision-making capability by guiding the critical thinking process and application of theories. Problem-based learning is the best way to learn medicine. Every case in the book has some practical problem-related questions for the reader's selfevaluation, followed by correct answers, and discussion on relevant topics and management. The book provides basic knowledge of various clinical problems that are faced by physicians. It analyses appropriate approach in diagnosing and management of problems. Provides real diagnostic and management skills which can be applied by practitioners. The clinical cases are compiled in stepwise pattern for physicians that focus on appropriate scientific approach for suitable diagnosis.

This book is intended to be concise yet highly informative and user friendly. It provides quick information of drug doses, adverse effects, contraindications of use and special precautions which has to be undertaken during therapy. The contents will be especially helpful not only for the students, but also for the busy practitioners. The clinical pearls and the comparative study of drugs discussed at the end of the chapters are for instant overview. This book precisely covers almost all important chapters of Pharmacology and would provide important at hand information for postgraduate aspirants too for their entrance examinations.

This book is the latest volume in the series presenting clinicians and medical students with the latest advances in medicine, with emphasis on endocrine and cardiovascular disorders. Presented as a collection of articles, the first chapters provide an overview of the field and discussion on medical teaching. The following sections cover the diagnosis and management of numerous conditions in everyday clinical practice. Separate chapters explore advances in other sub-specialties such as kidney disease, sepsis and asthma, and several complete sections are dedicated to Covid and associated disorders. Enhanced by clinical photographs and figures, this valuable text serves as a ready reckoner for different approaches to clinical case management. The previous volume (9789389587111) published in 2020.

The medical domain is home to many critical challenges that stand to be overcome with the use of data-driven clinical decision support systems (CDSS), and there is a growing set of examples of automated diagnosis, prognosis, drug design, and testing. However, the current state of AI in medicine has been summarized as "high on promise and relatively low on data and proof." If such problems can be addressed, a data-driven approach will be very important to the future of CDSSs as it simplifies the knowledge acquisition and maintenance process, a process that is time-consuming and requires considerable human effort. Diverse Perspectives and State-of-the-Art Approaches to the Utilization of Data-Driven Clinical Decision Support Systems critically reflects on the challenges that data-driven CDSSs must address to become mainstream healthcare systems rather than a small set of exemplars of what might be possible. It further identifies evidence-based, successful data-driven CDSSs. Covering topics such as automated planning, diagnostic systems, and explainable artificial intelligence, this premier reference source is an excellent resource for medical professionals, healthcare administrators, IT managers, pharmacists, students and faculty of higher education, librarians, researchers, and academicians.

Sold worldwide and translated into 13 languages, John Murtagh's General Practice is widely recognised as the gold standard reference for general practice and primary health care. Its emphasis on the importance of clinical reasoning, early diagnosis and treatment makes this the essential reference for medical students, trainees and general practitioners. Written by renowned general practitioners and educators, and with all content reviewed for currency by leading experts, the eighth edition provides fundamental knowledge and skills required for the challenging field of general practice. Key features: *Diagnostic strategy models for common presenting problems, including diagnostic triads *Clinical frameworks, including management and treatment *Evidence-based research, with all content reviewed for currency by leading experts *Extensive coverage of mental health, health promotion, women's health, and paediatric and geriatric care New to this edition: *New chapters on obesity, mood disorders, breast disorders, and traveller's health and tropical medicine *Updated and new information on genetic disorders, chronic pain and infectious diseases, including acute respiratory distress syndrome with reference to coronaviruses and COVID-19 *Restructure of table of contents to allow for easier navigation About the authors John Murtagh is Emeritus Professor in General Practice at Monash University; Professional Fellow of General Practice at the University of Melbourne; and Adjunct Clinical Professor in the Graduate School of Medicine, University of Notre Dame. Jill Rosenblatt is a general practitioner and was Adjunct Senior Lecturer in the School of Primary Health Care at Monash University. She received a Distinguished Service Award of the RACGP in 2014. Jill has a wealth of rural and urban medical experience. Justin Coleman is a general practitioner in the Tiwi Islands and was Senior Lecturer at Flinders University. He's on the Editorial Advisory Board of Diabetes Management Journal, a member of Choosing Wisely Australia (NPS) and a prolific writer for a number of publications. Clare Murtagh is a general practitioner in Sydney. She holds postgraduate qualifications in Dermatology, Medical Education, and Sexual and Reproductive Health.

Lippincott (R) Connect Featured Title Purchase the new print edition of this Lippincott (R) Connect title includes access to the digital version of the book, plus related materials such as videos and multiple-choice Q&A and self-assessments. This updated ninth edition of the leading medical physical examination pocket guide available today provides concise, authoritative guidance on how to perform the patient interview, physical examination, and other core assessments. This trusted pocket-sized reference includes fully illustrated, step-by-step techniques, retaining the easy-to-follow two-column format that correlates examination techniques on the left and abnormalities (clearly indicated in red) with differential diagnoses on the right. Now featuring an enhanced design, new content, and new student-friendly learning aids, Bates' Pocket Guide to Physical Examination and History Taking, Ninth Edition, is the ideal quick-reference resource for today's medical, PA, pharmacy, and nursing students. NEW! Expanded Unit 1 provides an overview of the components of the patient encounter and helps you ensure the most effective information-gathering and decision-making approaches. NEW! Algorithms provide helpful starting approaches for patients with common presenting symptoms. UPDATED! Restructured Regional Exam chapters enhance your understanding of overview material, examination techniques, and health promotion and counseling considerations. UPDATED! Photographs, illustrations, and references reinforce key content based on the latest evidence-based information. UPDATED! Text boxes are numbered to provide quick access to important summaries of clinical conditions and tips for challenging examination techniques. Detailed, highly illustrated tables of abnormal conditions display examination and clinical information in an easy-to-find, quick-reference format. Lippincott (R) Connect features: Full access to the digital version of the book with the ability to highlight and take notes on key passages for a more personal, efficient study experience. Carefully curated resources, such as interactive diagrams, audio and video tutorials, and self-assessment, all designed to facilitate further comprehension. Lippincott (R) Connect also allows users to create Study Collections to further personalize the study experience. With Study Collections you can: Pool content from books across your entire library into self-created Study Collections based on discipline, procedure, organ, concept or other topics. Display related text passages, video clips and self-assessment questions from each book (if available) for efficient absorption of material. Annotate and highlight key content for easy access later. Navigate seamlessly between book chapters, sections, self-assessments, notes and highlights in a single view/page.