This volume explores some of the most exciting recent advances in basic research on cellular RNA interference mechanisms and how this knowledge is leading to advances in the various fields.
* This series provides a forum for discussion of new discoveries, approaches, and ideas
* Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields

This volume explores some of the most exciting recent advances in basic research on molecular assembly in natural and engineered systems and how this knowledge is leading to advances in the various fields.
* This series provides a forum for discussion of new discoveries, approaches, and ideas
* Contributions from leading scholars and industry experts
* Reference guide for researchers involved in molecular biology and related fields

This issue of Medical Clinics of North America brings the physician up to date on the newest agents for antibacterial therapy.? New drugs are covered, as well as new approaches.? Topics include the newer fluoroquinolones; epidemiology, molecular mechanisms, and clinical management of pathogens resistant to antibacterial agents; current use for old antibacterial agents, including polymyxins, rifamycins, and aminoglycosides; topical antibacterial agents; newer beta-lactam antibiotics, including doripenem, ceftobiprole. ceftaroline, and cefepim; the use of antibacterial agents in renal failure; antibiotics for gram positive bacterial infections, including vancomycin, teicoplanin, quinupristin/dalfopristin, oxazolidinolones, daptomycin, telavancin, and ceftaroline; as well as macrolides, ketolides, and glycylcyclines, including azithromycin, clarithromycin, telithromycin, and tigecycline.

This year book brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice.

DNA methylation is essential for the normal development and functioning of organisms. This volume discusses the latest developments in this very active field of research. It presents the evolution of DNA methylation, mammalian DNA methyltransferases, DNA methylation and demethlyation, DNA methylation and silencing and the role it plays in medicine including cancer.

* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

This book presents some of the most advanced experimental systems in which the role of forces has been dissected. It explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces.

Presents some of the most advanced experimental systems in which the role of forces has been dissected.
It explores the physical principles accounting for how forces can affect soft matter such as our cells, and presents some of the methods used to measure or assess the role of forces.
Appeals to both physicists eager to get familiar with biological systems, and to biologists curious about the physical principles behind what they observe.

The global nitrogen cycle is the one most impacted by mankind. The past decade has changed our view on many aspects of the microbial biogeochemical cycles, including the global nitrogen cycle, which is mainly due to tremendous advances in methods, techniques and approaches. Many novel processes and the molecular inventory and organisms that facilitate them have been discovered only within the last 5 to 10 years, and the process is in progress. This volume provides state-of-the-art updates on methods and protocols dealing with the detection, isolation and characterization of macromolecules and their hosting organisms that facilitate nitrification and related processes in the nitrogen cycle as well as the challenges of doing so in very diverse environments.

Provides state-of-the-art update on methods and protocols Deals with the detection, isolation and characterization of macromolecules and their hosting organisms deals with the challenges ofvery diverse environments."

A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation.

Articles written and edited by experts in the field
Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events
Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Every year, numerous articles on critical care topics are published, and it is increasingly difficult for the busy practitioner to keep abreast of the latest developments. This book provides a detailed review of state of the art knowledge as well as the latest research findings. It covers the core aspects in excellent detail, but is not so comprehensive as to make its daily se unfeasible. For each condition considered, discussion of the pathophysiology is integrated with observations on diagnosis and treatment in order to allow a deeper understanding. The book is scientifically based, with extensive references to published research. This will allow readers to investigate their individual interests further and will enable physicians to base their approach upon evidence rather than upon traditions or routines. Accordingly, clinicians will be able to justify measures by providing a coherent, evidence-based strategy and relevant citations where needed. Core Knowledge in Critical Care Medicine will appeal to experienced practitioners as an aide-m moire, but will also be of great value to a wide range of more junior staff wishing to complement their background knowledge with important facts applicable to everyday practice.

The rapid development of new technologies has created a lasting impact in the healthcare sector during the past decades. Due to this influence, potential clinical problems have decreased while the quality of healthcare delivery and overall user friendliness has increased and contributed to cost-effective healthcare systems. Biomedical and Clinical Engineering for Healthcare Advancement is an essential reference source that discusses growth in healthcare applications driven by the adoption of new technologies, as well as the expansion of machine learning algorithms for clinical decision making. It focuses on combining vision, motion, data acquisition, and automated control to accelerate the development of affordable and portable medical devices. Featuring research on topics such as artificial intelligence, drug delivery, and retinal imaging, this book is ideally designed for healthcare professionals, biomedical engineers, biomedical professionals, clinicians, hospital directors, physicians, medical students, and clinical researchers.

Recent global and national debates have shown that demographic change, the rising incidence of chronic disease, and the unmet need for more personalized care are trends demanding a new, integrated approach to health and social care. The advancement and adoption of technology in both health and social care settings is a valuable tool for encouraging change and improving the quality and efficiency of care provided to patients and care clients. Achieving Effective Integrated E-Care Beyond the Silos presents a collection of real-life examples, frameworks, business models, financial implications, and methods of evaluating the technological tools that are enabling a more human-centered approach to health and social care. Based on relevant research in the field of integrated e-care, this publication is ideally designed for use by practitioners, researchers, and decision-makers in the care field.

Complementary and alternative medicine encompasses a wide range of modalities, including acupuncture, herbs and supplements, naturopathy, and body and mind therapies.? The use of these healing methods is increasing rapidly, and more and more patients are approaching primary care physicians with questions about them.? The purpose of this issue is to help doctors understand the evidence supporting and refuting complementary and alternative medicine techniques so they can provide patients with answers.? This is the second of a two-part series, and it focuses on application of complementary and alternative medicine techniques to disease states and body systems.

Presenting a cutting-edge theory for using humor in psychotherapy, counseling, and clinical intervention, this volume brings together a group of outstanding experts in the field of clinical intervention. Each chapter shows how humor can play a vital role in the promotion of wellness in general and in mental health wealthness in particular. It provides specific theoretical perspectives aimed at helping readers develop both their awareness of humor as a clinical tool and dexterity in using humor to facilitate productive change during the therapeutic process.

This book will be of interest to students and professionals in all areas of the helping and healing professions. In addition to the psychotherapeutic disciplines, it also has applications in human relations and communication-training fields.

This issue of the Medical Clinics of North America brings the practicing clinician up to date on the current challenges, new concepts, and management of hypertensive disease. Topics covered include risks in hypertension; new biological concepts of target organ involvement in hypertension; hypertension and the metabolic syndrome; aging versus hypertension; hypertension, systolic blood pressure, and large arteries; oxidative stress, endothelial dysfunction, and hypertension; current thinking about hypertensive heart disease; diastolic dysfunction as a link between hypertension and heart failure; hypertension and cardiac failure in its various forms; hypertension and atherogenesis; the kidney, hypertension, and remaining challenges; current thinking about renovascular hypertension; obesity and hypertension; and barriers to adherence in hypertension management.

Atrial fibrillation is the most common sustained arrhythmia in humans. An incredible worldwide effort from physicians, scientists and industry over the last decade has brought forth new insights and therapeutic tools. We are fortunate to have achieved a level of understanding about this complex disease that we can indeed cure some patients. While we proceed at full speed ahead looking for cures for the rest, we have taken this opportunity in the Medical Clinics of North America to reflect on how much we have learned and on the task that lies ahead. This issue opens with a historical perspective, discusses many of the clinical issues in the management of atrial fibrillation, such as cardioversion, anticoagulation and ablation, and concludes with the current guidelines for treatment and a view of the future.

Evolutionary Medicine is based upon the view that many contemporary social, psychological, and physical illnesses are related to an incompatability between current human lifestyles and environments and the conditions under which human biology developed. This book, featuring contributions from many of the leading workers in this devloping area, provides a good introduction and overview to this emerging field.

Fertility and Pregnancy: An Epidemiologic Perspective, is a lively overview of human reproduction: how it works, and what causes it to go wrong. Weaving together history, biology, obstetrics, pediatrics, demography, infectious diseases, molecular genetics, and evolutionary biology, Allen Wilcox brings a fresh coherence to the epidemiologic study of reproduction and pregnancy. Along the way, he provides entertaining anecdotes, superb graphs, odd tidbits and occasional humor that bring the topic to life.
The book is divided into two sections. The first lays the foundations - the basic principles of reproductive physiology, demography, infectious diseases, and genetics as they apply to human reproduction. The second part deals with the endpoints of reproductive epidemiology - a spectrum ranging from infertility and fetal loss to birth defects and the delayed effects of fetal exposures. The book closes with a discussion of unsolved problems, suggesting possible research projects for a new generation of epidemiologists. An extensive glossary makes this a valuable reference as well as an enjoyable read.

Intensive Care Medicine compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.