This issue of Medical Clinics of North America, guest edited by Dr. Lia Logio, is devoted to Common Symptoms in Outpatient Practice. Articles in this issue include: Evaluating and managing the patient with back pain, Update on Indigestion, Approach to the patient with a cough, Diagnosis and Management of Headaches, Current Approach to Constipation, Managing the Forgetful Patient: Best Practice for Cognitive Impairment, Evidence-based Approach to Palpitations, Solving the Problem of Insomnia: Current Practice, Approach to Knee Pain: Diagnosis and Treatment, Approach to Fatigue: Best Practice, Best Practices in the Management of Overweight and Obesity, Best Practice in Approaching Patients with Weight Loss, Common Complaints of the Hands and Feet, A Symptom-Directed Paradigm for the Evaluation and Management of Upper Respiratory Tract Infections, and more.

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier's Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs Jessica Jeffrey, Eugene Grudnikoff, Barry Sarvet and Rajeev Krishna, will cover key topics of importance surrounding Measurement-Based Care in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Evidence for the use of MBC in clinical practice; Validated Measures in Child Psychiatry and How to Use Them; Integrating MBC into Trainee Education; MBC In the Treatment of Depression; MBC in the Treatment of Anxiety; MBC in the Treatment of ADHD and disruptive behavior disorders; MBC in the Treatment of Substance Use Disorders; Implementing MBC in Various Practice Settings; Use of MBC Data to track Clinic Performance and Quality Outcomes; Use of MBC Data in Population Health Management; HIT resources to support MBC, among others.

This book presents recent outcomes of the collaborative "Tricorder" project, which brings together partners from industry, research institutes and hospitals to deliver an easy contactless alternative for electrocardiograms (ECG). Featuring contributions investigating the possible applications of laser Doppler vibrometry (LDV) signals for the remote measurement of vital parameters of the heart, the book provides insights into the vision and the history of the "Tricorder" project and the basic differences between the vibrocardiograms and electrocardiograms. It also discusses topics such as signal processing, heartbeat measurement techniques, respiration frequency and oxygen saturation determination, with a particular focus on the diagnostic value of the method presented, e.g., diagnosis of atrial fibrillation and estimation of the oxygen saturation in premature infants. Further, the authors review the advantages and drawbacks of the new method and the specific fields of application. This book will appeal to researchers and industry leaders interested in laser remote sensing for medical applications as well as medical professionals curious about new healthcare technologies.

"Superb This thoroughly delightful book explores, explains, and puts in context our biggest fear- our own mortality The very word "Cancer" evokes a primal fear that we are all mortal and will, at some point, die. My own experience, on a personal level with cancer, access ports, chemotherapy, radiation therapy, and major surgery was very sobering Dr Kevin Ryan has given us all a new perspective on how to live with and conquer our biggest fear This book is a must read for anyone living with cancer, their families, and the entire treatment community. When Tumor is the Rumor, and Cancer is the Answer will help each of us to triumph over this experience, regardless of the outcome "
-LT. Gen PK Carlton Jr. Surgeon General USAF (ret)

"A great cancer book should reduce anxiety with authority and comprehensive information helping those confronted marshal their internal resources and conquer their fears. Does such a book exist? You are about to read it"
-Maurie Markman MD FACP Senior Vice President of Clinical Affairs & National Director of Medical Oncology Cancer Treatment Centers Of America. Senior Vice President of Clinical Affairs and National Director of Medical Oncology, Cancer Treatment Centers Of America. Former Professor and Vice President of Clinical Research and Chairman of the Department of Gynecologic Medical Oncology, MD Anderson Cancer Center. Former Chairman of the Department of Hematology/Oncology and Director of the Taussig Cancer Center at the Cleveland Clinic Foundation. Former Vice-Chair, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York

This issue of Medical Clinics, guest edited by Dr. Andrew Dunn, is an Update in Hospital Medicine. Articles in this issue include: Sepsis, severe sepsis, and septic shock, Pneumonia, Acute congestive heart failure, Acute exacerbation of COPD, Acute manifestations of alcohol use disorder, Opioid use disorder, Acute Venous Thromboembolism, Acute liver Injury / Decompensated cirrhosis, Hospital-acquired infections, Peri-operative management of anticoagulation, Teamwork essentials for the hospitalist, Teaching at the bedside, and more.

Papers were presented at ISTRY-2006 Toyko under such headings as 'Updates on Chemistry of Indoles and Aromatic Metabolites Therefrom', 'The Bis-indole Indirubins: From Indigo Plant to Clinic', 'Systematic Tryptophan Depletion', 'Biochemistry and Molecular Biology of Tryptophan Metabolism' and 'Analytical Chemistry'.

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state-dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley

Light, Molecules, Reaction and Health offers a comprehensive overview of health-related, light-based processes and systems, paying special attention to molecular photochemistry. Users of photochemical methods and concepts in pharmacology and biomedicine will find detailed information on the basic processes underlying the biological effects of natural and artificial light-from the primary absorption event occurring in an endogenous or exogenous molecule in a biological compartment, to the final pathological or beneficial outcome. By emphasizing novel methods, including nanostructured materials in therapy and diagnostics, this book allows readers to critically interpret existing data with a goal of stimulating new research in phytotherapy and phytomedicine.

Medicine in a Day: Revision Notes for Medical Exams, Finals, UKMLA and Foundation Years covers all conditions in the UK Medical Licensing Assessment and more, within just one book! Prepared by a unique combination of authors - including early career stage doctors still close to what is required for exam success, expert educators and senior specialists - Medicine in a Day provides the trusted information you need most when time is short. Each chapter can be read in an hour, covering the medical and surgical specialties, Radiology, Anaesthetics and Critical Care, Emergency Medicine, Paediatrics, Obstetrics and Gynaecology, Psychiatry, Infectious Diseases, Clinical Epidemiology, commonly prescribed medications and more. The essential knowledge for each topic is presented simply and concisely, supported by bespoke illustrations. A large, carefully selected image collection reflects the views most commonly seen in exams, and includes X-rays, ECGs, CTs and clinical photographs, with dermatological conditions shown for diverse skin tones. Reach for Medicine in a Day when you need to study efficiently, prepare for medical exams, or refresh your memory at any stage of your career. The (printed) book also comes with access to the complete, downloadable eBook version, for easy quick reference, anytime, anywhere!

Pocket Medicine, 8th Edition, is a must-have resource for fast answers to the diagnostic and therapeutic questions you'll face on rounds and exams. Edited by Dr. Marc S. Sabatine and compiled by residents, fellows, and attending physicians at the world-renown Massachusetts General Hospital, this best-selling reference provides dependable, up-to-date information needed to make an accurate diagnosis and develop a state-of-the-art treatment plan. Featuring easily accessible bulleted lists, tables, and algorithms, Pocket Medicine provides focused coverage of internal medicine in the traditional, easy-to-use binding you know and love. Offers fast and easy access to essential information on the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology. Includes references to landmark papers to help you intelligently answer questions on rounds-all from a trusted source acceptable for use on rounds. Features user-friendly tabs and a two-color design to help you find information quickly, as well as a full-color, 16-page insert featuring radiology and pathology images. Provides ideal coverage for medical students, interns, residents, advanced practice nurses, and PAs. Prepare for board exams! Mirroring the organization of Pocket Medicine, Pocket Medicine High-Yield Board Review features 500 practice questions so you can practice for your board exam.

As the healthcare industry continues to expand, it must utilize technology to ensure efficiencies are maintained. Healthcare needs to move in a direction where computational methods and algorithms can relieve the routine work of medical doctors, leaving them more time to carry out more important and skilled tasks such as surgery. Computational Methods and Algorithms for Medicine and Optimized Clinical Practice discusses some of the most interesting aspects of theoretical and applied research covering complementary facets of computational methods and algorithms to achieve greater efficiency and support medical personnel. Featuring research on topics such as healthcare reform, artificial intelligence, and disease detection, this book will particularly appeal to medical professionals and practitioners, hospitals, administrators, students, researchers, and academicians.

A revision book intended primarily for candidates sitting their MRCP Part 1 examination and which covers all the essential basic sciences. It focuses on the recurring themes which come up in the questions. The book also includes a chapter on clinical pharmacology (which alone accounts for up to 30% of the questions), looking at aspects of drug-induced disease and drug interactions. Finally there is a chapter on statistics and epidemiology which is rarely covered in other texts, but is often included in the exam. Despite the changes to the teaching of the undergraduate in medicine and the integration of the basic sciences with clinical education, the junior doctor, faced with postgraduate examinations, is always going to be poorly prepared for those increasingly important subjects. This book presents the essential information in the form of lists, tables, diagrams and flow charts. Helps MRCP Part 1 candidates prepare for and pass their exam. Addresses an increasingly important topic in the exam. Addresses a topic that is vital to passing the exam, but which most candidates are poorly prepared for. Covers all the relevant basic science subjects plus includes clinical pharmacology. Is of use to candidates studying for other postgraduate exams such as PLAB, USMLE and MRCPCH. Is the first book of its kind in the membership market and is now regarded as essential for exam preparation.

Examining all the major research data since the 1940s, this book challenges two orthodox medical models: HIV as the cause of AIDS, and random genetic mutations as the cause of cancer. Based on the recent findings from Evolutionary Biology and Nitric Oxide research, it presents a fundamentally new understanding of the human cell, its double genome split between the cell nucleus and the mitochondria, and the role of energy production and signal modulation for immune reactions and carcinogenesis. Finally, it explains the concept of a new Cell Symbiosis Therapy[registered] for the treatment of all chronic diseases, including cancer. Now available in English for the first time, this book is a must-read for doctors, patients and anyone following the cutting edge of biology and immunology. With the blasting open of such doors of knowledge, the medical world will never again be the same.

Practical, clinically focused, and highly illustrated, this new guide includes content not covered in any other book, presented in a user-friendly format. Part I introduces the concepts of subjective evaluation, observation/posture, related referral joint testing, neurovascular testing, palpation, and range of motion testing. Part II comprises the bulk of the text, covering the major shoulder tests that clinicians perform. Part III features supplemental tests used in the clinical setting. Finally, Part IV pulls all the information together by testing students and clinicians alike with a series of case studies. The reader will also find extensive, up-to-date references for further research or study. The first text devoted solely to the musculoskeletal examination of the shoulder joint. Emphasizes research and objectivity, providing easy access to current research quantification of test procedure efficacy indication and clinical application. Contains an exhaustive review of examination and clinical tests, leading to a more accurate diagnosis and better course of care. Presents a combination of clinical tests, functional evaluation parameters, throwing and interval sport return/evaluation procedures, as well as seldom-presented closed chain tests, offering the practitioner a plethora of alternative tests. Highlights new tests for the shoulder, particularly in the area of labral and instability testing. Places a high degree of emphasis on documentation of test results, increasing the reader's objectivity of the shoulder exam process. Includes various combinations of patient presentation, emphasizing classic diagnoses and the combinations of test results from the evaluation procedures covered in the text. Case studies permit readers to test themselves and apply their knowledge to varied situations.