In this issue of Medical Clinics, Guest Editor Jeffrey Callen brings his considerable expertise to the topic of Dermatology. Top experts in the field cover key topics such as alopecia, psoriasis, Cutaneous manifestations of diabetes, Diagnosis and management of cellulitis, and more. Provides in-depth, clinical reviews in Dermatology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains more than 10 relevant, practice-oriented topics including Recognition and management of Severe Cutaneous Adverse Drug Reactions (including DRESS, SJS and TEN); Diagnosis and management of eczemas including atopic, hand dermatitis and contact dermatitis; Recognition, staging and management of melanoma; Diagnosis and management of leg ulcers; Approach to the patient with pruritus; and more.

Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research.

Produced by microbes on a large scale, methane is an important alternative fuel as well as a potent greenhouse gas. This volume focuses on microbial methane metabolism, which is central to the global carbon cycle. Both methanotrophy and methanogenesis are covered in detail. Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems, and field measurements. The state-of-the-art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field.

Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems, and field measurements The state-of-the-art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field

Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. This volume reviews the latest research and developments in this field.

* Discusses new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

This book explores serious diseases and disorders that most readers have never heard of, ranging from genetic, infectious, and environmental diseases to autoimmune, idiopathic, and mental disorders. Despite centuries of scientific study and medical research, there are still many human diseases and disorders that remain difficult to manage or are incurable. Some of these maladies are extremely rare, yet, together, they affect a substantial number of people. The 101 Most Unusual Diseases and Disorders examines seldom-seen illnesses, providing high school and college students with an excellent resource for research as well as supplying fascinating reading for general readers interested in diseases and medical science. This book provides clear, easy-to-understand, and scientifically grounded information on the vast number of unusual medical conditions that have been recorded, covering five kinds of diseases and disorders: genetic, infectious, environmental, mental, and "other," which constitutes diseases of autoimmune and unknown origin. Examples of the medical conditions addressed include autoimmune encephalitis, Ebola, kleptomania, Morgellons syndrome, orthorexia, pneumoconiosis, and Prader-Willi syndrome. Selected case studies enable readers to better empathize with the experiences of those who have these disorders and how these afflictions have affected their lives. Provides readers with interesting facts and insights into unusual or rarely seen diseases and disorders from the perspective of an experienced medical writer Supplies accessible information for students and general readers and serves as a jumping-off point for further research into an unusual topic or disorder Addresses a topic of high interest due to recent media attention on deadly contagious diseases such as Ebola as well as popular television shows that focus on uncommon and interesting medical conditions like House and Mystery Diagnosis Includes case studies that serve to "personalize" the content by highlighting the experiences of individuals affected by a particular disease

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs Jessica Jeffrey, Eugene Grudnikoff, Barry Sarvet and Rajeev Krishna, will cover key topics of importance surrounding Measurement-Based Care in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Evidence for the use of MBC in clinical practice; Validated Measures in Child Psychiatry and How to Use Them; Integrating MBC into Trainee Education; MBC In the Treatment of Depression; MBC in the Treatment of Anxiety; MBC in the Treatment of ADHD and disruptive behavior disorders; MBC in the Treatment of Substance Use Disorders; Implementing MBC in Various Practice Settings; Use of MBC Data to track Clinic Performance and Quality Outcomes; Use of MBC Data in Population Health Management; HIT resources to support MBC, among others.

This issue of Medical Clinics of North America, guest edited by Dr. Lia Logio, is devoted to Common Symptoms in Outpatient Practice. Articles in this issue include: Evaluating and managing the patient with back pain, Update on Indigestion, Approach to the patient with a cough, Diagnosis and Management of Headaches, Current Approach to Constipation, Managing the Forgetful Patient: Best Practice for Cognitive Impairment, Evidence-based Approach to Palpitations, Solving the Problem of Insomnia: Current Practice, Approach to Knee Pain: Diagnosis and Treatment, Approach to Fatigue: Best Practice, Best Practices in the Management of Overweight and Obesity, Best Practice in Approaching Patients with Weight Loss, Common Complaints of the Hands and Feet, A Symptom-Directed Paradigm for the Evaluation and Management of Upper Respiratory Tract Infections, and more.

Images from the Wards: Diagnosis and Treatment is an exciting visual resource for in-training and practicing physicians. James Studdiford, Marc Altshuler, Brooke Salzman, and Amber Tully present this comprehensive, focused image-based reference and review for diagnosis and treatment with compelling images-selected from a large bank of medical pictures in a teaching database at Jefferson Medical College-that underscore important teaching points. These 517 high-yield images represent what you might see during clinical rotations and encounter on a certification exam. The book provides self-assessment and Board-style multiple choice questions and clinical correlations to prepare you for USMLE Steps 2 and 3. This is the most effective clinical resource and review tool for licensure or re-certification. Presents the most common and important clinical images of cases that you will encounter in a hospital or on a licensure or certification exam through 517 illustrations. Features self-assessment and Board-style multiple choice questions based on clinical vignettes to support the learning and review process. Provides concise but detailed clinical correlations to serve as an effective daily clinical resource and review for USMLE Steps 2 and 3, certification exams, or recertification. Covers the staging and variations of each disease through images that clarify the entire process. Captures each disease process in a consistent format for quick and effective reference and review.

This issue of Medical Clinics, guest edited by Dr. Andrew Dunn, is an Update in Hospital Medicine. Articles in this issue include: Sepsis, severe sepsis, and septic shock, Pneumonia, Acute congestive heart failure, Acute exacerbation of COPD, Acute manifestations of alcohol use disorder, Opioid use disorder, Acute Venous Thromboembolism, Acute liver Injury / Decompensated cirrhosis, Hospital-acquired infections, Peri-operative management of anticoagulation, Teamwork essentials for the hospitalist, Teaching at the bedside, and more.

"Superb This thoroughly delightful book explores, explains, and puts in context our biggest fear- our own mortality The very word "Cancer" evokes a primal fear that we are all mortal and will, at some point, die. My own experience, on a personal level with cancer, access ports, chemotherapy, radiation therapy, and major surgery was very sobering Dr Kevin Ryan has given us all a new perspective on how to live with and conquer our biggest fear This book is a must read for anyone living with cancer, their families, and the entire treatment community. When Tumor is the Rumor, and Cancer is the Answer will help each of us to triumph over this experience, regardless of the outcome "
-LT. Gen PK Carlton Jr. Surgeon General USAF (ret)

"A great cancer book should reduce anxiety with authority and comprehensive information helping those confronted marshal their internal resources and conquer their fears. Does such a book exist? You are about to read it"
-Maurie Markman MD FACP Senior Vice President of Clinical Affairs & National Director of Medical Oncology Cancer Treatment Centers Of America. Senior Vice President of Clinical Affairs and National Director of Medical Oncology, Cancer Treatment Centers Of America. Former Professor and Vice President of Clinical Research and Chairman of the Department of Gynecologic Medical Oncology, MD Anderson Cancer Center. Former Chairman of the Department of Hematology/Oncology and Director of the Taussig Cancer Center at the Cleveland Clinic Foundation. Former Vice-Chair, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York

Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component.
This volume of "Advances in Genetics" presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research.

As the healthcare industry continues to expand, it must utilize technology to ensure efficiencies are maintained. Healthcare needs to move in a direction where computational methods and algorithms can relieve the routine work of medical doctors, leaving them more time to carry out more important and skilled tasks such as surgery. Computational Methods and Algorithms for Medicine and Optimized Clinical Practice discusses some of the most interesting aspects of theoretical and applied research covering complementary facets of computational methods and algorithms to achieve greater efficiency and support medical personnel. Featuring research on topics such as healthcare reform, artificial intelligence, and disease detection, this book will particularly appeal to medical professionals and practitioners, hospitals, administrators, students, researchers, and academicians.

**Finalist, PROSE Award in Clinical Medicine** A rich examination of the history of trans medicine and current day practice Surfacing in the mid-twentieth century, yet shrouded in social stigma, transgender medicine is now a rapidly growing medical field. In Trans Medicine, stef shuster makes an important intervention in how we understand the development of this field and how it is being used to "treat" gender identity today. Drawing on interviews with medical providers as well as ethnographic and archival research, shuster examines how health professionals approach patients who seek gender-affirming care. From genital reconstructions to hormone injections, the practice of trans medicine charts new medical ground, compelling medical professionals to plan treatments without widescale clinical trials to back them up. Relying on cultural norms and gut instincts to inform their treatment plans, shuster shows how medical providers' lack of clinical experience and scientific research undermines their ability to interact with patients, craft treatment plans, and make medical decisions. This situation defies how providers are trained to work with patients and creates uncertainty. As providers navigate the developing knowledge surrounding the medical care of trans folk, Trans Medicine offers a rare opportunity to understand how providers make decisions while facing challenges to their expertise and, in the process, have acquired authority not only over clinical outcomes, but over gender itself.