Examining all the major research data since the 1940s, this book challenges two orthodox medical models: HIV as the cause of AIDS, and random genetic mutations as the cause of cancer. Based on the recent findings from Evolutionary Biology and Nitric Oxide research, it presents a fundamentally new understanding of the human cell, its double genome split between the cell nucleus and the mitochondria, and the role of energy production and signal modulation for immune reactions and carcinogenesis. Finally, it explains the concept of a new Cell Symbiosis Therapy[registered] for the treatment of all chronic diseases, including cancer. Now available in English for the first time, this book is a must-read for doctors, patients and anyone following the cutting edge of biology and immunology. With the blasting open of such doors of knowledge, the medical world will never again be the same.

Practical, clinically focused, and highly illustrated, this new guide includes content not covered in any other book, presented in a user-friendly format. Part I introduces the concepts of subjective evaluation, observation/posture, related referral joint testing, neurovascular testing, palpation, and range of motion testing. Part II comprises the bulk of the text, covering the major shoulder tests that clinicians perform. Part III features supplemental tests used in the clinical setting. Finally, Part IV pulls all the information together by testing students and clinicians alike with a series of case studies. The reader will also find extensive, up-to-date references for further research or study. The first text devoted solely to the musculoskeletal examination of the shoulder joint. Emphasizes research and objectivity, providing easy access to current research quantification of test procedure efficacy indication and clinical application. Contains an exhaustive review of examination and clinical tests, leading to a more accurate diagnosis and better course of care. Presents a combination of clinical tests, functional evaluation parameters, throwing and interval sport return/evaluation procedures, as well as seldom-presented closed chain tests, offering the practitioner a plethora of alternative tests. Highlights new tests for the shoulder, particularly in the area of labral and instability testing. Places a high degree of emphasis on documentation of test results, increasing the reader's objectivity of the shoulder exam process. Includes various combinations of patient presentation, emphasizing classic diagnoses and the combinations of test results from the evaluation procedures covered in the text. Case studies permit readers to test themselves and apply their knowledge to varied situations.

This issue of Foot and Ankle Clinics, guest edited by Dr. Andrea Veljkovic, will discuss Managing Instabilities of the Foot and Ankle. Under the direction of the series Consulting Editor, Dr. Mark Myerson, the issue will cover a number of key topics including: Imaging of the foot and ankle for instability, Chronic Lateral Ankle Instability, Acute Lateral Ankle Instability, Percutaneous Minimally Invasive Treatment for Ankle Instability, Arthroscopic Treatment of Ankle Instability, Arthroscopic Treatment of Ankle Instability, Revision of Failed Surgical Lateral Ankle Instability Stabilization, Medial Ankle Instability, Spring Ligament Instability, Plantar Plate Injury and Angular toe deformity, Low-Energy Lisfranc injuries in an athletic population, and Turf Toe Injury, among others.

Using the popular question and answer format of The Secrets Series, this helpful mini reference offers practical tips, answers, and secrets from experts specializing in various areas of oral medicine. The evaluation, management, diagnosis, and treatment of various oral diseases arecovered. Topics include cardiovascular disease, bacterial endocarditis, endocrine disease, pregnancy, pulmonary disease, gastrointestinal disease, neurologic disease, diseases of the salivary glands and much more. Chapters on oral cancer detection and management as well as the pharmacology of drugs used in dentistry are also included.The content of all chapters has been updated and revised Follows question and answer format of The Secrets SeriesIncludes 200 illustrations depicting the various entities discussed Serves as a useful resource for dental students and practicing dentistsContributing authors are a diverse mix of specialists in the field of oral medicine

Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science-medicine, the latest technology, and clinical economics-the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine.

Implementing Precision Medicine in Best Practices of Chronic Airway Diseases provides a comprehensive overview of the application of precision medicine in airway diseases with a goal of promoting optimal control of disease, higher patient satisfaction and disease prevention. As medical research continues to fund this area, the book highlights the need for implementation of the principles of precision medicine into the bedside management of chronic airway diseases. It is clear that chronic airway diseases are heterogeneous and that a personalized approach is warranted whereby treatment is tailored to the level of the individual patient. Written for basic researchers, medical doctors and other healthcare practitioners this book provides guidance on the implementation of the principles of precision medicine into further research and daily clinical practice.

Pocket Medicine, 8th Edition, is a must-have resource for fast answers to the diagnostic and therapeutic questions you'll face on rounds and exams. Edited by Dr. Marc S. Sabatine and compiled by residents, fellows, and attending physicians at the world-renown Massachusetts General Hospital, this best-selling reference provides dependable, up-to-date information needed to make an accurate diagnosis and develop a state-of-the-art treatment plan. Featuring easily accessible bulleted lists, tables, and algorithms, Pocket Medicine provides focused coverage of internal medicine in the traditional, easy-to-use binding you know and love. Offers fast and easy access to essential information on the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology. Includes references to landmark papers to help you intelligently answer questions on rounds-all from a trusted source acceptable for use on rounds. Features user-friendly tabs and a two-color design to help you find information quickly, as well as a full-color, 16-page insert featuring radiology and pathology images. Provides ideal coverage for medical students, interns, residents, advanced practice nurses, and PAs. Prepare for board exams! Mirroring the organization of Pocket Medicine, Pocket Medicine High-Yield Board Review features 500 practice questions so you can practice for your board exam.

Marine enzymes and specialized metabolism - Part B, Volume 605 in the Methods in Enzymology series, highlights experimental methods on diverse marine enzymes involved in the construction of bioactive natural product molecules. Unique sections in this new release include discussions on polysaccharide-degrading enzymes from marine gastropods, radical SAM epimerases from sponge microbes, DMS/P demethylase in bacteria, reconstitution of particulate methane monooxygenase into membrane mimetics, the structure and function of cyanobactin enzymes, marine cyanobacterial polyketide beta-branching enzymology, marine cyanobacterial PKS-NRPS enzymology and structural biology, biochemical profiling of DMSP lyases, and more.

Learn not only how to recognize high-quality research, but how to improve your own research and apply it to patient care. Plus, find out how to start a journal club, write quality case reports and how to most effectively present your research to others. This book is ideal guide for students at both graduate and undergraduate levels who might be having difficulty with research concepts as well as for practiced clinicians interested in a fresh approach to clinical research. * A jargon-free guide to understanding and conducting research * Uses metaphors, visual images, and examples to simplify complex research concepts * Includes easy-to-do computer exercises to help you understand statistical concepts

Psychosomatic Health is an exploration of the relationship between physical and psychological wellbeing. It draws on postmodern and narrative theory to consider the psychosomatic processes which underpin and enhance health. The text adopts a psychoanalytic stance rooted in the work of D.W. Winnicott, and reviews the work of other major psychoanalytic figures on the question of body and mind, enabling students and practitioners to engage with a variety of perspectives. Clearly written and well illustrated with examples throughout, the author makes extensive use of infant observation extracts and real-life case studies to explore the experiences of movement and touch and their meanings for the individual. As a basis for working effectively with psychosomatic disturbance, the author introduces her original concept of 'body storylines'. Case studies explain how this therapeutic approach can be used to encourage therapists to think about their relationship to their experiences, their use of physicality and their use of their bodies as 'barometers of psychological change'. This broad ranging text pulls together contemporary developments from across a range of disciplines, including psychoanalytic theory, clinical psychology, medicine, complementary medicine and philosophy, to demonstrate a better understanding of clinical practice.

This issue of Medical Clinics, guest edited by Dr. Brian Garibaldi, is devoted to Clinical Examination. Articles in this issue include: Introduction to the Clinical Examination; The Enduring Diagnostic Value of the Physical Exam; The Physical Exam as Ritual - Social Sciences in the Context of the Physical Exam; The Hypothesis Driven Physical Exam; The Role of Technology in the "Clinical Exam 2.0"; Clinical Reasoning at the Bedside; The Outpatient Clinical Exam; The Electronic Health Record and the Clinical Exam; Communication and Ethics in the Clinical Exam; Improving Observational Skills to Enhance the Clinical Exam; The Role of Bedside Rounds in the Clinical Examination; Communication with Patients from Culturally and Socially Diverse Populations; Telemedicine and the Clinical Exam; Clinical Skills Assessment in the 21st Century; and Emerging Tools to Enhance Clinical Reasoning Skills.

Clinical research is heavily regulated and involves coordination of numerous pharmaceutical-related disciplines. Each individual trial involves contractual, regulatory, and ethics approval at each site and in each country. Clinical trials have become so complex and government requirements so stringent that researchers often approach trials too cautiously, convinced that the process is bound to be insurmountably complicated and riddled with roadblocks. A step back is needed, an objective examination of the drug development process as a whole, and recommendations made for streamlining the process at all stages. With Intelligent Drug Development, Michael Tansey systematically addresses the key elements that affect the quality, timeliness, and cost-effectiveness of the drug-development process, and identifies steps that can be adjusted and made more efficient. Tansey uses his own experiences conducting clinical trials to create a guide that provides flexible, adaptable ways of implementing the necessary processes of development. Moreover, the processes described in the book are not dependent either on a particular company structure or on any specific technology; thus, Tansey's approach can be implemented at any company, regardless of size. The book includes specific examples that illustrate some of the ways in which the principles can be applied, as well as suggestions for providing a better context in which the changes can be implemented. The protocols for drug development and clinical research have grown increasingly complex in recent years, making Intelligent Drug Development a needed examination of the pharmaceutical process.

Global Air Pollution in Aging: Reading Smoke Signals is a complete reference connecting environmental pollution research to the human aging process. Since 1800, lifespans have more than doubled as infections declined and medicine improved. But the 20th century introduced a new global scourge of air pollution from fossil fuels with the potential to damage arteries, hearts and lungs that has been related to chronic exposure of air pollution from fossil fuels. Risk areas of study include childhood obesity, brain damage associated with air pollution, increased risk for autism in children and dementia in older adults. In humans and animals, air pollution stimulates chronic inflammation in different organs, and genetic vulnerability to air pollution is being recognized, particularly for carriers of the Alzheimer risk gene ApoE4.

Advanced Perioperative Crisis Management is a high-yield, clinically-relevant resource for understanding the epidemiology, pathophysiology, assessment, and management of a wide variety of perioperative emergencies. Three introductory chapters review a critical thinking approach to the unstable or pulseless patient, crisis resource management principles to improve team performance and the importance of cognitive aids in adhering to guidelines during perioperative crises. The remaining sections cover six major areas of patient instability: cardiac, pulmonary, neurologic, metabolic/endocrine, and toxin-related disorders, and shock states, as well as specific emergencies for obstetrical and pediatric patients. Each chapter opens with a clinical case, followed by a discussion of the relevant evidence. Case-based learning discussion questions, which can be used for self-assessment or in the classroom, round out each chapter. Advanced Perioperative Crisis Management is an ideal resource for trainees, clinicians, and nurses who work in the perioperative arena, from the operating room to the postoperative surgical ward.

This issue of Medical Clinics, guest edited by Dr. Kimberly Peairs, is devoted to Care of Cancer Survivors. Articles in this issue include: Care Coordination and Transitions of Care; Cancer Survivorship in Adolescents and Young Adults; Long-term and Late Side Effects of Specific Cancer Types; Diet, Physical Activity, and Body Weight in Cancer Survivorship; Anxiety and Depression in Cancer Survivors; Cognitive Changes Related to Cancer Therapy; Cardiac Disease in the Cancer Survivor; Cancer-related Fatigue; Hormonal Changes and Sexual Dysfunction; Palliative Care Issues; Screening for Recurrence and Secondary Cancers; and Pulmonary Disease in the Cancer Survivor.

This issue of Medical Clinics, guest edited by Dr. Robert Saper, is devoted to Complementary and Integrative Medicine. Articles in this outstanding issue address integrative medicine in the areas of mental health disorders; sleep disorders; neurological conditions; cardiovascular disease; respiratory disorders; gastrointestinal disorders; gynecological conditions; oncology; rheumatologic conditions; pain management; geriatric and palliative care; and physician health and wellbeing.

Advances in Clinical Chemistry, Volume 82, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. This updated volume includes chapters on Calcium and Bone Metabolism Indices, Cytokines and MicroRNA in Coronary Artery Disease, Biological and molecular characterization of circulating tumor cells: A creative strategy for precision medicine?, Towards a blood-borne biomarker of chronic hypoxemia: Red cell distribution width and respiratory disease, miRNAs: nanomachines that microManage the pathophysiology of Diabetes mellitus, and Fortilin, A Potential Target for the Prevention and Treatment of Human Diseases. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

A Structure-Function Toolbox for Membrane Transporter and Channels, Volume 594, a new release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters in the updated serial include Cryo-EM on membrane proteins embedded in nanodics, Solid-Supported membrane-based electrophysiology on membrane transporters and channels, Saposin-lipoprotein scaffolds for structure determination of membrane transporters and channels, Single-molecule FRET on transporters, Dynamics of channels and transporters investigated by NMR, Structure-function studies on channels and transporters, and a section on MemStar, a new GFP-based expression and purification system for transporters and channels.

Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation. As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.