Fe-S Cluster Enzymes, Part A, Volume 595 is the first of two volumes focused on Fe-S cluster enzymes. New topics of note in this series include Electrochemistry of Fe/S Proteins, Genetic, biochemical and biophysical methods for studying Fe-S proteins and their assembly, Fluorescent reporters to track Fe-S cluster assembly and transfer reactions, Mechanism-based strategies for structural characterization of radical SAM reaction intermediates, Purification and Characterization of Recalcitrant Cobalamin-Dependent Radical S-adenosylmethionine Methylases, A polymerase with potential: the Fe-S cluster in Human DNA Primase, In Vitro Studies of Cellular Iron-sulfur Cluster Biosynthesis, Trafficking and Transport, and Fe-S cluster Hsp70 Chaperones: the ATPase cycle and protein interactions.

This volume provides a selection of chapters on new developments in various areas of clinical medicine, including dental, surgery, and general practice. These scientific chapters analyze the diagnostic processes and inform of new and novel diagnostic techniques. This book is divided into two sections; the first section contains review papers and includes an overview of experimental and clinical medicine, explaining its history to modern times. The second section presents a selection of original research papers from respected authors on a variety of topics.

The porphyrins, chlorophylls, bilins and related tetrapyrroles are vital for all living organisms. Natural and synthetic tetrapyrroles are used extensively in foods, cosmetics, biotechnology, pharmaceuticals, diagnostics and medicine. Methods for their separation and characterization therefore, have a very wide area of applications. Yet, there is a dearth of books dedicated to HPLC and HPLC/MS of tetrapyrroles. Lim addresses this problem admirably by providing practical HPLC and HPLC/MS protocols coupled with in-depth chromatographic and mass spectrometric reference data. These are invaluable in the analysis, identification and characterization of porphyrins, chlorophylls, bilins and other related compounds found in biological and clinical materials. HPLC method development and optimization for coupling to mass spectrometry are also described in rich detail. Sample preparation, and suggestions for avoiding procedural artifacts during extraction of clinical and biological samples are discussed. Clinical biochemists involved in biochemical diagnosis of human porphyrias will find this monograph assuredly helpful, as would analysts, biochemists and chemists involved in the separation, isolation and characterization of natural and synthetic tetrapyrroles. Undoubtedly, Lim has contributed a master-piece containing sufficient background material for beginners and up-to-date references for all researchers in the field.

Key Advances in Clinical Informatics: Transforming Health Care through Health Information Technology provides a state-of-the-art overview of the most current subjects in clinical informatics. Leading international authorities write short, accessible, well-referenced chapters which bring readers up-to-date with key developments and likely future advances in the relevant subject areas. This book encompasses topics such as inpatient and outpatient clinical information systems, clinical decision support systems, health information technology, genomics, mobile health, telehealth and cloud-based computing. Additionally, it discusses privacy, confidentiality and security required for health data. Edited by internationally recognized authorities in the field of clinical informatics, the book is a valuable resource for medical/nursing students, clinical informaticists, clinicians in training, practicing clinicians and allied health professionals with an interest in health informatics.

The median age of survival for those with cystic fibrosis has risen considerably in recent years. This text thoroughly examines the developments and breakthroughs which have led to this improvement in life expectancy. With a focus on the latest discoveries in the diagnosis and treatment of the disease, this book provides a comprehensive overview of the past, current and forthcoming advancements in cystic fibrosis research and clinical care.

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS). Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS. Highlights include: the definition, epidemiology, pathology, and pathogenesis of ARDS complications such as transfusion-related injury, and endothelium and vascular dysfunction the long-term outcomes of ARDS host defense and infection the latest developments in ARDS therapy: glucocorticoid therapy, surfactant therapy, mechanical ventilation, and mesenchymal stem cells predictive factors: gene expression profiling and biomarkers, and chemokines and cytokines advances in management strategies: fluid management, non-pulmonary and non-sepsis management, and glucose control

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease.

Since publication of the initial version of "Plagues & Poxes" in 1987, which had the optimistic subtitle "The Rise and Fall of Epidemic Disease," the rise of new diseases such as AIDS and the deliberate modification and weaponization of diseases such as anthrax have changed the way we perceive infectious disease.

With major modifications to deal with this new reality, the acclaimed author of "Civil War Medicine: Challenges and Triumphs" has updated and revised this series of essays about changing disease patterns in history and some of the key events and people involved in them. It deals with the history of major outbreaks of disease - both infectious diseases such as plague and smallpox and noninfectious diseases - and shows how they are in many cases caused inadvertently by human actions, including warfare, commercial travel, social adaptations, and dietary modifications. To these must now be added discussion of the intentional spreading of disease by acts of bioterrorism, and the history and knowledge of those diseases that are thought to be potential candidates for intentional spread by bioterrorists.

Among the many topics discussed are:

How the spread of smallpox and measles among previously unexposed populations in the Americas, the introduction of malaria and yellow fever from Africa via the importation of slaves into the Western hemisphere, and the importation of syphilis to Europe all are related to the modern interchange of diseases such as AIDS.

How the ever-larger populations in the cities of Europe and North America gave rise to "crowd diseases" such as polio by permitting the existence of sufficient numbers of non-immune people in sufficient numbers to keep the diseases from dying out.

How the domestication of animals allowed diseases of animals to affect humans, or perhaps become genetically modified to become epidemic human diseases.

Why the concept of deficiency diseases was not understood before the early twentieth century; disease, after all, was the presence of something abnormal, how could it be due to the absence of something? In fact, the first epidemic disease in human history probably was iron deficiency anemia.

How changes in the availability and nature of specific foods have affected the size of population groups and their health throughout history. The introduction of potatoes to Ireland and corn to Europe, and the relationship between the modern technique of rice milling and beriberi, all illustrate the fragile nutritional state that results when any single vegetable crop is the main source of food.

Why biological warfare is not a new phenomenon. There have been attempts to intentionally cause epidemic disease almost since the dawn of recorded history, including the contamination of wells and other water sources of armies and civilian populations; of course, the spread of smallpox to Native Americans during the French and Indian War is known to every schoolchild. With our increased technology, it is not surprising that we now have to deal with problems such as weaponized spores of anthrax.

Bonnie Prudden's revolutionary breakthrough in pain relief involves trigger points -- tender areas where muscles have been damaged from falls, childhood ailments, poor posture, and the stresses of daily life. Requiring no special training or equipment, myotherapy is a natural, simple technique that can be performed in the home. Illustrated with charts, photographs, and diagrams, Bonnie Prudden's step-by-step method has been hailed by doctors and patients for its extraordinary 95 percent success rate.

This practical manual reviews salient topics in Adolescent Medicine. The volume is practitioner-centered, focusing on the symptoms that bring a teenager to the clinician. Every chapter begins with a very brief clinical vignette, highlighting the patient's chief complaint or primary issue of concern.The handbook is divided into five primary sections: (1) Well Adolescent Care to include chapters such as the Annual Physical and Immunizations in Adolescence; (2) Common Problems of Adolescence such as Acne and Low Back Pain; (3) Reproductive Health Care issues such as Menstrual Disorders and Teen Pregnancy/Options Counseling; (4) Urgent Care matters including Acute Chest Pain and Scrotal Pathology: Pain and Masses; and finally, (5) Special Considerations to include chapters such as Cyberbullying and Sexting and Tobacco Use and Cessation Counseling.Chapters follow a uniform format with vignette as described above, followed by multiple choice questions designed to test the readers knowledge. Salient features related to the chapter topic follow, including relevant clinical "pearls" such as history, physical exam, laboratory and diagnostic studies and treatment strategies. For each chapter, issues that are unique to managing illness in adolescents are highlighted to distinguish them from adults and younger children. When applicable, a broad differential diagnosis is provided to help guide the reader. Easy to read tables are included to highlight and clearly summarize key aspects of the topic and the chapters end with answers to the Board-Style questions presented at the start.

"MRCP Part 2 Self-Assessment" is the perfect revision aid. Drawn from the highly successful Medical Masterclass material from the Royal College of Physicians of London, this concise volume is specifically designed to cover the topics and format found in the Membership to the Royal College of Physicians (MRCP) Part 1 examination. The large scale, lavishly illustrated, full-colour format makes it easy to comprehend complex topics.With contributions from an extensive list of prestigious and authoritative professionals, the questions cover all areas of assessment, including the scientific background the medicine, general clinical skills, acute medicine and a range of specialties. It is ideal for examination MRCP candidates, doctors preparing for the European Diploma in internal medicine and junior doctors wanting to revise their knowledge and skills.'This collection of self-assessment questions and explanatory answers has been drawn from Medical Masterclass, which is produced and published by the Royal College of Physicians of London. The questions have been specifically written to help doctors in their first few years of training to test and revise their medical knowledge and skills; and in particular to pass postgraduate examinations, such as the MRCP(UK)' - John D Firth, in the Introduction.

This second edition of the highly successful Easy Guide to OSCEs for Clinical Specialties provides a comprehensive yet succinct resource to get you through each clinical rotation, as well as the Final exam. Compiled by recently qualified doctors who have experienced the new OSCE system first hand, the book covers over 80 OSCE examination stations in a wide range of different subjects. Brand new to this edition are chapters on Psychiatry, non-accidental injury in children, and an 'On the Wards' section covering both Anaesthetics and Palliative Care. All management suggestions are updated in line with NICE guidance and evidence-base, and new time-saving, student friendly mnemonics have been added to make the book even more user-friendly. This book will ease the already burdensome workload of medical students, and help them pass their OSCEs to become junior doctors competent in a wide range of different skills in medical fields.

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book's educational utility.

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Chapters include Rheumatology; Infectious Disease; Hematology and Oncology; Kidney, Water, and Electrolytes; Pulmonary Disease; Heart and Cardiovascular Disease; The Digestive System; and Endocrinology, Diabetes, and Metabolism.

This issue of Medical Clinics, guest edited by Drs. Scott Kahan and Robert Kushner, is devoted to Practice-Based Nutrition Care. Articles in this outstanding issue include: Principles and Practice of Nutrition Assessment in Primary Care; Principles and Practice of Nutrition Counseling and Behavioral Medicine in Primary Care; Nutrition for the Prevention of Chronic Disease; Nutrition Recommendations in Pregnancy and Lactation; Nutrition Recommendations in Children; Nutrition Recommendations in Elderly and Aging; Nutrition Interventions for Cardiovascular Disease; Nutrition Interventions for Renal Disease; Nutrition Interventions for Diabetes Mellitus and Metabolic Syndrome; Nutrition Interventions for Chronic Liver Disease and NAFLD; Nutrition Interventions for Obesity; and Nutrition Interventions for Cancers.

Accessible, visually stimulating guide to clinical neuroanatomy, striking the perfect balance between regional and functional content Essential Clinical Neuroanatomy, 2nd Edition discusses the anatomy of the nervous system from the clinical perspective in easy-to-understand language, providing descriptions of the sensory, motor, and integration systems within the nervous system. Illustrations are included throughout in the clinical view using the axial radiologic standard of computed tomography and magnetic resonance imaging. To enable seamless reader comprehension, the text includes case studies, study questions, boxes of interest to highlight the clinically relevant neuroanatomy, learning objectives, an outline of each chapter’s material to be covered, multiple choice questions, and further reading resources. Essential Clinical Neuroanatomy, 2nd Edition contains information on: Topics important to clinical medicine, but often neglected in other neuroanatomy texts, such as trauma, infection, and congenital considerations Includes recent reviews and references with a focus on the cortical chapter and the imaging chapter where there is significant ongoing research Two new chapters on the peripheral and autonomic nervous systems Use of imaging studies used in clinical neuroanatomy, including how to evaluate these images Neuroanatomy of the central nervous system, covering an overview of the nervous system, blood vessels, meninges, and ventricles, neurodevelopment, the spinal cord, brain stem, cerebellum and cortex Sensory, motor, and integration systems, covering the visual system, auditory and vestibular system, olfaction and taste, central motor control, the limbic system and cortical integration Essential Clinical Neuroanatomy, 2nd Edition is the perfect resource for medical and health science students taking a course on neuroanatomy and as an on-going companion during those first steps in clinical practice. The text is also useful for those reviewing neuroanatomy for major licensing or competency examinations (National Board of Medical Examiners (NBME) United States Medical Licensure Exams (USMLE).

Enduring Change in Eating Disorders provides a unique perspective on the successful treatment of eating disorders, which are among the most debilitating and recalcitrant psychiatric diseases. Unique in the field, this book details effective Structural Family Therapy with qualitative follow-ups of up to 20 years. A practical approach providing concrete tools to the clinician to creating change that holds over time with bulimia, anorexia, and compulsive overeating. The text draws on cases from the author's practice of over twenty-five years and follows his approach in the theoretical tradition of Intensive Structural Family Therapy (IST). Chapters discuss the nature and significance of eating disorders, a review of current treatment approaches, and the importance of the family in the therapeutic process. Cases of eating disorders in youths and adults are provided as well as instances of bulimia, anorexia, and compulsive overeating. Three appendices provide the reader with information regarding the scientific basis of the IST model, the effectiveness of the approach in treating conditions other than eating disorders and preventing eating disorders.

Clinical Skills for Healthcare Assistants and Assistant Practitioners is an accessible, easy-to-read guide, outlining the fundamental and core skills integral to clinical practice. Fully updated in its second edition, this book is divided into three sections; the first looks at fundamental skills applicable to all staff, such as accountability, communication and record keeping. Section two explores core clinical skills such as respiratory care, pulse, blood glucose management and catheter care. Section three outlines complex clinical skills that require more in-depth training, such as medication and intravenous cannulation. An invaluable resource for healthcare assistants and assistant practitioners, this book will also be of use to newly qualified practitioners, and students in health and social care.

Containing papers carefully compiled for both their historical importance and contemporary relevance, Family Medicine: The Classic Papers brings together a team of experts, led by global family medicine leaders Michael Kidd, Iona Heath and Amanda Howe, who explain the importance of each selected paper and how it contributes to international health care, current practice and research. The papers demonstrate the broad scope of primary health care delivered by family doctors around the world, showcasing some of the most important research ever carried out in family medicine and primary care. This unique volume will serve as an inspiration to current family doctors and family medicine researchers and educators, as well as to doctors in training, medical students and emerging researchers in family medicine.

Inhaled therapies form the cornerstone for treatment of patients with asthma and COPD. Evolving technology has resulted in availability of a wide range of devices for delivery of inhaled drugs. The four different delivery systems -- pressurized metered-dose inhalers, slow mist inhalers, dry powder inhalers, and nebulizers -- are unique in design and require distinct inhalational instructions for correct use. This book provides current information about inhalation devices, including their advantages and disadvantages, with guidance for optimal techniques of use. The book emphasizes appropriate selection of inhalation devices based on patient and health care professional factors as well as device attributes that allow selection of the right medication in the right inhalation device at the right time for the right patient. Key Features: • Addresses the objective of precision medicine – the right medication in the right inhaler device at the right time. • Inputs by international thought leaders who have published widely on inhaled medications and/or inhaled delivery systems for clinicians, trainees and respiratory therapists. • Discusses the development of audio-based systems and smart inhalers for patient monitoring.

Clinically-orientated and focused squarely on the core curriculum, Medicine for Finals and Beyond delivers what medical students need to know in a manner that encourages learning and recall. The consistent, easy-to-navigate structure makes locating information simple and is tailored for exam success. Highly illustrated throughout, notes based information is supplemented by 'At A Glance textboxes', 'Emergency Presentations' and 'Must Know Checklists' for quick reference, while online question and answer material allows for self-testing during that inevitable last-minute revision. Key features: * Comprehensive - everything you need to know to pass your medical finals in a single volume * Accessible - systems-based chapters all follow a common structure * Convenient - summarises the ideal approach to the patient, including history and examination, clinical presentations, differential diagnosis and investigations * Focused - covers all the common conditions that medical students need to know for future practice * Relevant - designed with input from lecturers and students This brand-new revision aid for medical students will be a convenient companion throughout clinical studies and an ideal aide-memoire for those approaching their final examinations.

Herbert Rosenfeld makes a powerful case both for the intelligibility of psychotic symptoms and the potential benefits of their treatment by psychoanalytic means.

In addition to performing its prime function as a vehicle for scientific communications of varied colora- tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth. One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes. This is a very broad subject that calls for broader coverage than could be included in one book issue. However, I have elected to include only certain contributions that serve as general examples of the principles involved. There are six articles on enzyme regulation in hepatocyte culture. These include arginase and argino-succi- nate synthetase, y-glutamyl transferase and plasminogen activitor. Other regulatory enzymes that are discussed are protein kinases, 2,3-bisphosphoglycerate synthetases, carbamoyl phosphate synthetase, heme oxygenase, cytochrome P-450, tyrosine hydroxylase, fatty acid synthetase, acetyl eoA carboxylase, among others. Also included is the regulation of several enzyme messengers RNAs. As in the past, subscribers to the journal will receive this double volume as a continuation of regular issues of the journal Molecular and Cellular Biochemistry. This double volume will also be available separately in the form of a book issue to interested readers through Martinus Nijhoff Publishers. v.A. Najjar Part I Molecular and Cellular Biochemistry 53;54,11-21 (1983). (c) 1983, Martinus 1\ ij hoff Publishers. Boston. Printed in The Netherlands.

A complete, state-of-the-art bible of interprofessional primary care in one easy-to-use resource

This second edition of "Primary Care"continues to deliver succinct, current, and integrated information on the assessment, differential diagnosis, treatment, and management of individuals with commonly seen conditions in primary care settings. Written and edited by APNs in a wide range of specialties and other health professionals, it has been updated to place greater emphasis on guidance for differential diagnosis and on interprofessional primary care, lifestyle management, health promotion, risk reduction, and prevention. Also featured is extensive coverage of elderly/geriatric primary care, age, gender, and occupational considerations, palliative care, and evidence-based practice guidelines.

This comprehensive text distills and integrates required information from all arenas of primary care, so readers will find all the information they need in one easy-to-use resource. It presents current diagnostic criteria for each condition and includes relevant anatomy, pathology, and physiology. Epidemiology of the condition, including cultural and economic factors, is included as is prevention, risk identification, and screening. Also covered are related laboratory studies, the physical exam, wellness coaching, treatment options, potential pitfalls, and much more. Additionally, the book includes clinical "pearls," references, and chapter review by experts in each field. It will be of value to all interprofessional primary care providers, with a special focus on the needs of advanced practice MSN and DNP students, and as a course textbook for teaching primary health care topics. New to the Second Edition:

Increased focus on interprofessional primary care, including community care, team work, and wellness coaching Strong guidance on differential diagnosis Broader team of interprofessional authors and editors Emphasis on lifestyle management, health promotion, risk reduction, and disease prevention Special focus on elder/geriatric primary care and palliative care Evidence-based practice guidelines Focus on age, gender, and occupational considerations

Advances in Clinical Chemistry, Volume 71, is the latest installment in this internationally acclaimed series. This latest volume contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.