The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner- gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis- eases and encompasses the actions of autoantibodies, autoantigeu-autoanti- body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim- mune disorders. The first six articles are generally concerned with the mech- anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis- eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys- tem, leading to a redirection of the immune response, would be therapeuti- cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim- munity, and the role of regulatory T cells. Further, an interesting phenome- non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.

Human-computer confluence refers to an invisible, implicit, embodied or even implanted interaction between humans and system components. New classes of user interfaces are emerging that make use of several sensors and are able to adapt their physical properties to the current situational context of users. A key aspect of human-computer confluence is its potential for transforming human experience in the sense of bending, breaking and blending the barriers between the real, the virtual and the augmented, to allow users to experience their body and their world in new ways. Research on Presence, Embodiment and Brain-Computer Interface is already exploring these boundaries and asking questions such as: Can we seamlessly move between the virtual and the real? Can we assimilate fundamentally new senses through confluence? The aim of this book is to explore the boundaries and intersections of the multidisciplinary field of HCC and discuss its potential applications in different domains, including healthcare, education, training and even arts.

In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes - next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients - chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.

As we move into the 21st century it is becoming increasingly difficult to offer appropriate introductory clinical experiences for medical students. Many schools offer clinical experiences in the first year of medical school, when the learner has little background in the traditions and origins of the doctor-patient interaction. Others begin this process in the second year, after a professional language base has been established, but concise educational materials are scarce that integrate the meaning of the privileged clinical encounter with the process and content of interviewing and examining patients. In the tertiary hospitals, where most medical schools are based, the educators must provide an orienta tion to the clinical encounter, an intensely personal experience, in the midst of glittering technological marvels that easily distract both the novice physician and the wizened teacher. Understanding the context and historical basis for the privilege of interviewing and examining another person about intimate matters relating to health and disease is essential to this process. Considering these factors, this textbook is written to assist medical educators and medical students involved in early clinical training. As the demand for "high-tech" medicine has accelerated, so has the public concern over the loss of "high-touch" or compassionate, humane interactions with physicians. Physicians are perceived as more concerned with readouts from machines and fiberoptic views of the patient than with understanding and car ing about the people we have labeled as patients."

This handy pocket book will help veterinary nurses with all types of calculations. Numerous worked examples are included to delelop the reader's confidence in carrying out the procedures involved. Each type of calculation has its own separate section in the book and the authors have used the simplest possible method in explaining each one. The book is structured such a way that the reader can progress from a simple explanation of the arithmetic principles involved, to the application of these principles to essential veterinary calculations.

Qualified veterinary nurses and students alike will fine this book an invaluable reference source, whether performing relevant veterinary calculations or studying for professional examinations.

Key Features
Convenient size
Ideal as a self-teaching manual
Accessible and user-friendly style
Includes worked examples, self-test exercises and answers where appropriate

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. REAL-LIFE CASES SHARPEN YOUR CRITICAL THINKING SKILLS FOR YOUR CLERKSHIP AND THE SHELF EXAM Case Files: Psychiatry presents realistic clinical scenarios to enhance and hone your clinical decision-making skills. Sixty high-yield cases illustrate essential concepts in psychiatric care. Each case begins with a vignette accompanied by relevant open-ended questions designed to teach diagnostic or therapeutic approaches relevant to psychiatry. The answers that follow emphasize mechanisms and underlying principles. This sixth edition features a new format with bulleted summaries, shorter paragraphs, and clearer headings. Realistic cases are accompanied by questions that encourage you to think through DSM-5 diagnostic criteria and therapeutic options Real-life psychiatry cases with high-yield discussions aligned to clerkship guidelines USMLE-style review questions and clinical pearls accompany each case Primer on how to approach clinical problems and think like an experienced doctor

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

In this issue of Anesthesiology Clinics, guest editors Drs. Alison J. Brainard and Lyndsay M. Hoy oversee the topic of Total Well-being. Articles in this issue highlight perspectives from across multiple subsets of anesthesiology, including nutrition, arts and humanities, coaching, and the inequalities of medicine. The editors' goal is that readers will come away inspired, informed, and excited to create an approach for total well-being that can be tailored to their workplace and lives. Contains 19 practice-oriented topics including women in anesthesiology; parenting/lactation in anesthesia; intensivists and wellness, post-pandemic; early-career physician burnout; integrating antiracism into MedEd with health humanities program; and more. Provides in-depth clinical reviews on total well-being, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This volume is a collection of essays by Richard Wolin, a leading political theorist and intellectual historian. It is the follow up to Wolin's two recent, widely acclaimed books: Heidegger's Children and The Seduction of Unreason. In those books, he explored the legacy of Martin Heidegger and his impact on some of his most influential and notable students. He dealt particularly with the effect that Heidegger's subsequent embrace of fascism and National Socialism had on these students. Delving further in his next book, Wolin explored the question of why philosophers and intellectuals have been drawn to antiliberal, antidemocratic fascism. The essays in this book are focused on European Political Thought particularly with figures associated with the Frankfurt School. The collection represents a virtual who's who of European political thinkers with essays on Walter Benjamin, Adorno, Marcuse, Arendt, Heidegger, Weber, Jaspers, and Carl Schmitt. Moving beyond these thinkers and those books, this collection will also include essays on contemporary political issues such as post-communist revolutions, human rights, global democracy, the revival of republicanism, and religion and public life.

Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.

Trainees in preparation for the MRCP examination will welcome the much-anticipated new edition of this 'gold standard' revision book. Revised and updated throughout to encompass new developments in medical diagnostics and therapeutics, and restructured to reflect the recent changes in the format of the Part 2 written examination, the book continues to offer a more detailed and examination-orientated approach than other revision guides on the market. The appeal of the book lies not only in the careful adherence to the examination format, but also in the invaluable hints it provides on exam technique, with suggestions of information that will be helpful when tackling the exam presented in a 'revision-friendly' boxed format.

Throughout the UK, and elsewhere, medical schools are focusing more on objective structured clinical examinations (OSCEs) and veering away from old style medical and surgical finals. OSCEs for Medical and Surgical Finals takes a systematic approach to preparing for these new exams, giving you crucial insights into how to score well. Written by junior doctors who recently sat the exams, this book will show you how to predict and prepare for the stations you will face. As it leads you through the cases and the examiners' mark sheets, it teaches you how to pick up every point, with extra tips on how to impress and where to go to add to your practice and experience. For overseas doctors, this book also provides essential preparation for the clinical component of the PLAB exam. Key features: * Handy, pocket-sized book * Exam focused, with key tips on how to prepare and excel on exam day * Chapters on practical skills, communication, chronic disease management, discharge planning, psychiatric histories, focused history and management, and examination * Packed with real OSCE scenarios and model mark sheets OSCEs for Medical and Surgical Finals is an essential book for all medical students and PLAB candidates.

Does the psyche have an affect on health? The Psyche of the Body is a passionate and well-informed plea for a Jungian version of psychosomatic medicine and psychotherapy. Many cases of physical illness show evidence of the effect of psychic involvement, both in origin and treatment. Yet to date the majority of study into psychosomatic illness has been purely empirical, with little theory to help interpret and put results into context. Illustrated by vivid clinical illustrations of case histories, The Psyche of the Body reviews the long history of psychosomatic medicine and models of the relationship between psyche and body that have evolved over time, and presents a full revision of research in the field over the last twenty years. It presents a much-needed theoretical model together with practical guidelines that demonstrate how the psychological aspects of specific illnesses should be handled in therapy and analysis. Practicing and training Jungian analysts, as well as all those involved in clinical treatment, will find the interdisciplinary approach to psychosomatic medicine promoted in this book fascinating reading.

Psychiatry Algorithms for Primary Care is a practical, quick reference guide to psychiatric assessment and mental healthcare in general practice. Providing algorithms informed by evidence-based guidelines, this easy-to-use resource helps busy medical and healthcare professionals quickly assess mental health problems, make informed treatment decisions, and understand when referrals to specialist mental health services are appropriate. Drawing from their extensive experience in general practice and psychiatry, the authors provide clear and authoritative guidance on a wide range of common psychiatric disorders, complex scenarios, and special considerations. Unique visual management algorithms define assessment, diagnosis, investigations and management for each condition, including Bipolar Affective Disorder, Psychosis, Depression, Dementia, and Attention Deficit Hyperactivity Disorder. Up-to-date information on medication choices and counselling strategies is found throughout the text. Designed for informing swift clinical decisions in demanding primary care settings, this indispensable reference guide: Conforms to the diagnostic criteria in the current edition of the World Health Organization's International Classification of Diseases Contains algorithms informed by the Royal College of General Practitioners (RCGP), Royal College of Psychiatrists (RCPsych), and the National Institute for Health and Care Excellence (NICE) guidelines Explores common complaints that can suggest psychological or psychiatric disorders, such as insomnia and fatigue Outlines special mental health considerations related to children, intellectual disability, autism, the elderly, and pregnancy Includes appendices covering commonly prescribed drugs and physical examinations for patients with severe mental illness Features numerous self-assessment questions and links to online reference tools for General Practitioners Psychiatry Algorithms for Primary Care is a much-needed resource for medical students and trainees, physicians and healthcare professionals in general practice, nurse practitioners, and practitioners in other fields such as urgent care and emergency medicine.

Following the super-success of their MRCP Part 2 volume, the authors adapt their special teaching skills to the needs of MRCP Part 1 and similar exams in internal medicine. The book consists of 360 'Best of 5' multiple choice questions (1,800 clinical decision) reflecting the latest exam format. It covers all areas of clinical medicine needed by exam candidates and includes psychiatry and applied basic science. The answers contain full didactic explanations to ensure the reader understands each condition or topic, and features lists, tables and tutorials to guide candidates in their revision and exam technique. The book has proved invaluable to young doctors studying for higher exams in internal medicine and to medical tutors preparing post graduate examinations.

Help your clients achieve victory over chronic pain and lead more fulfilling lives This insightful and informative book will help you deliver better pain management services to the people you care for. Incorporating biomedical, surgical, psychological, social, and spiritual perspectives, it provides vital, up-to-date information about how to reduce physical pain and explores techniques for improving people's ability to cope with it. Helpful tables provide easy access to information on medications for pain and managing side effects. Chronic Pain: Biomedical and Spiritual Approaches is filled with resources for the person in pain and for the health or religious professionals working to help them. It gives you very specific suggestions on how to manage chronic pain, including detailed information about medications, alternative therapies, psychological treatments, and spiritual strategies for pain management. The book is completed by two thoughtful appendixes: one examining pain medications and ways to manage their side effects and the other providing scriptural passages that can comfort those in pain. In addition to his experiences treating patients with chronic pain, the author suffers from chronic pain and disability himself. In this very personal book, he explores ways to help people coping with: low back pain fibromyalgia rheumatologic pain headaches the pain of multiple sclerosis other types of chronic unrelenting pain Chronic Pain: Biomedical and Spiritual Approaches can help people in pain and their families by showing them how to lead satisfying, joy-filled lives--whether their pain goes away or not. It is an essential reference book for everyone who works with pain sufferers as well as patients and their families

Interaction between professionals/students in various disciplines leads to greater respect, cooperation, and practical knowledge for all Interprofessional Collaboration in Occupational Therapy, written by experienced occupational therapists, examines successful programs and models of practice involving collaboration between OT clinicians and allied health professionals. This vital information can help you deliver services to the elderly, the underserved, and the chronically ill that are more effective than traditional primary care models.This book will show you how to apply the concepts of interprofessional collaboration to: increase professional competence and public accountability improve the cost-effectiveness of the way your resources are used gain better evidence-based decision-making skills make more effective referrals avoid duplication of services to clients make better use of faculty time and classroom space by teaching subjects common to various health professions--anatomy, physiology, kinesiology, and other basic sciences

A thought-provoking look at women's health in developing nations! This book shows how war, military regimes, industrialization, urbanization, and social upheaval have all affected the choices Southeast Asian women make about their health and health care. When you read these first-person accounts from Thailand, Cambodia, Vietnam, and Burma, you'll be drawn into the lives of women dealing with drastic changes in their societies. The meticulous case studies in this book examine how social, cultural, and economic forces contribute to the way women make personal health care decisions. Women's Health in Mainland Southeast Asia offers a thought-provoking look into the lives of women in this developing part of the world. Topics addressed in Women's Health in Mainland Southeast Asia include: a proposed new approach to women's health, where treatment is determined by society, culture, and gender rather than by biology alone the relationship between menstruation and other aspects of life for Burmese women the politics of abortion in Thailand the difficulties of seeking care for reproductive tract infections in Vietnam the influence of local culture on the treatment of reproductive health problems in northeast Thailand occupational health hazards faced by women working in the electronics industry in northern Thailand the links between migration, sex work, and HIV/AIDS among female garment factory workers in Cambodia

This book focuses on the aerosol treatment of lung diseases, recent improvements in the understanding of proper dosage, and major innovations in device technology applied to clinical practice.
Examines the behavior of inspired spherical particles in the respiratory tract
Featuring over 1300 references, drawings, tables, photographs, and micrographs, Drug Delivery to the Lung
outlines the history of inhaled medications in the treatment of respiratory disease
describes aspects of respiratory structure to inhalation therapy emphasizing developmental changes
compares existing in vitro/in vivo correlations for key aerosol modalities with lung model predictions
discusses particle diameter measurement, particle size statistics, and aerosol test methods
reviews the clinical effects of altering the deposition site of various classes of aerosolized drugs
surveys the development of novel, efficient, and convenient nebulizer systems
details breath-actuated and spacer devices constructed for children
analyzes dry-powder and pressurized metered dose inhalers
considers the transition from CFCs to new environmentally friendly chemical propellants
and more
Giving the clinician an overview of factors essential to understanding drug delivery via nebulization, Drug Delivery to the Lung is a superlative reference for pulmonologists; physiologists; pharmaceutical scientists; immunologists; allergists; analytical, organic, and medicinal chemists and biochemists; chemical, genetic, and process engineers; and medical and graduate school students in these disciplines.

This is a concise handbook providing a quick clinical reference on Chinese medicinal treatments for many diseases, based on traditional Chinese medicine theory and practice. Organized by different clinical conditions and diseases, it provides clinicians and healthcare professionals with definitions and recommended treatment methods, especially herbal medicine formulae. In addition to being a comprehensive quick reference source, this handbook also conveys a generalized understanding of Traditional Chinese Medicine.

This edition has several new contributors - all of them are leading international authorities in the field. All the chapters have been thoroughly re-written and updated. Several new high quality clinical, radiographic images, gross pathology specimen photographs, and photomicrographs have been included in this edition for the readers' convenience. This edition documents the rapid advances that have occurred at a blistering pace in TB diagnosis, universal drug-susceptibility testing [DST] and treatment of dug-susceptible and drug-resistant TB, including multidrug-resistant and extensively drug-resistant TB [M/XDR-TB], programmatic management of drug-resistant TB, public-private mix, the ENGAGE-TB approach, and END TB strategy, among others. The present edition includes recent classification of drugs and drug combinations including recent generation quinolones, bedaquiline and linezolid used in treating M/XDR-TB and a chapter detailing the latest developments in the field of laboratory diagnosis and management of NTM diseases. Thoroughly revised, updated and rewritten to present a comprehensive account of tuberculosis (TB) and nontuberculous mycobacterial diseases. Beginning with insights into the history and epidemiology of tuberculosis, the book deals extensively with the current understanding of the immunology, and immunopathogenetic mechanisms of this disease. The clinical presentation, laboratory diagnosis, the treatment of TB of various organ systems, prevention and control of TB are extensively covered. Chapters have also been devoted to HIV-TB co-infection, drug-resistant TB (including M/XDR-TB), ethical and legal issues in TB, Revised National Tuberculosis Control Programme, Global TB Control Programme, and the role of medical schools in TB Control Programmes. Includes revised chapter on nontuberculous mycobacterial diseases. This edition will be an asset to both undergraduate and postgraduate medical students, a source of reference to the researchers. Will help practicing doctors to update their knowledge and aid in rationale, scientific and efficient management of patients with TB.

Septic shock remains a serious medical condition with high mortality. Despite many advances in intensive care medicine and antibiotic devel- ment, this has not changed appreciably in the last 20 years. Frustratingly, over the same period of time, enormous advances have been made in understa- ing the underlying pathogenic mechanisms of this condition. This has resulted in the development of several novel therapies for septic shock, which, despite excellent theoretical grounds for their efficacy, have failed in altering mort- ity attributable to sepsis. The reasons for these failures are multiple, but it is clear that further research is required aimed at increasing our understanding of the basic pat- physiological processes that occur following infection. Research into septic shock draws upon a number of different disciplines, ranging from molecular and cellular biology to physiological measurements on whole animals. Septic Shock Methods and Protocols is an attempt to draw together into one volume a number of protocols that are of use in the investigation of the mechanisms of septic shock. I have divided the book into five sections. The first deals with endotoxin, the lipopolysaccharide component of the Gram-negative cell m- brane that can mimic many of the features of septic shock. Gram-positive organisms are found increasingly as causes of septic shock, and several - pects of toxins produced from these bacteria are considered in the second s- tion.

The Sapporo International Symposium on "Recent Advances in Nitric Oxide Research" was held in Sapporo, Japan, in 1997, following the Fifth International Meeting on the Biology of Nitric Oxide in Kyoto, Japan, organized by Dr. Salvador Moncada, Dr. Noboru Toda, and Dr. Hiroshi Maeda. The field of nitric oxide research continues to expand rapidly, and our understanding of the physiological and pathophysiological roles of NO has increased greatly. The Kyoto Meeting was stimulating and informative, providing impetus for the Sapporo Symposium, which I had the great honor to organize. To communicate the information from these events, Dr. Ichiro Sakuma and I decided to publish this book. The contents of its chapters were contributed by the participants who were active at the Sapporo symposium and cover the majority of the presentations made during that symposium. Dr. Csaba Szabo of Children's Hospital Medical Center in Cincinnati (U. S. A. ) reviews the roles of peroxynitrite and poly(ADP-ribose)synthetase in shock, inflammation, and reperfusion injury, and Dr. David A. Geller and his colleagues of the University of Pittsburgh (U. S. A. ) review the regulation and function of NO in the liver. As contributions from the Hokkaido University School of Medicine (Sapporo), Dr. Hiroko Togashi and colleagues present their data on transient cerebral ischemia and NO production, Dr.

The germs of the ideas in this book became implanted in me during my experience as a resident in clinical pathology at Boston University Medical Center. At the time, I had inklings that the test results churned out by our laboratories were more than scientific facts. As a philosophically unsophisticated young physician, however, I had no language or framework to analyze what I saw as a deep philosophical problem, a problem largely unrecognized by most physicians. The test results provided by our laboratories were accurate and of great practical importance for patient care. However, most of the physicians who relied on our test results to diagnose and treat their patients either did not have the time or interest to consider the philosophical issues inherent in diagnosis, or, like me, had inadequate means to further analyze them. It was more than ten years later that I began doctoral studies in philosophy, and I was fortunate to find a faculty that was supportive ofmy efforts to address the problem. This book began as my doctoral dissertation in the Department of Philosophy at Georgetown University. I would like to acknowledge the assistance of my mentor, Robert Veatch, Ph. D. Our conversations during my Georgetown years led me in new and often fascinating directions. I would also like to acknowledge the help of Kenneth Schaffner, M. D. , Ph. D.