Evidence for the efficacy of behavioral approaches to the treatment and management of physical illness is mounting, as is the evidence for behavioral interventions for psychological disorders. A pressing question that remains is how to effectively treat co-morbid physical and psychological illnesses. Diseases co-occur more often than not, and the co-occurrence of physical and psychological illnesses is associated with greater impairment and healthcare costs. Unfortunately, the treatment literature has traditionally been disease-specific, with fewer insights and discoveries regarding the underlying processes of co-morbid physical and psychological illnesses, and even fewer of approaches to treatment.Research on co-morbidities between physical and psychological illnesses has focused primarily on depression. Quite extensive literatures describe the negative impact of depression on type 2 diabetes, cardiovascular disease, cancer, obesity, pain, and other physical illnesses. More recently, higher rates of physical illness have been documented in individuals with bipolar disorder, anxiety disorders, schizophrenia, and impulse control disorders. Studies emanating from the National Comorbidity Survey-Replication (NCS-R), the only U.S. population-based database that includes diagnostic information on all DSM-IV psychological disorders, have revealed strong links between a number of physical and psychological illnesses. These data draw attention to the prevalence of physical and psychological co-morbidities at the population level, which has stimulated research on the biobehavioral mechanisms of those co-morbidities, with the goal of developing and improving treatment approaches. As this area of research grows, practical resources are needed for clinicians and researchers who encounter individuals with co-morbid physical and psychological illnesses in their work. This book is the first to provide a comprehensive overview of psychological co-morbidities of physical illness, biological and behavioral mechanisms of those co-morbidities, and implications for treatment. Each chapter focuses on a physical condition, such as obesity, type 2 diabetes, HIV infection, tobacco dependence, cardiovascular disease, cancer, asthma, pain, irritable bowel syndrome, autoimmune disorders, and obstetric/gynecological conditions. Chapters are structured to cover 1) the epidemiology of the most prevalent co-morbid psychological disorders within that physical condition (e.g., depression and other mood disorders, anxiety disorders, psychotic disorders, impulse control disorders, and eating disorders; 2) biobehavioral mechanisms of the co-morbidity; 3) a review of the behavioral treatment literature including evidence-based practice guidelines (where available); and 4) treatment considerations including issues of stepped care, evidence-based treatment decisions, treatment sequencing, treatment blending, treatment interactions, and contraindications. Content is guided by available research evidence and relevant theoretical models, and it is presented in such a way as to inform clinical practice, identify important gaps in the research literature, and provide directions for future research. The book serves as a tool for clinicians and researchers who work in the area of behavioral medicine in medical, academic, and/or training settings. Patients with psychological and medical co-morbidities may be encountered by clinicians working in either mental health or medical settings, where the presenting problem could be either the psychological disorder or the medical disorder. As such, assessment and treatment issues are discussed from both perspectives. For the clinician, the book reviews brief assessment tools, provides practical summaries of the treatment outcome literature and treatment considerations (e.g., treatment sequencing, contraindications), and includes treatment decision hierarchies that help the clinician incorporate each facet of evidence-based decisions (the evidence, patient characteristics, and their own expertise). For the researcher, the book brings together the literature for the medical and psychological disorder, highlighting still unanswered research questions relevant to the co-morbidity. Literature relevant to the underlying biobehavioral mechanisms of the co-morbidity as well as treatment are summarized. While a vast literature exists for the treatment of these disorders in isolation, one important purpose of this book is to bring together this literature to uncover specific areas in need of future study that will further our understanding of why different disorders co-occur and the best ways to treat them when they do.

In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Amrita Sethi brings her considerable expertise to the topic of Submucosal and Third Space Endoscopy. Endoscopic submucosal dissection (ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node metastasis. ESD techniques require advanced skills, and this issue brings together top experts in the field who provide the information endoscopists need to improve these skills. Contains 15 practice-oriented topics including building the toolbox of devices to optimize a practice in submucosal endoscopy; understanding the principles of electrocautery for submucosal endoscopy; endoscopic submucosal dissection in the colon and rectum; techniques for peroral endoscopic myotomy, from mouth to anus; management of adverse events of submucosal endoscopy; and more. Provides in-depth clinical reviews on submucosal and third space endoscopy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Medically unexplained somatic symptoms are problematic in psychiatry, primary care settings, and other clinical areas. The burden they impose on health-care systems constitutes a significant public health problem. At the international symposium "Rethinking Somatoform Disorders," this problem was addressed by specialists working in somatoform disorders, psychiatric nosology, epidemiology, and biological and cross-cultural psychiatry. The meeting was the third of the Keio University International Symposia for Life Sciences and Medicine, in collaboration with the World Health Organization and the World Psychiatric Association.

This is the second and updated version of the Textbook of Allergy for the Clinician. It is a unique book in the field of allergy. The uniqueness lies in the international character of the book with contributors representing both the East and West. This book represents the diversity of issues affecting patients in the specialty of allergy, asthma & immunology. There is some discussion of the basic mechanisms involved and extensive elaboration for the clinicians. This book will appeal to medical students, residents and fellows undergoing training as well as consultants in academic and clinical practice settings. The color plates, especially in the section on Aerobiology, will help in the interaction between the patient and consultant in identifying the plant or flora which is the causative factor. The differences and similarities between the Eastern and Western approaches in the practice of the specialty are being addressed for the first time in a book.

Psychiatry Algorithms for Primary Care is a practical, quick reference guide to psychiatric assessment and mental healthcare in general practice. Providing algorithms informed by evidence-based guidelines, this easy-to-use resource helps busy medical and healthcare professionals quickly assess mental health problems, make informed treatment decisions, and understand when referrals to specialist mental health services are appropriate. Drawing from their extensive experience in general practice and psychiatry, the authors provide clear and authoritative guidance on a wide range of common psychiatric disorders, complex scenarios, and special considerations. Unique visual management algorithms define assessment, diagnosis, investigations and management for each condition, including Bipolar Affective Disorder, Psychosis, Depression, Dementia, and Attention Deficit Hyperactivity Disorder. Up-to-date information on medication choices and counselling strategies is found throughout the text. Designed for informing swift clinical decisions in demanding primary care settings, this indispensable reference guide: Conforms to the diagnostic criteria in the current edition of the World Health Organization's International Classification of Diseases Contains algorithms informed by the Royal College of General Practitioners (RCGP), Royal College of Psychiatrists (RCPsych), and the National Institute for Health and Care Excellence (NICE) guidelines Explores common complaints that can suggest psychological or psychiatric disorders, such as insomnia and fatigue Outlines special mental health considerations related to children, intellectual disability, autism, the elderly, and pregnancy Includes appendices covering commonly prescribed drugs and physical examinations for patients with severe mental illness Features numerous self-assessment questions and links to online reference tools for General Practitioners Psychiatry Algorithms for Primary Care is a much-needed resource for medical students and trainees, physicians and healthcare professionals in general practice, nurse practitioners, and practitioners in other fields such as urgent care and emergency medicine.

The Bibliotheca Teubneriana, established in 1849, has evolved into the world's most venerable and extensive series of editions of Greek and Latin literature, ranging from classical to Neo-Latin texts. Some 4-5 new editions are published every year. A team of renowned scholars in the field of Classical Philology acts as advisory board: Gian Biagio Conte (Scuola Normale Superiore di Pisa) Marcus Deufert (Universitat Leipzig) James Diggle (University of Cambridge) Donald J. Mastronarde (University of California, Berkeley) Franco Montanari (Universita di Genova) Heinz-Gunther Nesselrath (Georg-August-Universitat Goettingen) Dirk Obbink (University of Oxford) Oliver Primavesi (Ludwig-Maximilians Universitat Munchen) Michael D. Reeve (University of Cambridge) Richard J. Tarrant (Harvard University) Formerly out-of-print editions are offered as print-on-demand reprints. Furthermore, all new books in the Bibliotheca Teubneriana series are published as eBooks. The older volumes of the series are being successively digitized and made available as eBooks. If you are interested in ordering an out-of-print edition, which hasn't been yet made available as print-on-demand reprint, please contact us: [email protected] All editions of Latin texts published in the Bibliotheca Teubneriana are collected in the online database BTL Online.

One of the fascinations of psychiatry is that it is amenable to many different approaches. In seeking to account for mental disorder, for example, it is pos sible to explore the meaning and significance of symptoms in the psychody namic sense, to examine the social determinants of illness, or to adopt an es sentially biological viewpoint in investigating links between physiological and psychological dysfunction .. As a clinical discipline it may be practiced in the community, in the specialized clinic or hospital, or shoulder-to-shoulder with other medical practitioners in the general hospital. This richness and diversity are at once a strength and a weakness, attracting practitioners with a wide range of talents and interests, yet sometimes leading to polarizations and false an titheses. The so-called "medical model" of psychiatry has come under a good deal of attack, and deservedly so when claiming an exclusive provenance over all types and aspects of mental disorder. What cannot be gainsaid, however, is the central role of medicine in relation to many parts of the field, and the success in terms of understanding and therapy that has resulted from medicine's in volvement. Nor can it be doubted, after the most cursory acquaintance with the physically or mentally ill, that the relationship between these two forms of suffering is often so close and so mutually reinforcing that distinctions are drawn somewhat arbitrarily. This last is perhaps the cardinal reason for the alliance between medicine and psychiatry."

At the Sixth Wiggers Bernard Conference, a group of scientists from various disciplines discussed new findings relating to nitric oxide synthase inhibitor in shock, sepsis, and organ failure. Dedicated to the presentation and discussion of both positive and negative findings related to the use of NOS inhibitors, the meeting served as a forum for issues relating to specific and non-specific inhibitors, as well as the role of nitric oxide-oxygen radical interactions. Both experimental and clinical data were presented in the trauma and sepsis field.

Alles Wissenswerte uber das kardiovaskulare System auf einen Blick! The Cardiovascular System at a Glance ist das Referenzwerk des Fachgebiets. Die neueste Auflage prasentiert einen integrierten pragnanten UEberblick, von den Grundlagen bis zur Anwendung mit einer Vielzahl von Abbildungen. Neue Inhalte zu Schlaganfall, Untersuchungsmethoden und Bildgebung, Herzblock und EKG, Myopathien und Kanalopathien. Das Fachbuch geht noch einen Schritt weiter und bietet neue und aktualisierte Fallstudien sowie Multiple-Choice-Fragen auf einer begleitenden Website. - Verbindet Grundlagen und klinische Themen. - Kurze Kapitel, deren Inhalte sich leicht aneignen lassen. - Beschreibt Anatomie und Histologie, Blut und Blutstillung, Zellphysiologie, Form und Funktion, Regulierung und Integration der kardiovaskularen Funktion, Anamnese, Untersuchung und Nachforschungen, Pathologie und Therapieansatze. - Mit einer Fulle ansprechender, farbiger Illustrationen als Erganzung und Erlauterung des Textes. In der 5. Auflage ist The Cardiovascular System at a Glance das ideale Lehrbuch fur Studenten der Medizin, Assistenzarzte, Studenten anderer Fachgebiete im Gesundheitswesen und Pflegepersonal in der Kardiologie.

In this issue of Anesthesiology Clinics, guest editors Drs. Alison J. Brainard and Lyndsay M. Hoy oversee the topic of Total Well-being. Articles in this issue highlight perspectives from across multiple subsets of anesthesiology, including nutrition, arts and humanities, coaching, and the inequalities of medicine. The editors' goal is that readers will come away inspired, informed, and excited to create an approach for total well-being that can be tailored to their workplace and lives. Contains 19 practice-oriented topics including women in anesthesiology; parenting/lactation in anesthesia; intensivists and wellness, post-pandemic; early-career physician burnout; integrating antiracism into MedEd with health humanities program; and more. Provides in-depth clinical reviews on total well-being, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The immune system has evolved mechanisms enabli ng it to discriminate between self and non-self constituents. A normally functioning organism is naturally unresponsive to self antigens originating from clonal deletion, aner- gy, or an active suppression of self-reactive T cells. The wide spectrum of autoimmune responses may be divided into systemic and organ-specific dis- eases and encompasses the actions of autoantibodies, autoantigeu-autoanti- body complexes, and sensitized T lymphocytes. The aim of this book is to review the current understandin g, concepts and hypotheses regarding the pathogenesis and therapeutic approaches in autoim- mune disorders. The first six articles are generally concerned with the mech- anisms operating in autoimmune phenomena, whereas the subsequent reviews discuss particular phenomena in representative autoimmune dis- eases. The introductory article underlines the significance of the interactions between antigen-specific T cells and other elements ot the immune system and proposes that not suppression, but rather activation of the immune sys- tem, leading to a redirection of the immune response, would be therapeuti- cally beneficial. The next articles present the importance of costim ulatory signals in determining various types of immune responses, including autoim- munity, and the role of regulatory T cells. Further, an interesting phenome- non of epitope spreading as a mechanism for the progression of autoimmune diseases is presented.

In 2009 the University Medicine Greifswald launched the "Greifswald Approach to Individualized Medicine" (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes - next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients - chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.

Human-computer confluence refers to an invisible, implicit, embodied or even implanted interaction between humans and system components. New classes of user interfaces are emerging that make use of several sensors and are able to adapt their physical properties to the current situational context of users. A key aspect of human-computer confluence is its potential for transforming human experience in the sense of bending, breaking and blending the barriers between the real, the virtual and the augmented, to allow users to experience their body and their world in new ways. Research on Presence, Embodiment and Brain-Computer Interface is already exploring these boundaries and asking questions such as: Can we seamlessly move between the virtual and the real? Can we assimilate fundamentally new senses through confluence? The aim of this book is to explore the boundaries and intersections of the multidisciplinary field of HCC and discuss its potential applications in different domains, including healthcare, education, training and even arts.

As we move into the 21st century it is becoming increasingly difficult to offer appropriate introductory clinical experiences for medical students. Many schools offer clinical experiences in the first year of medical school, when the learner has little background in the traditions and origins of the doctor-patient interaction. Others begin this process in the second year, after a professional language base has been established, but concise educational materials are scarce that integrate the meaning of the privileged clinical encounter with the process and content of interviewing and examining patients. In the tertiary hospitals, where most medical schools are based, the educators must provide an orienta tion to the clinical encounter, an intensely personal experience, in the midst of glittering technological marvels that easily distract both the novice physician and the wizened teacher. Understanding the context and historical basis for the privilege of interviewing and examining another person about intimate matters relating to health and disease is essential to this process. Considering these factors, this textbook is written to assist medical educators and medical students involved in early clinical training. As the demand for "high-tech" medicine has accelerated, so has the public concern over the loss of "high-touch" or compassionate, humane interactions with physicians. Physicians are perceived as more concerned with readouts from machines and fiberoptic views of the patient than with understanding and car ing about the people we have labeled as patients."

Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

This volume is a collection of essays by Richard Wolin, a leading political theorist and intellectual historian. It is the follow up to Wolin's two recent, widely acclaimed books: Heidegger's Children and The Seduction of Unreason. In those books, he explored the legacy of Martin Heidegger and his impact on some of his most influential and notable students. He dealt particularly with the effect that Heidegger's subsequent embrace of fascism and National Socialism had on these students. Delving further in his next book, Wolin explored the question of why philosophers and intellectuals have been drawn to antiliberal, antidemocratic fascism. The essays in this book are focused on European Political Thought particularly with figures associated with the Frankfurt School. The collection represents a virtual who's who of European political thinkers with essays on Walter Benjamin, Adorno, Marcuse, Arendt, Heidegger, Weber, Jaspers, and Carl Schmitt. Moving beyond these thinkers and those books, this collection will also include essays on contemporary political issues such as post-communist revolutions, human rights, global democracy, the revival of republicanism, and religion and public life.

From the author of the bestselling introduction to evidence-based medicine, this brand new title makes sense of the complex and confusing landscape of implementation science, the role of research impact, and how to avoid research waste. How to Implement Evidence-Based Healthcare clearly and succinctly demystifies the implementation process, and explains how to successfully apply evidence-based healthcare to practice in order to ensure safe and effective practice. Written in an engaging and practical style, it includes frameworks, tools and techniques for successful implementation and behavioural change, as well as in-depth coverage and analysis of key themes and topics with a focus on: * Groups and teams * Organisations * Patients * Technology * Policy * Networks and systems. How to Implement Evidence-Based Healthcare is essential reading for students, clinicians and researchers focused on evidence-based medicine and healthcare, implementation science, applied healthcare research, and those working in public health, public policy, and management.

Trainees in preparation for the MRCP examination will welcome the much-anticipated new edition of this 'gold standard' revision book. Revised and updated throughout to encompass new developments in medical diagnostics and therapeutics, and restructured to reflect the recent changes in the format of the Part 2 written examination, the book continues to offer a more detailed and examination-orientated approach than other revision guides on the market. The appeal of the book lies not only in the careful adherence to the examination format, but also in the invaluable hints it provides on exam technique, with suggestions of information that will be helpful when tackling the exam presented in a 'revision-friendly' boxed format.

Much research over the past 30 to 40 years has shown that the inflammatory response, while critical for host defense during microbial infection, may itself play a central role in the pathogenesis of sepsis. Although key mediators responsible for this injury have been identified, efforts clinically to augment our conventional antimicrobial and supportive therapies during sepsis with agents modulating the inflammatory response have been unsuccessful. As a result, the mortality associated with this lethal syndrome, especially when complicated by shock, has remained persistently high. Unfortunately, during this same period of time, the incidence of sepsis has accelerated as other fields of medicine have relied increasingly on therapies that predispose to infection. While frustrating, overall this experience in the field of sepsis has not been without value. Most importantly, it has helped define on several different levels the complexity of the septic patient. Recognizing and addressing this complexity as discussed by each of the contributors to Evolving Concepts in Sepsis and Septic Shock may now provide new inroads into the treatment of sepsis.

Now in its third edition, this small and accessible guide contains essential information for the safe prescribing of the most commonly used drugs in the NHS. The Top 100 Drugs combines the best elements of a students' textbook with those of a prescribers' manual. It gives equal weight to essential information on the science of pharmacology as well as the real-world practicalities of prescribing, all in an accessible and clear format. Written by leaders in the field of clinical pharmacology, this popular book has been fully revised and updated to include the drugs used today, including monoclonal antibodies and antiviral drugs for COVID-19. With common indications, mechanism of action, adverse effects, important interactions and a clinical tip for each drug as well as questions to test knowledge, this book is key to helping students understand everything they need to know about the drugs they are likely to use in practice. Compact and easy to follow - can be carried around on the wards Logically ordered - offers multiple ways to find the drug you are looking for A Clinical Tip for each drug, drawn from the authors' experience 100 self-assessment questions to encourage integration and revision of knowledge and understanding Fully updated to include the most commonly prescribed drugs today, based on original research led by the authors of over 1 billion community prescriptions and approximately 1 million hospital prescriptions All drug monographs extensively reviewed and updated Dedicated section emergency drugs Updated self-assessment material, now including calculation and prescription-writing questions, in addition to single-best-answer questions

Fifty years since it was first published and now fully revised, Macleod's remains the textbook of choice for medical students, junior doctors, nurses and allied health practitioners who understand that excellence in clinical examination is integral to good practice. The fifteenth edition will teach you how to take a history and carry out proficient clinical examination, in order to elicit the key clinical symptoms and signs of disease. It covers general principles, relevant history, examination and investigations for all the major body systems - and how to effectively apply these skills to specific clinical situations and prepare for assessment. Macleod's Clinical Examination is enhanced with 32 supplementary videos demonstrating key clinical examination routines described in the book, many new and revised for this edition in line with latest guidance and best practice. Primarily focused on the practical skills required by medical students and early career stage clinicians Explains the physical basis of clinical signs to aid understanding Introduces the formulation of a differential diagnosis Provides logical initial investigations for each body system Comes with access to the complete, fully searchable and downloadable eBook Enhanced sections on adapting skills to particular situations, including the challenges of remote consultation and infection control Updated text and images, to ensure the content is relevant to a diverse readership and patient population Latest clinical decision-making models to aid the learner's diagnostic reasoning 8 brand new videos produced especially for this edition covering: Obstetric examination Gynaecological examination Assessment of fluid balance Examination of the hand and wrist Examination of the foot and ankle Examination of the neck Examination of the foot in diabetes and peripheral vascular disease The timed up and go test

Help your clients achieve victory over chronic pain and lead more fulfilling lives This insightful and informative book will help you deliver better pain management services to the people you care for. Incorporating biomedical, surgical, psychological, social, and spiritual perspectives, it provides vital, up-to-date information about how to reduce physical pain and explores techniques for improving people's ability to cope with it. Helpful tables provide easy access to information on medications for pain and managing side effects. Chronic Pain: Biomedical and Spiritual Approaches is filled with resources for the person in pain and for the health or religious professionals working to help them. It gives you very specific suggestions on how to manage chronic pain, including detailed information about medications, alternative therapies, psychological treatments, and spiritual strategies for pain management. The book is completed by two thoughtful appendixes: one examining pain medications and ways to manage their side effects and the other providing scriptural passages that can comfort those in pain. In addition to his experiences treating patients with chronic pain, the author suffers from chronic pain and disability himself. In this very personal book, he explores ways to help people coping with: low back pain fibromyalgia rheumatologic pain headaches the pain of multiple sclerosis other types of chronic unrelenting pain Chronic Pain: Biomedical and Spiritual Approaches can help people in pain and their families by showing them how to lead satisfying, joy-filled lives--whether their pain goes away or not. It is an essential reference book for everyone who works with pain sufferers as well as patients and their families

Interaction between professionals/students in various disciplines leads to greater respect, cooperation, and practical knowledge for all Interprofessional Collaboration in Occupational Therapy, written by experienced occupational therapists, examines successful programs and models of practice involving collaboration between OT clinicians and allied health professionals. This vital information can help you deliver services to the elderly, the underserved, and the chronically ill that are more effective than traditional primary care models.This book will show you how to apply the concepts of interprofessional collaboration to: increase professional competence and public accountability improve the cost-effectiveness of the way your resources are used gain better evidence-based decision-making skills make more effective referrals avoid duplication of services to clients make better use of faculty time and classroom space by teaching subjects common to various health professions--anatomy, physiology, kinesiology, and other basic sciences