In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Jeffrey H. Newcorn and Timothy E. Wilens bring their considerable expertise to the topic of Updates in Pharmacologic Strategies in ADHD. Top experts in the field cover key topics such as PK of stimulants pharmacogenomics, stimulants, nonstimulants, neurotherapeutics, and more. Contains 15 relevant, practice-oriented topics including special groups: ADHD+, such as mood/ dysregulation and disruptive behavior; SUD; autism; tics, Tourette syndrome, and anxiety; sleep; cardiovascular; college-aged; transitional-aged youth; adults; and more. Provides in-depth clinical reviews on pharmacologic strategies in ADHD, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.

In this issue of Anesthesiology Clinics, guest editors Drs. Alison J. Brainard and Lyndsay M. Hoy oversee the topic of Total Well-being. Articles in this issue highlight perspectives from across multiple subsets of anesthesiology, including nutrition, arts and humanities, coaching, and the inequalities of medicine. The editors' goal is that readers will come away inspired, informed, and excited to create an approach for total well-being that can be tailored to their workplace and lives. Contains 19 practice-oriented topics including women in anesthesiology; parenting/lactation in anesthesia; intensivists and wellness, post-pandemic; early-career physician burnout; integrating antiracism into MedEd with health humanities program; and more. Provides in-depth clinical reviews on total well-being, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

This new addition to the popular Essentials series provides a broad, general introduction to the topic of simulation within clinical education. An ideal tool for both teaching and learning, Essential Simulation in Clinical Education provides a theoretical and practical introduction to the subject of simulation, whilst also offering strategies for successful use of simulators within general clinical education and demonstrating best practice throughout. This timely new title provides: The latest information on developments in the field, all supported by an evidence-base Content written by a global team of experts Discussion of policy and strategy initiatives to ground simulation within the healthcare context Practical examples of cases, including inter-professional learning. A superb companion for those involved in multi-disciplinary healthcare teaching, or interested in health care education practices, Essential Simulation in Clinical Education is the most comprehensive guide to the field currently available.

This unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement's founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today's modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks to the future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an "insider's" tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.

"Medical Mycology: cellular and Molecular" techniques is a clear and concise overview of the subject that details the techniques essential for ongoing research in the area. Drawing together contributions from both scientists and clinicians working in the field, the text will provide a valuable perspective on the applicability of specific techniques to patient care.

A wide range of molecular, immunological and cytological techniques are discussed throughout, with the inclusion of protocol section in each chapter designed to provide both a background a up-to-date account of the applications of each procedure. Every technique is fully referenced and illustrations are provided where required to enhance student understanding. comprehensive introduction to the key techniques critical to the study of medical mycology clear explanation of how each technique is applied in the lab contributions from internationally recognised experts in the field outlines the background to many techniques required for the successful completion of a research project

An invaluable reference for students of microbiology, biochemistry and molecular biology as well as postgraduates and researchers in the field of medical mycology looking for an up-to-date overview of the latest laboratory techniques.

The lifelong care required for bariatric surgery patients often presents colleagues in the office with the situation of having to identify surgical and nutritive complications related to the previous surgery. This often requires very specialized knowledge not only of the surgical procedures themselves, but especially of the metabolic changes that follow surgery.  Based on many years of experience in the leading surgical obesity centers in Germany, the editors have compiled this book. It offers practical guidance for the follow-up care of obesity patients who have undergone surgery. With practical relevance, the book supports general practitioners and internists in their competence to recognize and treat postoperative changes and complications. The diverse and complex physiological changes are explained as well as the necessary knowledge of surgical procedures. The topics of nutrition, deficiencies and supplementation after surgery, possible complications and intervention options are highlighted. Monitoring of pregnancy following bariatric surgical intervention also takes on special emphasis.

This innovative book provides a unique perspective on the biomedical and societal implications of personalized medicine and how it will help mitigate the healthcare crisis and rein in ever-growing expenditure. It introduces the reader to underlying concepts at the heart of personalized medicine - pharmacogenomics, targeted therapies and individualized diagnosis and treatment - and shows how, with the advent of genomic technologies, clinicians will have the capability to predict and diagnose disease more efficiently. Advocating a patient-centred approach at the heart of care, this introduction to personalized medicine, the science behind it, its economic effects, its effects upon patients and its overall implications for society will be invaluable to clinicians, to healthcare providers and to patients.

In this issue of Child and Adolescent Psychiatric Clinics, guest editors Deborah R. Simkin and L. Eugene Arnold bring their considerable expertise to the topic of complimentary and integrative medicine. Top experts in the field cover key topics such as ADHD, Sleep Disorders, Anxiety, Psychosis, and more. Contains 13 practice-oriented topics including anxiety, substance abuse, PTSD, obesity, eating disorders, and more.  Provides in-depth clinical reviews on complementary and integrative medicine, offering actionable insights for clinical practice.  Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. 

Here are 101* of the best ideas to make the most effective use of your time on the ward. Over 250 contributors, including students, doctors, nurses, pharmacists, and therapists from 18 countries, help make you the finest doctor you can be

Pocket-sized for 'dipping into' during a spare moment or a couple of hours on the ward, this short guide is ideal for medical students on rotation or junior doctors who wish to boost learning and motivation.

*There are actually 100 ideas. Now it's your turn to develop tip 101 Submit your ideas to www.101things.org

In this issue of Medical Clinics, guest editor Melissa B. Weimer brings her considerable expertise to the topic of Substance Use Disorders. Provides in-depth, clinical reviews on the latest updates in Substance Use Disorders, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Biotechnology in Healthcare presents up-to-date knowledge on the emerging field of biotechnology as applied to the healthcare industry. Biotechnology has revolutionized healthcare in the last two decades by developing and introducing novel diagnostics, therapeutics, and preventive measures; whether it is noncommunicable or communicable disease, primary or secondary care, or public health, it has shown its immense potential to provide a solution to the healthcare providers, physicians, and allied health care professionals. The second volume, Applications and Initiatives, contains 19 chapters focused on the applications of biotechnology related to public healthcare, hospital management, oncology, neurodegenerative and infectious diseases, regenerative medicine, IVF, clinical trials, precision food, FMGCs, PPCPs, pharmaceuticals, and smart technologies to monitor pandemic. Further, this volume also presents government initiatives and entrepreneurship challenges in healthcare biotechnology sector. This is a valuable resource for students, biotechnologists, bioinformaticians, clinicians, and members of biomedical and healthcare fields who need to understand more about the promising developments of the emerging field of biotechnology in healthcare.

In this issue of Child and Adolescent Psychiatric Clinics, new Consulting Editor and Issue Guest Editor Justine Larson brings her considerable expertise in the latest hot topics in child and adolescent psychiatry. Top experts in the field cover key topics such as bullying, depression intervention, the biological effects of childhood trauma, childhood trauma and psychosis, and more. Provides in-depth, clinical reviews on the latest hot topics in child and adolescent psychiatry, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 15 relevant, practice-oriented topics including Social Media as It Interfaces with Psychosocial Development and Mental Illness in Transitional Age Youth; Mental Health Care of Detained Youth and Solitary Confinement and Restraint Within Juvenile Detention Facilities; Adverse Childhood Experiences, Resilience and Mindfulness-Based Approaches Common Denominator Issues for Children with Emotional, Mental, or Behavioral Problems; #KidsAnxiety and Social Media; and more.

Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science. New focus on high-yield, core knowledge necessary for clerkships or residencies in medicine, with concise, complete coverage of the core principles of medicine and how they apply to patient care. Each section describes key physiology and biochemistry, followed by comprehensive accounts of the diseases of the organ system or field covered in the chapters. Full-color design enhances readability and retention of concepts, while numerous imaging videos cover cardiovascular disease, endoscopy, sphincterotomy, and more. Superb images and photographs vividly illustrate the appearance and clinical features of disease. New chapters cover Women's Cancer and Transitions in Care from Children to Adults with Pulmonary Disease. Student Consult features include web-only extras, additional figures and tables, clinical photos, radiologic images, video procedures, imaging studies, and audio recordings. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Now in its fifth edition, the Oxford Handbook of Emergency Medicine is the essential rapid-reference guide to emergency medicine for everyone from junior doctors to specialist registrars, nurse practitioners, and paramedics. New and improved, the Handbook has been thoroughly revised throughout, with 100 extra illustrations and the latest guidelines and treatment advice, completely overhauled chapters on Medicine, Obstetrics and Gynaecology, and Paediatric emergencies, and new topics on treatment escalation, end-of-life care, and sepsis. Clear and concise, extensively updated, and packed with a host of new X-rays to aid identification and treatment, this Handbook has everything you need to thrive in the demanding world of emergency medicine today.

First published in 1993. Routledge is an imprint of Taylor & Francis, an informa company.

Cardiac resynchronization therapy is a new therapy for advanced heart failure patients. This therapy has been shown to improve quality of life, exercise capacity, NYHA classification, and even reverse the detrimental "reverse remodeling" that occurs in advanced heart failure - in patients already receiving optimal pharmacological therapy.

The typical patient has NYHA III/IV HF symptoms, a QRS > 120 ms, LVEDD > 55 mm, without any indication required for pacing. The therapy is available in an ICD device, too. CRT has been shown to be effective in patients with both ischemic and non-ischemic cardiomyopathy.

The implant procedure is part of a learning curve. Many physicians who already perform electrophysiology procedures, or PPM, or ICD implants are the ideal implanter - but are surprised at the challenges this implant presents. This book will help "flatten" the learning curve for new physician implanting, and will provide a "guide' for those who have already started implanting.

The success rate is about 90o after 10 years of application, we have found that there are still patients who do not get access to this great therapy because of the complexity of the patient's anatomy, or physician skills.

The book is written by three authors with a great deal of experience culminating in over 3000 cases between them.

This book is intended for cardiologists who currently implant either or both pacemakers and cardioverter defibrillators with cardiac resynchronization therapy (also called bi-ventricular pacing), or plan to implant in the future. This book will be extremely useful for the new cardiologist in training who is learning to implant devices.

This book is a toolkit for young academic physicians and researchers to learn the behaviors and steps necessary for achieving success in academia. Written by a successful academic clinician, the book shares his personal experience alongside his years of successfully teaching and mentoring young medical professionals. The author's main aim is to provide insightful tips and tricks that will hopefully not only motivate the reader to persevere through difficult competitive periods in his or her life, but also provide him or her with a strategic behavioral plan that will solidify his or her work habits and ensure success. This book begins with a chapter about why knowledge and learning should be communicated, and then expands on that mindset through both general behavioral changes and those specific to the life of an academic researcher, like writing articles. Some key topics covered in the text include: The importance of sharing knowledge and the associated public and personal benefits Taking one step at a time and planning out work into small, attainable goals Developing a growth mindset The importance of collaboration and successful mentors This is an ideal guide for young academic physicians and researchers working in universities, academic health sciences centers, and research institutes hoping to learn how to achieve success in academia. It could also prove useful to more established academics that need a refresher or a new perspective on their work and goals.

Textbook of Lifestyle Medicine The Textbook of Lifestyle Medicine provides foundational knowledge essential to students and scientists across various disciplines to better understand this new area of research and practice. Incorporating the latest evidence-based research on the relationships between lifestyle factors and disease, this unique book discusses the practical tools necessary to address growing public health crises such as obesity, cancer, diabetes, and cardiovascular disease using a holistic approach to physical, mental, and spiritual wellness. The book offers comprehensive and up-to-date coverage of how lifestyle medicine professionals can prevent and mitigate 'Lifestyle Diseases'. Clear and accessible chapters explore modifiable lifestyle factors that positively affect health, nutrition, exercise, sleep, stress control, and social support, and highlight the negative impact of smoking, alcohol abuse, and other unhealthy lifestyles. Topics include sleep physiology, the genetic background and development of noncommunicable diseases (NCDs), the characteristics and principles of healthy lifestyle, the clinical significance of physical activity, and the mechanisms connecting social interaction and health implications. This important resource: Discusses the global burden and risk factors of the modern disease epidemic Covers a variety of nutritional approaches including the Mediterranean Diet and the Dietary Approaches to Stop Hypertension (DASH) diet Features in-depth coverage of the Mediterranean Lifestyle, a holistic approach to health and wellness Includes a clinical practice section and appendices on preventive medicine and public health tools and recommendations Contains key points, take-home messages, self-assessment questions, color artwork and numerous references, citations, internet links, and further reading suggestions Written by two world experts in this growing field, the Textbook of Lifestyle Medicine is a must-have volume for students and practitioners in nutrition, exercise physiology, psychology, addiction therapy, sleep therapy, as well as physicians, nurses, and other health professionals wanting to expand their knowledge and practice.

ABC of Domestic and Sexual Violence is a practical guide for all health care professionals who are looking after abused individuals (whether knowingly or not) and who wish to learn more in order to help their patients. It employs a positive and hands on approach, emphasising simple history taking skills and clinical tips and pitfalls to help demystify what is often considered a sensitive or difficult subject area. This new ABC title covers background and epidemiology, including: international and cultural perspectives, common presentations, how to identify abuse, and guidance on subsequent acute and longer-term medical and psychosocial interventions. It provides guidance on legal perspectives including documentation and sources of help and advice. While focusing mainly on women, it will also cover aspects relating to children and men. It also incorporates victim testimonies and case scenarios throughout. From a multidisciplinary team of contributors ABC of Domestic and Sexual Violence is ideal for all general practitioners, accident and emergency, practice nurses, health visitors, midwives, social workers, and other primary and secondary care health care professionals.

ald s Heart Disease ald s Heart Disease

A concise, easy-to-read source of essential tips and skills for writing research papers and career management In order to be truly successful in the biomedical professions, one must have excellent communication skills and networking abilities. Of equal importance is the possession of sufficient clinical knowledge, as well as a proficiency in conducting research and writing scientific papers. This unique and important book provides medical students and residents with the most commonly encountered topics in the academic and professional lifestyle, teaching them all of the practical nuances that are often only learned through experience. Written by a team of experienced professionals to help guide younger researchers, A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing features ten sections composed of seventy-four chapters that cover: qualities of research scientists; career satisfaction and its determinants; publishing in academic medicine; assessing a researcher's scientific productivity and scholarly impact; manners in academics; communication skills; essence of collaborative research; dealing with manipulative people; writing and scientific misconduct: ethical and legal aspects; plagiarism; research regulations, proposals, grants, and practice; publication and resources; tips on writing every type of paper and report; and much more. An easy-to-read source of essential tips and skills for scientific research Emphasizes good communication skills, sound clinical judgment, knowledge of research methodology, and good writing skills Offers comprehensive guidelines that address every aspect of the medical student/resident academic and professional lifestyle Combines elements of a career-management guide and publication guide in one comprehensive reference source Includes selected personal stories by great researchers, fascinating writers, inspiring mentors, and extraordinary clinicians/scientists A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing is an excellent interdisciplinary text that will appeal to all medical students and scientists who seek to improve their writing and communication skills in order to make the most of their chosen career.

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

An original account of willful ignorance and how this principle relates to modern probability and statistical methods

Through a series of colorful stories about great thinkers and the problems they chose to solve, the author traces the historical evolution of probability and explains how statistical methods have helped to propel scientific research. However, the past success of statistics has depended on vast, deliberate simplifications amounting to willful ignorance, and this very success now threatens future advances in medicine, the social sciences, and other fields. Limitations of existing methods result in frequent reversals of scientific findings and recommendations, to the consternation of both scientists and the lay public.

"Willful Ignorance" "The Mismeasure of Uncertainty" exposes the fallacy of regarding probability as the full measure of our uncertainty. The book explains how statistical methodology, though enormously productive and influential over the past century, is approaching a crisis. The deep and troubling divide between qualitative and quantitative modes of research, and between research and practice, are reflections of this underlying problem. The author outlines a path toward the re-engineering of data analysis to help close these gaps and accelerate scientific discovery.

"Willful Ignorance: The Mismeasure of Uncertainty "presents essential information and novel ideas that should be of interest to anyone concerned about the future of scientific research. The book is especially pertinent for professionals in statistics and related fields, including practicing and research clinicians, biomedical and social science researchers, business leaders, and policy-makers.

This book focuses on the practical application of good clinical practice (GCP) fundamentals and provides insight into roles and responsibilities included in planning, executing, and analyzing clinical trials. The authors describe the design of quality into clinical trial planning and the application of regulatory, scientific, administrative, business, and ethical considerations. Describes the design of quality into the clinical trial planning Has end-of-chapter questions and answers to check learning and comprehension Includes charts that visually summarize the content and allow readers to cross-reference details in relevant chapters Offers a companion website containing supplemental training resources