The surge in COVID-19 cases leading to hospitalizations around the world quickly depleted hospital resources and reserves, forcing physicians to make extremely difficult life-or-death decisions on ventilator allocation between patients. Leaders in academia and industry have developed numerous ventilator support systems using both consumer- and industry-grade hardware to sustain life and to provide intermediate respiratory relief for hospitalized patients. This book is the first of its kind to discuss the respiratory pathophysiology underlying COVID-19, explain ventilator mechanics, provide and evaluate a repository of innovative ventilator support devices conceived amid the pandemic, and explain both hardware and software components necessary to develop an inexpensive ventilator support device. This book serves both as a historical record of the collaborative and innovative response to the anticipated ventilator shortage during the COVID-19 pandemic and as a guide for physicians, engineers, and DIY'ers interested in developing inexpensive transitory ventilator support devices.

The Fifth World Congress of the International Society for Diseases of the Esophagus was held in the historic city of Kyoto, Japan, from August 5 through 8, 1992. Approximately 40 countries throughout the world participated and roughly 500 presentations were made. Excellent authors were selected and they were requested to send in their manuscripts for publication of this book. It is our ardent hope that this book will prove to be beneficial to the doctor interested in the esophagus and that it will provide the reader with first-hand information from leading scientists and clinicians in this field. The incidence of esophageal diseases vary greatly from country to country and in recent years, worldwide interest in these diseases has resulted in various international studies. The International Society for Diseases of the Esophagus was inaugurated by Professor Komei Nakayama in 1979 and since that time it has actively contributed to the exchange of information regarding these diseases and has made endeavors in bringing about advancement in the struggle against diseases of the esophagus in every way possible.

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Many advances in vitamin D physiology and biochemistry have been made in recent years. Vitamin D metabolites and analogs have found increasing application in clinical medicine. The purpose of this text is to review what is known about vitamin D physiology and draw attention to areas of vitamin D research that have changed within the last 2-3 years. Additionally, information concerning clinical aspects of vitamin D is also presented. More than 40 scientists have generously contributed chapters to this text; I thank them for their efforts. As might be expected, not everyone has the same point of view. Finally, I would like to acknowledge the secretarial and editorial efforts of Mrs. Cheryl Collins without whom this book would not have been completed. CONTRIBUTORS ETSUKO ABE, Department of Biochemistry, School of Dentistry, Showa University, 1-5-8, Hatanodai, Shinagawa-KU, Tokyo 142, Japan DAVID J. BAYLINK, Department of Medicine, Loma Linda University, Loma Linda, CA, and Pettis Veterans Hospital, 11201 Benton Street, Loma Linda, CA, 92357, USA NORMAN H. BELL, Department of Medicine, Medical University of South Carolina and Veterans Administration Medical Center, 109 Bee Street, Charleston, SC, 29403, USA WARNER M. BURCH, Jr. , Departments of Medicine and Physiology, Duke Univer sity Medical Center, Durham, NC, 27710, USA DAVID V. COHN, ICCRH, Inc. , 1238 Wyncrest Court, Arden Hills, MN, 55112, USA ROBERT A. CORRADINO, Department of Physiology, New York State College of Veterinary Medicine, Cornell University, 720 VRT, Ithaca, NY, 14853, USA HECTOR F.

Vascular changes that occur in the human retina and choroid have frequently been studied through the use of light microscopy. This technique has marked limitations, however, in that it shows changes only in limited localized sites, often with the effects of various systemic diseases indistinguishable. Newer techniques of corrosion cast scanning electron microscopy and transmission electron microscopy provide a much clearer three-dimensional view of retinal and choroidal vasculatures, the results of which will be useful for the interpretation of ocular fundus changes seen in individual systemic diseases. Retinal and choroidal vascular changes due to aging, arteriosclerosis, spontaneous hypertension, and diabetes mellitus in the rat have been investigated and are described in this book, which will be of interest to those in the fields of ophthalmology, anatomy, and pathology. This book is a leading source of information on the use of electron microscopy in a new field of interest. .

This book presents recent outcomes of the collaborative "Tricorder" project, which brings together partners from industry, research institutes and hospitals to deliver an easy contactless alternative for electrocardiograms (ECG). Featuring contributions investigating the possible applications of laser Doppler vibrometry (LDV) signals for the remote measurement of vital parameters of the heart, the book provides insights into the vision and the history of the "Tricorder" project and the basic differences between the vibrocardiograms and electrocardiograms. It also discusses topics such as signal processing, heartbeat measurement techniques, respiration frequency and oxygen saturation determination, with a particular focus on the diagnostic value of the method presented, e.g., diagnosis of atrial fibrillation and estimation of the oxygen saturation in premature infants. Further, the authors review the advantages and drawbacks of the new method and the specific fields of application. This book will appeal to researchers and industry leaders interested in laser remote sensing for medical applications as well as medical professionals curious about new healthcare technologies.

Pocket-sized and portable, Instant Work-ups: A Clinical Guide to Medicine offers all of the critical information physicians need to know in order to evaluate and diagnose a patient. The content is uniquely presented as a patient would present his or her case: with symptoms and abnormalities, as opposed to a diagnosis. Practical and easy to use, it provides clear work-up plans for the most commonly encountered medical conditions, providing quick, focused guidance with the flexibility to adapt to each unique patient. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Pocket-sized design makes it perfect for quick reference in the clinical setting. Covers approximately 80 of the most commonly encountered medical conditions. Chapters are alphabetically organized by topic for easy reference. Topics are presented as a sign, symptom, or abnormal lab reading as a patient would present his or her case. Every topic includes a brief background discussion, a list of important related materials, and a detailed list of the next lab or radiographic tests. Describes each diagnostic test and includes algorithms for each topic to help guide diagnosis.

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state-dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley

A comprehensive examination of all critical aspects of Disaster Victim Identification (DVI) As the frequency of both natural and man-made mass fatality disasters increases worldwide, the establishment of clear standards and best practices within the field of Disaster Victim identification (DVI) is of vital importance. Whereas most countries assign jurisdiction to law enforcement agencies following Interpol guidelines, DVI is the responsibility of the medical examiner and coroner in the United States. Disaster Victim Identification in the 21st Century is the first book of its kind to directly address the needs of DVI practitioners in the United States, covering the full spectrum of DVI from traditional methods such as fingerprints, odontology, and anthropology to advanced DNA identification technology. Approaching DVI from three perspectives--academic, government, and private industry--this comprehensive volume examines the history and current state of the discipline, the ongoing formation of national standards, the various methods of human identification, and the key challenges and future of DVI. In-depth chapters are written by leaders in the field with personal experience in human identification and mass fatality events. Provides practitioners with practical guidance on planning and taking part in DVI based on current national standards and best practices Discusses continued improvement in both traditional and emerging DVI methods Includes non-region-specific case studies and recommendations that can be easily adapted for international use Examines ethical and legal considerations in DVI, including suggestions for standardizing the victim identification process Describes the critical role of the Victim Information Center (VIC) in providing the comparative information required to go beyond presumptive identifications Part of the American Association for Forensic Sciences (AAFS) series, Disaster Victim Identification in the 21st Century: A US Perspective is an indispensable resource for forensic scientists, disaster planners, policymakers, medical examiners and coroners, law enforcement and emergency personnel, and upper-level undergraduate and graduate students in forensic sciences and emergency management.

You won't believe what the U.S. Department of Agriculture permits farmers to inject into beef cattle, sheep, poultry, and dairy cows. After all, the faster an animal gains weight, the more quickly it can be slaughtered and sped to your dinner table. More telling yet, the USDA has mandated that organic food cannot contain added hormones, antibiotics, synthetic pesticides, irradiated components, genetically modified organisms, or reprocessed sewage.

That means non-organic foods most likely contain these additives, all of which may be detrimental to your health, or even deadly. While the government insists that residual hormones and antibiotics in food are harmless, research proves otherwise. In "Organic for Health," cancer and liver disease survivor Sandy Powers shares firsthand knowledge of antibiotics in seafood, pesticide absorption in fruits, diminished vitamin levels in vegetables, and additives that can trigger hyperactivity and asthma. And she brings the healing and restorative power of organic foods, rich in vitamins and minerals that are not over-produced by chemical agents, into sharp focus.

"Organic for Health" will convince you to avoid conventionally grown foods laden with the biggest offenders, and more important, to fill your body with the clean, potent vitamins and minerals in organic foods that truly honor your health.

The MRCP PACES examination is a highly sought-after qualification worldwide and an essential part of postgraduate medical training in the UK. Fully up-to-date with the current exam format, the Pack also reflects the recent changes to Station 5. In each of these two volumes, the authors include clinical cases which mimic the style and approach of the MRCP PACES exam. These sample cases equip the reader attempting the exam with the skills and knowledge necessary for success, and provide an overview of evidence-based medicine for competency-based training. Across both volumes, the authors explore all aspects of the candidate's performance, from clinical examination, to presentation, communication and medical ethics and up-to-date clinical evidence.
This two-volume pack represents great value to the reader and offers a complete revision packages for the MRCP PACES exam.
Volume 1 includes over 150 cases, covering Stations 1, 3 and 5.
Volume 2 includes 75 cases, covering Stations 2 and 4.

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

The successful implementation of evidence into practice is dependent on aligning the available evidence to the particular context through the active ingredient of facilitation. Designed to support the widely recognised PARIHS framework, which works as a guide to plan, action and evaluate the implementation of evidence into practice, this book provides a very practical 'how-to' guide for facilitating the whole process. This text discusses: undertaking an initial diagnosis of the context and reaching a consensus on the evidence to be implemented; how to link the research evidence with clinical and patients' experience and local information in the form of audit data or patient and staff feedback; the range of diagnostic, consensus building and stakeholder consultation methods that can be helpful; a description of facilitator roles and facilitation methods, tools and techniques; some of theories that underpin the PARIHS framework and how these have been integrated to inform a revised version of PARIHS Including internationally-sourced case study examples to illustrate how the facilitation role and facilitation skills have been applied in a range of different health care settings, this is the ideal text for those interested in leading or facilitating evidence based implementation projects, from the planning stage through to evaluation.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. REAL-LIFE CASES SHARPEN YOUR CRITICAL THINKING SKILLS FOR YOUR CLERKSHIP AND THE SHELF EXAM Case Files: Family Medicine presents realistic clinical scenarios to enhance and hone your clinical decision-making skills. Sixty high-yield cases illustrate essential concepts in patient care. Each case begins with a vignette accompanied by relevant open-ended questions designed to teach diagnostic or therapeutic approaches relevant to family medicine. The answers that follow emphasize mechanisms and underlying principles. This sixth edition features a new format with bulleted summaries, shorter paragraphs, and clearer headings. Realistic cases are accompanied by questions that encourage you to think through the differential diagnosis and treatment options Real-life family medicine cases with high-yield discussions aligned to clerkship guidelines USMLE-style review questions and clinical pearls accompany each case Primer on how to approach clinical problems and think like an experienced doctor

Now in its third edition, this small and accessible guide contains essential information for the safe prescribing of the most commonly used drugs in the NHS. The Top 100 Drugs combines the best elements of a students' textbook with those of a prescribers' manual. It gives equal weight to essential information on the science of pharmacology as well as the real-world practicalities of prescribing, all in an accessible and clear format. Written by leaders in the field of clinical pharmacology, this popular book has been fully revised and updated to include the drugs used today, including monoclonal antibodies and antiviral drugs for COVID-19. With common indications, mechanism of action, adverse effects, important interactions and a clinical tip for each drug as well as questions to test knowledge, this book is key to helping students understand everything they need to know about the drugs they are likely to use in practice. Compact and easy to follow - can be carried around on the wards Logically ordered - offers multiple ways to find the drug you are looking for A Clinical Tip for each drug, drawn from the authors' experience 100 self-assessment questions to encourage integration and revision of knowledge and understanding Fully updated to include the most commonly prescribed drugs today, based on original research led by the authors of over 1 billion community prescriptions and approximately 1 million hospital prescriptions All drug monographs extensively reviewed and updated Dedicated section emergency drugs Updated self-assessment material, now including calculation and prescription-writing questions, in addition to single-best-answer questions

Do you want the task of keeping up-to-date to be enjoyable rather than a chore? Do you feel that you risk losing touch with advances occurring in medical specialties other than your own? If so, then keep reading.An Insider's Guide to the Medical Specialties is written to allow physicians of all grades to absorb knowledge with the minimum of effort, and a degree of pleasure. Generalists need to be skilled in the management of the early stages of a very diverse range of conditions. Never having heard of an investigation or hanging on to dated misconceptions about a patient's prognosis can be frustrating at best, and dangerous at worst. The aim of this book is to strike a balance between refreshing old knowledge and updating the reader on significant advances that have occurred in a particular specialty. Over forty consultants and trainees have contributed to An Insider's Guide to the Medical Specialties. The content will be of interest to consultants and trainees in the medical specialties, general practitioners, and others. At times entertaining, irreverent and controversial, this is not a book to be left nestling in the pocket of a white coat or gathering dust on a shelf.

This text is aimed at potential clinical investigators (usually physicians), especialy those thinking about doing clinical trials to evaluate new drugs - mostly sponsored by pharmaceutical companies. It is the attempt by one clinical investigator to share his experiences and insights, in the hope that other can share in the excitement of clinical research while avoiding some of the pitfalls that inevitably beset the clinical triallist. The book provides practical advice on how to interact with various "monitors", auditors and project leaders running the trial. It also gives advice on how to recruit patients to the trials. The author looks at subjects such as allocation of time, space and staff. This book is predominantly aimed at doctors performing clinical trials for pharmaceutical companies and will be of great help to Heads of Clinical Research in Pharmaceutical companies - also to academic staff in university clinical departments, particularly pharmacology.

Pocket Medicine, 8th Edition, is a must-have resource for fast answers to the diagnostic and therapeutic questions you'll face on rounds and exams. Edited by Dr. Marc S. Sabatine and compiled by residents, fellows, and attending physicians at the world-renown Massachusetts General Hospital, this best-selling reference provides dependable, up-to-date information needed to make an accurate diagnosis and develop a state-of-the-art treatment plan. Featuring easily accessible bulleted lists, tables, and algorithms, Pocket Medicine provides focused coverage of internal medicine in the traditional, easy-to-use binding you know and love. Offers fast and easy access to essential information on the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology. Includes references to landmark papers to help you intelligently answer questions on rounds-all from a trusted source acceptable for use on rounds. Features user-friendly tabs and a two-color design to help you find information quickly, as well as a full-color, 16-page insert featuring radiology and pathology images. Provides ideal coverage for medical students, interns, residents, advanced practice nurses, and PAs. Prepare for board exams! Mirroring the organization of Pocket Medicine, Pocket Medicine High-Yield Board Review features 500 practice questions so you can practice for your board exam.

How to Promote Wellbeing is a timely resource designed to help all healthcare practitioners promote and protect their own and their patients' wellbeing and mental health. Focusing on practical strategies and guidance, this much-needed book explores approaches for reducing burnout, managing stress, coping with pressure in healthcare settings, recognising signs of impaired decision-making, and much more. Written specifically for busy healthcare practitioners, the book offers focused and succinct chapters on topics ranging from behaviours to improve resilience and mindfulness, to approaches for maintaining work-life balance when confronted with excessive workloads and organisational pressures. Throughout the text, evidence-based tools and techniques are provided to improve the practitioner's health and facilitate the delivery of high-quality care. Covering a wide range of clinical situations and important issues, this book: Examines global, organisational, and individual problem factors affecting mental health and wellbeing Discusses the impacts of chronic stress, burnout, technological and environmental factors, work-associated trauma, and sources of wellbeing strain Identifies factors that negatively affect patients' wellbeing in hospital, clinic, and outpatient settings Offers guidance for emergencies and available resources for those in personal crisis Includes a mental health and wellbeing toolkit, including assessments and strategies How to Promote Wellbeing is indispensable reading for doctors, nurses, dentists, therapists, counsellors, and other clinicians and health professionals.

In this issue of Medical Clinics of North America, guest editors Drs. Anand V. Kulkarni and K. Rajender Reddy bring their considerable expertise to the topic of Hepatology: An Update. Top experts in the field cover key topics such as NAFLD; hepatic manifestations of a systemic illness; cirrhosis and portal hypertension; hepatic encephalopathy; ICU care of the patient with cirrhosis; hepatocellular carcinoma; liver transplantation for the non-hepatologist; and more. Contains 15 relevant, practice-oriented topics including the global burden of chronic liver disease; the rising epidemic of alcoholic hepatitis; inpatient hepatology consultation; frailty and sarcopenia; and more. Provides in-depth clinical reviews on hepatology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Advances in Clinical Chemistry, Volume 88, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.