This issue of Medical Clinics of North America, guest edited by Roy Colven, MD, is devoted to Dermatology. Articles in this issue include: Topical Therapy Primer for the Non-dermatologist; The Role of Biologic Therapies in Dermatology; Commonly Used Non-biologic Systemic Therapies in Dermatology; Diseases of Skin Appendages: Acne, Alopecia, and Hyperhidrosis; Common Procedures in Dermatology; Skin Cancer Epidemiology, Detection, and Management; Psoriasis and Cardiovascular Disease; Cutaneous Adverse Drug Reactions; Consultative Inpatient Dermatology; Approach to the Patient with Diffuse Blisters; Teledermatology; Nail Disease for the Primary Care Provider; Rheumatologic Skin Disease; and Common Pediatric Skin Diseases.

This issue of Medical Clinics, guest edited by Drs. Marc Shalaby and Edward Bollard, is devoted to Quality Patient Care: Making Evidence-Based, High Value Choices. Articles in this issue include: Cardiovascular testing in asymptomatic patients: carotid duplex, cardiac stress testing, screen for PVD; Utility of echocardiogram in the evaluation of heart murmurs; Evidenced-based recommendations for the evaluation of palpitations in the primary care setting; Radiologic evaluation of common orthopedic complaints: low back pain, non-traumatic knee/shoulder/hip pain, and ankle injuries; Indications and usefulness of common injections for non-traumatic orthopedic complaints - shoulder, trochanteric bursa, epidural injections, tennis elbow, and knee; The evidence-based evaluation of chronic cough; Evaluation of uncomplicated headache; Evaluation of syncope; Pre-operative assessment: Cataract surgery, pre-operative EKG testing, screening for cardiopulmonary disease, urinalysis, coagulation studies, other lab assessments; The approach to occult GI bleed; The role of EGD surveillance for patients with Barrett's esophagus; The evidence-based evaluation of iron deficiency anemia; Cancer screening in the elderly; Utilization and safety of common over the counter dietary/nutritional supplements, herbal agents and homeopathic compounds for disease prevention; Utilization of oxygen for the patient with dyspnea; IV fluids, enteral or parenteral nutrition; and Symptom control at the end of life.

1. Chronic Fatigue Syndrome in the Elderly: Another Geriatric Syndrome.- 2. Development of the 1994 Chronic Fatigue Syndrome Case Definition and Clinical Evaluation Guidelines.- 3. The Chronic Fatigue Syndrome: An Update on Important Issues.- 4. Efforts to Reduce Heterogeneity in Chronic Fatigue Syndrome Research.- 5. Nonrestorative Sleep, Musculoskeletal Pain, Fatigue, and Psychological Distress in Chronic Fatigue Syndrome, Fibromyalgia, Irritable Bowel Syndrome, Temporal Mandibular Joint Dysfunction Disorders (CFIT).- 6. Arguments for a Role of Abnormal Ionophore Function in Chronic Fatigue Syndrome.- 7. Cytokine Patterns Associated with Chronic Fatigue Syndrome.- 8. Chronic Fatigue Syndrome: Possible Integration of Hormonal and Immunological Observations.

Clinical decision support systems, medical applications, and electronic health records each help to ensure the provision of efficient, accurate healthcare services, thereby providing patients with a better experience and overall reducing health care costs. Advancing Technologies and Intelligence in Healthcare and Clinical Environments Breakthroughs is a prime resource for both academic researchers and practitioners looking to advance their knowledge of the interdisciplinary areas of healthcare information technology and management research. This book addresses innovative concepts and critical issues in the emerging field of health information systems and informatics, with an emphasis on sustainable computer information systems, ensuring healthcare efficiency, and denoising MRI and ECG outputs.

This issue of Medical Clinics of North America, guest edited by Paul S. Pottinger and Christopher A. Sanford, is devoted to Travel and Adventure Medicine. Articles in this issue include: Immunizations; Malaria; Personal Protection Measures; Traveler's Diarrhea; Urban Medicine and Trauma; Care of the Healthcare Provider; Evaluation of the Ill Returned Traveler; The Ethics of Medical Volunteerism; High-Altitude Medicine; Dive Medicine; Wilderness Medicine, Including First Aid & Hypo/Hyperthermia; The Medical Kit; Adventure Sports: Spelunking, water exposures; and Resources for the Provider and Opportunities in Further Training in Travel and Adventure Medicine.

Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic.

the Atlas of AIDS Co-infection illustrates imaging features and clinical outcomes of AIDS related diseases. The common/uncommon opportunistic infections and malignancies are well covered, including bacterial (e.g. Staphylococcus, Rhodococcus equi), fungal (e.g. Penicillium marneffei, Pneumocystis pneumonia, Pulmonary aspergillosis, Mucormycosis) and mycobacterial infections (Mycobacterium tuberculosis, Non-tuberculous Mycobacteria), lymphoma, as well as AIDS related disease in children with AIDS. Excellent photographs (X-ray and CT imaging) reveal the common imaging features of different diseases in different stages of treatment. Co-infections are common in the late stage of AIDS, consistent with considerable overlap of CT findings that are displayed in one single section and some of the cases in several sections. At last, there are excellent descriptions of differential diagnosis based on the same appearance (e.g. diffuse pulmonary miliary nodules, mediastinal and abdominal lymphadenopathy). Learning variety of different imaging will enrich the radiologists experience and knowledge about AIDS-related diseases, and also help clinicians making timely diagnosis and appropriate optimal treatment. It belongs in the library of each Radiologist, HIV expert and all of who care about Infectious Diseases.

This issue of Medical Clinics of North America, Guest Edited by Douglas S. Paauw, MD is devoted to Comprehensive Care of the Patient with Chronic Illness. Dr. Paauw has assembled a group of expert authors to review the following topics: Primary Care of the Homeless Patient; Primary Care of the Patient with Chronic Liver Disease; Primary Care of the Transplant Patient; Primary Care of the Patient with CRI; Primary Care of the Patient with Alcoholism; Primary Care of the Childhood Cancer Survivor; Primary Care of the Immigrant Patient; Primary Care of the HIV Patient; Primary Care of the Patient with Chronic Lung Disease; Primary Care of the Patient with Sarcoid; and Primary Care of the Patient with Inflammatory Bowel Disease.

Specialists join forces in this new volume to offer a complete, practical guide for understanding and treating obesity and eating disorders. The contributors provide a solid background on the problem, give relevant, detailed discussions of prominent issues, and suggest treatment methods from case studies. With this book in hand, professional counselors including social workers, psychologists, nutritionists, psychiatrists, nurses, dieticians, and health directors will have the information they need to handle specific problems of weight control.

Artists have always known intuitively what science is just beginning to discover: that creating a visual image through any medium can produce physical and emotional benefits for both the creator as well as those who view it. Most important, you don't need to think of yourself as an artist or even believe you have any "talent" to tap into the healing powers of art.

In this remarkable testament to the power of creativity, Barbara Ganim shows step-by-step how to use art to heal body, mind, and spirit. By using guided meditation and artistic techniques, you can gain insight and clarity into depression, anxiety, rage, and even illnesses, including cancer, arthritis, and AIDS.

At once inspirational and instructive, "Art and Healing" will teach you how to connect with negative, painful, and even repressed emotions and then express them through drawing, painting, sculpture, or collage. Releasing these feelings through the creative process frees up the immune system and clears the mind, allowing the body to fight off disease and begin to heal emotional wounds. Filled with actual stories from those who have triumphed over adversity and with more than a hundred different pieces of artwork created using this groundbreaking method, "Art and Healing" is sure to provide the tools needed for healing body and spirit.

Cord Blood Stem Cells and Regenerative Medicine discusses the current applications for cord blood stem cells and techniques for banking cord blood. Cord blood, blood from the umbilical cord and placenta of an infant, represents an alternate source of stem cells that can be used to treat a myriad of disorders. Cord blood stem cells are being used more frequently and studied more seriously, as evidenced by the explosion of scientific literature on the topic. Currently, clinical and pre-clinical trials are being done in the field, treating conditions as severe as heart failure. Coupled with regenerative medicine, cord blood stem cells potentially carry the future of research and medicine in treating tissue damage, genetic disorders, and degenerative diseases. Read about new applications for cord blood stem cells and new techniques for banking cord blood - the future of regenerative medicine therapy.

Evidence synthesis is the evaluation or analysis of research evidence and opinion on a specific topic to aid in decision-making in health care. Although the science of evidence synthesis has developed most rapidly in relation to the meta-analysis of numerical data linked to theories of cause and effect, the further development of theoretical understandings and propositions of the nature of evidence, its role in health care delivery, and the facilitation of improved global health have increased rapidly since 2000. The articles appearing in this issue examine the role of evidence synthesis in nursing and health care and are written by expert translational scientists from across the world. Three introductory articles overview evidence synthesis and its role in evidence-based health care; methods, issues, and trends in the systematic review of health care evidence; and the development of a robust evidence base for nursing. Subsequent articles explore the impact of systematic reviews on policy and practice in a variety of settings, including perioperative care, pediatrics, rehabilitation and long-term/continuing care, mental health, and public health. The final articles discuss the impact of evidence on health policy and practice and the complexities of translating evidence into policy and practice. These articles show the importance of synthesizing evidence and translating policy and practice into action in our quest to improve health care and health outcomes.

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics.

The sodium channel, a ubiquitous member of the cardiac, neural, and muscular conduction systems, has been implicated in the pathogenesis of an array of human diseases. Mutations associated with the cardiac sodium channel are responsible for a wide spectrum of disorders. The cardiac sodium channel and associated disorders are comprehensively examined in this issues of the Cardiac Electrophysiology Clinics.

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.
First of two volumes focusing on protein kinase inhibitors in research and medicinePart of the Methods in Enzymology serial with authors who are experts in their disciplines

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation.

This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics of North America serves as an aid to identification of 70 of the more important head and neck syndromes, and organized using the same nosology as in the landmark text of Robert Gorlin. As such, it should be useful to a varied audience, including not only the oral and maxillofacial surgeon but also the oral pathologist, the practitioner of oral medicine, and members of the craniofacial team--the orthodontist, pediatric dentist, speech and language specialist, geneticist, plastic surgeon, ENT specialist, pediatrician, nurse coordinator, and others. Areas covered include: Craniosynostosis Syndromes; Syndromes Affecting Bone; Metabolic and Autoimmune Syndromes; Syndromes Affecting Skin and Mucosa; Hamartoneoplastic Syndromes; Branchial Arch Syndromes; Clefting Syndromes; Syndromes Affecting the Central Nervous System; Chromosomal Syndromes; Syndromes with Unusual Facies; and Syndromes with Unusual Dental Findings or Gingival Components.

This issue begins with an overview that distinguishes evidence-based practice (EBP) and translation science, followed by a description of Hawaii's statewide EBP program that uses active and multifaceted translation science strategies to facilitate the rate and extent of adoption of EBP changes. With one exception, the remaining articles describe individual EBP projects from five different health care facilities that used the Iowa Model to guide their work. Each article includes an evidence summary, a description of implementation strategies, an evaluation of the innovation, and lessons learned. These completed projects were initiated between 2009 and 2012, address a variety of topical nursing issues, and, for the most part, focus on preventing complications (ie, blood sugar elevations, increased lengths of stay, extubation failures, noise-related injury, pain, surgical site infections, pneumonia, restraint use, delirium, and fever). An additional article describes the use of evidence to inform simulation-based learning, a possible strategy for ensuring competencies in and compliance with EBP interventions. Nursing leaders will come away with solid information about utilizing EBP to improve patient outcomes. The Hawaii program demonstrates that health care quality can be realized by employing the best available evidence and empowering the nursing workforce. It also offers a glimpse of the care that the future nursing workforce could provide to create a health system that provides accessible, affordable and quality care to everyone in the United States.