Written specifically for the conventional medical healthcare provider, Medicinal Herbs in Primary Care forms an integral part of the primary care tool belt. Through a series of system-based disease tables, this unique title provides quick, authoritative guidance for the busy practitioner whose patient is requesting guidance on medicinal herbs. The disease tables are supported by herbal monographs that provide expanded details of the available preclinical and clinical evidence laid out in a system-based sequence. Together with the section on herbal basics, this practical reference contains the information today's medical healthcare providers need to develop familiarity with and confidence in the prescription of medicinal herbs. Provides quick answers and evidence-based prescribing guidance for medicinal herbs while also addressing complexities and co-morbidities in patient care. Features 48 system-based disease tables that identify herbs based on strength of evidence and indicate the scope of potential benefits for other conditions the patient may have. Includes 55 monographs for the most common medicinal herbs, with safety and precaution guidelines, summaries of preclinical and clinical trials, chemical constituents and actions, and prescription options for each. Contains an introductory section on the basics of medicinal herbs that dispels common misconceptions regarding herbal medicine. Discusses key topics such as herb-drug interactions, and includes information on SARS-COV-2 where appropriate. Uses typical medical abbreviations throughout for ease of use, and provides a glossary of terms for non-medical and alternative health care providers. Helps conventional medical practitioners partner with patients to determine safe herbal options when appropriate, and ensure safety and efficacy of herbal use. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from $200 million in 1950 to $1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of "magic bullets", we must now apply "magic strategies" that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies.

The scope and significance of cytoplasmic inheritance has been the subject of one of the longest controversies in the history of genetics. In the first major book on the history of this subject, Jan Sapp analyses the persistent attempts of investigators of non-Mendelian inheritance to establish their claims, in the face of strong resistance from nucleo-centric geneticists and classical neo-Darwinians. A new perspective on the history of genetics is offered, as he explores the oppositions which have shaped theoretical thinking about heredity and evolution throughout the century: materialism/vitalism, reductionism/holism, preformation/epigenesis, neo-Darwinism/neo-Lamarckism, gradualism/saltationism.

Behavioural science to develop effective health professional education serves as a practical guide in the cutting-edge area of health professional education and behavioural science. This textbook will provide practical evidence-based guidance to enhance the real world impact of your health professional training, To aid in seamless reader comprehension, chapters work through clear step by step stages, with boxes to verify understanding, along with examples to work through and links to further reading if readers want to understand more about underlying theory. The book also contains a series of templates which can be adapted for use by the reader. Sample topics covered in Behavioural Science to develop effective health professional education include: Education and training as a behaviour change intervention, covering language of learning and behaviour change, with examples of behaviour change intervention approaches Defining the behaviours that you want to change, intended behavioural outcomes (IBOs), and specifying your IBOs Exploring the influences on behaviours, covering Influences on practice, and how to explore influences on each IBO Developing training to change behaviour, covering active ingredients of behaviour change activities, and the process of creating behaviourally informed training For postgraduate and undergraduate health professional courses, continuing professional development providers, and providers of health professional training in medicine, nursing, dentistry, and allied health professions, Behavioural Science to develop effective health professional education is an essential resource on the subject that helps make education and training more effective.

This volume provides a selection of chapters on new developments in various areas of clinical medicine, including dental, surgery, and general practice. These scientific chapters analyze the diagnostic processes and inform of new and novel diagnostic techniques. This book is divided into two sections; the first section contains review papers and includes an overview of experimental and clinical medicine, explaining its history to modern times. The second section presents a selection of original research papers from respected authors on a variety of topics.

The first edition of Genomics and Clinical Medicine provided an overview of genomics-based advances in disease susceptibility, diagnosis, and prediction of treatment outcomes in various areas of medicine. Since its publication, the science of genomics has made tremendous progress, and exciting new developments in biotechnology and bioinformatics have created possibilities that were inconceivable only a few years ago. This completely revised second edition of Genomic Medicine reflects the rapidly changing face of applied and translational genomics in the medical and health context and provides a comprehensive coverage of principles of genetics and genomics relevant to the practice of medicine. The first section lays foundation to the practice of genomic medicine. New chapters in this section include bioinformatics, proteomics, microbial genomics and genomic education. Detailed discussions of genetic/genomic testing and screening and the ethical, legal, and social issues (ELSI) crucially address genethics and genomethics in the practice of Genomic Medicine. The second section includes clinical practice oriented chapters highlighting genomic applications (array comparative genomic hybridization, exome genome sequencing and new generation generation sequencing) in clinical diagnosis of congenital developmental malformations, Mendelian genetic disorders, and complex cardiovascular, neuro-psychiatric, ophthalmic, dermatologic, inflammatory and pediatric disorders. Separate chapters discuss microbial genomics with emphasis on the role of genomics in targeted antimicrobial therapy and development of genomic class of new vaccines. New developments in gene/ cell-based somatic therapy, regenerative medicine and targeted molecular therapy are discussed in respective chapters. All chapters are thoroughly indexed and supported by a carefully compiled glossary relevant to genetic and genomic medicine.

Cessation of tobacco use is the need of the hour given that it is the single largest cause of disease and premature death in the world. This book covers epidemiology and risks, user classification, nicotine replacement therapy, pharmacological aids, behavioral modification and patient counseling techniques, along with personalized action plan development. Key Features Covers all aspect of tobacco cessation. Provides guidance on differential diagnosis and includes useful decision-making flowcharts. Provides step-by-step guidance to counsel tobacco users in routine clinical practice. Discusses the process of setting up a cessation centre. Facilitates in-depth understanding of the subject through case studies at the end of each chapter

In the age of genomics, oncogenetics is a growing discipline. It is defined as the identification and management of families where there is a suspected hereditary risk of cancer. This relatively new discipline is part of a modern medicine that aims to be both preventive and predictive. Constitutional Oncogenetics gives precise descriptions of the main syndromes that cause a predisposition for cancer. The first part examines the most common syndromes in the majority of the world, including the heightened hereditary risk of breast and ovarian cancer and Lynch syndrome. The second part introduces less common infracentesimal syndromes, such as Bloom syndrome and Fanconi syndrome. This book is intended for oncogenetic practitioners and other specialists, as well as medical students.

Clinical medicine, as a thinking discipline, is concerned not only with what clinicians do, but why. When physicians act in medicine they have some purpose or goal in mind. What they actually do and how they go about it is in the service of their purposes and their goals. Such goals cover a wide range of topics centering on patients, the doctor-patient relationship, the acts of doctoring patients, and the goals involved in being a physician among other physicians working within the institutions of medicine. The Nature of Clinical Medicine takes its direction from a catalog of goals of medicine that range from the expected diagnosis and treatment of diseases to wider concerns for patients, for physicians, and for medicine itself. The chapters are specific in teaching the kinds of knowledge that clinicians require in order to be able to achieve these goals. The central focus of the clinician and of this book is the patient. According to Eric Cassell, everything else, including the disease, is secondary. Using many examples from real-life medical practice, each chapter examines the different kinds of thought involved in caring for the patient. Cassell takes on a variety of difficult issues, from thinking about values to developing wisdom. The care of the dying, what thinking itself is, and finally, why would one want to do this exciting and rewarding but difficult work, come under discussion in this book.

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

The Understanding the Prostate chart is an overview of a component of the male reproductive system. Zones of the prostate are shown, along with a diagram of a digital rectal exam. Additional graphics and text describe prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer. Heavy cover stock with protective varnish for durability.

There is no single truth regarding the recognition and management of IBD. In this regards the old dictum "there is no disease but the patient" should be the golden rule. Nowadays, more complicated Crohn's disease cases at relatively young ages are not unusual. Various clinical and extraintestinal manifestations have been seen rarely until now. The evolution of the therapeutic armamentarium is now a double-edged sword since "more drugs" may mean "more side-effects, less compliance and a more critical attitude of health authorities towards the cost of treatment". Education of the patient and the family, creation of empathy and a positive rapport with the patient and a careful analysis of confounding/contributing factors to the disease behaviour are essential elements of optimal therapy of IBD patients. This book contains the proceedings of Falk Symposium 159, entitled IBD 2007 -- Achievements in Research and Clinical Practice, held in Istanbul, Turkey, on May 4--5, 2007, where opinion leaders with worldwide reputations discuss IBD and related issues in a less well-known part of the world with respect to prevalence, disease behaviour and patient characteristics, as well as the difficulties faced in differential diagnosis and management.

Following the familiar, easy-to-use at a Glance format and in full-colour, Pathology at a Glance is an accessible introduction and revision text for medical students. Reflecting changes to the curriculum content and assessment methods employed by medical schools, this new edition provides a user-friendly overview of pathology to encapsulate all that the student needs to know. Pathology at a Glance, Second Edition: Addresses the key principles of pathology that are central to medicine Contains full-colour artwork throughout, making the subject easy to understand Presents schematic diagrams on the left page and concise explanations on the right Is divided into three sections, covering general and systematic pathology and clinical case examples Contains self-assessment material, including 10 structured case study questions Covers general pathology mechanisms and the clinical pathology of body systems Provides key information on the epidemiology, pathogenesis and clinical features of the major diseases Revision of many chapters, particularly gynaecological pathology, acute cardiac syndromes, paediatric tumours and haematopathology This book is an invaluable resource for all medical students, of equal benefit for those starting their study of pathology or approaching finals; for junior doctors approaching their membership exams and anybody who needs a handy reference.

This unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement's founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today's modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks to the future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an "insider's" tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.

This issue of Medical Clinics, guest edited by Dr. Robert A. Smith and Dr. Kevin Oeffinger, is devoted to Cancer Screening and Prevention. Articles in this important issue cover the development of cancer screening guidelines, implementing cancer screening in the clinical setting, and screening for colorectal, lung, cervical, prostate, skin, and ovarian cancer.

Practical Transfusion Medicine Practical Transfusion Medicine, Sixth Edition The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

From insulin comas and lobotomy to incarceration; those who suffered bipolar disorder endured dangerous, ineffective treatments for centuries until a breakthrough in the 1950s offered salvation. Lithium's efficacy at both ending and preventing manic depressive episodes was discovered by John Cade, whose years running a psychiatric ward as a prisoner of war sparked a hunch that put him on the path to revelation. The miraculous metal has since salvaged an untold number of lives but even after its healing power was discovered, it was decades before the medical community could be convinced that lithium was not only safe but life-saving. Walter A. Brown reveals how close we came to missing out on this extraordinary drug and showcasing the possibilities of scientific curiosity.

Welcome to the Clinics Collections! We have taken a multidisciplinary approach and selected the most recent and vital articles throughout all of our Clinics series and combined them into a single source on Precision Medicine. Articles are featured from multiple Clinics to highlight the range of specialties covering this major medical issue. Such information is essential to successful interdisciplinary teamwork and patient care. The articles within, written from different medical perspectives, will give deeper insight into how each specialty cares for its patients. The challenge in Precision Medicine involves specialized treatment planning with the ultimate goal of successful patient outcomes. The articles selected provide a unique entry into sharing best concepts for the entire medical team to learn and implement. Areas of focus include breast cancer, lung cancer, melanoma, arthritis, sleep medicine, and pediatric oncology. Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format.

Well over two million medical students, doctors and other health professionals around the globe have owned a copy of Davidson's Principles and Practice of Medicine since it was first published over 70 years ago. Now in its 24th Edition, this thoroughly updated textbook describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine, and explains how to recognise, investigate, diagnose and manage them. Taking its origins from Sir Stanley Davidson's much-admired lecture notes, Davidson's has endured because it keeps pace with how modern medicine is taught and provides a wealth of trusted information in an easy-to-read, concise and beautifully illustrated format. Key features: Part 1 'Fundamentals of Medicine' - provides an account of the principles of genetics, immunology, infectious diseases, population health, oncology and pain management, along with a discussion of the core principles behind clinical decision-making and good prescribing. Part 2 'Emergency and Critical Care Medicine' - covers medical emergencies in poisoning, envenomation and medicine in austere environments, as well as common presentations in acute medicine and the recognition and management of the critically ill. Part 3 'Clinical Medicine'- covers the major medical specialties, each thoroughly revised and brought fully up to date. A new section on COVID-19 has been added and the impact of this infection is described throughout the book. Clinical Examination overviews - extended and updated to summarise the main elements for each system. Presenting Problems sections - provide a clear pathway for the assessment of and approach to the most common complaints in each specialty. Practice Point summaries - detail the practical skills that medical students and junior doctors must acquire. Emergency boxes - emphasise the core knowledge needed to manage acutely ill patients. In Old Age, In Pregnancy and In Adolescence boxes - highlight differences in the practice of medicine in these patient groups, and illustrate the interfaces between medical, obstetric and paediatric services. The text is extensively illustrated - with over 1000 diagrams, clinical photographs, and radiology and pathology images. The global perspective is enhanced by an International Advisory Board of experts from 11 countries and by leading authors from around the world. The complete, downloadable eBook version is included with your (print copy) purchase - for easy access on your portable device, anytime, anywhere! Now enhanced with: NEW interactive self-assessment material - over 150 Questions and Answers test your understanding of chapter key points and aid efficient exam preparation Davidson's will serve readers everywhere as a core text that integrates medical science with clinical medicine, conveying key knowledge and practical advice in a highly accessible and readable format. REVIEWS Beautifully constructed with superb clarity of style - Davidson's continues to provide for students, doctors and other health professionals a sound basis for the practice of medicine. Royal Society of Medicine and Society of Authors Medical Book Awards This book comes through where others fail: an excellent textbook, easy to read and superb value. British Medical Journal

**Finalist, PROSE Award in Clinical Medicine** A rich examination of the history of trans medicine and current day practice Surfacing in the mid-twentieth century, yet shrouded in social stigma, transgender medicine is now a rapidly growing medical field. In Trans Medicine, stef shuster makes an important intervention in how we understand the development of this field and how it is being used to "treat" gender identity today. Drawing on interviews with medical providers as well as ethnographic and archival research, shuster examines how health professionals approach patients who seek gender-affirming care. From genital reconstructions to hormone injections, the practice of trans medicine charts new medical ground, compelling medical professionals to plan treatments without widescale clinical trials to back them up. Relying on cultural norms and gut instincts to inform their treatment plans, shuster shows how medical providers' lack of clinical experience and scientific research undermines their ability to interact with patients, craft treatment plans, and make medical decisions. This situation defies how providers are trained to work with patients and creates uncertainty. As providers navigate the developing knowledge surrounding the medical care of trans folk, Trans Medicine offers a rare opportunity to understand how providers make decisions while facing challenges to their expertise and, in the process, have acquired authority not only over clinical outcomes, but over gender itself.

Clinical trials are an important part of medicine and healthcare today, deciding which treatments we use to treat patients. Anyone involved in healthcare today must know the basics of running and interpreting clinical trial data. Written in an easy-to-understand style by authors who have considerable expertise and experience in both academia and industry, this book covers all of the basics of clinical trials, from legal and ethical issues to statistics, to patient recruitment and reporting results.
*Jargon-free writing style enables those with less experience to run their own clinical trials and interpret data.
*Book contains an ideal mix of theory and practice so researchers will understand both the rationale and logistics to clinical trial medicine.
*Expert authorship whose experience includes running clinical trials in an academic as well as industry settings.
*Numerous illustrations reinforce and elucidate key concepts and add to the book's overall pedagogy.

Clinicians at all levels must consider a myriad of tests in the diagnostic process, requiring an up-to-date understanding of changing technology and the demands of time- and cost-efficiency. Ferri's Best Test, 5th Edition, is a unique, easy-to-use guide that simplifies complex information and helps you choose the best test to supplement your clinical diagnostic skills. It includes both lab and imaging tests for concise, convenient access to all diagnostic test options for more than 200 common diseases and disorders. . Practical, concise, spiral-bound, and pocket-sized-designed from cover to cover for quick, on-the-go reference. . Three convenient sections provide quick access to key information on clinical laboratory testing, diagnostic imaging, and diagnostic algorithms. . New and updated content on cardiac computed tomography angiography, computed tomography perfusion imaging, COVID-19, and much more. . Coverage of 23 new laboratory tests and 14 new diseases and disorders. . Essential information on indications, advantages, disadvantages, approximate costs, normal ranges, typical abnormalities, likeliest causes, and more. . Experienced author Dr. Fred Ferri uses a unique, easy-to-follow format to simplify complex information and help you choose the best test for every patient. . New appendices on electrocardiography and respiratory testing and function. . Comparison tables and illustrations help improve your test selection. . Enhanced eBook version included with purchase. Your enhanced eBook includes an image collection with access on a variety of devices.

This issue of Foot and Ankle Clinics, guest edited by Dr. Andy Molloy, will discuss Correction of Severe Foot and Ankle Deformities. This issue is one of four selected each year by long time series Consulting Editor, Dr. Mark Myerson. Topics in this issue will include: Correction of severe hallux valgus with metatarsus adductus; Treatment of stage IV flatfoot; Reconstruction of severe ankle and pilon fracture malunions; Multiplanar deformity correction using patient specific guides; Managing severe malunited calcaneus fractures; Correction of the neglected clubfoot in the adolescent and adult patient; Surgical strategies in Hereditary Sensory Motor neuropathy; An approach to managing midfoot Charcot deformities; My algorithm for treating hindfoot and ankle Charcot deformity; Strategies for salvage arthrodesis following failed total ankle replacement; among others.

The pathophysiology of sepsis can be regarded as a series of steps, beginning with the invasion of normally sterile tissue by microbes and the elaboration of various pro-inflammatory mediators. The final common pathway is often the development of the multiple organ dysfunction syndrome (MODS). Whereas a great deal has been learned during the past quarter century about the inflammatory processes associated with sepsis (and other related conditions, such as ischemia/reperfusion injury), our understanding is far less developed with respect to the pathophysiological events that lead to organ dysfunction under these conditions. Nevertheless, efforts by both clinical and laboratory scientists are leading to new knowledge in this area. The chapters in this volume provide a state-of-the-art overview of many aspects of the pathophysiology of organ dysfunction in critical illness.

This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.