Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods.

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation.

Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS). Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS. Highlights include: the definition, epidemiology, pathology, and pathogenesis of ARDS complications such as transfusion-related injury, and endothelium and vascular dysfunction the long-term outcomes of ARDS host defense and infection the latest developments in ARDS therapy: glucocorticoid therapy, surfactant therapy, mechanical ventilation, and mesenchymal stem cells predictive factors: gene expression profiling and biomarkers, and chemokines and cytokines advances in management strategies: fluid management, non-pulmonary and non-sepsis management, and glucose control

Fe-S Cluster Enzymes, Part A, Volume 595 is the first of two volumes focused on Fe-S cluster enzymes. New topics of note in this series include Electrochemistry of Fe/S Proteins, Genetic, biochemical and biophysical methods for studying Fe-S proteins and their assembly, Fluorescent reporters to track Fe-S cluster assembly and transfer reactions, Mechanism-based strategies for structural characterization of radical SAM reaction intermediates, Purification and Characterization of Recalcitrant Cobalamin-Dependent Radical S-adenosylmethionine Methylases, A polymerase with potential: the Fe-S cluster in Human DNA Primase, In Vitro Studies of Cellular Iron-sulfur Cluster Biosynthesis, Trafficking and Transport, and Fe-S cluster Hsp70 Chaperones: the ATPase cycle and protein interactions.

General practitioners and other primary care professionals have a leading role in contemporary health care, which Trisha Greenhalgh explores in this highly praised new text. She provides perceptive and engaging insights into primary health care, focussing on:

- its intellectual roots
- its impact on the individual, the family and the community
- the role of the multidisciplinary team
- contemporary topics such as homelessness, ethnic health and electronic records.

Concise summaries, highlighted boxes, extensive referencing and a dedicated section on effective learning make this essential reading for postgraduate students, tutors and researchers in primary care.

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From the foreword by Julian Tudor Hart
""Trish Greenhalgh, in her frequent columns in the British Medical Journal...more than any other medical journalist spoke to her fellow GPs in the language of experience, but never without linking this to our expanding knowledge from the whole of human science."

"When I compare the outlines of primary care so lucidly presented in this wonderful book, obviously derived from rich experience of real teaching and learning, with the grand guignol theatre of London medical schools when I was a student 1947-52, the advance is stunning.""

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""Trish Greenhalgh is one of the international stars of general practice and a very clever thinker. This new book is a wonderful resource for primary health care and general practice. Every general practice registrar should read this book and so should every general practice teacher and primary care researcher.""

Professor Michael Kidd, Head of the Department of General Practice, University ofSydney and Immediate Past President of The Royal Australian College of General Practitioners

""This important new book by one of primary care's most accomplished authors sets out clearly the academic basis for further developments in primary health care. Health systems will only function effectively if they recognise the importance of high quality primary care so I strongly recommend this book to students, teachers, researchers, practitioners and policy makers.""

Professor Martin Marshall, Deputy Chief Medical Officer, Department of Health, UK

Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions.

Clinical Skills for Healthcare Assistants and Assistant Practitioners is an accessible, easy-to-read guide, outlining the fundamental and core skills integral to clinical practice. Fully updated in its second edition, this book is divided into three sections; the first looks at fundamental skills applicable to all staff, such as accountability, communication and record keeping. Section two explores core clinical skills such as respiratory care, pulse, blood glucose management and catheter care. Section three outlines complex clinical skills that require more in-depth training, such as medication and intravenous cannulation. An invaluable resource for healthcare assistants and assistant practitioners, this book will also be of use to newly qualified practitioners, and students in health and social care.

Key Advances in Clinical Informatics: Transforming Health Care through Health Information Technology provides a state-of-the-art overview of the most current subjects in clinical informatics. Leading international authorities write short, accessible, well-referenced chapters which bring readers up-to-date with key developments and likely future advances in the relevant subject areas. This book encompasses topics such as inpatient and outpatient clinical information systems, clinical decision support systems, health information technology, genomics, mobile health, telehealth and cloud-based computing. Additionally, it discusses privacy, confidentiality and security required for health data. Edited by internationally recognized authorities in the field of clinical informatics, the book is a valuable resource for medical/nursing students, clinical informaticists, clinicians in training, practicing clinicians and allied health professionals with an interest in health informatics.

Data Literacy: How to Make Your Experiments Robust and Reproducible provides an overview of basic concepts and skills in handling data, which are common to diverse areas of science. Readers will get a good grasp of the steps involved in carrying out a scientific study and will understand some of the factors that make a study robust and reproducible.The book covers several major modules such as experimental design, data cleansing and preparation, statistical analysis, data management, and reporting. No specialized knowledge of statistics or computer programming is needed to fully understand the concepts presented. This book is a valuable source for biomedical and health sciences graduate students and researchers, in general, who are interested in handling data to make their research reproducible and more efficient.

The Orthopedic Examination. Evaluation of the Child with Extremity Pain. Musculoskeletal Manifestations of Child Abuse. Developmental Orthopedics. Caring for the Child with Motor Delay. Congenital and Related Defects of the Skeleton. Abnormalities of Skeletal Growth. Sports Injuries in Children. Spinal Disease in Childhood Musculoskeletal Trauma. Evaluating the Child with Arthritis. Index.

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease.

The median age of survival for those with cystic fibrosis has risen considerably in recent years. This text thoroughly examines the developments and breakthroughs which have led to this improvement in life expectancy. With a focus on the latest discoveries in the diagnosis and treatment of the disease, this book provides a comprehensive overview of the past, current and forthcoming advancements in cystic fibrosis research and clinical care.

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. Chapters include Rheumatology; Infectious Disease; Hematology and Oncology; Kidney, Water, and Electrolytes; Pulmonary Disease; Heart and Cardiovascular Disease; The Digestive System; and Endocrinology, Diabetes, and Metabolism.

This second edition of the highly successful Easy Guide to OSCEs for Clinical Specialties provides a comprehensive yet succinct resource to get you through each clinical rotation, as well as the Final exam. Compiled by recently qualified doctors who have experienced the new OSCE system first hand, the book covers over 80 OSCE examination stations in a wide range of different subjects. Brand new to this edition are chapters on Psychiatry, non-accidental injury in children, and an 'On the Wards' section covering both Anaesthetics and Palliative Care. All management suggestions are updated in line with NICE guidance and evidence-base, and new time-saving, student friendly mnemonics have been added to make the book even more user-friendly. This book will ease the already burdensome workload of medical students, and help them pass their OSCEs to become junior doctors competent in a wide range of different skills in medical fields.

Enduring Change in Eating Disorders provides a unique perspective on the successful treatment of eating disorders, which are among the most debilitating and recalcitrant psychiatric diseases. Unique in the field, this book details effective Structural Family Therapy with qualitative follow-ups of up to 20 years. A practical approach providing concrete tools to the clinician to creating change that holds over time with bulimia, anorexia, and compulsive overeating. The text draws on cases from the author's practice of over twenty-five years and follows his approach in the theoretical tradition of Intensive Structural Family Therapy (IST). Chapters discuss the nature and significance of eating disorders, a review of current treatment approaches, and the importance of the family in the therapeutic process. Cases of eating disorders in youths and adults are provided as well as instances of bulimia, anorexia, and compulsive overeating. Three appendices provide the reader with information regarding the scientific basis of the IST model, the effectiveness of the approach in treating conditions other than eating disorders and preventing eating disorders.

This issue of Medical Clinics, guest edited by Drs. Scott Kahan and Robert Kushner, is devoted to Practice-Based Nutrition Care. Articles in this outstanding issue include: Principles and Practice of Nutrition Assessment in Primary Care; Principles and Practice of Nutrition Counseling and Behavioral Medicine in Primary Care; Nutrition for the Prevention of Chronic Disease; Nutrition Recommendations in Pregnancy and Lactation; Nutrition Recommendations in Children; Nutrition Recommendations in Elderly and Aging; Nutrition Interventions for Cardiovascular Disease; Nutrition Interventions for Renal Disease; Nutrition Interventions for Diabetes Mellitus and Metabolic Syndrome; Nutrition Interventions for Chronic Liver Disease and NAFLD; Nutrition Interventions for Obesity; and Nutrition Interventions for Cancers.

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book's educational utility.

1. Chronic Fatigue Syndrome in the Elderly: Another Geriatric Syndrome.- 2. Development of the 1994 Chronic Fatigue Syndrome Case Definition and Clinical Evaluation Guidelines.- 3. The Chronic Fatigue Syndrome: An Update on Important Issues.- 4. Efforts to Reduce Heterogeneity in Chronic Fatigue Syndrome Research.- 5. Nonrestorative Sleep, Musculoskeletal Pain, Fatigue, and Psychological Distress in Chronic Fatigue Syndrome, Fibromyalgia, Irritable Bowel Syndrome, Temporal Mandibular Joint Dysfunction Disorders (CFIT).- 6. Arguments for a Role of Abnormal Ionophore Function in Chronic Fatigue Syndrome.- 7. Cytokine Patterns Associated with Chronic Fatigue Syndrome.- 8. Chronic Fatigue Syndrome: Possible Integration of Hormonal and Immunological Observations.

Containing papers carefully compiled for both their historical importance and contemporary relevance, Family Medicine: The Classic Papers brings together a team of experts, led by global family medicine leaders Michael Kidd, Iona Heath and Amanda Howe, who explain the importance of each selected paper and how it contributes to international health care, current practice and research. The papers demonstrate the broad scope of primary health care delivered by family doctors around the world, showcasing some of the most important research ever carried out in family medicine and primary care. This unique volume will serve as an inspiration to current family doctors and family medicine researchers and educators, as well as to doctors in training, medical students and emerging researchers in family medicine.