Part of the Masterpass series, Focused clinical Assessment in 10 Minutes for MRCGP is the definitive study guide for GP trainees at any stage of their specialist training, in particular, those preparing for the CSA. This comprehensive yet straightforward book provides a unique structure for the focused clinical assessment and a new approach to the management of everyday problems encountered in general practice, in 10 minutes. It bridges the gap between consultation theory and the real world; combining language, motivation, knowledge and empathy, enabling GP trainees to gather information, organise their thoughts, pinpoint a diagnosis and communicate this to both patient and examiner.

There is a paucity of high-value examination-style questions for final-year medical undergraduates. This book uses true (and modified) clinical scenarios (for realism), appropriate and pragmatic clinical questions (for clinical reasoning), and provides readers with explanations and tips in solutions (for self-reflection). The good reception received from Vol. 1 is the main stimulus for this Vol. 2.The book will useful for:

There is a paucity of high-value examination-style questions for final-year medical undergraduates. This book uses true (and modified) clinical scenarios (for realism), appropriate and pragmatic clinical questions (for clinical reasoning), and provides readers with explanations and tips in solutions (for self-reflection). The good reception received from Vol. 1 is the main stimulus for this Vol. 2.The book will useful for:

This issue of Medical Clinics, Guest Edited by Dr. Kerry B. Dunbar, is devoted to Gastroenterology. Articles in this issue include: Proton Pump Inhibitors: What the Internist Needs to Know; Management of Refractory GERD; Colonoscopy, Polypectomy, and the Risk of Bleeding; Pancreatic Cysts: Sinister Findings or 'Incidentalomas'?; The Future of Non-Alcoholic Fatty Liver Disease Treatment; Effective Treatments for Irritable Bowel Syndrome; The Revolution in Treatment of Hepatitis C; Diet and the Role of Food in GI Symptoms; Eosinophilic Esophagitis; Colorectal Cancer Screening: Is Colonoscopy the Best Option?; Celiac Disease and Gluten Sensitivity; Management of Chronic Pancreatitis; and Helping Patients with Gastroparesis.

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the "research" that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection.

Guest edited by Drs. Jonathan Essary Becker and Christopher Todd Maley, this issue of Child and Adolescent Psychiatric Clinics will cover several key areas of interest related to Neuromodulation in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Articles in this issue include: Ethical/Legal issues with neuromodulation, Pediatric anesthesia and ECT, TMS, depression, and adolescents, Psychosis and ECT in children/adolescents, Anti-NMDA receptor encephalitis and ECT, Autism and ECT, Catatonia and children/adolescents and ECT, and Transcranial direct current stimulation.

Hyponatremia is a common electrolyte disorder found in a variety of settings. Manifestations range from subtle abnormalities to convulsions and death. New treatment options, such as Antidiuretic Hormone (ADH) antagonists, have created the need for a resource presenting the latest evidence and clinical approaches. Hyponatremia: Evaluation and Treatment is a comprehensive review of hyponatremia, with an emphasis on managing this disorder from diagnosis to treatment. The incidence and occurrence of acute and chronic hyponatremia in general terms are covered, as well as disorders of the central nervous system, heart and liver with their relation to hyponatremia. Common clinical scenarios are presented along with both traditional and new methods of treatment. Authored by experts on this disorder from around the world, experienced members of the medical community and trainees alike will find Hyponatremia as an indispensible guide to diagnosis, managing and treating patients with hyponatremia.

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations. Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbations: is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use examines current and breakthrough pharmacologic and non-pharmacologic treatments includes COPD-causing exacerbations such as viral and bacterial infections discusses the negative environmental factors relating to COPD

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

This issue of Medical Clinics, guest edited by Dr. Cheston B. Cunha, is devoted to Antimicrobial Stewardship. Articles in this issue include: Principles of Antimicrobial Stewardship; Antibiotic Resistance in Stewardship; Therapy of Resistant Organisms: A Stewardship Approach; Optimal Antibiotic Dosing Strategies; The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship; Role of Education in Antimicrobial Stewardship; Role of the Hospital Epidemiologist in Antimicrobial Stewardship; Role of the Clinical Microbiology Laboratory in Antimicrobial Stewardship; Role of New and Rapid Diagnostics In Antimicrobial Stewardship; Antimicrobial Stewardship in the Community Hospital; Antimicrobial Stewardship in Long-Term Care Facilities; Role of the Pharmacist in Antimicrobial Stewardship; Pharmacoeconomic Considerations of Antimicrobial Stewardship Programs; Principles of IV-to-PO Switch and PO therapy; Role of Technology in Antimicrobial Stewardship; and Metrics of Antimicrobial Stewardship Programs.

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Physical Diagnosis Secrets, 3rd Edition, offers practical, up-to-date coverage of the full range of essential topics in physical diagnosis and health assessment. This highly regarded resource features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series (R) format gives you the most return for your time - succinct, easy to read, engaging, and highly effective. Fully revised and updated throughout, with highly illustrated coverage of the history and physical exam, followed by assessment techniques that are weighted based on their clinical importance. Online assessment includes audio clips of the heart and lung. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Bulleted lists, mnemonics, practical tips from leaders in the field - all providing a concise overview of important board-relevant content. Multiple-choice questions online provide opportunities for further self-assessment. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

General practitioners and other primary care professionals have a leading role in contemporary health care, which Trisha Greenhalgh explores in this highly praised new text. She provides perceptive and engaging insights into primary health care, focussing on:

- its intellectual roots
- its impact on the individual, the family and the community
- the role of the multidisciplinary team
- contemporary topics such as homelessness, ethnic health and electronic records.

Concise summaries, highlighted boxes, extensive referencing and a dedicated section on effective learning make this essential reading for postgraduate students, tutors and researchers in primary care.

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From the foreword by Julian Tudor Hart
""Trish Greenhalgh, in her frequent columns in the British Medical Journal...more than any other medical journalist spoke to her fellow GPs in the language of experience, but never without linking this to our expanding knowledge from the whole of human science."

"When I compare the outlines of primary care so lucidly presented in this wonderful book, obviously derived from rich experience of real teaching and learning, with the grand guignol theatre of London medical schools when I was a student 1947-52, the advance is stunning.""

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""Trish Greenhalgh is one of the international stars of general practice and a very clever thinker. This new book is a wonderful resource for primary health care and general practice. Every general practice registrar should read this book and so should every general practice teacher and primary care researcher.""

Professor Michael Kidd, Head of the Department of General Practice, University ofSydney and Immediate Past President of The Royal Australian College of General Practitioners

""This important new book by one of primary care's most accomplished authors sets out clearly the academic basis for further developments in primary health care. Health systems will only function effectively if they recognise the importance of high quality primary care so I strongly recommend this book to students, teachers, researchers, practitioners and policy makers.""

Professor Martin Marshall, Deputy Chief Medical Officer, Department of Health, UK

Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field.

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

Assisted reproduction techniques have led to the birth of 8 million babies worldwide Assisted reproduction techniques (ART), in particular in-vitro fertilization and intra-cytoplasmic sperm injection, are the most advanced forms of infertility treatment. They involve numerous counseling, medical, surgical and laboratory-based steps. At each step various problems and complications could be encountered that challenge even the most experienced ART practitioners. Moreover, patients with complex medical disorders may require ART, presenting further challenges. Assisted Reproduction Techniques will stimulate resourceful thinking in the ART practitioner when faced with these challenges. It outlines various management options, the reasoning behind them, and the evidence on which they are based to enable the practitioner to choose the most suitable solution for the needs of each patient. Written by 171 internationally renowned experts, Assisted Reproduction Techniques follows the patient's journey throughout the whole ART process, with chapters on: Counseling and preparation Pituitary suppression and ovarian stimulation Oocyte retrieval Embryo transfer The luteal phase The ART laboratory The male patient The ART pregnancy General and organizational issues Each of the 116 concise chapters includes clinical cases, background, evidence-based practical management options, preventive measures, key-point summaries of the important details and answers to questions patients ask. Assisted Reproduction Techniques first edition has established its place as a "must read" for ART trainees and practitioners alike, and in this second edition all chapters have been updated, with the addition of new ones addressing training issues, organizational and business skills, and social media use in ART.

Can you adapt to the wide variety of learning environments in medicine? Can you show your best abilities in the exams at the same time as learning to be a doctor? Can you balance your studies with an enjoyable social life? Can you develop your professionalism and manage your 'digital footprint'? How to Succeed at Medical School will help you learn these vital skills, and much more. Written by experienced medical school teachers and packed full of case studies, illustrations, quotes from other students, tip boxes, exercises, portfolios and learning techniques to help you communicate, study and revise - it s an essential resource to help you thrive at medical school. This thoroughly updated second edition includes new chapters on Professionalism and Teaching, and provides invaluable insight into what to expect from the start of medical school right through to the start of your medical career.

Nutritional Aspects of Bone Health provides an in-depth review of the role of diet in the development and maintenance of bone health throughout the lifecycle, and prevention of osteoporosis in later life. The book is multi-authored by the world's leading researchers in this area, who have come together to formulate the first ever textbook on nutritional aspects of bone health, and includes the current and cutting edge science underpinning the prevention of bone disease. The book is structured such that, in the first section, an overview is provided on what is meant by the terms bone health and osteoporosis and includes key areas such as epidemiology, genetics and the impact of non-nutritional exogenous factors influencing the skeleton. The second section details the established nutritional factors affecting bone health, namely calcium and vitamin D. Section three focuses on the role of macronutrients and macrominerals in bone health, namely protein, phosphorus, sodium and potassium, including the criticality of acid-base homeostasis to skeletal integrity. Section four addresses the effects of microminerals, trace elements, vitamin K, vitamin A and isoflavones on bone. Section five focuses attention on key issues connected with the influence of diet and anorexia and bulimia on bone health including nutrition and bone growth; nutrient: gene interactions; nutrient: drug interactions; and the final section discusses the effect of diet on reduction of fracture risk; the cost-effectiveness of nutritional supplements; and nutritional strategies for prevention and treatment of osteoporosis. The book is targeted at a number of key audiences. Whilst there is a focus on the academic research world and those principally involved in education, at both undergraduate and postgraduate levels, the book will also be of considerable interest to those participating in the treatment and prevention of osteoporosis, namely those working in the medical and health promotion fields. Furthermore, Nutritional Aspects of Bone Health will be of particular interest to the food industry as the popularity of foods designed to target specific health issues increases, and nutritional therapy has a critical role to play in this major public health problem.

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation.

Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods.

ABC of Equality, Diversity and Inclusion in Healthcare Improve inclusion, for both patients and staff, in your healthcare environment Fulfilment in personal and professional life is facilitated by feeling able to bring one’s complete self to work. The promotion of Equality, Diversity & Inclusion (EDI) and its support in the workplace is crucial to achieving this. Diverse and inclusive teams are characterised by good people management, leading to better decision-making and improved performance which staff wellbeing and patient safety depend on. Though issues including racism, sexism and homophobia have roots in wider society, they also exist across healthcare systems worldwide. They contribute to problems with recruitment and retention of staff and can make patients reluctant to access the care they need and deserve. The ABC of Equality, Diversity and Inclusion in Health summarises the key issues and the impacts on both patients and staff of excluding people from good healthcare solely on the basis of who they are. As well as considering impacts on individuals and teams, we consider also how inclusion can be improved for the benefit of everyone—all patients and all staff. Topics include: Racism in healthcare Women in healthcare Sexual orientation and gender identity Disability, disparities and ableism in medicine Teaching equality, diversity, and inclusion in healthcare The authors are distinguished healthcare practitioners whose personal and professional lives have been enriched by the diversity of all they meet through their work and who are passionate about ensuring positive change for colleagues and patients. This book aims to contribute to important discussions about how to ensure systemic change that will enable an inclusive culture by recognising and celebrating diversity. ABC of Equality, Diversity and Include (EDI) in Healthcare is essential reading for students and professionals who want to champion inclusivity and fulfilment in a workplace environment. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/email

Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

Data Literacy: How to Make Your Experiments Robust and Reproducible provides an overview of basic concepts and skills in handling data, which are common to diverse areas of science. Readers will get a good grasp of the steps involved in carrying out a scientific study and will understand some of the factors that make a study robust and reproducible.The book covers several major modules such as experimental design, data cleansing and preparation, statistical analysis, data management, and reporting. No specialized knowledge of statistics or computer programming is needed to fully understand the concepts presented. This book is a valuable source for biomedical and health sciences graduate students and researchers, in general, who are interested in handling data to make their research reproducible and more efficient.

Experimental Analysis of Enzyme Mechanism Using Isotope Effects, Volume 596, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Chapters in this comprehensive update include Measurement of enzyme binding isotope effects, Chemical ligation and isotope labeling to locate dynamic effects, Measurement of heavy enzyme isotope effects, Extracting kinetic isotope effects from a global analysis of reaction progress curves, KIE of metabolic flux and enzymes, Solvent and Primary KIE on Flavin Enzymes, and The Rapid Determination of Primary Deuterium Isotope Effects on Enzyme-Catalyzed Proton Transfer at Carbon in 50/50 HOH/DOD. Readers who are interested in applying or understanding this research will find useful methods currently used for measuring isotope effects on solution and enzyme reactions.

Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.