This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.

During the past decade, significant progress in molecular and cellular te- niques has greatly advanced our understanding of the wound healing p- cess. Many of these new techniques have been utilized in the context of more classic models of wound healing. The combination of new and classic approaches has allowed scientists to make exciting discoveries in the field of tissue repair, resulting in an explosion of information about the healing p- cess. Importantly, these new findings have great relevance beyond wound healing itself. The injury repair process cuts across many disciplines, exte- ing to such broad fields as cancer, inflammation, and atherosclerosis. The relevance of the field to these many disciplines has generated great interest in models and methods for the study of wound healing. The goal of Wound Healing: Methods and Protocols is to provide scientists from many dis- plines with a compendium of classic and contemporary protocols from r- ognized experts in the field of wound healing. We hope this volume will be useful not only to those working within the field itself, but also to scientists from other disciplines who wish to adapt wound healing models to their own experimental needs. The process of wound healing encompasses many different biologic p- cesses, including epithelial growth and differentiation, fibrous tissue prod- tion and function, angiogenesis, and inflammation.

Medicine in a Day: Revision Notes for Medical Exams, Finals, UKMLA and Foundation Years covers all conditions in the UK Medical Licensing Assessment and more, within just one book! Prepared by a unique combination of authors - including early career stage doctors still close to what is required for exam success, expert educators and senior specialists - Medicine in a Day provides the trusted information you need most when time is short. Each chapter can be read in an hour, covering the medical and surgical specialties, Radiology, Anaesthetics and Critical Care, Emergency Medicine, Paediatrics, Obstetrics and Gynaecology, Psychiatry, Infectious Diseases, Clinical Epidemiology, commonly prescribed medications and more. The essential knowledge for each topic is presented simply and concisely, supported by bespoke illustrations. A large, carefully selected image collection reflects the views most commonly seen in exams, and includes X-rays, ECGs, CTs and clinical photographs, with dermatological conditions shown for diverse skin tones. Reach for Medicine in a Day when you need to study efficiently, prepare for medical exams, or refresh your memory at any stage of your career. The (printed) book also comes with access to the complete, downloadable eBook version, for easy quick reference, anytime, anywhere!

There are 41 chapters in the manual under different section heads dealing with physiology, clinical applications, use in different types of respiratory failure, including end of life situations, and limitations, challenges as well as its use in pediatrics. This flagship book of ISCCM one of the first of its kind in India. Covers all aspects of noninvasive ventilation from initiation to disease specific conditions. Evidence-based and updated protocols have been used in easy to read format with flowcharts and diagrams. Stalwarts in this field have contributed to this book. This book will be helpful to all postgraduates, intensivists and physicians.

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.

A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.

This textbook on statistics is written for students in medicine, epidemiology, and public health. It builds on the important role evidence-based medicine now plays in the clinical practice of physicians, physician assistants and allied health practitioners. By bringing research design and statistics to the fore, this book can integrate these skills into the curricula of professional programs. Students, particularly practitioners-in-training, will learn statistical skills that are required of today's clinicians. Practice problems at the end of each chapter and downloadable data sets provided by the authors ensure readers get practical experience that they can then apply to their own work.

Bonnie Prudden's revolutionary breakthrough in pain relief involves trigger points -- tender areas where muscles have been damaged from falls, childhood ailments, poor posture, and the stresses of daily life. Requiring no special training or equipment, myotherapy is a natural, simple technique that can be performed in the home. Illustrated with charts, photographs, and diagrams, Bonnie Prudden's step-by-step method has been hailed by doctors and patients for its extraordinary 95 percent success rate.

This book on and signs and symptoms, which is indexed in alphabetical order from which the physician will be able to weave a clinical narrative, anatomically and pathophysiologically explicit, to form the accurate diagnostic hypotheses. It is compact, handy and bedside clinical companion book for all dedicated healthcare professionals who are committed to evaluate the patient accurately on the basis of signs and the symptoms. Consists of 91 chapters, enriched with knowledge of about more than 100 contributors. Covers almost all the possible signs and the symptoms, commonly seen in the day-to-day clinical practice. Useful in evaluating the patients in early stages of the complaints and also helpful in initial treatment and management. This book is helpful for undergraduates, postgraduates, residents, and emergency physicians.

This book focuses on improving decision-making capability by guiding the critical thinking process and application of theories. Problem-based learning is the best way to learn medicine. Every case in the book has some practical problem-related questions for the reader's selfevaluation, followed by correct answers, and discussion on relevant topics and management. The book provides basic knowledge of various clinical problems that are faced by physicians. It analyses appropriate approach in diagnosing and management of problems. Provides real diagnostic and management skills which can be applied by practitioners. The clinical cases are compiled in stepwise pattern for physicians that focus on appropriate scientific approach for suitable diagnosis.

This book is intended to be concise yet highly informative and user friendly. It provides quick information of drug doses, adverse effects, contraindications of use and special precautions which has to be undertaken during therapy. The contents will be especially helpful not only for the students, but also for the busy practitioners. The clinical pearls and the comparative study of drugs discussed at the end of the chapters are for instant overview. This book precisely covers almost all important chapters of Pharmacology and would provide important at hand information for postgraduate aspirants too for their entrance examinations.

Most readers are familiar with the "real Princess Diana." This book is about a courageous woman, Diane Cummings, who was the first person with the Tetralogy of Fallot (a congenital heart defect) to be operated upon by Dr. Willis J. Potts in 1946. He was the pioneer surgeon who developed an operation for this syndrome in infants who at the time were deemed too young to have the operation. Diane went on to lead a full life while subsequently undergoing four more open-heart operations done by leaders in the field For this to have happened, she survived four episodes of subacute bacterial endocarditis due to unusual bacteria. She was fortunate to be treated by a series of doctors who have been and still are the pioneers in the treatment of congenital heart disease. The doctors were: Dr. Willis J. Potts of Children's Hospital in Chicago, the originator of the Potts' operation; the father and son team of Drs. James and John Kirklin who were at the University of Alabama Heart Center; and Dr. Joseph Dearani of the Mayo Clinic. She was a true inspiration during the remaining forty-five years of her life. She died in January 2007, having lived a full life for 62 years. This made her one of the longest survivors on record of Potts' original operation. This is her story.

In the age of genomics, oncogenetics is a growing discipline. It is defined as the identification and management of families where there is a suspected hereditary risk of cancer. This relatively new discipline is part of a modern medicine that aims to be both preventive and predictive. Constitutional Oncogenetics gives precise descriptions of the main syndromes that cause a predisposition for cancer. The first part examines the most common syndromes in the majority of the world, including the heightened hereditary risk of breast and ovarian cancer and Lynch syndrome. The second part introduces less common infracentesimal syndromes, such as Bloom syndrome and Fanconi syndrome. This book is intended for oncogenetic practitioners and other specialists, as well as medical students.

This edition has several new contributors - all of them are leading international authorities in the field. All the chapters have been thoroughly re-written and updated. Several new high quality clinical, radiographic images, gross pathology specimen photographs, and photomicrographs have been included in this edition for the readers' convenience. This edition documents the rapid advances that have occurred at a blistering pace in TB diagnosis, universal drug-susceptibility testing [DST] and treatment of dug-susceptible and drug-resistant TB, including multidrug-resistant and extensively drug-resistant TB [M/XDR-TB], programmatic management of drug-resistant TB, public-private mix, the ENGAGE-TB approach, and END TB strategy, among others. The present edition includes recent classification of drugs and drug combinations including recent generation quinolones, bedaquiline and linezolid used in treating M/XDR-TB and a chapter detailing the latest developments in the field of laboratory diagnosis and management of NTM diseases. Thoroughly revised, updated and rewritten to present a comprehensive account of tuberculosis (TB) and nontuberculous mycobacterial diseases. Beginning with insights into the history and epidemiology of tuberculosis, the book deals extensively with the current understanding of the immunology, and immunopathogenetic mechanisms of this disease. The clinical presentation, laboratory diagnosis, the treatment of TB of various organ systems, prevention and control of TB are extensively covered. Chapters have also been devoted to HIV-TB co-infection, drug-resistant TB (including M/XDR-TB), ethical and legal issues in TB, Revised National Tuberculosis Control Programme, Global TB Control Programme, and the role of medical schools in TB Control Programmes. Includes revised chapter on nontuberculous mycobacterial diseases. This edition will be an asset to both undergraduate and postgraduate medical students, a source of reference to the researchers. Will help practicing doctors to update their knowledge and aid in rationale, scientific and efficient management of patients with TB.

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.

Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine provides a comprehensive overview of current and emerging issues in genomic data sharing. In this book, international leaders in genomic data examine these issues in-depth, offering practical case studies that highlight key successes, challenges and opportunities. Sections discuss the eMERGE Network, Undiagnosed Disease Network, Vanderbilt Biobank, Marshfield Clinic Biobank, Minnesota Authorization, Rochester Epidemiology Project, NIH sponsored biobanks, GINA, and Global Alliance for Genomics and Health (GA4GH). In addition to these perspectives from the frontlines, the book also provides succinct overviews of ethical, legal, social and IT challenges. Clinician investigators, clinicians affiliated with academic medical centers, policymakers and regulators will also gain insights that will allow them to navigate the increasingly complex ethical, social and clinical landscape of genomic data sharing.

Nitric Oxide in Transplant Rejection and Anti-Tumor Defense represents a unique combination of three interrelated topics that is unavailable in any other single work: The detection and visualization of nitric oxide in biological materials using EPR spectroscopy and EPR imaging; Nitric oxide in immune mechanisms of allograft rejection; and The involvement of nitric oxide in anti-tumor defense. By bringing together specialists from these three disciplines, the book investigates the common molecular and cellular mechanisms underlying phenomena in transplants and oncology. In addition, the book provides an introduction to biological applications of EPR spectroscopy and imaging. Nitric Oxide in Transplant Rejection and Anti-Tumor Defense will appeal to researchers and graduate-level students investigating transplant rejections and their immune mechanisms, anti-tumor immune defenses, novel types of contrast agents for EPR imaging, and biological applications of EPR spectroscopy and EPR imaging.

This memoir recalls a physician's life in several cultures, East and West, and the challenges and blessings of marriages into two Indian communities. The author describes remarkable personalities that influenced his life, as well as the conflicts and successes of scientific and clinical projects in academia and the World Health Organization. He lived adventures, great and small, in travels, in angling around the world, and in sailing. An adventure of a different sort is the discovery of new paths of creative and spiritual fulfillment in later life.

Proceedings of an international symposium, held in Ulm, Germany, September 21-24, 1994