Presenting a cutting-edge theory for using humor in psychotherapy, counseling, and clinical intervention, this volume brings together a group of outstanding experts in the field of clinical intervention. Each chapter shows how humor can play a vital role in the promotion of wellness in general and in mental health wealthness in particular. It provides specific theoretical perspectives aimed at helping readers develop both their awareness of humor as a clinical tool and dexterity in using humor to facilitate productive change during the therapeutic process.

This book will be of interest to students and professionals in all areas of the helping and healing professions. In addition to the psychotherapeutic disciplines, it also has applications in human relations and communication-training fields.

Ion channel dysfunction in humans leads to impairment of the excitable processes necessary for the normal function of several tissues, such as muscle and brain. It follows that an increasing number of human diseases have been associated with malfunctioning ion channels, many of which have a genetic component.
This volume of "Advances in Genetics" presents a broad and comprehensive overview of the inherited channelopathies in humans, including clinical, genetic and molecular aspects of these conditions. Keeping true to the scope of the serial, novel genomic and modeling research approaches and a review of potential therapeutic approaches for each of these conditions are also incorporated.

The OSCEs have become a part of most examinations in Critical Care Medicine. This book will be of great help to the examinees. The contents have been divided into two sections one is Questions and the second is Answers. It contains chapters on Respiratory Medicine, Neurology, Nephrology, Microbiology and Infection Control, Hemodynamics, Drugs, Biochemistry, Miscellaneous, and Case Scenarios. Contains nearly 330 questions with model answers. Questions range from the old tests, new techniques and devices, and results of laboratory and other investigations. Also covers questions on all organ systems and different ways these systems may be affected by the disease. The answers are structured from examination point-of-view. These will help the examinees in developing the skills to face the objective structured clinical examinations (OSCEs) in their examination.

MRI in Practice continues to be the number one reference book and study guide for the registry review examination for MRI offered by the American Registry for Radiologic Technologists (ARRT). This latest edition offers in-depth chapters covering all core areas, including: basic principles, image weighting and contrast, spin and gradient echo pulse sequences, spatial encoding, k-space, protocol optimization, artefacts, instrumentation, and MRI safety. The leading MRI reference book and study guide. Now with a greater focus on the physics behind MRI. Offers, for the first time, equations and their explanations and scan tips. Brand new chapters on MRI equipment, vascular imaging and safety. Presented in full color, with additional illustrations and high-quality MRI images to aid understanding. Includes refined, updated and expanded content throughout, along with more learning tips and practical applications. Features a new glossary. MRI in Practice is an important text for radiographers, technologists, radiology residents, radiologists, and other students and professionals working within imaging, including medical physicists and nurses.

This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. Mitochondrial Medicine: Volume I, Probing Mitochondrial Function focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Mitochondrial Medicine provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.

An Exciting New Approach to Regaining Health Without Surgery!

Fact: By the time they reach menopause 40 percent of American women have at least one uterine fibroid; 600,000 women are diagnosed each year.

Fact: Fibroids are the leading cause of hysterectomy, the second most common surgical procedure performed on women.

Fact: Natural, holistic medicine can heal fibroids without invasive surgery.

Fibroid tumors, while usually benign, can swell a woman's uterus to the size of a basketball, frequently causing heavy menstrual bleeding, cramping, bladder infections, and even infertility. Most doctors recommend surgery as the only answer. Now this innovative holistic program brings new hope for a surgery-free life to millions of American women.

Dr. Allan Warshowsky combines traditional Western medicine and holistic science to cure not just the fibroid condition but also the underlying imbalances and systemic dysfunctions that can cause fibroids. With an exciting program of diet, exercise, supplements, herbs, and mind/spirit work, Dr. Warshowsky shows fibroid sufferers how to become the strong, healthy women they deserve to be.

The book deals with the role of both oxygen- and nitrogen-centred free radicals in inflammatory diseases such as rheumatoid arthritis. The well-known involvement of the superoxide anion radical in the bactericidal action of inflammatory cells suggests that radicals and the inflammatory response are inextricably linked. The widespread involvement of radicals in human disease seems inevitable, because inflammation is such a conspicuous component of human disease. For the first time, the present text integrates contributions from leading research groups who have been investigating the role of radicals within the context of all stages of inflammtion, such as the recruitment of inflammatory cells, their bactericidal action, inflammatory tissue destruction and inflammatory cell death by apoptosis. The chapters are broadly organised so that they trace the clinical course of the acute and chronic inflammtory response, emphasising the therapeutic implications of recent data on the contribution of nitric oxide and related nitrogen-centred species. The book will be of interest to academic and industrial researchers and clinicians with interests in the fields of inflammation or free radical biology.

Intensive Care Medicine compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

During the past decade, significant progress in molecular and cellular te- niques has greatly advanced our understanding of the wound healing p- cess. Many of these new techniques have been utilized in the context of more classic models of wound healing. The combination of new and classic approaches has allowed scientists to make exciting discoveries in the field of tissue repair, resulting in an explosion of information about the healing p- cess. Importantly, these new findings have great relevance beyond wound healing itself. The injury repair process cuts across many disciplines, exte- ing to such broad fields as cancer, inflammation, and atherosclerosis. The relevance of the field to these many disciplines has generated great interest in models and methods for the study of wound healing. The goal of Wound Healing: Methods and Protocols is to provide scientists from many dis- plines with a compendium of classic and contemporary protocols from r- ognized experts in the field of wound healing. We hope this volume will be useful not only to those working within the field itself, but also to scientists from other disciplines who wish to adapt wound healing models to their own experimental needs. The process of wound healing encompasses many different biologic p- cesses, including epithelial growth and differentiation, fibrous tissue prod- tion and function, angiogenesis, and inflammation.

This textbook on statistics is written for students in medicine, epidemiology, and public health. It builds on the important role evidence-based medicine now plays in the clinical practice of physicians, physician assistants and allied health practitioners. By bringing research design and statistics to the fore, this book can integrate these skills into the curricula of professional programs. Students, particularly practitioners-in-training, will learn statistical skills that are required of today's clinicians. Practice problems at the end of each chapter and downloadable data sets provided by the authors ensure readers get practical experience that they can then apply to their own work.

A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.

There are 41 chapters in the manual under different section heads dealing with physiology, clinical applications, use in different types of respiratory failure, including end of life situations, and limitations, challenges as well as its use in pediatrics. This flagship book of ISCCM one of the first of its kind in India. Covers all aspects of noninvasive ventilation from initiation to disease specific conditions. Evidence-based and updated protocols have been used in easy to read format with flowcharts and diagrams. Stalwarts in this field have contributed to this book. This book will be helpful to all postgraduates, intensivists and physicians.

A remarkable spectrum of novel immunoreceptors sharing related immunoglobulin-like domains and signaling potential has been identified in recent years. These receptors have attracted widespread interest because they resemble the TCR, BCR, and FcR complexes in their ability to serve as activating or inhibitory receptors on the cells that bear them. Moreover, they are well positioned to affect both innate and adaptive immunity. The full range of ligands for these new receptor families is still not known, and understanding of their physiological roles is far from complete. This volume is the first attempt to summarize and highlight all known aspects of immunoglobulin-like receptors, providing a topical overview of the roles and characteristic features of the immunoglobulin-like receptors and related molecules in the immune system. Researchers in immunology, molecular biology, cell biology, clinical medicine, and pharmacology will find this book invaluable.

Most readers are familiar with the "real Princess Diana." This book is about a courageous woman, Diane Cummings, who was the first person with the Tetralogy of Fallot (a congenital heart defect) to be operated upon by Dr. Willis J. Potts in 1946. He was the pioneer surgeon who developed an operation for this syndrome in infants who at the time were deemed too young to have the operation. Diane went on to lead a full life while subsequently undergoing four more open-heart operations done by leaders in the field For this to have happened, she survived four episodes of subacute bacterial endocarditis due to unusual bacteria. She was fortunate to be treated by a series of doctors who have been and still are the pioneers in the treatment of congenital heart disease. The doctors were: Dr. Willis J. Potts of Children's Hospital in Chicago, the originator of the Potts' operation; the father and son team of Drs. James and John Kirklin who were at the University of Alabama Heart Center; and Dr. Joseph Dearani of the Mayo Clinic. She was a true inspiration during the remaining forty-five years of her life. She died in January 2007, having lived a full life for 62 years. This made her one of the longest survivors on record of Potts' original operation. This is her story.

RESEARCHING MEDICAL EDUCATION Researching Medical Education is an authoritative guide to excellence in educational research within the healthcare professions presented by the Association for the Study of Medical Education and AMEE. This text provides readers with key foundational knowledge, while introducing a range of theories and how to use them, illustrating a diversity of methods and their use, and giving guidance on practical researcher development. By linking theory, design, and methods across the spectrum of health professions education research, the text supports the improvement of quality, capacity building, and knowledge generation. Researching Medical Education includes contributions from experts and emerging researchers from five continents. The text includes information on: Developing yourself and your practice as a health professions education researcher Methods and methodologies including ethnography/digital ethnography, visual methods, critical discourse analysis, functional and corpus linguistics, critical pedagogy, critical race theory and participatory action research, and educational neuroscience methods Theories including those where relationships between context, environment, people and things matter (e.g., complexity theory, activity theory, sociomateriality, social cognitive theories and participatory practice) and those which are more individually focused (e.g., health behaviour theories, emotions in learning, instructional design, cognitive load theory and deliberate practice) Includes 10 brand new chapters Researching Medical Education is the ideal resource for anyone researching health professions education, from medical school to postgraduate training to continuing professional development. "This is an extraordinary text that combines theory and practice in medical education research. The authors represent the who's who of medical education research, and their wisdom and insights will help guide novice and experienced researchers alike." --David M. Irby, Professor Emeritus of Medicine, University of California, San Francisco, USA "Research in health professions education is maturing. This is clearly evidenced by the second edition of Researching Medical Education. In 30 chapters this book takes you on an exciting voyage on research theories and research methodologies. This book is a comprehensive resource for anyone engaging in research in health professions education." -- Cees van der Vleuten, former Director of the School of Health Professions Education, Maastricht University, The Netherlands

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

A comprehensive and authoritative review of the most important scientific and clinically relevant topics today in ligaments, tendons, and capsular biology, including their biomechanics and surgical reconstruction. The authors review the basic science of tendons in the hand and shoulder ligaments, the current clinical status of the shoulder and cruciate ligaments, and the latest advances in research on the healing of ligament and tendon to bone, artificial ligaments, and gene therapy. They also cover the major type 1 collagen soft tissues that are of particular interest to upper extremity surgeons and sports medicine specialists.

Individuals' responses to their chronic illness or disability (CID) vary widely. Some are positive and productive, some negative and self-defeating, and some have elements of both. Coping with Chronic Illness and Disability synthesizes the growing literature on these coping styles and strategies by analyzing how individuals with CID face challenges, find and use their strengths, and alter their environment to fit their life-changing realities. The book's first section provides readers with the major theories and conceptual perspectives on coping, with special emphasis on social aspects and models of coping with different types of CID. In Part Two, an array of specific medical conditions is covered. Each chapter supplies a clinical description, current empirical findings on coping, effective medical, physical, and psychological interventions, employment issues, and social concerns. conditions, such as cancer, heart disease, diabetes, arthritis, spinal cord injuries, and traumatic brain injury; in-depth coverage of HIV/AIDS, chronic pain, and severe mental illness; coverage of therapeutic modalities adopted for treatment of people with CID; review of the current state of coping theory and research; and, an appendix of instruments frequently used in assessment of coping. The editors' skillful balance between theoretical and practical material will help rehabilitation specialists (particularly psychologists, counselors, social workers, and health-care providers) develop new insights into promoting successful coping, and discern new means of changing its less effective forms. Students in the helping professions, as well as individuals experiencing CID, may also find this multifaceted book useful for understanding some of the psychosocial dynamics of living with CID.