The book deals with the role of both oxygen- and nitrogen-centred
free radicals in inflammatory diseases such as rheumatoid
arthritis. The well-known involvement of the superoxide anion
radical in the bactericidal action of inflammatory cells suggests
that radicals and the inflammatory response are inextricably
linked. The widespread involvement of radicals in human disease
seems inevitable, because inflammation is such a conspicuous
component of human disease. For the first time, the present text
integrates contributions from leading research groups who have been
investigating the role of radicals within the context of all stages
of inflammtion, such as the recruitment of inflammatory cells,
their bactericidal action, inflammatory tissue destruction and
inflammatory cell death by apoptosis. The chapters are broadly
organised so that they trace the clinical course of the acute and
chronic inflammtory response, emphasising the therapeutic
implications of recent data on the contribution of nitric oxide and
related nitrogen-centred species. The book will be of interest to
academic and industrial researchers and clinicians with interests
in the fields of inflammation or free radical biology.
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