Ilana and Martin Gerschlowitz are an ordinary middle-class South African family – young, newly married with bright, promising futures. Ilana falls pregnant and gives birth to David, a happy, healthy baby boy. At 10 months old, David suffers recurring ear infections, and at 11 months old a terrible fever sends him to hospital. David’s behaviour abruptly changes – he no longer looks at his parents, his motor and budding language skills disappear, and the light in his eyes dims. It is the beginning of a journey with autism that few parents would ever want to encounter, and yet a staggering number of children are now diagnosed with autism, and the number of diagnoses rises every year.

Ilana and Martin work tirelessly to understand David’s autism diagnosis, and to search for ways to treat their son. The couple arrange an international autism conference, open a treatment centre for autistic children, and begin outreach programs for underprivileged families dealing with autism.

Ilana falls pregnant again and their third son, Aaron, develops normally. And then the unthinkable happens – at 16 months Aaron develops ear infections and they decide to insert grommets. Immediately after the procedure, they realise that Aaron is not behaving in his usual manner. Within days, it becomes clear that Aaron, too, has developed autism, and their journey begins afresh. Armed with the knowledge gained from years of treating David, the couple set about ensuring that Aaron’s condition is treated swiftly and carefully.

Since the first edition of HIV and AIDS Education, Care and Counselling was published almost 20 years ago, it has become the standard handbook in Africa for thousands of HIV and AIDS practitioners. However, ongoing HIV and AIDS research requires regular revisions to the handbook for it to remain current with developments in prevention and treatment. Consequently, this new edition has been updated with input from two new specialist co-authors. This has strengthened the multicultural and multidisciplinary approach of this edition to Africa's unique challenges.

Handbook of HIV Medicine represents the knowledge, skill and experience of more than sixty experts in HIV medicine, making it the definitive reference book for southern Africa.

This third edition remains invaluable for doctors, medical students, and primary health care workers, presenting an updated approach to critical issues. It is ideal for quick reference in urban and rural clinics and hospital wards.

The handbook is targeted specifically at the needs of the developing world and contains guidelines on antiretroviral therapy, HIV emergencies, and adult and paediatric HIV medicine.

Oprah Winfrey and renowned brain development and trauma expert, Dr. Bruce Perry, discuss the impact of trauma and adverse experiences and how healing must begin with a shift to asking, “what happened to you?” rather than “what’s wrong with you?”

Through wide-ranging, and often deeply personal conversation, Oprah Winfrey and Dr. Perry explore how what happens to us in early childhood – both good and bad - influences the people we become. They challenge us to shift from focusing on, “What’s wrong with you?” or “Why are you behaving that way?,” to asking, “What happened to you?” This simple change in perspective can open up a new and hopeful understanding for millions about why we do the things we do, why we are the way we are, providing a road map for repairing relationships, overcoming what seems insurmountable, and ultimately living better and more fulfilling lives.

Many of us experience adversity and trauma during childhood that has lasting impact on our physical and emotional health. And as we’re beginning to understand, we are more sensitive to developmental trauma as children than we are as adults. ‘What happened to us’ in childhood is a powerful predictor of our risk for physical and mental health problems down the road, and offers scientific insights in to the patterns of behaviors so many struggle to understand.

A survivor of multiple childhood challenges herself, Oprah Winfrey shares portions of her own harrowing experiences because she understands the vulnerability that comes from facing trauma at a young age. Throughout her career, Oprah has teamed up with Dr. Bruce Perry, one of the world’s leading experts on childhood trauma. He has treated thousands of children, youth, and adults and has been called on for decades to support individuals and communities following high-profile traumatic events. Now, Oprah joins forces with Dr. Perry to marry the power of storytelling with the science and clinical experience to better understand and overcome the effects of trauma.

In conversation throughout the book, the two focus on understanding people, behavior, and ourselves in the context of personal experiences. They remove blame and self-shaming, and open up a space for healing and understanding. It’s a subtle but profound shift in our approach to trauma, and it’s one that allows us to understand our pasts in order to clear a path to our future - opening the door to resilience and healing in a proven, powerful way.

Grounded in the latest brain science and brought to life through compelling narratives, this book shines a light on a much-needed path to recovery – showing us our incredible capacity to transform after adversity.

Navigating motherhood from the age of 18, Kim Stephens shelved her inner journo and embraced a life of media sales and sports marketing, working with some of the biggest sports brands globally, and locally, whilst pursuing her own ultra-running ambitions.

Arguing vehemently against the possibility that she was running from her own truth, Covid-19 wiped out Kim’s possibilities for continued escape. After three children, two divorces and a gradual sexual awakening, Kim found herself at 40-something virtually unemployed, with all the time in the world to write, sip gin and study a general response to one of the world’s most draconian lockdowns. Her humorous observations of middle-class South African behaviour through the various levels of lockdown earned her a certain notoriety and a degree of viral success, and with that the courage to put it all into a book.

Hold the Line tells the story of teenage pregnancy, the situational blindness of white South Africa, the disappointment of divorce and the deep joy found through true awakening. Stitched together with the lockdown writing that Kim penned for a growing base of followers, she shares a more in-depth life story with her usual candid self-deprecation.

Written to rattle a few truths from within its readers, Hold the Line ends ironically as the world begins to follow a potential third World War via TikTok.

Coovadia’s Paediatrics and Child Health offers a renowned and comprehensive guide to the clinical diagnosis, treatment and management of specific child health conditions and diseases.

With an emphasis on primary care, and addressing both theoretical- and applied aspects, the text adopts a problem-based approach that supports the holistic management of children’s health. Presenting a strong focus on the regional context, the text offers extensive discussion of localized issues, conditions and influences, and of the challenges and diseases that are particular to the southern African region.

Supporting effective learning and diagnosis, the eighth edition now includes a colour photographs and images that illustrate clinical conditions, where appropriate.

The gripping and shocking story of three generations of the Sackler family and their roles in the stories of Valium and Oxycontin, by the prize-winning, bestselling author of Say Nothing.

The Sackler name adorns the walls of many storied institutions – Harvard; the Metropolitan Museum of Art; Oxford; the Louvre. They are one of the richest families in the world, known for their lavish donations in the arts and the sciences. The source of the family fortune was vague, however, until it emerged that the Sacklers were responsible for making and marketing Oxycontin, a blockbuster painkiller that was a catalyst for the opioid crisis-an international epidemic of drug addiction which has killed nearly half a million people.

In this masterpiece of narrative reporting and writing, Patrick Radden Keefe exhaustively documents the jaw-dropping and ferociously compelling reality. Empire of Pain is the story of a dynasty: a parable of 21st century greed.

Walkley Award-winning journalist, Sharri Markson is the Investigations Editor at The Australian and host of prime-time show Sharri on Sky News Australia.

The origins of Covid-19 are shrouded in mystery. Scientists and government officials insisted, for a year and a half, that the virus had a natural origin, ridiculing anyone who dared contradict this view. Tech giants swept the internet, censoring and silencing debate in the most extreme fashion. Yet it is undeniable that a secretive facility in Wuhan was immersed in genetically manipulating bat-coronaviruses in perilous experiments. And as soon as the news of an outbreak in Wuhan leaked, the Chinese military took control and gagged all laboratory insiders.

Part-thriller, part-expose, What Really Happened in Wuhan is a ground-breaking investigation from leading journalist Sharri Markson into the origins of Covid-19, the cover-ups, the conspiracies and the classified research. It features never-before-seen primary documents exposing China's concealment of the virus, fresh interviews with whistleblower doctors in Wuhan and crucial eyewitness accounts that dismantle what we thought we knew about when the outbreak hit.

With unprecedented access to Washington insiders, Markson takes you inside the White House, with senior Trump lieutenants revealing first-hand accounts of fiery Oval Office clashes and new stories of compromised government advisors and censored scientists.

Bravely reported and chillingly laid out, Markson brings to light the stories of the pandemic from the people on the ground: the scientists and national security officials who raised uncomfortable truths and were labelled conspiracy theorists, until government agencies began to suspect they might have been right all along. These brave individuals persisted through bruising battles and played a crucial role in investigating the origins of Covid-19 to finally, in this book, bring us closer to the truth of what really happened in Wuhan.

Healing Your Thyroid Naturally is a no-nonsense guide about the impact of food and diets on healing your thyroid.

Dr Emily Lipinski, a Doctor of Naturopathic Medicine, incorporates the latest research in thyroid health and provides easy dietary guidance to help you on your journey to thyroid balance. With chapters such as 'The Iodine Debate', 'Food Sensitivities' and 'Going Gluten Free', Healing your Thyroid Naturally highlights many topics that are integral to understanding how food impacts thyroid health. Through her own journey with Hypothyroidism, Dr Emily Lipinski learned that healing the thyroid requires much more than just medication.

Combining her medical background with her love of food and passion for natural approaches she has helped herself, and countless patients, to regain control over their thyroid problems.

For those who could read between the lines, the censored news out of China was terrifying. But the president insisted there was nothing to worry about. Fortunately, we are still a nation of skeptics. Fortunately, there are those among us who study pandemics and are willing to look unflinchingly at worst-case scenarios.

Michael Lewis’s taut and brilliant nonfiction thriller pits a band of medical visionaries against the wall of ignorance that was the official response of the Trump administration to the outbreak of COVID-19. The characters you will meet in these pages are as fascinating as they are unexpected.

A thirteen-year-old girl’s science project on transmission of an airborne pathogen develops into a very grown-up model of disease control. A local public-health officer uses her worm’s-eye view to see what the CDC misses, and reveals great truths about American society. A secret team of dissenting doctors, nicknamed the Wolverines, has everything necessary to fight the pandemic: brilliant backgrounds, world-class labs, prior experience with the pandemic scares of bird flu and swine flu…everything, that is, except official permission to implement their work.

Michael Lewis is not shy about calling these people heroes for their refusal to follow directives that they know to be based on misinformation and bad science. Even the internet, as crucial as it is to their exchange of ideas, poses a risk to them. They never know for sure who else might be listening in.

Now in its third edition, Pharmacology in Clinical Practice has been updated to ensure it remains up-to-date and relevant.

Particular care has been taken to simplify and clarify difficult concepts by explaining the links between pharmacology and physiology by providing definitions of new concepts, and using plain language for ease of understanding. Fundamental concepts, such as pharmacodynamics and pharmacokinetics, are well covered in a matter that is accessible and clear. Individual chapters cover the various systems of the body.

Updates include:

• A colour plate to illustrate the links between pharmacology and physiology
• Additional information on side-effects, contra-indications and patient education for groups of drugs
• A guide on how to access this information, to assist with exam preparation and nursing practice
• An updated chapter on nursing management of drug preparations and treatment
• An updated chapter on clinical applications
• A chapter on the legal framework for dispensing and prescribing.

Child Health for All offers a comprehensive, up-to date and accessible introduction to population child health for undergraduate and postgraduate students of various health science disciplines.

The text addresses a broad scope of content, including environmental- policy and law-, health system-, clinical-, family-, and community aspects of public health, and offers effective strategies for the promotion, protection and improvement of children’s health. Engaging with current global plans and strategies, such as the Sustainable Development Goals and the Survive, Thrive and Transform strategy, the text discusses strategies for the promotive, preventive and service delivery aspects of healthcare. The work addresses the multiple dimensions and determinants of health, covering all stages of the child's life course from pre-conception to late adolescence, and considers responses to the health needs of children by the health and associated social sectors.

Presenting a critical appraisal of issues and challenges common to many low- and middle-income contexts, and drawing in detail on South African conditions and influences, policy and regulatory frameworks, health services infrastructure and health system considerations, the text has wide application to the realities of the southern African and similar regions.

This outstanding text gives students a solid grounding in clinical and experimental neuropsychology. The author is a leading authority whose engaging writing style and thorough yet concise coverage of brain localization, anatomy, and their links to cognitive function make the book ideal for undergraduate or graduate use. It is illustrated with more than 60 figures, including six color plates.New to This Edition: *Incorporates more than two decades of major advances in the field--including developments in basic science, assessment, rehabilitation, and clinical research.*Coverage of neuroimaging.*Chapter on degenerative diseases and profound brain injury.

Reverse Your Diabetes provides all the information and support you need to take control of type 2 diabetes and, potentially, to reverse it.

Based on the latest research and proven results, this clear and effective programme outlines the key steps you need to take to turn around your health: watch what you eat, get more active, monitor your progress and commit to change. Written by diabetes expert Dr David Cavan and in association, Reverse Your Diabetes also tackles the myths and misinformation about type 2 diabetes.

This is an essential book that will empower you to take control of your diabetes and maximise your health for good.

Where is South Africa going now? And where will South Africa be in five years’ time? Much has been written about the country’s past, but is enough thought being given to its future? Is South Africa in danger of again losing its way, given its pressing socio-economic challenges?

Prominent economist Raymond Parsons has drawn together a powerful collection of expert thinkers, economists and analysts who tackle these issues head on as well as offering timely solutions to several of South Africa’s most pressing problems, drawing key lessons from the past in crystallising what South Africa needs to do to create a better future.

After the so-called ‘lost decade’ under the Zuma administration, South Africans had high hopes that President Ramaphosa would deliver on his promise of a ‘new dawn’. Yet despite high expectations that the country would finally turn the corner and settle onto a path of stronger inclusive growth and better governance, socioeconomic conditions have deterioriated. Growth remains negligible, unemployment has worsened and the fiscus is under considerable strain. Will SA be able to break out of its present ‘growth trap’ without falling into a ‘debt trap’?

The country is also facing global headwinds in the form of volatile market conditions, shifting geopolitics, and a fast-changing and disruptive technological landscape which threatens to leave all but the most well-prepared behind. So how must the different strands of policy – ranging from purely economic issues to broader questions around education and the rule of law – now knit together to create a bigger, stronger and better SA economy in future?

If the vision of a well-functioning society is to be realised, policy uncertainty about the road ahead must be generally tackled at the highest level to facilitate job-rich growth. And business and civil society, in its turn, must take a long-term view of South Africa’s future and commit energy and resources to bringing about change which is both productive and transformational.

Recession, Recovery & Reform will offer compelling new insights into how South Africa can unlock its potential in the years ahead. The publication of this title a month ahead of the ANC policy conference in June 2020, at which President Ramaphosa’s political and economic ‘track record’ will be widely assessed, ensures it will be a must-read for all who are concerned about South Africa’s well-being and who are willing to believe that a ‘new dawn’ is indeed possible.

Obstetrics is a unique field of medical care because, in its uncomplicated or natural form, pregnancy, labour and delivery are not diseases, but normal physiological events constituting an integral part of human life.

Three equally important facets form the basis of obstetrics: the needs of the pregnant woman, the wellbeing of the baby, and the ability to perform a medical intervention should either of these be threatened - before, during and after birth. Clinical obstetrics is an authoritative and up-to-date textbook dealing with current obstetric practice and focusing specifically on conditions and problems prevailing in South Africa. Clinical obstetrics covers a wide range of topics from physiological adaptations, diagnosis and management of normal pregnancy and delivery, to teratogenesis, red cell allo-immunisation, congenital abnormalities and pre-term labour. It also discusses the risks involved in poor progress in labour, abnormal fetal lie and presentation, viral infections and multiple pregnancies. There are separate sections for medical and surgical conditions, as well as diagnostic procedures.

Clinical obstetrics is aimed primarily at medical students, but will also be of great value to nurses, registrars in obstetrics and gynaecology, general practitioners and specialists in this field.

When Lauren Segal receives a call from her husband one wintry morning in 2014, the furthest thing from her mind is her biopsy results. For two years she’s been living a cancer-free existence after a double mastectomy that has put her in the clear. The call shatters the foundation of her world – the lump she thought was scar tissue is malignant. Her cancer is back.

Cancer: A Love Story is the intimately searing memoir of a four-time cancer survivor. The book magnificently tracks Lauren’s journey to come to terms with the untold challenges of facing the dreaded disease. Forced to face her needle phobia, the author leads the reader into her crumbling world as she confronts the terrors of treatment – from debilitating chemo to nuking radiation. Death is her uninvited companion.

But in the midst of her lonely horror, in a quest for deeper meaning, Lauren discovers the unexpected gift of awareness of unanticipated opportunities that cancer presents – to confront her unmasked humanity – her fears, strengths and weaknesses.

“Throughout my arduous journey into the world of cancer, I have discovered that proximity to death brings with it a new proximity to life. I have learned that luck and unluck, happiness and distress, hope and despair are tightly coiled into a life well lived.” Lauren’s story removes the enormous stigma that still surrounds breast cancer; it tackles the deep fear surrounding diagnoses and treatment and it encourages us to take control of our health. It ultimately triumphs by showing the reader how a person in any unwanted life situation can come out on the other side. The book also provides vital insights for professionals involved in the care of cancer patients and a hugely informative section on chemo tips for those undergoing treatment.

Artificial Intelligence for Neurological Disorders provides a comprehensive resource of state-of-the-art approaches for AI, big data analytics and machine learning-based neurological research. The book discusses many machine learning techniques to detect neurological diseases at the cellular level, as well as other applications such as image segmentation, classification and image indexing, neural networks and image processing methods. Chapters include AI techniques for the early detection of neurological disease and deep learning applications using brain imaging methods like EEG, MEG, fMRI, fNIRS and PET for seizure prediction or neuromuscular rehabilitation. The goal of this book is to provide readers with broad coverage of these methods to encourage an even wider adoption of AI, Machine Learning and Big Data Analytics for problem-solving and stimulating neurological research and therapy advances.

Targeted Nanomedicine for Breast Cancer Therapy provides a compilation of treatment approaches for breast cancer, including conventional receptor targeting methods and novel strategies like stimuli responsive methods and tumor micro-environment responsive strategies. This book compiles the most important information on the state-of-the-art therapeutics, including breast cancer biomarkers and design principles of bio-responsive nanosystems. Presented in two parts, sections cover basic and receptor mediated targeting approaches and examine tumor microenvironment mediated approaches. This is a useful book for pharmaceutical scientists and basic and clinical scientists working in the research area of breast cancer and drug discovery both from academics and industry. Worldwide, breast cancer is the most common cancer in women, however, breast cancer therapy is always challenging. This book aims to help researchers remain updated on the most targeted nanomedicine research available.

Introduction to Basic Aspects of the Autonomic Nervous System, Sixth Edition, Volume One is an all-encompassing reference on the autonomic nervous system's basic function, dysfunction and pathology. This volume describes the anatomy of the autonomic nervous system and its role in the regulation of blood pressure, body temperature, respiration, micturition, digestion and renal function. Additional chapters focus on the autonomic modulation of the neuroendocrine system, sexual function, and immunity. There is also a chapter on mummies and the autonomic nervous system. With these chapters, readers will gain extensive knowledge on the autonomic nervous system's anatomy, functional organization and neurochemistry, which is critical to care for patients with autonomic disorders and guide patient-oriented research.

Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

The Pituitary, Fifth Edition continues the tradition of a cogent blend of basic science and clinical medicine. The comprehensive text written by expert pituitary scholars is devoted to the pathogenesis, diagnosis and treatment of pituitary disorders. The new fifth edition has been extensively revised to reflect the most recent data on new research advances in tumorigenesis and new therapeutic approaches for pituitary tumors, particularly in acromegaly and Cushing disease. Notably, new chapters devoted to the Pituitary-Immune Interface and Pituitary Radiotherapy have been included, along with a chapter on Aggressive Pituitary Adenomas developed to align with the WHOs Classification of Pituitary Tumors. Furthermore, new authors have been invited, ensuring a fresh perspective on critical issues in the field. This extensive body of knowledge is useful for students, trainees, physicians, and scientists who need to understand critical pituitary functions and how to care for patients with pituitary disorders.

Encyclopedia of Infection and Immunity, Four Volume Set provides new insights into the interactions between bacteria, fungi, parasites and their hosts. Specific areas of interest include host cellular and immune response to microbes, molecular mechanisms of action of beneficial microbes or host-associated microbial communities, microbial pathogenesis, virulence factors, experimental models of infection, host resistance or susceptibility, and the generation of innate and adaptive immune responses. Comprised of over 200 chapters written and edited by leading experts in the field, this book will serve as a key resource for students, researchers, academics and industry practitioners in the fields of microbiology, immunology, and infectious diseases. More than 100 years after Robert Koch and Louis Pasteur established the microbial etiology of communicable diseases, the field of microbiology is experiencing a second period of rapid growth and expansion, driven by the realization that changes in host-associated microbial communities might be at the root of a broad spectrum of noncommunicable human diseases. These advances follow on the heels of recent progress in high-throughput sequencing technology, which has provided a wealth of information on the human microbiome and its physiological potential.

Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments.

Women's healthcare regarding polycystic ovarian syndrome remains challenging. Patients often go from one specialist to another trying to fully understand and management the disorder. Women often go years before a diagnosis, seeing three or more doctors before a confirmed diagnosis. Polycystic Ovarian Syndrome: Challenging Issues in the Modern Era of Individualized Medicine brings together multiple medical disciplines to improve the care of women with PCOS. Such a multidisciplinary clinical and scientific approach integrates obstetrics and gynecology, pediatric and medical endocrinology, internal medicine, genetics, psychology and laboratory medicine into relevant translational clinical and scientific discussions that update both the scientific understanding of PCOS and the diagnosis and management of all aspects of the syndrome. The impact of PCO on the onset of puberty is subdivided in sub sections to get a better understanding of this condition and the management at different stages in a woman's life.