All those involved in maternity care need to be aware of the issues women face when considering HIV and pregnancy. Since the first reported cases of AIDS two decades ago there has been much research into the HIV virus, and attitudes have changed as knowledge has increased. Today, a much better understanding of HIV and related AIDS conditions has enabled the midwife to apply evidence-based guidelines to everyday practice. It is essential that midwives are aware of the most up-to-date research findings so that they can ensure they offer their clients the best possible care during pregnancy and childbirth. HIV in Pregnancy and Childbirth takes a comprehensive look at the subject in a practical manner, covering epidemiology, transmission, the disease progress and the provision of holistic pregnancy care. Fully referenced with useful appendices and website addresses, this is an essential purchase for all healthcare professionals.An exploration of the latest research into the HIV virus focussing on issues specifically relevant to pregnant women and the newborn Written by a midwife who specialises in counselling HIV-positive women, this book deals with the issues midwives are most likely to encounter in practice Discusses the latest findings on breastfeeding and routes of transmission of the virus Includes guidelines and recommendations for the management of infected healthcare workers

This book provides a detailed overview of cancer theranostics applications of magnetic iron oxide nanoparticles. Their synthesis, characterization, multifunctionality, disease targeting, biodistribution, pharmacokinetics and toxicity are highlighted, along with current examples of clinical trials of magnetic nanoparticles in cancer theranostics, and their future scopes and challenges.

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.
Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells.

The important aspects of nutrition, drugs and vaccines are explained in a simple manner so that it will be easily understood. Combination of drugs can be dangerous and should be avoided as far as possible. The indications, contraindications, adverse effects of various medicines and vaccines are discussed in detail which will be helpful for the monitoring of patients. Designed for medical students which will help them to understand various facts in nutrition such as positive and negative aspects of nutrition, feeding and various other nutritional factors. Basics of x-rays and radiological features of various clinical conditions are discussed in detail. Indications, contraindications and adverse effects of various medicine and vaccines are discussed in detail. Mnemonics for easy remembrance and recollection.

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that constitue immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
Immunology is vital to the understanding of infection and disease. Application of this information may lead to resistance and cures for higher animals and humans.

The book is divided into three sections: The first section covers basic materials (from choice of suture materials to why powdered gloves can cause latex allergy), instruments (such as why scissors are right or left handed) and basic techniques (for example, how to deliberately tie a slip knot and how to avoid doing so accidentally!). The second section covers local anaesthetic agents and techniques. The third section describes the most commonly performed operations and the complications that may be encountered including how to avoid and how to deal with them. There are also chapters that deal with the highly important but often neglected topics of biometry and orbital and lens implant biomaterials and design. Throughout, the scientific basis has been emphasized where possible. Professionals who work with ophthalmic patients such as nursing staff and optometrists will also find a clear description of the commonly performed procedures to be of interest. * an easy-to-use book, rectifying any immediate gaps in surgical knowledge * a highly practical text which covers everything that the ophthalmic trainee needs to know * beautifully illustrated text, covering all the basic procedures from anesthesia to instruments, wounds and their aftercare to the most commonly performed ophthalmic operations

This up-to-date text offers a practical approach to the theory and practice of how spectacle lenses are made and how they work in correcting vision. It also covers the more fundamental aspects of spectacle lens dispensing with relevance to areas such as visual optics and geometric optics.Pitched at the correct level for study - easy to follow for undergraduates Theory is related to practical reality - so students can take the textbook through to the early years of practice Extensive examples enable the reader to follow through calculations - great for revision and quick reference!

This quick reference guide, with its easy-to-use format, can be used as a revision tool for professional examinations as well as a tutorial aid for lecturers. It will, therefore, be an essential purchase for trainees and specialists in anaesthesia, intensive care and emergency medicine as well as providing continuing medical education for established senior staff. * Illustrative case scenarios to emphasize the safe, modern approach to a wide variety of problems in the field of paediatric anaesthesia and intensive care * Topics reflecting the scope of current practice with questions and answers * Key references for further reading

A comprehensive text that looks at respiratory disorders in general, but concentrates on those that are more prevalent in tropical regions. The text is extremely well-illustrated and provides a comprehensive view of different respiratory diseases. A highlight of the book is the discussion on the threat of pulmonary tuberculosis and its unsolved challenges. The epidemiology, the subtle variation in clinical presentation, and the natural history of respiratory diseases in regional contexts have been clearly emphasized. This second edition has been thoroughly revised and updated. Prevailing concepts in lung cancer, asthma, interstitial lung disease, and several other diseases have been discussed at length. The section on newer diagnostic aids involving genetic and molecular biology, has been extensively revised. Every chapter of every section is illustrated wherever necessary with high-quality images contributing to a better understanding of the text.

This book is primarily aimed to cover the Indian system of examination (both the University and the National Board). The current seventh edition has been thoroughly revised and updated to cover the international examinations like the Royal College, London (RCOG), Royal College, Ireland (RCPI), and the American Board of Examinations (USMLE). This revision manual is a high yield concise book that covers all the contemporary examination systems. Covers comprehensively the entire zone of clinical, practical and viva-voce part of the examination, fulfilling university course curricula. Answers are framed in a simple and concise way for easy understanding and reproduction. Chapters on endoscopy (laparoscopy and hysteroscopy) and robotic surgery in gynecology have been incorporated to keep the reader up-to-date with the progress in science and technology. Model answers are provided to guide candidates in how to answer the theory questions. Topics on ultrasonography, doppler studies, computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), laparoscopic and hysteroscopic surgery and robotic surgery have been incorporated. SBAs and MCQs are presented with model answers. Clinical photographs, graphs, sketches and line drawings have been included.

This casebook is a compilation of independent cases seen and documented by the respective authors. Each patient tells a story. In some cases the patient comes with an uncommon diagnosis, while in others the diagnosis is not rare, but important management issues are discussed. The largest number of cases included pertain to diabetes. In one or two instances, similar patients have been seen by different authors. They have been included to show the similarities and differences in approach amongst colleagues. Suggested reading at the end of each case supplement the text. Includes real-world case studies. Cases are arranged subject-wise, starting from adrenals. Each case is meant to be read independently. Covers a wide range of uncommon clinical problems and unusual clinical presentation. Suggested reading at the end of each case will further enrich reader’s experience.

Migraine treatment improved considerably with the advent of the 'triptans' in the 1990s. While the drugs used previously for headache treatment had efficacy, some compounds had bothersome side effects and their overuse could lead to severe complications. In the early days of the triptans, it was widely presumed that migraine was no longer a treatment problem. However, it has gradually been recognized that a significant proportion of patients are not responsive to triptans or do not tolerate them. It is now clear that, even with effective treatment, patients with frequent migraine attacks are not treated well exclusively with acute medications. This is partly because patients are still bothered by the attacks and partly because frequent intake of acute medication may result in medication-overuse headache. These problems have led to a renewed interest in preventive migraine drugs.
Part of the Frontiers in Headache Research series, this book summarizes the several promising new avenues for the development of future drugs for the treatment of migraine, including cortical-spreading depression inhibition, nitric oxide synthase inhibition and calcitonin gene-related peptide (CGRP) receptor antagonism, as well as other potential targets. The book presents frontline knowledge of these evolving modalities as far as it is available in the public domain. It is hoped that readers and their patients will find it exciting to learn about all the novel possibilities, and also that the impressive research advances in migraine will lead to increased funding, not only of migraine but also of other types of headache.

The life and work of Joseph Babinski (1857-1932) has been revisited by two French physicians whose enthusiasm for the subject is reflected in the depth and breadth of documentary sources. From Babinski's Polish roots, his father (an intrepid revolutionist, his brother(the gold miner and famous gastronome Ali-Bab to the Babinski circle, his friends, his colleagues and his disciples, the reader will find a refreshing perspective on a particularly fascinating period in French medicine. His scientific contribution is analyzed in detail, with for the first time a complete bibliography of his publications. These includes not only the Babinski Sign, but also the earlier and heretofore less-known concerning pathological anatomy and histology, the papers on cutaneous and tendinous reflexes, cerebellar and vestibular semeiology, hysteria and pithiatism, localization of spinal cord compression s and the birth of French neurosurgery.

The book is a comprehensive and practical guide to the students, trainees, practitioners and gynecologic oncology workers about premalignant and malignant condition of the vulva. It covers all the cancers of the vulva, as well as the surgical and medical aspects of vulvar disease.

With a wealth of sound practical advice, from the authors' years of extensive experience, this book will be invaluable for all those prescribing aerobic exercise programmes for cardiovascular health including: general practitioners, physiotherapists, nurses, exercise instructors and advisors.Covers traditional and contemporary approaches Many easy-to-use charts for the calculation of exercise intensities and aerobic exercise programmes Well referenced and thoroughly tested

Our ability to map and intervene in the structure of the human brain is proceeding at a very quick rate. Advances in psychiatry, neurology, and neurosurgery have given us fresh insights into the neurobiological basis of human thought and behavior. Technologies like MRI and PET scans can detect early signs of psychiatric disorders before they manifest symptoms. Electrical and magnetic stimulation of the brain can non-invasively relieve symptoms of obsessive-compulsive disorder, depression and other conditions resistant to treatment, while implanting neuro-electrodes can help patients with Parkinsons and other motor control-related diseases. New drugs can help regenerate neuronal connections otherwise disrupted by schizophrenia and similar diseases.
All these procedures and drugs alter the neural correlates of our mind and raise fascinating and important ethical questions about their benefits and harms. They are, in a sense, among the most profound bioethical questions we face, since these techniques can touch on the deepest aspects of the human mind: free will; personal identity; the self; and the soul. This is the first single-author book on what has come to be known as neuroethics. Walter Glannon uses a philosophical framework that is fully informed by cutting edge neuroscience as well as contemporary legal cases such as Terri Schiavo, to offer readers an introduction to this fascinating topic. He starts by describing the state of the art in neuroscientific research and treatment, and gives the reader an up-to-date picture of the brain. Glannon then looks at the ethical implications of various kinds of treatments, such as: whether or not brain imaging will end up changing our viewson free will and moral responsibility; whether patients should always be told that they are at future risk for neurological diseases; if erasing unconscious emotional memories implicated in depression can go too far; if forcing behavior-modifying drugs or surgery on violent offenders can ever be justified; the implications of drugs that enhance cognitive abilities; and how to define brain death and the criteria for the withdrawal of life-support. While not exhaustive, Glannons work addresses a wide range of fascinating issues and his pathbreaking work should appeal to philosophers, psychiatrists, neurologists, neurosurgeons, radiologists, psychologists, and bioethicists.

This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

In the late 1980s, a promising new treatment for breast cancer emerged: high-dose chemotherapy with autologous bone marrow transplantation or HDC/ABMT. By the 1990s, it had burst upon the oncology scene and disseminated rapidly before having been carefully evaluated. By the time published studies showed that the procedure was ineffective, more than 30,000 women had received the treatment, shortening their lives and adding to their suffering. This book tells of the rise and demise of HDC/ABMT for metastatic and early stage breast cancer, and fully explores the story's implications, which go well beyond the immediate procedure, and beyond breast cancer, to how we in the United States evaluate other medical procedures, especially life-saving ones.
It details how the factors that drove clinical use--patient demand, physician enthusiasm, media reporting, litigation, economic exploitation, and legislative and administrative mandates--converged to propel the procedure forward despite a lack of proven clinical effectiveness. It also analyzes the limited effect of technology assessments before randomized clinical trials evaluated decisively the procedure and the ramifications of this system on healthcare today.
Sections of the book consider the initial conditions surrounding the emergence of the new breast cancer treatment, the drivers of clinical use, and the struggle for evidence-based medicine. A concluding section considers the significance of the story for our healthcare system.

After her diagnosis of triple negative breast cancer (TNBC), health journalist Patricia Prijatel did what any reporter would do: start investigating the disease, how it occurs, and how it's treated. While she learned that important research was emerging, she found a noticeable lack of resources on the disease, which affects 70,000 women a year and differs from hormone-positive breast cancer in important ways, including prognosis and treatment options. Hormone negative breast cancer disproportionately affects younger women and African-American women - and it can be more dangerous than other types of breast cancer. But there are many reasons to be hopeful, as Prijatel learned. Through her blog, Positives About Negative, she has met hundreds of women who have told her their stories and shared their fears, confusion, and frustration. After her recovery, she began writing this book to provide the first dedicated resource for women diagnosed with TNBC. Surviving Triple Negative Breast Cancer delivers research-based information on the biology of TNBC; the role of genetics, family history, and race; how to navigate treatment options; and a plethora of strategies to reduce the risk of recurrence, including diet and lifestyle changes. In clear, approachable language, Prijatel provides an accessible guide to understanding a pathology report and a vast array of scientific studies. Woven throughout the book are stories of women who have faced TNBC. These are mothers, wives, daughters, and sisters who went through a variety of medical treatments and then got on with life - one competes in triathlons, two had babies after being treated with chemo, one got remarried in her 50s, and one just celebrated the 30th birthday of the son she was nursing when she was diagnosed. With honesty and humor, Prijatel's inspiring story shows the heart of a survivor. Her message is that TNBC is a disease to take seriously, with proper and occasionally aggressive treatment, but it is not automatically a killer. Most women diagnosed with the disease do survive. Surviving Triple Negative Breast Cancer is a roadmap for women who want to be empowered through their treatment and recovery.

Headache Medicine has recently become an official medical subspecialty. Practitioners who specialize in the field come from many different backgrounds including neurology, internal medicine, anesthesiology, rehabilitation medicine, family medicine, psychiatry, dentistry and others. A great deal of research is being done in HM, and, as a result, the field is one which is growing rapidly in every way. Interestingly, most patients with headache are not being treated by specialists in HM, in large part because of the vast numbers of patients requiring medical attention for headache disorders, and the relatively small number of bona fide specialists. Thus, there is a need for resources to guide these practitioners as they manage headache patients. There are several excellent scholarly texts in the field and numerous books for the public about headache. There are really no concise manuals of HM, however, there are books aimed at the bulk of skilled practitioners taking care of the major share of headache sufferers, who wish to understand the important concepts of diagnosis, treatment, and prognosis in this complex field. This is the aim of Dr. Levin's book which consists of 4 parts: Part 1- Headache Medicine Basic Science, Part 2- Diagnosis of Primary Headache Disorders, Part 3- Diagnosis of Secondary Headache Disorders, and Part 4- Headache Treatment.
Chapters in each section are concise, but include cutting edge information about these aspects of headache medicine. The organization of the contents of this book is similar to the Curriculum for Headache Medicine designed by the United Council for Neurologic Subspecialties (UCNS) which is the organization responsible for accreditingHeadache Medicine training programs and accrediting individual practitioners. The content of the book mirrors that of the UCNS board examination as well. Chapters include key tables and illustrations. Review questions are included at the end of each chapter and serve as a study resource. The editor is a charter diplomate of the UCNS HM examination and has directed board review courses for the American Headache Society and Headache Cooperative of New England. All of the eligible chapter authors have taken and passed this exam as well. The International Classification of Headache Disorders is used throughout this text and a concerted effort has been made to base content on evidence when available, rather than personal practices. Each chapter is intended as a stand alone monograph and as a result the book can be read in virtually any order.