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Books > Medicine > Clinical & internal medicine
An essential, comprehensive, and practical guide to understanding, measuring, and modifying patients' adherence behavior to optimize treatment outcomes, this book covers all major aspects of adherence in dermatology. The first section describes current knowledge on the magnitude and impact of nonadherence; the second outlines measuring adherence in the context of databases, trials and practice. The third section addresses adherence in key skin diseases and the fourth covers numerous strategies to improve adherence by mitigating specific patient barriers. All sections emphasize ways to optimize communication with patients: the foundation for producing successful health behavior change. Low adherence helps explain why, despite effective treatments existing for all major dermatologic conditions, many patients still fail to improve. When clinicians endeavour to maximize adherence, with the aid of evidence-based strategies, these drugs will often realise their potential. This book devotes special attention to understanding why individuals may be nonadherent, so that each patient can receive a suitable treatment regimen, with a personalized plan of action. This book is designed for clinicians at all levels, serving as both introductory training for medical students and residents, and an update on the field for experienced practitioners. Researchers and policymakers will also benefit from its coverage of research methods and the impact of nonadherence in specific diseases. Adherence in Dermatology bridges the gap between outcomes researchers and clinicians by explaining the latest findings in plain language, with examples from everyday dermatologic practice.
This handbook on orbital, lacrimal and eyelid emergencies deals with such situations in a practical manner guiding the ophthalmologists in accurate handling and making them more proficient and confident in managing vision and life-threatening emergencies. With 51 chapters and more than 350 images, this book covers all the eye emergencies that generalist and specialist ophthalmologists can expect to come across in their day to day practices. It can be argued that the orbit can no more be called 'Pandora's Box' because of the unpredictable nature of its contents. This perception has changed over the years due to the advent of improved diagnostic, in particular, imaging techniques. However, since medical residency provides very little exposure to orbital and adnexal disorders, most clinicians are inexperienced and unsure about their management. Facing an emergency situation where improper management can rapidly worsen the condition leading to blindness or even death of the patient is every ophthalmologist's nightmare. The emergent nature of these conditions does not always provide for a leeway to refer these patients to an orbit and oculoplasty specialist, who are few and far between. By the time the patient reaches his destination, his vision maybe irrevocably lost. The legal implications of such mismanagement can be significant too. This book is a quick and essential resource to manage and refer eye emergencies with confidence.
This book presents and explains the latest developments in surgery for congenital digestive tract malformations, tumors, abdominal trauma, and the most important acquired digestive disorders. Particular attention is paid to minimally invasive and innovative techniques. In addition to clear descriptions of the surgical procedures that highlight useful tips and tricks, for each condition the clinical presentation is well illustrated and information is provided on pathogenesis. The book also includes general chapters that address the anatomy of the abdomen in children, diagnostic issues, the problem of clinical nutrition, and other aspects of management in pediatric patients with gastrointestinal pathologies. Pediatric Digestive Surgery will serve as a comprehensive and up-to-date reference for all pediatric surgeons. It will provide the trainee with easily understood, concise guidance while offering the more experienced surgeon valuable updates on the latest thinking and practice in the field.
This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.
This book is oriented towards post-graduates and researchers with interest in proteomics and its applications in clinical biomarker discovery pipeline. Biomarker discovery has long been the research focus of many life scientists globally. However, the pipeline starting from discovery to validation to regulation as a diagnostic or therapeutic molecule follows a complex trajectory. This book aims to provide an in-depth synopsis on each of these developmental phases attendant to biomarker "life cycle" with emphasis on the emerging and significant role of proteomics. The book begins with a perspective on the role of biorepositories and need for biobanking practices in the developing world. The next chapter focuses on disease heterogeneity in context to geographical bias towards susceptibility to the disease and the role of multi-omics techniques to devise disruptive innovations towards biomarker discovery. Chapter 3 focuses on various omics-based platforms that are currently being used for biomarker discovery, their principles and workflow. Mass spectrometry is emerging as a powerful technology for discovery based studies and targeted validation. Chapter 4 aims at providing a glimpse of the basic workflow and considerations in mass spectrometry based studies. Rapid and aptly targeted research funding has often been deemed as one of the decisive factors enabling excellent science and path breaking innovations. With the need for sophistication required in multi-omics research, Chapter 5 focuses on innovative funding strategies such as crowdfunding and Angel philanthropy. Chapter 6 provides the latest advances in education innovation, the premise and reality of bioeconomy especially in a specific context of the developing world, not to mention the new concept of "social innovation" to link biomarkers with socially responsible and sustainable applications. Chapter 7, in ways similar to biomarkers, discusses the biosimilars as a field that has received much focus and prominence recently due to their immense potential in clinical and pharmaceutical innovation literatures. The broader goal post-biomarker discovery is to translate their use in clinics. However, the road from bench-to-bed side is arduous and complex that is subject to oversight from various national and international regulatory bodies. Chapter 8 underscores these regulatory science considerations and provides a concise overview on intellectual property rights in biomarker discovery. Thus, this book contributed by eminent biomarker scientists, clinicians, translational researchers and social scientists holistically covers the various facets of the biomarker discovery journey from "cell to society" in developing world. The lessons learned and highlighted here are of interest to the life sciences community in a global and interdependent world.
Since the first edition of this book was published, much new knowledge has been gained on hemangiomas and vascular malformations. This revised and updated second edition, written by worldwide leaders in the field, fully reflects this progress. Important improvements in the treatment of hemangiomas are reviewed, including the use of beta-blockers and other medical therapies as well as advances in interventional treatments and the treatment of hemangiomas in specific locations. Vascular malformations are being investigated with increasing frequency all over the world and new challenges are emerging regarding both diagnosis and treatment. This edition considers the current role of the full range of diagnostic imaging techniques -magnetic resonance imaging, computed tomography, nuclear medicine techniques, angiography, and phlebography. The various treatment options, including laser, interventional radiological, and surgical techniques, are then presented in detail. A further individual section is devoted to the study and treatment of lymphatic malformations and dysplasias, and a series of chapters also focus on problems in the treatment of malformations in particular locations, including the thorax and viscera. This book, in atlas format, is exceptional in providing clinically relevant information on the diagnosis and treatment of both hemangiomas and vascular malformations. It will appeal to all professionals who encounter these conditions in their daily clinical practice.
In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This second volume is dedicated to basic pathologies of the two most common osteoarticular diseases affecting large segments of the Western population, osteoarthritis and chondrodysplasias. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage biology and pathobiology.
This pocketbook is an evidence-based educational resource that provides a concise overview of diagnosis, treatment and long-term management of relapsing-remitting multiple sclerosis. An ideal clinical handbook for a wide range of medical professionals, this handbook includes international guidelines, clinically relevant clinical trial data, and an introduction to emerging therapies. Handbook of Relapsing-Remitting Multiple Sclerosis is a comprehensive overview of recent advances in this indication, enhanced by high quality figures and clinical images.
This book reviews the various emerging infectious diseases that show a significant association with uveitis, describing and explaining their ocular manifestations with the aid of color illustrations. In addition, it presents brief reports of further emerging infections that are associated with uveitis in rare cases. The coverage is wide ranging, encompassing diverse emerging bacterial, viral, parasitic and fungal infections. Individual chapters are also devoted to important re-emergent diseases such as syphilis and tuberculosis, with the focus on new data on epidemiology, diagnosis and management. Emerging infectious diseases are defined as "those whose incidence in humans has increased within the past two decades or threatens to increase in the near future". Emergence may be due to the spread of a new agent, to the recognition of an infection that has been present in the population but has gone undetected, or to the realization that an established disease has an infectious origin. This book will be an invaluable source of information on all aspects of uveitis in these diseases.
This book presents the theory of influenza and its imaging characteristics. The first section introduces readers to the fundamental theory of influenza, including the etiology, epidemiology and pathogenesis of influenza, influenza-related diseases, and imaging technologies. The second section is divided into 5 chapters and includes extensive DR, CT and MRI images on H1N1 influenza, H5N1, H7N9, H5N6 and H10N8 avian influenza.
This book highlights the most significant diseases for humans and their dogs, cats and horses. The examples discussed, which include allergies, osteoporosis, cancer and many more, illustrate that humans and their companion animals may in fact develop similar diseases. The reader - whether expert or interested lay - can thus directly compare between human and animal patients. The animal patient thereby represents a natural disease model, which besides the experimental models, is urgently needed to improve the therapeutic options for both humans and animals.
Vitamin D deficiency, circulating levels lower than 15 ng/ml, is an epidemic disease worldwide with more than a billion people suffering of it in the beginning of the 21-century. Besides its impact on mineral and bone metabolism, these low vitamin D levels are also associated with a diversity of non-skeletal complications, among them cardiovascular disease, diabetes mellitus, multiple sclerosis, cancer, tuberculosis, and immune system dysfunction. Chronic Kidney Disease is also a very common disease, affecting more than 10% of the world population, ranging from stage 1 to stage 5 before dialysis. Approximately 1% of the population in industrialized countries is affected by end-stage renal disease (ESRD), needing a renal replacement therapy either hemodialysis or peritoneal dialysis, and ultimately by renal transplantation. Those CKD patients are more susceptible to exhibit reduced vitamin D stocks. Consequently, more than eighty percent of CKD patients have either insufficient or deficient vitamin D levels for multiple reasons.
This book presents recent advances in translational research on muscular dystrophy (MD) to physicians and researchers, including cutting-edge research on the disease such as regenerative medicine, next-generation DNA sequencing, and nucleic acid therapies. It also describes the current systems for clinical trials and MD patient databases, resources, which will support the early realization of clinical application and improve patients' quality of life. MD is the one of the most widely known inherited neuromuscular diseases and is classified into diverse types by symptoms, age of onset, mode of inheritance, and clinical progression. With the development of molecular biology, the occurrence mechanisms of each type of MD are gradually being elucidated. Although there is no known permanent cure yet, the stage of treatment research has now advanced to clinical trials.
This book provides a comprehensive up-to-date review of juvenile angiofibroma, with contributions from all relevant specialties. Starting with a brief introduction to the history, etiology and relevant anatomy, the book goes on to discuss the pathology, clinical features and treatment of this disease in depth, concluding with a summary of current controversies. Juvenile Angiofibroma is aimed at a global audience of otolaryngologists, endoscopists, head and neck surgeons, maxillofacial surgeons, pathologists, radiologists and geneticists.
Comprised exclusively of clinical cases involving osteonecrosis of the femoral head (ONFH), this concise, practical casebook will provide orthopedic surgeons with the best real-world strategies to properly diagnose and treat both pre- and post-collapse conditions. Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as the case outcome and clinical pearls and pitfalls. Part I discusses pre-collapse treatments aimed at the early stages of ONFH, including the use of bisphosphonates, stem cell therapy and minimally invasive core decompression. Chapters presenting post-collapse treatments aimed at preserving the femoral head comprise part II, including non-vascularized bone grafting, osteochondral transfer and transtrochanteric osteotomy. Cases covering post-collapse total hip arthroplasty (THA) and common complications round out the presentation. Osteonecrosis of the Femoral Head: A Clinical Casebook will be an excellent resource for orthopedic surgeons, residents and fellows treating hip pain.
Do you suffer from heartburn? Is an ulcer bothering you? Are the difficult symptoms of irritable bowel syndrome compromising your life? If so, you are not alone. You are that one out of every three Americans that suffers from chronic digestive problems. Whether it's constipation, diarrhea, gas, hemorrhoids, ulcers, heartburn, colitis, gallstones, or one of the many other digestive tract problems, Dr. Steven Peikin's self-help nutritional program will help keep you out of the doctor's office--and feeling great. Based on the latest research and his own clinical experience, Dr. Peikin prescribes a healthy diet high in fiber and low in fat, spices, lactose, and caffeine. He provides a detailed list of "flag foods" to avoid in the case of specific problems; shows you how to use exercise, over-the-counter drugs, prescription drugs, and stress management to complement the program; and offers advice for coordinating the program with weight loss (or weight gain), working with medical professionals, and measuring progress. "Highly recommended for its thorough coverage, sound advice, and healthy suggestions,"* Gastrointestinal Health--now revised and updated with the latest information on new drugs and research--is everything you need to know to find fast relief from a wide range of gastrointestinal difficulties. Library Journal
This comprehensive and authoritative text takes an integrated approach to childbirth trauma, focusing on anal sphincter injuries and perineal morbidity, as well as other lower urinary tract dysfunctions secondary to childbirth. In recent years there has been an increasing emphasis on childbirth injury. Research based on clinical evaluation and anal ultrasound has improved our understanding of these significant childbirth related complications, their associated morbidity and their long-term sequelae. Despite extensive research interest, clinical focus and institutional national and international guidelines, outcomes are still not optimal and debates continue. Complete with full-color illustrations, Childbirth Trauma is a useful guide for clinicians and researchers in this field.
This book comprehensively covers endometrial carcinoma, a type of gynecological cancer that is often overlooked but of great interest. Although the incidence of the disease is rapidly increasing, both per se and as part of familial cancer syndromes, there is a great deal of controversy regarding its diagnosis, evaluation and management. This book underlines the significance of endometrial carcinoma, highlights key prevention measures, charts its evaluation, and addresses the stage-by-stage management of this malignancy, with particular attention to the role of minimally invasive surgery. Further, it includes a chapter on future perspectives including robotics, targeted therapies and other developments in the offing. Overall, the book provides a comprehensive guide to endometrial cancer, which if approached properly, can have an excellent prognosis, thus saving many lives and/or achieving substantially improved quality of life.>
This landmark book is the most extensive and complete oculofacial plastic surgery guide available in the market. Updated and broadened from the three previous editions, it includes advances in the use of surgical navigation systems, and new techniques and treatments for diseases involving the eyelid, orbital and lacrimal system. Organized across 11 sections of in-depth, expertly written text,Ā Smith and Nesiās Ophthalmic Plastic and Reconstructive Surgery, Fourth EditionĀ has taken the best of the fieldās classic reference text and expanded upon it.Ā Detailed chapters cover a multitude of topics relating to various ocular surgeries, pediatric considerations, ocular traumas, and anatomy. Supplemented with a myriad of high-quality illustrations,Ā Smith and Nesiās Ophthalmic Plastic and Reconstructive Surgery, Fourth EditionĀ is an indispensable reference for oculoplastics surgeons and physicians in other fields. Ā
This book is a practical guide to the cryopreservation and transplantation of oocytes, embryos, and ovarian and testicular tissue for fertility preservation. Illustrated with a wealth of figures and photos, it provides updated techniques for clinicians, technicians, and researchers. This book also gives insights into in vitro activation (IVA), in vitro growing (IVG), and in vitro maturation (IVM), with both basic research and future directions. These techniques combined with cryopreservation will improve the chances of reproduction. Cryopreservation is essential to protect fertility in cancer patients who undergo treatment with radioiodine or chemotherapy, which may cause damage to their reproductive organs, and also for primary ovarian insufficiency patients. The book also includes a chapter on the risk of the presence of malignant cells in ovarian tissue. Both editors are pioneering researchers in this field.
This handbook is a collection of clinical narratives that underscore the heterogeneous and unpredictable presentation of multiple sclerosis (MS) and give real-world clinical context to recent drug developments. This accessible and concise publication is intended to be used by a wide range of medical professionals, from specialist neurologists to medical trainees with an interest in neurology. An ideal clinical resource, Case Studies in Multiple Sclerosis provides an evidence-based discussion of each case, with an aim to enhance effective diagnosis and treatment of patients with MS and MS-related conditions.
This book addresses the growing problem of multimorbidity in cancer patients and survivors with the focus on how to best integrate the effective cancer care with the care of multiple chronic conditions. As cancer is more prevalent in older individuals, many patients with cancer also suffer from other chronic conditions that impact on the uptake, tolerance and outcomes of cancer treatment and their long term mortality and morbidity. In addition, cancer and its treatment increase the risk of future chronic conditions. Readers will examine the prevalence and predictors of chronic conditions in cancer, impact of chronic conditions on screening and treatment, evidence for preventative strategies that address both cancer and chronic conditions, emerging management and care integration strategies and directions for management of multimorbidity in special cancer populations - the very young, the very old and those at the end of life. Authored by clinicians and researchers from diverse expertise including epidemiology, sociology, hematology, medical oncology, palliative care, pharmacy and representing Australia, New Zealand, US, Canada and the Netherlands, the book brings an international perspective to a problem that affects all cancer settings. The book is going to be of interest to diverse professionals interested in cancer control including epidemiologists, public health researchers, policy makers as well as clinicians dealing with cancer patients within specialist cancer and non-cancer and primary care settings.
This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
This book aims to address all degrees of perineal trauma as well as interventions to reduce the risk of their occurrence and management of future pregnancies . Perineal trauma affects a significant number of women worldwide every year. The inadequate assessment and management of perineal trauma can cause significant complications to women at a very critical time of their life. These can consequently lead to serious long-term problems.
An overview of the diagnosis, treatment, and long-term management of diabetic-related kidney disease in clinical practice. Includes an evidence-based discussion of currently available and experimental drug therapies currently in development, guided by international consensus guidelines. Ideal for physicians, medical trainees, nurses and other medical professional that regularly screen and treat patients with all types of diabetes. |
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