**Finalist, PROSE Award in Clinical Medicine** A rich examination of the history of trans medicine and current day practice Surfacing in the mid-twentieth century, yet shrouded in social stigma, transgender medicine is now a rapidly growing medical field. In Trans Medicine, stef shuster makes an important intervention in how we understand the development of this field and how it is being used to "treat" gender identity today. Drawing on interviews with medical providers as well as ethnographic and archival research, shuster examines how health professionals approach patients who seek gender-affirming care. From genital reconstructions to hormone injections, the practice of trans medicine charts new medical ground, compelling medical professionals to plan treatments without widescale clinical trials to back them up. Relying on cultural norms and gut instincts to inform their treatment plans, shuster shows how medical providers' lack of clinical experience and scientific research undermines their ability to interact with patients, craft treatment plans, and make medical decisions. This situation defies how providers are trained to work with patients and creates uncertainty. As providers navigate the developing knowledge surrounding the medical care of trans folk, Trans Medicine offers a rare opportunity to understand how providers make decisions while facing challenges to their expertise and, in the process, have acquired authority not only over clinical outcomes, but over gender itself.

The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The purpose of this NATO-ARW was to bring together experts (both clinical and scientific) in all three interrelated fields to review the current basic and clinical position and discuss future developments particularly with respect to future research aimed at determining the basic biochemical lesion involving hydrolytic enzymes involved in human disease and the use of these enzymes in diagnosis. As well as formal lectures from established researchers, the meeting also involved a number of lively round-table discussions on future developments and presentations from younger research workers, all of which are recorded in this Proceedings and which contribute to the success of the meeting.

For more than 30 years, the highly regarded Secrets Series (R) has provided students and practitioners in all areas of health care with concise, focused, and engaging resources for quick reference and exam review. Physical Diagnosis Secrets, 3rd Edition, offers practical, up-to-date coverage of the full range of essential topics in physical diagnosis and health assessment. This highly regarded resource features the Secrets' popular question-and-answer format that also includes lists, tables, pearls, memory aids, and an easy-to-read style - making inquiry, reference, and review quick, easy, and enjoyable. The proven Secrets Series (R) format gives you the most return for your time - succinct, easy to read, engaging, and highly effective. Fully revised and updated throughout, with highly illustrated coverage of the history and physical exam, followed by assessment techniques that are weighted based on their clinical importance. Online assessment includes audio clips of the heart and lung. Top 100 Secrets and Key Points boxes provide a fast overview of the secrets you must know for success in practice and on exams. Bulleted lists, mnemonics, practical tips from leaders in the field - all providing a concise overview of important board-relevant content. Multiple-choice questions online provide opportunities for further self-assessment. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations. Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbations: is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use examines current and breakthrough pharmacologic and non-pharmacologic treatments includes COPD-causing exacerbations such as viral and bacterial infections discusses the negative environmental factors relating to COPD

Hyponatremia is a common electrolyte disorder found in a variety of settings. Manifestations range from subtle abnormalities to convulsions and death. New treatment options, such as Antidiuretic Hormone (ADH) antagonists, have created the need for a resource presenting the latest evidence and clinical approaches. Hyponatremia: Evaluation and Treatment is a comprehensive review of hyponatremia, with an emphasis on managing this disorder from diagnosis to treatment. The incidence and occurrence of acute and chronic hyponatremia in general terms are covered, as well as disorders of the central nervous system, heart and liver with their relation to hyponatremia. Common clinical scenarios are presented along with both traditional and new methods of treatment. Authored by experts on this disorder from around the world, experienced members of the medical community and trainees alike will find Hyponatremia as an indispensible guide to diagnosis, managing and treating patients with hyponatremia.

Provides the essential information that health care researchers and health professionals need to understand the basics of qualitative research Now in its fourth edition, this concise, accessible, and authoritative introduction to conducting and interpreting qualitative research in the health care field has been fully revised and updated. Continuing to introduce the core qualitative methods for data collection and analysis, this new edition also features chapters covering newer methods which are becoming more widely used in the health research field; examining the role of theory, the analysis of virtual and digital data, and advances in participatory approaches to research. Qualitative Research in Health Care, 4th Edition looks at the interface between qualitative and quantitative research in primary mixed method studies, case study research, and secondary analysis and evidence synthesis. The book further offers chapters covering: different research designs, ethical issues in qualitative research; interview, focus group and observational methods; and documentary and conversation analysis. A succinct, and practical guide quickly conveying the essentials of qualitative research Updated with chapters on new and increasingly used methods of data collection including digital and web research Features new examples and up-to-date references and further reading The fourth edition of Qualitative Research in Health Care is relevant to health care professionals, researchers and students in health and related disciplines.

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation.

TEXTBOOK OF EPIDEMIOLOGY The gold standard in epidemiological texts In the second edition of Textbook of Epidemiology, a distinguished team of researchers deliver an extensively updated and comprehensive exploration of epidemiological methods, illuminating the tools for studying the distribution and risk factors of health states and events in populations. An introduction to epidemiological methods with recent and broadly applicable examples End-of-chapter self-assessment questions for readers to check their understanding of key concepts, with answer keys and further enrichment materials available on a companion website A brand-new chapter covering methods for systematic reviews and meta-analysis Accessible material appropriate for clinical practitioners and researchers from around the world Perfect for professionals working in clinical medicine and public health, Textbook of Epidemiology will also earn a place in the libraries of allied health professionals seeking a one-stop resource or to re-immerse themselves in specific methodological topics and practices.

Clinical research is heavily regulated and involves coordination of numerous pharmaceutical-related disciplines. Each individual trial involves contractual, regulatory, and ethics approval at each site and in each country. Clinical trials have become so complex and government requirements so stringent that researchers often approach trials too cautiously, convinced that the process is bound to be insurmountably complicated and riddled with roadblocks. A step back is needed, an objective examination of the drug development process as a whole, and recommendations made for streamlining the process at all stages. With Intelligent Drug Development, Michael Tansey systematically addresses the key elements that affect the quality, timeliness, and cost-effectiveness of the drug-development process, and identifies steps that can be adjusted and made more efficient. Tansey uses his own experiences conducting clinical trials to create a guide that provides flexible, adaptable ways of implementing the necessary processes of development. Moreover, the processes described in the book are not dependent either on a particular company structure or on any specific technology; thus, Tansey's approach can be implemented at any company, regardless of size. The book includes specific examples that illustrate some of the ways in which the principles can be applied, as well as suggestions for providing a better context in which the changes can be implemented. The protocols for drug development and clinical research have grown increasingly complex in recent years, making Intelligent Drug Development a needed examination of the pharmaceutical process.

Advanced Perioperative Crisis Management is a high-yield, clinically-relevant resource for understanding the epidemiology, pathophysiology, assessment, and management of a wide variety of perioperative emergencies. Three introductory chapters review a critical thinking approach to the unstable or pulseless patient, crisis resource management principles to improve team performance and the importance of cognitive aids in adhering to guidelines during perioperative crises. The remaining sections cover six major areas of patient instability: cardiac, pulmonary, neurologic, metabolic/endocrine, and toxin-related disorders, and shock states, as well as specific emergencies for obstetrical and pediatric patients. Each chapter opens with a clinical case, followed by a discussion of the relevant evidence. Case-based learning discussion questions, which can be used for self-assessment or in the classroom, round out each chapter. Advanced Perioperative Crisis Management is an ideal resource for trainees, clinicians, and nurses who work in the perioperative arena, from the operating room to the postoperative surgical ward.

This unique book presents a wealth of information on common presentations and illnesses, presented as medical case studies. It is useful for exam preparation, as a quick reference guide for working doctors, and as an interesting read for all those interested in medicine. 250 Clinical Cases covers a wide variety of conditions, providing in-depth insights into the most relevant topics, classified by system. Cases are accompanied by common viva voce examination questions as well as more advanced level questions that will help the reader develop a deeper understanding. Now in its sixth edition, the book has been fully updated to reflect current evidence and relevance for working doctors. It will help everyone, from medical students to consultants, to find the hidden clinical gems and historical background they need to achieve true clinical excellence. 250 clinical cases in print - provides a comprehensive overview of all relevant topics Conversational and accessible style - suitable for medical students Based on the latest evidence - provides an ideal quick reference guide 'Ward round' type question and answer section - ideal for exam preparation Cases alphabetised by system for easy navigation Easily portable size - fits into any medical bag An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud Self-assessment by system Interesting medical emergency presentations Procedures for the core medical curriculum Topics updated for clinical relevance Multiple choice questions replaced with open answer questions

Clinically-orientated and focused squarely on the core curriculum, Medicine for Finals and Beyond delivers what medical students need to know in a manner that encourages learning and recall. The consistent, easy-to-navigate structure makes locating information simple and is tailored for exam success. Highly illustrated throughout, notes based information is supplemented by 'At A Glance textboxes', 'Emergency Presentations' and 'Must Know Checklists' for quick reference, while online question and answer material allows for self-testing during that inevitable last-minute revision. Key features: * Comprehensive - everything you need to know to pass your medical finals in a single volume * Accessible - systems-based chapters all follow a common structure * Convenient - summarises the ideal approach to the patient, including history and examination, clinical presentations, differential diagnosis and investigations * Focused - covers all the common conditions that medical students need to know for future practice * Relevant - designed with input from lecturers and students This brand-new revision aid for medical students will be a convenient companion throughout clinical studies and an ideal aide-memoire for those approaching their final examinations.

Practical Transfusion Medicine Practical Transfusion Medicine, Sixth Edition The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

The median age of survival for those with cystic fibrosis has risen considerably in recent years. This text thoroughly examines the developments and breakthroughs which have led to this improvement in life expectancy. With a focus on the latest discoveries in the diagnosis and treatment of the disease, this book provides a comprehensive overview of the past, current and forthcoming advancements in cystic fibrosis research and clinical care.

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS). Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS. Highlights include: the definition, epidemiology, pathology, and pathogenesis of ARDS complications such as transfusion-related injury, and endothelium and vascular dysfunction the long-term outcomes of ARDS host defense and infection the latest developments in ARDS therapy: glucocorticoid therapy, surfactant therapy, mechanical ventilation, and mesenchymal stem cells predictive factors: gene expression profiling and biomarkers, and chemokines and cytokines advances in management strategies: fluid management, non-pulmonary and non-sepsis management, and glucose control

Enabling Participation provides a key reference work for health and education practitioners who wish to optimise outcomes for children, young people and families where there is an individual with a childhood onset neurodisability. By focusing on participation -- what is it, how to measure it and how to influence it - the book aims to support professionals to utilise the most recent developments in the field. Written in five parts, the book provides the reader with knowledge about the concept of participation; detailed understanding of how varying contexts influence participation outcomes; how to measure participation as an outcome and as a process; how to intervene to promote participation outcomes; and future directions and challenges. Chapters provide diverse examples of evidence-based practices and are enriched by scenarios and vignettes to engage and challenge the reader to consider how participation in meaningful activities might be optimised for individuals and their families. The book's practical examples aim to facilitate knowledge transfer, clinical application and service planning for the future.

This second edition of the highly successful Easy Guide to OSCEs for Clinical Specialties provides a comprehensive yet succinct resource to get you through each clinical rotation, as well as the Final exam. Compiled by recently qualified doctors who have experienced the new OSCE system first hand, the book covers over 80 OSCE examination stations in a wide range of different subjects. Brand new to this edition are chapters on Psychiatry, non-accidental injury in children, and an 'On the Wards' section covering both Anaesthetics and Palliative Care. All management suggestions are updated in line with NICE guidance and evidence-base, and new time-saving, student friendly mnemonics have been added to make the book even more user-friendly. This book will ease the already burdensome workload of medical students, and help them pass their OSCEs to become junior doctors competent in a wide range of different skills in medical fields.

Die 3. Auflage von Practical Pediatric Gastrointestinal Endoscopy ist eine umfassende und aktuelle Untersuchung zur Leistungsfahigkeit der Endoskopie bei Kleinkindern, Kinder und jungen Erwachsenen. Einsteiger in die padiatrisch gastrointestinale Endoskopie erhalten in diesem ausfuhrlichen Bedienungsleitfaden mit unzahligen Schritt-fur-Schritt-Anleitungen schnell das notwendige Wissen fur die Praxis. Auch erfahrene Endoskopiker und Gastroenterologen profitieren, frischen ihre Kenntnisse zu bewahrten Ablaufen bei Standardverfahren auf und koennen sich mit weiterfuhrenden Themenkomplexen beschaftigen. Practical Pediatric Gastrointestinal Endoscopy zeigt die signifikanten und wichtigen Unterschiede endoskopischer Untersuchungen bei Erwachsenen und Kindern. Auf diese Unterschiede geht das Praktikerbuch ein: - Gastrointestinale Pathologie - Feinheiten von Diagnoseverfahren bei Kindern - Einsatz der therapeutischen Endoskopie bei besonderen Erkrankungen und Stoerungen im Kindesalter - Anasthesie und Sedierung - Training und Erhalt praktischer Fertigkeiten - Differenzierte endoskopische Verfahren aus der endoskopischen Praxis bei Erwachsenen, angepasst fur Eingriffe bei Kindern sowie Methoden fur Stoerungen und Probleme, die uberwiegend im Kindesalter vorkommen Dieser Leitfaden gehoert in die Handbibliothek der Experten, die diagnostische und therapeutische Eingriffe mit dem Endoskop bei Kindern vornehmen, und eroeffnet neue Moeglichkeiten in dem dynamischen Fachgebiet.

"MRCP Part 2 Self-Assessment" is the perfect revision aid. Drawn from the highly successful Medical Masterclass material from the Royal College of Physicians of London, this concise volume is specifically designed to cover the topics and format found in the Membership to the Royal College of Physicians (MRCP) Part 1 examination. The large scale, lavishly illustrated, full-colour format makes it easy to comprehend complex topics.With contributions from an extensive list of prestigious and authoritative professionals, the questions cover all areas of assessment, including the scientific background the medicine, general clinical skills, acute medicine and a range of specialties. It is ideal for examination MRCP candidates, doctors preparing for the European Diploma in internal medicine and junior doctors wanting to revise their knowledge and skills.'This collection of self-assessment questions and explanatory answers has been drawn from Medical Masterclass, which is produced and published by the Royal College of Physicians of London. The questions have been specifically written to help doctors in their first few years of training to test and revise their medical knowledge and skills; and in particular to pass postgraduate examinations, such as the MRCP(UK)' - John D Firth, in the Introduction.

The lungs provide a significant opportunity for the introduction of both therapeutic and toxic chemicals into the human body. In occupational and domestic environments, hazardous chemicals can enter the body through the lungs via gases, aerosols, and particulates from natural and anthropogenic sources. Fully updated with new research and discoveries since the last edition, Inhalation Toxicology, Third Edition presents contributions from internationally recognized scientists in the academic, commercial/industrial, and governmental sectors. A pragmatic resource for practicing professionals and students, the book comprehensively examines the relationship between the respiratory system and the toxicology of inhaled substances. Topics include: Regulatory aspects of exposure and testing Testing equipment and procedures Respiratory allergy and irritation of the respiratory tract Risk assessment Toxicology theory Toxicology modeling Toxic effects of some individual toxicants New topics in this third edition include collection and characterization of airborne particulate matter, the inhalation toxicology of asbestos fibers and nanoparticles, and the development of lung-on-a-chip technology for predicting in vivo responses. Each chapter concludes with thought-provoking questions and answers, enhancing the book's educational utility.

Individuals with childhood-onset physical and developmental disabilities often have special needs around exercise and physical activity. However, most books on this topic are written for exercise science experts who may not always be the frontline service provider. The aim of this practical guide is to enable clinicians, and others involved in the provision of rehabilitation services to train and foster physical activity and physical fitness across the lifespan. It includes chapters on the principles of fitness testing and training, how to engage safely in physical activity, how to measure physical activity levels tracking progress and what to do if pain arises. It includes disorder-specific chapters that apply the general principles of physical activity training to specific diagnoses including autism, traumatic brain injury and juvenile arthritis.

A comprehensive guide to the theory, research and practice of violence risk management The Wiley Handbook of What Works in Violence Risk Management: Theory, Research and Practice offers a comprehensive guide to the theory, research and practice of violence risk management. With contributions from a panel of noted international experts, the book explores the most recent advances to the theoretical understanding, assessment and management of violent behavior. Designed to be an accessible resource, the highly readable chapters address common issues associated with violent behavior such as alcohol misuse and the less common issues for example offenders with intellectual disabilities. Written for both those new to the field and professionals with years of experience, the book offers a wide-ranging review of who commit acts of violence, their prevalence in society and the most recent explanations for their behavior. The contributors explore various assessment approaches and highlight specialized risk assessment instruments. The Handbook provides the latest evidence on effective treatment and risk management and includes a number of well-established and effective treatment interventions for violent offenders. This important book: Contains an authoritative and comprehensive guide to the topic Includes contributions from an international panel of experts Offers information on violence risk formulation Reveals the most recent techniques in violence risk assessment Explains what works in violence intervention Reviews specialty clinical assessments Written for clinicians and other professionals in the field of violence prevention and assessment, The Wiley Handbook of What Works in Violence Risk Management is unique in its approach because it offers a comprehensive review of the topic rather than like other books on the market that take a narrower view.

Containing papers carefully compiled for both their historical importance and contemporary relevance, Family Medicine: The Classic Papers brings together a team of experts, led by global family medicine leaders Michael Kidd, Iona Heath and Amanda Howe, who explain the importance of each selected paper and how it contributes to international health care, current practice and research. The papers demonstrate the broad scope of primary health care delivered by family doctors around the world, showcasing some of the most important research ever carried out in family medicine and primary care. This unique volume will serve as an inspiration to current family doctors and family medicine researchers and educators, as well as to doctors in training, medical students and emerging researchers in family medicine.

Enduring Change in Eating Disorders provides a unique perspective on the successful treatment of eating disorders, which are among the most debilitating and recalcitrant psychiatric diseases. Unique in the field, this book details effective Structural Family Therapy with qualitative follow-ups of up to 20 years. A practical approach providing concrete tools to the clinician to creating change that holds over time with bulimia, anorexia, and compulsive overeating. The text draws on cases from the author's practice of over twenty-five years and follows his approach in the theoretical tradition of Intensive Structural Family Therapy (IST). Chapters discuss the nature and significance of eating disorders, a review of current treatment approaches, and the importance of the family in the therapeutic process. Cases of eating disorders in youths and adults are provided as well as instances of bulimia, anorexia, and compulsive overeating. Three appendices provide the reader with information regarding the scientific basis of the IST model, the effectiveness of the approach in treating conditions other than eating disorders and preventing eating disorders.