A concise, easy-to-read source of essential tips and skills for writing research papers and career management In order to be truly successful in the biomedical professions, one must have excellent communication skills and networking abilities. Of equal importance is the possession of sufficient clinical knowledge, as well as a proficiency in conducting research and writing scientific papers. This unique and important book provides medical students and residents with the most commonly encountered topics in the academic and professional lifestyle, teaching them all of the practical nuances that are often only learned through experience. Written by a team of experienced professionals to help guide younger researchers, A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing features ten sections composed of seventy-four chapters that cover: qualities of research scientists; career satisfaction and its determinants; publishing in academic medicine; assessing a researcher's scientific productivity and scholarly impact; manners in academics; communication skills; essence of collaborative research; dealing with manipulative people; writing and scientific misconduct: ethical and legal aspects; plagiarism; research regulations, proposals, grants, and practice; publication and resources; tips on writing every type of paper and report; and much more. An easy-to-read source of essential tips and skills for scientific research Emphasizes good communication skills, sound clinical judgment, knowledge of research methodology, and good writing skills Offers comprehensive guidelines that address every aspect of the medical student/resident academic and professional lifestyle Combines elements of a career-management guide and publication guide in one comprehensive reference source Includes selected personal stories by great researchers, fascinating writers, inspiring mentors, and extraordinary clinicians/scientists A Guide to the Scientific Career: Virtues, Communication, Research and Academic Writing is an excellent interdisciplinary text that will appeal to all medical students and scientists who seek to improve their writing and communication skills in order to make the most of their chosen career.

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An original account of willful ignorance and how this principle relates to modern probability and statistical methods

Through a series of colorful stories about great thinkers and the problems they chose to solve, the author traces the historical evolution of probability and explains how statistical methods have helped to propel scientific research. However, the past success of statistics has depended on vast, deliberate simplifications amounting to willful ignorance, and this very success now threatens future advances in medicine, the social sciences, and other fields. Limitations of existing methods result in frequent reversals of scientific findings and recommendations, to the consternation of both scientists and the lay public.

"Willful Ignorance" "The Mismeasure of Uncertainty" exposes the fallacy of regarding probability as the full measure of our uncertainty. The book explains how statistical methodology, though enormously productive and influential over the past century, is approaching a crisis. The deep and troubling divide between qualitative and quantitative modes of research, and between research and practice, are reflections of this underlying problem. The author outlines a path toward the re-engineering of data analysis to help close these gaps and accelerate scientific discovery.

"Willful Ignorance: The Mismeasure of Uncertainty "presents essential information and novel ideas that should be of interest to anyone concerned about the future of scientific research. The book is especially pertinent for professionals in statistics and related fields, including practicing and research clinicians, biomedical and social science researchers, business leaders, and policy-makers.

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

The Future of Clinical Research and Health Care: From Empirical to Precision MedicineClinical and Statistical Considerations in Personalized Medicine explores recent advances related to biomarkers and their translation into clinical development. Leading clinicians, biostatisticians, regulators, commercial professionals, and researchers address the opportunities and challenges in successfully applying biomarkers in drug discovery and preclinical and clinical development. Robust Biomarkers for Drug Development and Disease TreatmentThe first four chapters discuss biomarker development from a clinical perspective. Coverage ranges from an introduction to biomarkers to advances in RNAi screens, epigenetics, and rare diseases as targets for personalized medicine approaches. Subsequent chapters examine the statistical considerations in applying a personalized medicine approach, including multiplicity in pharmacogenomics. The last chapter assesses the regulatory issues involved in using biomarkers. Improve Patient Care and Reduce Costs and Side EffectsDespite the vast amount of literature on biomarkers, there is no comprehensive book that integrates the clinical and statistical components. This book is one of the first to incorporate both the clinical and statistical aspects of biomarkers in the personalized medicine paradigm. Covering a wide spectrum of personalized medicine-related topics, it presents state-of-the-art techniques for advancing the application of biomarkers in drug discovery and development.

Im seit 1985 jährlich als Buch erscheinenden Arzneiverordnungs-Report werden die Rezepte für die Patienten der gesetzlichen Krankenversicherung (GKV) mit Methoden der evidenzbasierten Medizin analysiert.Seit dieser Zeit bietet der Report eine unabhängige Informationsmöglichkeit über die verschiedenen Komponenten der Arzneimittelverordnung und trägt damit zur Transparenz des Arzneimittelmarkts, zur Bewertung von Arzneimitteln und zu einer sowohl zweckmäßigen und sicheren evidenzbasierten als auch wirtschaftlichen Arzneitherapie bei.

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules Features interactive computer simulations, available online through a companion website at: http://www.uri.edu/pharmacy/faculty/rosenbaum/basicmodels.html Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications Reviews of the 1st edition: This is an ideal textbook for those starting out and also for use as a reference book ." (International Society for the Study of Xenobiotics) and I could recommend Rosenbaum s book for pharmacology students because it is written from a perspective of drug action ...Overall, this is a well-written introduction to PK/PD . (British Toxicology Society Newsletter)

Kleinians is a compelling account of the extraordinary revolution in psychology pioneered by the psychoanalyst Melanie Klein and nine of her colleagues and followers, including Susan Isaacs, Joan Riviere, Wilfred Bion, Frances Tustin and Hanna Segal.

Drawing on her experience as a professor, writer and therapist, Janet Sayers tells the story of this revolution through an account of the personal and public lives of its main architects, their families and patients. The result is a lively mixture of biography, psychoanalytic theory and individual case studies. The author begins with Klein's pioneering extension of Freud's theories to the analysis of very young children. This led to her claim that from birth onwards children internalize figures from their outer world, resulting in an interaction of inner and outer factors which then govern our psychology. Sayers shows how, sometimes with bitter controversy, this radical insight was variously developed, and is still being developed by Klein's followers, thereby enormously enhancing our understanding of the creative and destructive factors shaping our everyday lives.

Kleinians continues the engaging biographical approach of Sayers's previous successful collections, Mothering Psychoanalysis and Freudian Tales, and will be appealing and informative to all those interested in psychology -- to students and specialists (in psychiatry, psychotherapy, counselling and social work), and to general readers alike.

In this issue of Gastrointestinal Endoscopy Clinics of North America, guest editor Dr. Amrita Sethi brings her considerable expertise to the topic of Submucosal and Third Space Endoscopy. Endoscopic submucosal dissection (ESD) is now recognized as one of the preferred treatment modalities for premalignant gastrointestinal epithelial lesions and early gastric cancer without lymph node metastasis. ESD techniques require advanced skills, and this issue brings together top experts in the field who provide the information endoscopists need to improve these skills. Contains 15 practice-oriented topics including building the toolbox of devices to optimize a practice in submucosal endoscopy; understanding the principles of electrocautery for submucosal endoscopy; endoscopic submucosal dissection in the colon and rectum; techniques for peroral endoscopic myotomy, from mouth to anus; management of adverse events of submucosal endoscopy; and more. Provides in-depth clinical reviews on submucosal and third space endoscopy, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

The definitive companion for medical science study and revision Medical Sciences at a Glance consolidates the scientific knowledge a student needs to know to provide a solid framework of key facts to build on. Concise, easy to follow, written specifically for medical students, and using the unique at a Glance style to convey key concepts, Medical Sciences at a Glance also demonstrates vital links between different topics and across systems. It is the perfect resource for bridging the gap between A-Level and university, studying a new topic, revising for exams, or refreshing knowledge while on placement. Key features: * Fully cross-referenced to Medicine at a Glance: together they cover the core concepts of an entire medical degree * Highlights key points and their clinical relevance for quick revision and retention of what s most important * Brings together all the scientific content on a medical course in one easy-to-read, highly-illustrated title * Accompanied by a companion website at ataglanceseries.com/medicalsciences featuring interactive multiple-choice questions and key points for revision Medical Sciences at a Glance provides the vital scientific grounding needed to succeed at medical school.

In this issue of Child and Adolescent Psychiatric Clinics, guest editors Drs. Paula Riggs, Jesse D. Hinckley, and J. Megan Ross bring their considerable expertise to the topic of Adolescent Cannabis Use. Marijuana use has been an ongoing problem for teens and adolescents, but with the legalization of marijuana in many parts of the U.S., accessibility is becoming greater than ever before. Marijuana use in teens can have negative physical, social, and psychological impacts, and this issue is designed to help practicing clinicians address marijuana use and abuse in their patients. Contains 13 practice-oriented topics including the impact of cannabis legalization on adolescent cannabis use; cannabis use disorder; the impact of adolescent cannabis use on neurocognitive and brain development; prevention; screening, brief, intervention, and referral to treatment; brief interventions for cannabis use disorder; and more. Provides in-depth clinical reviews on adolescent cannabis use, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In The Esophagus werden die Anatomie, die Physiologie und die Pathologie der Speiseroehre betrachtet. Diese sechste, umfassend uberarbeitete und aktualisierte Auflage enthalt zudem Informationen uber die Diagnose und Behandlung verschiedener Erkrankungen der Speiseroehre. Das Werk umfasst Behandlungsrichtlinien, die mit den beiden groessten Gesellschaften fur Gastroenterologie in den USA, der ACG und der AGA, abgestimmt sind. Schliesslich gehoeren zwei ehemalige Vorsitzende dieser Organisationen zu den Mitherausgebern. Fortschritte in der Diagnostik werden ebenso vorgestellt wie Entwicklungen in der chirurgischen und medikamentoesen Therapie. Ein einmaliges Team von Herausgebern und Autoren hat an der sechsten Auflage von The Esophagus mitgewirkt, das in Farbe gedruckt ist und uberall dort zum Einsatz kommt, wo die Anatomie, Physiologie und Pathologie der Speiseroehre Thema und Lehrstoff sind. Auf einer begleitenden Website sind alle Abbildungen aus dem Buch im PowerPoint-Format zu finden. www.wiley.com/go/richter/esophagus6e

This book advocates a new approach to the clinical management of the musculoskeletal system in children with cerebral palsy based on the concept of intervention to a complex adaptive system with the aim of improving the lived experience of the child with cerebral palsy. Provides a critical review of the current understanding and management of musculoskeletal deformity in children with CP, in the context of the available evidence base and models of clinical practice. Transfers current understanding of muscle and bone physiology and impairment, from the realms of research into mainstream clinical thinking Discusses an alternative clinical model of assessment and intervention, focusing on impairment of muscle growth and function Considers the musculoskeletal system in a child with cerebral palsy as a linked system of interactive processes and subsystems, extending from individual molecules to the child and their environment. The concepts discussed regarding clinical knowledge, evidence, causation, and complex adaptive systems are relevant to the clinician, child, and family, and the possibility of new models and new therapeutic approaches offer exciting future opportunities to improve the child's interaction with, and experience of, the world of which they are a part.

This fourth edition of Peter Gotzsche's 'Rational Diagnosis and Treatment' argues that clinical decision-making should be built from first principles. By asking relevant questions, such as 'how reliable are various sorts of data?', 'how has the disease classification evolved over time, and is it logical?', fewer mistakes will be made by the practising physician and trainee.

This beautifully written book integrates the science and statistical approach of evidence-based medicine with the art and humanism of medical practice. It stresses that, whenever possible, clinical decisions must be based on the best evidence from clinical research; but also highlights the pitfalls of such research and the problems involved in applying evidence from groups of patients to the individual patient.

Such an intellectually challenging book is ideal for medical students, practitioners and doctors who require theoretical and practical clinical skills to help ensure that they apply theory to their practice, to achieve the best possible outcomes.

How does the diagnostic process narrow down options, and what are the pitfalls in diagnostic reasoning?

How do randomness, the spontaneous course of the disease, the placebo effect, luck and clinical trials come together?

What is the nature of reasoning?

What is the true value of the published literature?

How do commercial interests distort our perceptions about drugs?

Should people get screened for cancer and other diseases?

New edition contains:

Updated sections on placebo and meta-analysis

Sections on different research designs, focusing on advantages and limitations

Notes on increased medicalisation and the effectsof cancer screening on healthy people

Updated section on alternative medicine

Greater focus on insufficient reporting of harms of interventions

Additional text on academic freedom.

Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields.

A practical, introductory guide to the best use of Patient Reported Outcomes (PROs) to improve the quality of health care and patient health. * Only title to exclusively introduce, explain and show how PROs can be best used to improve healthcare and patient outcomes * Includes real life examples and case studies of PROs in practice * Assesses the growing evidence base for PROs in practice * Editor team from Office of Health Economics (OHE), The King's Fund and King s College London with contributions from practising clinicians, GPs and other healthcare professionals

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings's College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

The process of discovery of medicinal compounds has evolved over millennia, from Neanderthal man's use of medicinal herbs to the highly-evolved techniques of biotechnology and high-throughput screening used by today's medicinal chemists. "Drug Discovery - A History" reviews the full panoply of discovery of therapeutic compounds in use today.

The book is divided into three parts. The first, the Legacy of the Past, gives an overview of medicinal compounds in society, ranging from the earliest use of medicinal herbs through the ancient civilisations in Mesopotamia, Egypt, Greece, and Rome, concluding with an overview of development of life-saving organic compounds in the 20th century. The second part examines the commonest source of the drug - the natural world. Prototypes from vegetable, animal, and microbial sources are described in separate chapters, as are the medicinal compounds prepared from them. The problem of relying on nature as a source of drug prototypes is confronted. Part Three considers synthetic compounds that have served as drug prototypes, the role of serendipity in providing these synthetic prototypes, and a review of compounds derived from them.

"Drug Discovery - A History" is essential reading for medicinal chemists, pharmacologists, organic chemists, physicians, researchers and anyone with an interest in the development of therapeutic drugs.

Are you new to clinical teaching and looking for practical advice? Would you like to challenge and improve your current teaching style? Do you want to direct change in teaching practice within a department or institution? If your answer to any of the above is yes, then Making Sense of Clinical Teaching is the resource for you. It offers the novice and more experienced teacher concise advice in how to pinpoint and build upon existing strengths, address areas where confidence is lacking, develop mentoring skills, challenge existing practice, and influence strategic developments. Making Sense of Clinical Teaching will enable you to: Add new skills to your teaching repertoire Stimulate your creative thinking Challenge current practice and facilitate the development of new strategies Improve your coaching and mentoring skills and ultimately meet the needs of your students and improve their learning experience

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Completely revised and including new additional material, this second edition of the bestselling Get Through MRCGP: Clinical Skills Assessment provides candidates with a definitive, one-stop revision resource for the CSA part of the MRCGP examination.

• Fully revised in accordance with the current MRCGP and MRCGP(INT) curriculum
• Mock examinations cover a spread of topics and skills outlined in the RCGP curriculum
• Comprehensive discussion of areas that stations test and detailing points needing to be covered to achieve the best results
• Brand new material including six new cases and task boxes to refocus the reader's attention on the different challenges of each station
• Completely rewritten introductory chapter
• Offers valuable advice on how to approach the exam, focus time in day-to-day GP surgeries and how to develop skills required to pass the CSA

Written by an experienced author team that has extensive knowledge of both national and international primary care clinical skills assessment, Get Through MRCGP: Clinical Skills Assessment, Second Edition is essential reading for postgraduate candidates preparing for this challenging examination.

"Vital Notes on Accountability" is a concise, accessible guide which provides students and newly qualified staff with an understanding of key issues in professional practice. Nurses are accountable for their own practice and require a thorough understanding of their core responsibilities which underpin everyday practice in the health service today.

This introductory text in the 'Vital Notes for Nurses' series sets out a framework for accountability which consists of four 'pillars' - legal, ethical, employment and professional accountability - against which clinical issues can be considered.

* Presents legal, ethical, employment and professional issues in an accessible way
* Explores accountability, professional regulation, sources of funding and treatment in the health service
* Examines complaints, human rights, negligence, consent, and confidentiality
* Explores further applications in accountability
* Each chapter includes learning objectives, scenarios and case studies