With over 430 patient instruction fact sheets and an additional 123 patient instruction sheets online, the new edition of Griffith's Instructions for Patients by Stephen W. Moore, MD, helps patients understand what their illness is, how it will affect their regular routine, what self care is required, and when to call a doctor. Consistently formatted and organized by topic for easy use, it provides descriptions of each illness, including frequent signs and symptoms, possible causes, risks, preventive measures, expected outcomes, possible complications, and treatments. Newly added topics include Chronic Pain Syndrome; Dry Eye Syndrome; Incontinence, Fecal; In?uenza, H1N1; Methicillin-Resistant Staphylococcus Aureus (MRSA); Mold Allergy; Patellofemoral Pain Syndrome; Perimenopause; Sarcopenia; Spinal Stenosis; and Stroke, Silent. Printable instruction sheets in English and Spanish, 23 separate patient information guides to various types of diets (from "Adult Regular Healthy Diet" to "Weight-Reduction Diet") are downloadable at expertconsult.com. Quickly find what you need with consistently formatted guides - organized by topic for easy use! Help your patients understand what their illness is, how it will affect their regular routine, what self care is required, and when to call a doctor thanks to over 430 patient education guides (and an additional 123 guides online!) reflecting the latest therapeutic information. Ensure the best patient encounters and outcomes with downloadable, customizable English and Spanish patient education guides on expertconsult.com. Educate your patients about timely topics such as Chronic Pain Syndrome; Dry Eye Syndrome; Incontinence, Fecal; In?uenza, H1N1; Methicillin-Resistant Staphylococcus Aureus (MRSA); Mold Allergy; Patellofemoral Pain Syndrome; Perimenopause; Sarcopenia; Spinal Stenosis; and Stroke, Silent. Improve patient compliance, speed recovery and increase understanding with this fully updated edition.

According to the late American preacher Samuel McChord Crothers, "The trouble with facts is that there are so many of them." Nowhere is this saying more apposite than in medicine.

Core Clinical Medicine is an intentionally short book aimed at the clinical student in his or her first clinical year. It is designed to be an accessible text that is easy to read from cover to cover, which gives the incoming student a non-specialized overview of the basics of general clinical medicine. The book covers the main pathological processes that can be at work, then considers the clinical disease that these processes bring to the different systems of the body.

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume: Examines the effect of selected pollutants on the upper airways of both humans and experimental animals-emphasizing mechanistic issues in the process Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

The porphyrins, chlorophylls, bilins and related tetrapyrroles are vital for all living organisms. Natural and synthetic tetrapyrroles are used extensively in foods, cosmetics, biotechnology, pharmaceuticals, diagnostics and medicine. Methods for their separation and characterization therefore, have a very wide area of applications. Yet, there is a dearth of books dedicated to HPLC and HPLC/MS of tetrapyrroles. Lim addresses this problem admirably by providing practical HPLC and HPLC/MS protocols coupled with in-depth chromatographic and mass spectrometric reference data. These are invaluable in the analysis, identification and characterization of porphyrins, chlorophylls, bilins and other related compounds found in biological and clinical materials. HPLC method development and optimization for coupling to mass spectrometry are also described in rich detail. Sample preparation, and suggestions for avoiding procedural artifacts during extraction of clinical and biological samples are discussed. Clinical biochemists involved in biochemical diagnosis of human porphyrias will find this monograph assuredly helpful, as would analysts, biochemists and chemists involved in the separation, isolation and characterization of natural and synthetic tetrapyrroles. Undoubtedly, Lim has contributed a master-piece containing sufficient background material for beginners and up-to-date references for all researchers in the field.

Why the "Second Edition" is the must-have guide for all pulmonologists and particle research scientists:
STAY INFORMED - nine brand new chapters cover recent developments and research, with several chapters focusing solely on the fast-developing area of man-made and naturally occurring nano-sized particles
GAIN FULL UNDERSTANDING OF ALL ASSOCIATED DISCIPLINES - including topics and concerns in pulmonology and respiratory medicine, toxicology, and environmental research
KNOW WHAT TO EXPECT as a disease progresses, from a distinguished team of over 40 experts who detail all stages of particle-lung interactions, from inhalation of particles to clearance from the organism
LEARN MORE ABOUT FREQUENTLY NEGLECTED TOPICS - such as the beneficial developments and uses of inhaled man-made particles and reduced side-effects of alternate therapies

Now in its sixth edition, this guide sets out international and standard practice and is an invaluable reference for medical and scientific editors and authors. Scholarly journals often quote this booklet as a guide in their instructions to authors. An invaluable reference for editors and authors Includes fully updated sections on metrication and SI units, symbols and nomenclature, layout of references and proof correction

This unique book presents a wealth of information on common presentations and illnesses, presented as medical case studies. It is useful for exam preparation, as a quick reference guide for working doctors, and as an interesting read for all those interested in medicine. 250 Clinical Cases covers a wide variety of conditions, providing in-depth insights into the most relevant topics, classified by system. Cases are accompanied by common viva voce examination questions as well as more advanced level questions that will help the reader develop a deeper understanding. Now in its sixth edition, the book has been fully updated to reflect current evidence and relevance for working doctors. It will help everyone, from medical students to consultants, to find the hidden clinical gems and historical background they need to achieve true clinical excellence. 250 clinical cases in print - provides a comprehensive overview of all relevant topics Conversational and accessible style - suitable for medical students Based on the latest evidence - provides an ideal quick reference guide 'Ward round' type question and answer section - ideal for exam preparation Cases alphabetised by system for easy navigation Easily portable size - fits into any medical bag An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud Self-assessment by system Interesting medical emergency presentations Procedures for the core medical curriculum Topics updated for clinical relevance Multiple choice questions replaced with open answer questions

"MRCP Part 2 Self-Assessment" is the perfect revision aid. Drawn from the highly successful Medical Masterclass material from the Royal College of Physicians of London, this concise volume is specifically designed to cover the topics and format found in the Membership to the Royal College of Physicians (MRCP) Part 1 examination. The large scale, lavishly illustrated, full-colour format makes it easy to comprehend complex topics.With contributions from an extensive list of prestigious and authoritative professionals, the questions cover all areas of assessment, including the scientific background the medicine, general clinical skills, acute medicine and a range of specialties. It is ideal for examination MRCP candidates, doctors preparing for the European Diploma in internal medicine and junior doctors wanting to revise their knowledge and skills.'This collection of self-assessment questions and explanatory answers has been drawn from Medical Masterclass, which is produced and published by the Royal College of Physicians of London. The questions have been specifically written to help doctors in their first few years of training to test and revise their medical knowledge and skills; and in particular to pass postgraduate examinations, such as the MRCP(UK)' - John D Firth, in the Introduction.

This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine's Hermann Blumgart Award.

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the "research" that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

Comprehensive, accessible, and grounded in case law, Occupational Health Law has been an established authority in the field for over thirty years, and continues to provide practical coverage of occupational health, incorporating changes in the legal framework to reflect the very latest developments. The sixth edition of this indispensable reference work includes substantial new information on European law, the legal and ethical duties of occupational health professionals, medical records and confidentiality, data protection, compensation for work-related injury, the gig economy, the Equality Act and disability discrimination, and much more. Covers the provision of occupational health services, the legal liability of occupational health professionals, confidentiality, health surveillance, compensation and equal opportunity legislation Includes extensively revised content which aligns with current legislation and case law Contains new chapter summaries and highlighted key information boxes throughout Occupational Health Law, Sixth Edition, is the definitive resource for occupational health and safety professionals, from nurses, physicians and safety officers to HR managers, policy makers, risk managers, and employment lawyers.

Since angiotensin II is one of the most potent vasoconstrictors and an important stimulus for the secretion of aldosterone from the adrenal gland, the development of of angiotensin II inhibitors is an important step in regulating blood pressure. This class of drug is well-tolerated by pateints and these drugs have the added advantage over ACE inhibitors in that they are not associated with cough. Because most drugs can be given once daily and, like ACEIs, they have a useful additive hypotensive effect in combination with diuretics, they are a welcome therapeutic tool in the treatment of hypertension. This Second Edition builds on the success of the first and brings to the reader all the latest developments, clinical trial data, and the contributors's personal perspectives when treating patients with angiotensin II receptors antagonists. -offers chapters by well-known contributors in the fields of both hypertension and heart failure, especially with regard to pharmacological interventions -covers the new role of AIIR in neuroprotection -builds upon the strengths of the first edition

A comprehensive review of clinical and exploratory aspects of lung (LT) and heart-lung transplantation (HLT), this reference focuses on cumulative data from the International Registry with data on outcomes associated with LT and HLT worldwide. Collecting in-depth discussions on graft dysfunction, infectious complications, and indications of LT for specific disease states including emphysema, cystic fibrosis, myriad interstitial lung diseases, and pulmonary hypertension, this guide explores the most current technologies and best practices affecting lung and heart-lung transplant surgeries.

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at risk for VILI.

A cluster randomization trial is one in which intact social units, or clusters of individuals, are randomized to different intervention groups. Trials randomizing clusters have become particularly widespread in the evaluation of non-therapeutic interventions, including lifestyle modification, educational programmes and innovations in the provision of health care. The increasing popularity of this design among health researchers over the past two decades has led to an extensive body of methodology on the subject. This is the first book to present a systematic and united treatment of this topic; it contains distinctive chapters on the history of cluster randomized trials, ethical issues and reporting guidelines.

The unique and award-winning Unofficial Guides series is a collaboration between senior students, junior doctors and specialty experts. This combination of contributors understands what is essential to excel on your course, in exams and in practice - as well as the importance of presenting information in a clear, fun and engaging way. Packed with hints and tips from those in the know, when you are in a hurry and need a study companion you can trust, reach for an Unofficial Guide. Designed for medical students, nurses, junior doctors and other healthcare professionals, The Unofficial Guide to Practical Skills contains step-by-step guidance to over 50 core practical procedures. Information is easy to follow and procedures are explained clearly - along with expert practical tips. This book covers the essential skills you'll need throughout your course and for the OSCEs. It also provides a succinct, day-to-day reference for those in practice. Wide range of procedures covered - more than any other book of its kind Accompanying mark schemes and typical exam questions to simulate real-life assessment Fully illustrated with over 200 color photos/illustrations Model answers so you can check how well you are performing Content aligned to the latest GMC/MLA requirements Additional stations covering lateral flow tests, PPE, using a hospital bed Standardisation of different scenarios New COVID guidance More answers to examiner questions in each scenario

Addressing issues at the forefront of interest for the Clinical Trial Materials Professional (CTMP), this Second Edition highlights the most critical concepts related to the planning, manufacturing, packaging, labeling, distribution, reconciliation, and quality and regulatory control of clinical trial materials. It offers authoritative chapters by esteemed researchers and consultants in industry on the current and evolving state of clinical supplies operations. Tracking emerging trends and the development of new technologies, this Second Edition helps the CTMP operate effectively in the international sphere and reviews regulatory processes for drug approvals in the United States and Europe.

Drawing on interdisciplinary, cross-national perspectives, this open access book contributes to the development of a coherent scientific discourse on social exclusion of older people. The book considers five domains of exclusion (services; economic; social relations; civic and socio-cultural; and community and spatial domains), with three chapters dedicated to analysing different dimensions of each exclusion domain. The book also examines the interrelationships between different forms of exclusion, and how outcomes and processes of different kinds of exclusion can be related to one another. In doing so, major cross-cutting themes, such as rights and identity, inclusive service infrastructures, and displacement of marginalised older adult groups, are considered. Finally, in a series of chapters written by international policy stakeholders and policy researchers, the book analyses key policies relevant to social exclusion and older people, including debates linked to sustainable development, EU policy and social rights, welfare and pensions systems, and planning and development. The book's approach helps to illuminate the comprehensive multidimensionality of social exclusion, and provides insight into the relative nature of disadvantage in later life. With 77 contributors working across 28 nations, the book presents a forward-looking research agenda for social exclusion amongst older people, and will be an important resource for students, researchers and policy stakeholders working on ageing.

Summarizing discussions from the Vancouver Orbital Symposium, this reference assembles recent perspectives from world renowned orbital specialists, pathologists, radiologists, and scientists to highlight advances and challenges in the diagnosis and management of orbital disease-covering recent aspects of orbital inflammatory and infectious disorders, issues in oncology, thyroid disease, and orbital vascular disorders, as well as topics concerning the future of imaging and orbital surgery.

Analyzing ground-breaking research, this reference highlights the impact of sleep deprivation on the well-being of the individual and society-presenting current theories on the function of sleep, the effects of sleep deprivation on patients with medical and psychiatric conditions, as well as providing interpretative and methodological results in comparative studies of sleep deprivation.

Attracting the attention of the medical community, exhaled breath condensate is a completely non-invasive method for sampling secretions from the airways. Analysis of exhaled breath condensate is potentially useful for monitoring airway inflammation and in pharmacological therapy. With its non-invasive nature, this method may be suitable for longitudinal studies even in children and in patients with lung severe disease. New Perspectives in Monitoring Lung Inflammation provides an introduction to the analysis of exhaled breath condensate for monitoring lung inflammation. The book presents current knowledge on the physicochemical properties of exhaled breath condensate and its formation in the airways and covers important aspects of the methodology. It details markers, and classes of markers, of airway inflammation in separate chapters and discusses the use of the technique in adults and children. The text also reviews the implications for drug development and future research. The volume concludes with an overview of lung inflammation focusing on basic and clinical pharmacology of important mediators. Presenting a comprehensive view of exhaled breath condensate, the text explains how this method could play a major role in the diagnosis and therapy of lung diseases, and may launch a new era in respiratory medicine.

Clinical practice guidelines were initially developed within the context of evidence-based medicine with the goal of putting medical research findings into practice. However, physicians do not always follow them, even when they seem to apply to the particular patient they have to treat. This phenomenon, known as clinical inertia, represents a significant obstacle to the efficiency of care and a major public health problem, the extent of which is demonstrated in this book. An analysis of its causes shows that it stems from a discrepancy between the objective, essentially statistical nature of evidence-based medicine on the one hand and the physician's own complex, subjective view (referred to here as "medical reason") on the other. This book proposes a critique of medical reason that may help to reconcile the principles of evidence-based medicine and individual practice. The author is a diabetologist and Professor of Endocrinology, Diabetology and Metabolic Diseases at Paris 13 University. He has authored several books, including one to be published by Springer (Philosophy and Medicine series) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care. , Diabetology and Metabolic Diseases at the Paris 13-University. He has also published Pourquoi Se soigne-t-on, Enquete sur la rationalite morale de l'observance (2007), Clinique de l'Observance, L'Exemple des diabetes (2006), and Une theorie du soin, Souci et amour face a la maladie (2010). An English adaptation of the first book is published by Springer (Philosophy and Medicine) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care.

Since publication of the initial version of "Plagues & Poxes" in 1987, which had the optimistic subtitle "The Rise and Fall of Epidemic Disease," the rise of new diseases such as AIDS and the deliberate modification and weaponization of diseases such as anthrax have changed the way we perceive infectious disease.

With major modifications to deal with this new reality, the acclaimed author of "Civil War Medicine: Challenges and Triumphs" has updated and revised this series of essays about changing disease patterns in history and some of the key events and people involved in them. It deals with the history of major outbreaks of disease - both infectious diseases such as plague and smallpox and noninfectious diseases - and shows how they are in many cases caused inadvertently by human actions, including warfare, commercial travel, social adaptations, and dietary modifications. To these must now be added discussion of the intentional spreading of disease by acts of bioterrorism, and the history and knowledge of those diseases that are thought to be potential candidates for intentional spread by bioterrorists.

Among the many topics discussed are:

How the spread of smallpox and measles among previously unexposed populations in the Americas, the introduction of malaria and yellow fever from Africa via the importation of slaves into the Western hemisphere, and the importation of syphilis to Europe all are related to the modern interchange of diseases such as AIDS.

How the ever-larger populations in the cities of Europe and North America gave rise to "crowd diseases" such as polio by permitting the existence of sufficient numbers of non-immune people in sufficient numbers to keep the diseases from dying out.

How the domestication of animals allowed diseases of animals to affect humans, or perhaps become genetically modified to become epidemic human diseases.

Why the concept of deficiency diseases was not understood before the early twentieth century; disease, after all, was the presence of something abnormal, how could it be due to the absence of something? In fact, the first epidemic disease in human history probably was iron deficiency anemia.

How changes in the availability and nature of specific foods have affected the size of population groups and their health throughout history. The introduction of potatoes to Ireland and corn to Europe, and the relationship between the modern technique of rice milling and beriberi, all illustrate the fragile nutritional state that results when any single vegetable crop is the main source of food.

Why biological warfare is not a new phenomenon. There have been attempts to intentionally cause epidemic disease almost since the dawn of recorded history, including the contamination of wells and other water sources of armies and civilian populations; of course, the spread of smallpox to Native Americans during the French and Indian War is known to every schoolchild. With our increased technology, it is not surprising that we now have to deal with problems such as weaponized spores of anthrax.