This practical manual reviews salient topics in Adolescent Medicine. The volume is practitioner-centered, focusing on the symptoms that bring a teenager to the clinician. Every chapter begins with a very brief clinical vignette, highlighting the patient's chief complaint or primary issue of concern.The handbook is divided into five primary sections: (1) Well Adolescent Care to include chapters such as the Annual Physical and Immunizations in Adolescence; (2) Common Problems of Adolescence such as Acne and Low Back Pain; (3) Reproductive Health Care issues such as Menstrual Disorders and Teen Pregnancy/Options Counseling; (4) Urgent Care matters including Acute Chest Pain and Scrotal Pathology: Pain and Masses; and finally, (5) Special Considerations to include chapters such as Cyberbullying and Sexting and Tobacco Use and Cessation Counseling.Chapters follow a uniform format with vignette as described above, followed by multiple choice questions designed to test the readers knowledge. Salient features related to the chapter topic follow, including relevant clinical "pearls" such as history, physical exam, laboratory and diagnostic studies and treatment strategies. For each chapter, issues that are unique to managing illness in adolescents are highlighted to distinguish them from adults and younger children. When applicable, a broad differential diagnosis is provided to help guide the reader. Easy to read tables are included to highlight and clearly summarize key aspects of the topic and the chapters end with answers to the Board-Style questions presented at the start.

This is the first book to clearly and fully demonstrate the process of using theory to guide nursing research and professional practice. It describes a step-by-step format for evaluating nursing theory's applicability to research, a format that links theory (both middle-range and grand theory) to research on a wide range of clinical populations and care delivery systems. The book describes how theory analysis models are used to examine various nursing phenomena as they relate to nursing research and professional practice, and provides key examples of how this is accomplished.

The book takes the reader through the process of using a theory to guide research from inception of a research question to evaluation of future research. International experts in theory-related nursing research describe twelve theories that have previously been applied to research and practice and six theories that can be applied to future research and practice. Using a consistent analytic framework, each chapter applies a specific theory (from either nursing, psychology, sociology, or management) to a particular clinical population or care delivery issue. These encompass clinical, administrative, and educational nursing settings. The consistent format facilitates ease of comparison across different theories. Generous use of figures and tables further demonstrates the complex relationships between and among concepts embedded in the theories.

Key Features: Demonstrates a systematic format for evaluating middle-range and grand nursing theory's applicability to research Links theory to clinical practice at patient population and care delivery levels Provides a useful template for students of nursing disciplinary knowledge development Presents the scholarship of international researchers of theory-related nursing Includes theories from nursing, psychology, sociology, and management

Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine provides a comprehensive overview of current and emerging issues in genomic data sharing. In this book, international leaders in genomic data examine these issues in-depth, offering practical case studies that highlight key successes, challenges and opportunities. Sections discuss the eMERGE Network, Undiagnosed Disease Network, Vanderbilt Biobank, Marshfield Clinic Biobank, Minnesota Authorization, Rochester Epidemiology Project, NIH sponsored biobanks, GINA, and Global Alliance for Genomics and Health (GA4GH). In addition to these perspectives from the frontlines, the book also provides succinct overviews of ethical, legal, social and IT challenges. Clinician investigators, clinicians affiliated with academic medical centers, policymakers and regulators will also gain insights that will allow them to navigate the increasingly complex ethical, social and clinical landscape of genomic data sharing.

All pathology residents must have a good command of clinical chemistry, toxicology, immunology, and laboratory statistics to be successful pathologists, as well as to pass the American Board of Pathology examination. Clinical chemistry, however, is a topic in which many senior medical students and pathology residents face challenges. "Clinical Chemistry, Immunology and Laboratory Quality Control" meets this challenge head on with a clear and easy-to-read presentation of core topics and detailed case studies that illustrate the application of clinical chemistry knowledge to everyday patient care.

This basic primer offers practical examples of how things function in the pathology clinic as well as useful lists, sample questions, and a bullet-point format ideal for quick pre-Board review. While larger textbooks in clinical chemistry provide highly detailed information regarding instrumentation and statistics, this may be too much information for students, residents, and clinicians. This book is designed to educate senior medical students, residents, and fellows, and to "refresh" the knowledge base of practicing clinicians on how tests are performed in their laboratories (i.e., method principles, interferences, and limitations).
Takes a practical and easy-to-read approach to understanding clinical chemistry and toxicologyCovers all important clinical information found in larger textbooks in a more succinct and easy-to-understand mannerCovers essential concepts in instrumentation and statistics in such a way that fellows and clinicians understand the methods without having to become specialists in the fieldIncludes chapters on drug-herb interaction and pharmacogenomics, topics not covered by textbooks in the field of clinical chemistry or laboratory medicine

Blood Science The second edition of the leading introduction to blood science, with updated new illustrations and case studies Blood Science: Principles and Pathology integrates hematology and blood transfusion, -clinical biochemistry, and immunology to provide a thorough introduction to this rapidly expanding discipline. Reflecting recent changes in education and training for healthcare scientists, this comprehensive textbook covers the analytical techniques used in blood -science, the diagnosis and management of various blood disorders, and more. Fully revised, the second edition presents new case studies and high-quality images -throughout, illustrating the practical skills and knowledge required by today's under-graduate students and practitioners. Detailed yet accessible chapters contain learning objectives and summaries, links to further readings and resources, and real-world case studies with easy-to-follow interpretations. Throughout the text, the authors highlight how laboratory data and clinical details are used to investigate patients with actual or suspected diseases in real-world scenarios: Multi-disciplinary view merging biochemical, hematological, immunological, and genetical knowledge into a single discipline: Blood science Discusses advances in molecular genetics identifying mutations resulting in the occurrence of certain pathological conditions such as leukaemia Presents an expanded concluding chapter with detailed case reports that integrate biochemistry, immunology, and haematology, which all contribute to the investigation of respective conditions Explains the potentials for developing tests such as non-coding RNAs Offers further reading suggestions to dive even deeper into discussed subjects and concepts Designed to meet the needs of undergraduate students taking blood science modules in biomedical, biological, and healthcare science programs, Blood Science: Principles and Pathology, Second Edition is also an invaluable guide for new graduates entering the field, as well as those training for professional qualifications or working with blood samples in laboratory-based environments.

Ancient Egyptian medicine employed advanced surgical practices, while the prevention and treatment of diseases relied mostly on natural remedies and magical incantations. Following the successful first volume of The Medicine of the Ancient Egyptians, which dealt with surgical practices and the treatment of women and children, this second volume explores a wide range of internal medical problems that the Egyptian population suffered in antiquity, and various methods of their treatment. These include ailments of the respiratory, digestive, and circulatory systems, chiefly heart diseases of various types, coughs, stomachaches, constipation, diarrhea, internal parasites, and many other medical conditions. Drawing on formulas and descriptions in the Ebers papyrus and other surviving ancient Egyptian medical papyri, as well as physical evidence and wall depictions, the authors present translations of the medical treatises together with commentaries and interpretations in the light of modern medical knowledge. The ancient texts contain numerous recipes for the preparation of various remedies, often herbal in the form of pills, drinks, ointments, foods, or enemas. These reveal a great deal about ancient Egyptian physicians and their deep understanding of the healing properties of herbs and other medicinal substances. Illustrated with thirty-five photographs and line drawings, The Medicine of the Ancient Egyptians: 2: Internal Medicine is highly recommended reading for scholars of ancient Egyptian medicine and magic, as well as for paleopathologists, medical historians, and physical anthropologists.

Making speedy and appropriate clinical decisions and then choosing the best course of action is an essential skill for doctors. Exploring initial medical assessment, 100 Cases in Clinical Medicine presents 100 scenarios commonly seen by medical students and junior doctors in the emergency or outpatient department, on the ward, or in the community setting. Each case begins with a succinct summary of the patient's history, examination, and initial investigation. The text includes photographs where relevant and questions on the diagnosis and management of each case. The answers provide a detailed discussion on each topic, with further illustration where appropriate. Most of the cases included are common problems but the book also includes more unusual cases to illustrate specific points and to emphasize that rare things do present. The first 20 cases are arranged by systems; the next 80 are in random order because symptoms such as breathlessness and pain may relate to many different clinical problems in various systems. These true-to-life cases will teach students and junior doctors to recognize important clinical symptoms and signs and to develop the diagnostic and management skills needed for the cases they will encounter on the job.

This new volume of "Methods in Enzymology" continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization scienceContains sections on such topics as and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure

The function and life span of endothelial cells have a large impact upon the quality and expectancy of an individual's life. During low perfusion, the adaptation of different cells to hypoxia precipitate the aggressive progression of diseases. Although the clinical studies have convincingly shown that endothelial dysfunction occurs whenever the biological functions or bioavailability of nitric oxide are impaired, in all these scenarios, the role of endothelial cell-destructive process cross-talk is yet poorly understood. This book focuses on the contribution of molecular mechanisms to endothelial dysfunction in related metabolic disorders.

Clinicians at all levels must consider a myriad of tests in the diagnostic process, requiring an up-to-date understanding of changing technology and the demands of time- and cost-efficiency. Ferri's Best Test, 5th Edition, is a unique, easy-to-use guide that simplifies complex information and helps you choose the best test to supplement your clinical diagnostic skills. It includes both lab and imaging tests for concise, convenient access to all diagnostic test options for more than 200 common diseases and disorders. . Practical, concise, spiral-bound, and pocket-sized-designed from cover to cover for quick, on-the-go reference. . Three convenient sections provide quick access to key information on clinical laboratory testing, diagnostic imaging, and diagnostic algorithms. . New and updated content on cardiac computed tomography angiography, computed tomography perfusion imaging, COVID-19, and much more. . Coverage of 23 new laboratory tests and 14 new diseases and disorders. . Essential information on indications, advantages, disadvantages, approximate costs, normal ranges, typical abnormalities, likeliest causes, and more. . Experienced author Dr. Fred Ferri uses a unique, easy-to-follow format to simplify complex information and help you choose the best test for every patient. . New appendices on electrocardiography and respiratory testing and function. . Comparison tables and illustrations help improve your test selection. . Enhanced eBook version included with purchase. Your enhanced eBook includes an image collection with access on a variety of devices.

Working With Families in Medical Settings provides mental-health professionals with the tools they need to figure out what patients and families want and how, within the constraints imposed by 21st-century healthcare setting, to best give them the care they need. Psychiatrists and other clinicians who work in medical settings know that working with a patient with a chronic illness usually entails work with that patient's family as well as with other medical professionals. Some families need education; others have specific difficulties or dysfunctions that require skilled assessment and intervention. It is up to the clinician to find productive ways to work with common themes in family life: expressed emotion, levels of resilience, life-cycle issues, and adaptation to illness, among others. Enter Working With Families in Medical Settings, which shines a spotlight on the major issues professional caregivers face and shows them how to structure an effective intervention in all kinds of settings. Psychiatrists, particularly those in psychosomatic medicine, and other clinicians who work with the medically ill will find Working With Families in Medical Settings to be an essential resource and guide to productive relationships with patients and their families.

Working With Families in Medical Settings provides mental-health professionals with the tools they need to figure out what patients and families want and how, within the constraints imposed by 21st-century healthcare setting, to best give them the care they need. Psychiatrists and other clinicians who work in medical settings know that working with a patient with a chronic illness usually entails work with that patient s family as well as with other medical professionals. Some families need education; others have specific difficulties or dysfunctions that require skilled assessment and intervention. It is up to the clinician to find productive ways to work with common themes in family life: expressed emotion, levels of resilience, life-cycle issues, and adaptation to illness, among others. Enter "Working With Families in Medical Settings," which shines a spotlight on the major issues professional caregivers face and shows them how to structure an effective intervention in all kinds of settings. Psychiatrists, particularly those in psychosomatic medicine, and other clinicians who work with the medically ill will find "Working With Families in Medical Settings" to be an essential resource and guide to productive relationships with patients and their families.

This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule "magic bullet" interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States - from $200 million in 1950 to $1.2 billion in 2010 - has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of "magic bullets", we must now apply "magic strategies" that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies.

Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue -fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

With the rapid increase in the world's population, and the improvements in health and longevity, the demographic profile is altering and resulting in changes in the patterns of nutritional problems. There is a global epidemic of diet-related non-communicable diseases and, until now, industrialised countries have largely borne the brunt of it. In the last thirty years, however, there have been large increases in the mortality rates from diet-related chronic diseases, both in Eastern Europe and in rapidly developing countries in transition. Diet, Nutrition and Chronic Disease: Lessons from Contrasting Worlds is the sixth of a series of annual public health forums organised by the London School of Hygiene & Tropical Medicine. It summarises the current state of the art of our understanding of the problem of non-communicable diseases and their primary prevention, and aims to:
* Increase international awareness of the global burden of non-communicable diseases and in particular to highlight the trends in developing countries.
* Evaluate the impact of changes in diet, nutrition and lifestyle that predispose to chronic non-communicable diseases in modern societies.
* Share knowledge of the growing problems of non-communicable diseases and experiences related to its prevention between health professionals of developing and developed countries.
* Identify and prioritise major research issues and suggest strategies to deal with the global epidemic of chronic non-communicable diseases.
This book is an invaluable volume for public health professionals and nutritionists, health and nutrition policy makers and researchers, national governments and international agencies concernedwith population health and nutrition.

Innovations in technology have hugely enhanced the diagnostic capabilities of today's practising clinicians. Yet the traditional art of detecting clinical signs through expert examination techniques remains a fundamental competence for training and practising clinicians, central to the delivery of safe and effective patient care. This first edition of Macleod's Essential Examination provides an innovative, concise account of each body system examination, delivering the information in a compact, portable format for use at home and in the clinical environment. It can be used in conjunction with the more extensive and hugely successful 'parent' textbook Macleod's Clinical Examination, with which it is closely integrated, or as a stand-alone aide-memoire. This quick-reference, highly practical guide will assist in preparation for OSCEs and in clinical practice. Each chapter follows a consistent format, opening with typical OSCE scenarios followed by a concise 'point by point' examination template. This is then expanded with a detailed description of each aspect of the examination process, including specific instructions around technique and information about key clinical signs to consider. Exam tips are also provided, along with typical questions likely to be asked during an OSCE. Answers are given are at the end of each chapter, making it an invaluable resource for both self-assessment and in peer-to-peer learning. The book provides a standardised framework for examination of all the major body systems. Using a novel tabular approach the book provides a clear set of guidelines on what to do at each stage of the clinical examination. It also reminds the reader what are the corresponding key points to think about and sets out associated exam tips. The exam tips are subsequently linked to potential examiner's questions. Each system ends with a reminder of how to present the findings and relevant tips to maximise your success.

The Changing Era of Diseases not only explores how to end humanity's suffering from illness, but also attempts to explain the challenging problems that may arise from the control of future disease. It provides a novel perspective on how to understand the changing patterns of disease, disease development, and defense from an evolutionary point-of-view in an effort to ally the life sciences and historical approaches. Topics cover the origin of disease, its pandemic infectious manifestation, chronic and late chronic diseases, strategies of the human body to fight diseases, methods of ending diseases, and future medical systems are featured. The book is a valuable source for researchers interested in systematic approaches to disease and students who are interested in understanding the evolution of diseases and how we have succeeded in fighting them.

Mastery of quality health care and patient safety begins as soon as we open the hospital doors for the first time and start acquiring practical experience. The acquisition of such experience includes much more than the development of sensorimotor skills and basic knowledge of the sciences. It relies on effective reasoning, decision making, and communication shared by all health professionals, including physicians, nurses, dentists, pharmacists, physiotherapists, and administrators. A Primer on Clinical Experience in Medicine: Reasoning, Decision Making, and Communication in Health Sciences is about these essential skills. It describes how physicians and health professionals reason, make decisions, and practice medicine. Covering the basic considerations related to clinical and caregiver reasoning, it lays out a roadmap to help those new to health care as well as seasoned veterans overcome the complexities of working for the well-being of those who trust us with their physical, mental, and spiritual health. The book provides a step-by-step breakdown of the reasoning process for clinical work and clinical care. It examines both general and medical ways of thinking, reasoning, argumentation, fact finding, and using evidence. Outlining the fundamentals of decision making, it integrates coverage of clinical reasoning, risk assessment, diagnosis, treatment, and prognosis in evidence-based medicine. It also: Describes how to evaluate the success (effectiveness and cure) and failure (error and harm) of clinical and community actions Considers communication with patients and outlines strategies, successes, failures, and possible remedies-including offices, bedside, intervention, and care settings Examines strategies, successes, failures, and possible remedies for communication with peers-including interpersonal communication, morning reports, rounds, and research gatherings The book describes vehicles, opportunities, and environments for enhanced professional communication, including patient interviews, clinical case reports, and morning reports. It includes numerous examples that demonstrate the importance of sound reasoning, decision making, and communication and also considers future implications for research, management, planning, and evaluation.

Modern medicine is one of humankind's greatest achievements.Yet today, frequent medical errors and irreproducibility in biomedical research suggest that tremendous challenges beset it. Understanding these challenges and trying to remedy them have driven considerable and thoughtful critical analyses, but the apparent intransigence of these problems suggests a different perspective is needed. Now more than ever, when we see options and opportunities for healthcare expanding while resources are diminishing, it is extremely important that healthcare professionals practice medicine wisely. In Medical Reasoning, neurologist Erwin B. Montgomery, Jr. offers a new and vital perspective. He begins with the idea that the need for certainty in medical decision-making has been the primary driving force in medical reasoning. Doctors must routinely confront countless manifestations of symptoms, diseases, or behaviors in their patients. Therefore, either there are as many different "diseases" as there are patients or some economical set of principles and facts can be combined to explain each patient's disease. The response to this epistemic conundrum has driven medicine throughout history: the challenge is to discover principles and facts and then to develop means to apply them to each unique patient in a manner that provides certainty. This book studies the nature of medical decision making systematically and rigorously in both an analytic and historical context, addressing medicine's unique need for certainty in the face of the enormous variety of diseases and in the manifestations of the same disease in different patients. The book also examines how the social, legal, and economic circumstances in which medical decision-making occurs greatly influence the nature of medical reasoning. Medical Reasoning is essential for those at the intersection of healthcare and philosophy.

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

There is growing pressure to ensure that patients receive care that is proven effective and subsequently, a tremendous need to train mental health practitioners in the latest in Evidence-Based Practice (EBP). "Evidence-Based Treatment Planning for Posttraumatic Stress Disorder DVD Companion Workbook" covers presenting problems stemming from anxiety after a traumatic event. The DVD (sold separately) demonstrates the techniques and treatment interventions covered in the lecture. This workbook guides staff in implementation of the interventions with their clients subsequent to the DVD training. Ideal for training mental health professionals at any level.

EMQs are a popular method of assessing how broad a knowledge of medicine an undergraduate has acquired. They can, however, be difficult to prepare for, and the best way to build understanding and confidence is with practice. Presenting 100 key EMQs covering the core areas of medicine and surgery, care had been taken by the authors to structure the questions and answers so that they reflect accurately the themes uncountered during study and, specifically, in final exams. Each subject covered is accompanied by a revision section which summarises key points and cross references them to other questions for revision purposes. Questions related to pharmacology, an area which many students find particularly challenging, are threaded throughout the book where relevant, mirroring the integrated teaching methods common to most medical schools. The second edition of EMQs in Clinical Medicine has been thoroughly revised and updated to reflect medical developments, while retaining the clear and comprehensive approach and popular revision boxes of its predecessor. The authors' first-hand experience of EMQ-based examinations, and awareness of the importance of reliable and accurate revision guides to medical students, ensure EMQs in Clinical Medicine remains and invaluable resource for all medical students undertaking the clinical part of their training, and an ideal companion during finals preparation.

Clinical Chemistry: Principles, Techniques, and Correlations, Ninth Edition is the most student-friendly clinical chemistry text available today.

The Ninth Edition keeps students at the forefront of what continues to be one of the most rapidly advancing areas of laboratory medicine with clear explanations that balance analytic principles, techniques, and correlation of results with coverage of disease states.

The book not only demonstrates the how of clinical testing, but also the what, why, and when of testing correlations to help students develop the knowledge and interpretive and analytic skills they'll need in their future careers.

Strategies for successfully updating and improving health care organizations of all kinds Health care is always evolving and improving. However, the rapid speed of medical advancement can make the adoption of new technologies and practices a challenging process - particularly in large organizations and complex networks. Any projected impact upon quality and outcomes of care must be carefully evaluated so that changes may be implemented in the most efficacious and efficient manner possible. Improving Patient Care equips professionals and policymakers with the knowledge required to successfully optimize health care practice. By integrating scientific evidence and practical experience, the text presents a cohesive and proven model for practice change and innovation, complete with analysis of innovation, target group and setting; selection and application of strategies; and evaluation of process, outcomes and costs. This new third edition also includes: Newly written chapters on clinical performance feedback, patient engagement, patient safety, evaluation designs, and methods for process evaluation Increased emphasis on the role of contextual influences in implementation and improvement New research examples from across the world and updated scientific literature throughout Designed to help promote safer and more efficient, patient-centered care and better outcomes, Improving Patient Care is an essential resource for healthcare providers, quality assessors, and students of health services research, health management, and health policy.