This updated volume explores a wide variety of clinical applications of PCR such as detecting DNA methylation, detection of viruses and protozoa in infectious diseases, estimation of gene copy number aberrations, primer extension coupled with mass spectroscopy, and high throughput NGS techniques. The application of PCR has shown incredible value in the study of genomics and transcriptomics, not only for discovery but also for routine clinical applications, and it forms the cornerstone of personalized medicine. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, Clinical Applications of PCR, Third Edition serves as an ideal guide for researchers aiming to understand the principles behind each application and for their implementation in the laboratory.

Early and accurate recognition of an acutely ill child is essential. Ideal for quick reference, this pocket-sized guide puts all the crucial information at your fingertips.

The Nursing & Health Survival Guides have evolved - take a look at our our app for iPhone and iPad.

A pioneering guide for the management of tics and habit disorders Managing Tic and Habit Disorders: A Cognitive Psychophysiological Approach with Acceptance Strategies is a complete client and therapist program for dealing with tics and habit disorders. Groundbreaking and evidence-based, it considers tics and habit disorders as part of the same spectrum and focuses on the personal processes that are activated prior to a tic and habit rather than the tic or habit itself. By drawing on acceptance and mindfulness strategies to achieve mental and physical flexibility in preparing action, individuals can release unnecessary tension, expend less effort and ultimately establish control over their tic or habit. The authors explain how to identify the contexts of thoughts, feelings and activities that precede tic or habit onset, understand how self-talk and language can trigger tic onset, and move beyond unhelpful ways of dealing with emotions - particularly in taking thoughts about emotions literally. They also explore how individuals can plan action more smoothly by drawing on existing skills and strengths, and overcome shame by becoming less self-critical and more self-compassionate. They conclude with material on maintaining gains, developing new goals, and creating a more confident and controlled lifestyle. Managing Tic and Habit Disorders is a thoughtful and timely guide for those suffering from this sometimes all-consuming disorder, and the professionals who set out to help them.

The textbook "Fundamentals of Ionizing Radition Dosimetry" bundled with the workbook containing solutions to the exercises is the perfect pair for anyone seriously interested in radiation dosimetry.

This book is a practical guide for psychiatrists to use when treating patients for medical issues. Over the past 10-20 years, the number of medications prescribed for psychiatric illnesses has steadily increased, and psychiatric practitioners are frequently called upon to manage medical issues and side effects that result from psychotropic treatment. Covering a wide range of conditions from thyroid disorders to cardiac disease, this book is a helpful resource for understanding common adverse medical effects that occur when psychotropic drugs are administered. Presented in a practical format, each chapter discusses management of a particular medical problem or side effect and then provides a summary and flowchart of the major points highlighted in that chapter. Each chapter contains an overview of key medications causing a particular side effect. The book also includes special topics such as psychotropic prescribing in medical illness and tips on electrocardiographic interpretation. This easy-to-reference book aims to bridge the gap between medicine and psychiatry by elaborating on medical conditions seen in routine outpatient psychiatric practice. It serves as an invaluable tool for mental health providers, nurses, health educators, and pharmacologists alike.

This new book for medical students contains over 60 of the most commonly encountered OSCE stations in medicine and surgery. The OSCEs are arranged according to type of skill; for example history-taking, ethics and communication, physical examination. This is an accessible book for students under pressure who are revising for a clinical OSCE. It provides simple advice, tips about preparation, and will be easily understood. It provides sample OSCE station questions and simulated patient scripts (with answers) for practice at home.

General Practice Cases at a Glance is a workbook of clinical scenarios, ideal for those working in general practice, on their GP rotations, or looking to improve their history-taking, diagnostic and management planning skills. Written by practising teaching GPs, it provides an accessible overview of the richness and complexity of general practice. With 50 engaging consultations, covering all age ranges and a broad spread of clinical areas, each symptom-based chapter begins with the clinical presentation of a patient, before going on to uncover the full history and examination. As you work through each true-to-life case, there are red flag symptoms, useful charts and tables, and further resources to deepen your knowledge. General Practice Cases at a Glance: * Is suitable for clinical students, Foundation doctors, and those preparing for the MRCGP's CSA * Includes 50 case scenarios from across the medical spectrum, from mental health and paediatrics to musculoskeletal and ENT medicine * Is comprehensively illustrated * Features current clinical guidelines, and charts and tables to accompany each case * Is the companion volume to General Practice at a Glance, ISBN 978-0-470-65551-1, (Awarded First Prize in the Primary health care category at the 2013 BMA Medical Book Awards) but is also a stand-alone resource

Each chapter is written by a speech and language therapist specialising in psycholinguistic approaches to investigation and intervention. Authors were invited to present a single case in one of four given areas aACAACA" speech processing, lexical processing, sentence processing and pragmatics. The editors have provided introductions to each subject area and a discussion of the findings at the end of each section.

Cessation of tobacco use is the need of the hour given that it is the single largest cause of disease and premature death in the world. This book covers epidemiology and risks, user classification, nicotine replacement therapy, pharmacological aids, behavioral modification and patient counseling techniques, along with personalized action plan development. Key Features Covers all aspect of tobacco cessation. Provides guidance on differential diagnosis and includes useful decision-making flowcharts. Provides step-by-step guidance to counsel tobacco users in routine clinical practice. Discusses the process of setting up a cessation centre. Facilitates in-depth understanding of the subject through case studies at the end of each chapter

Medical decision making has evolved in recent years, as more complex problems are being faced and addressed based on increasingly large amounts of data. In parallel, advances in computing power have led to a host of new and powerful statistical tools to support decision making. Simulation-based Bayesian methods are especially promising, as they provide a unified framework for data collection, inference, and decision making. In addition, these methods are simple to implement and can help to address the most pressing practical and ethical concerns arising in medical decision making.

• Provides an overview of the necessary methodological background, including Bayesian inference, Monte Carlo simulation, and utility theory.
• Driven by three real applications, presented as extensively detailed case studies.
• Case studies include simplified versions of the analysis, to approach complex modelling in stages.
• Features coverage of meta-analysis, decision analysis, and comprehensive decision modeling.
• Accessible to readers with only a basic statistical knowledge.

This book presents a collection of accounts by internationally renowed experts on current techniques in the instrumental investigation of speech and disorders of speech.

Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1 represents a multidisciplinary approach to food fortification. This book aims to disseminate important material pertaining to the fortification of foods from strategic initiatives to public health applications. Optimal nutritional intake is an essential component of health and wellbeing. Unfortunately situations arise on a local or national scale when nutrient supply or intake is deemed to be suboptimal. As a consequence, ill health occurs affecting individual organs or causing premature death. In terms of public health, malnutrition due to micronutrient deficiency can be quite profound imposing economic and social burdens on individuals and whole communities. This comprehensive text examines the broad spectrum of food fortification in all its manifestations. Coverage includes sections on definitions of fortifications, fortified foods, beverages and nutrients, fortifications with micronutrients, biofortification, impact on individuals, public health concepts and issues, and selective methods and food chemistry. Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1 is an indispensable text designed for nutritionists, dietitians, clinicians and health related professionals.

This book provides medical students and physicians with a practical, step-by-step guide on how to write and publish a medical case report. The case report is the traditional way for physicians to describe their unique or unusual cases to a broad audience and it plays an important role in the discovery of new diseases or syndromes, unusual manifestations of disease, important adverse drug reactions, and the generation of hypotheses for further study. This book guides readers through the process from choosing a case to report on to finding a publisher and then comment on future directions and potential new uses of case reports, including expanded computer case databases to optimize care for individual patients and new applications in medical education. Interspersed throughout the text are example case reports, many written by the authors, with commentary on their experiences working with those reports to provide context and aid readers in creating clear, concise, and useful case reports.

Over the past decade, the healthcare industry has adopted games as a powerful tool for promoting personal health and wellness. Utilizing principles of gamification to engage patients with positive reinforcement, these games promote stronger attention to clinical and self-care guidelines, and offer exciting possibilities for primary prevention. Targeting an audience of academics, researchers, practitioners, healthcare professionals, and even patients, the Handbook of Research on Holistic Perspectives in Gamification for Clinical Practices reviews current studies and empirical evidence, highlights critical principles of gamification, and fosters the increasing application of games at the practical, clinical level.

Neonatal Haematology This unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike. Authored by two of the world's leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as: Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn) Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion Haematological signs of neonatal infection: causes of neutrophil left shift, leucoerythroblastosis, and toxic granulation Paediatric haematologists, consultant haematologists, and trainees in haematology can use the succinct, well-written content in this book as a useful helping hand during consultation. Biomedical scientists will also value the work as a laboratory reference.

This concise, easy-to-read guidebook is designed as a go-to resource for clinician educators working to establish the foundation for a successful academic career. This book begins with preliminary lessons such as interviewing for a first faculty position, how to prepare a robust curriculum vitae, how to evaluate a letter of offer, and understanding the process of academic promotion. Further chapters highlight the refinement of essential academic skills, including how to effectively give a lecture, how to approach clinical supervision, incorporating technology in educational innovation, and how to give feedback, among other topics. Chapters pertaining to clinical care cover a range of topics, including how to maintain excellent clinical documentation, how to evaluate clinical research, and how to avoid medico-legal problems. Clinician educators, while essential to the academic workforce, often feel overwhelmed by the newness and breadth of responsibilities that go with their first faculty job. Addressing that problem, this guidebook also emphasizes careful attention to preserving a healthy work/life balance as clinician educators navigate the demands of their professional and personal lives. The Clinician Educator Guidebook: Steps and Strategies for Advancing Your Career is derived from the larger acclaimed text, The Academic Medicine Handbook, and is an indispensable resource for a unique group of dedicated faculty who play an essential role in academic medicine.

When you are ready to implement measures to improve patient safety, this is the book to consult. Charles Vincent, one of the world's pioneers in patient safety, discusses each and every aspect clearly and compellingly. He reviews the evidence of risks and harms to patients, and he provides practical guidance on implementing safer practices in health care.

The second edition puts greater emphasis on this practical side. Examples of team based initiatives show how patient safety can be improved by changing practices, both cultural and technological, throughout whole organisations. Not only does this benefit patients; it also impacts positively on health care delivery, with consequent savings in the economy.

"Patient Safety" has been praised as a gateway to understanding the subject. This second edition is more than that - it is a revelation of the pervading influence of health care errors, and a guide to how these can be overcome.

..". The beauty of this book is that it describes the complexity of patient safety in a simple coherent way and captures the breadth of issues that encompass this fascinating field. The author provides numerous ways in which the reader can take this subject further with links to the international world of patient safety and evidence based research... One of the most difficult aspects of patient safety is that of implementation of safer practices and sustained change. Charles Vincent, through this book, provides all who read it clear examples to help with these challenges" From a review in Hospital Medicine by Dr Suzette Woodward, Director of Patient Safety.

Access 'Essentials of Patient Safety - Free Online Introduction': www.wiley.com/go/vincent/patientsafety/essentials

Das vorliegende Buch entstand im Nachgang zur 1. LAGO-Tagung (Landesarbeitsgemeinschaft Onkologische Versorgung Land Brandenburg e. V.), Onkologie im Land Brandenburg (Febr. 2000). Dieser Tagungsband soll dazu dienen, zentrale Aspekte aus dem Bereich der letzten Lebensphase krebskranker Menschen anzusprechen. Hierbei spielen die medizinische Behandlung und die pflegerische Betreuung eine ebenso groAe Rolle wie die psychosoziale Betreuung der Betroffenen und auch ihrer AngehArigen. Es geht um den menschlichen Umgang mit einer tAdlichen Krankheit, um LebensqualitAt und MenschenwA1/4rde. Das Buch beinhaltet Themen wie "Medizin und Sterben," die "Pflege von Sterbenden" sowie die "Bedeutung der Kommunikation im Betreuungsteam und mit Sterbenden." Weiterhin stehen VortrAge zur "Netzwerkarbeit" im Zentrum, die sich mit dem Sterben und dem Tod von Menschen beschAftigt, die eigentlich erst am Anfang ihres Lebens stehen - von Kindern. Ferner werden Aspekte der Trauerarbeit und TrauerbewAltigung aufgezeigt. Die Auseinandersetzung mit diesem Thema und der Austausch von Erfahrungen sollen dazu beitragen, die Belange von betroffenen Patienten und deren AngehArigen zu verdeutlichen und weiterhin zu verbessern sowie das Wissen um die letzte Lebensphase eines jeden Menschen zu vertiefen.

Psychosocial problems appear within a medical context worldwide, and are a major burden to health. Psychosomatic Medicine: An International Primer for the Primary Care Setting takes a uniquely global approach in laying the foundations of bio psychosocial basic care (such as recognizing psychosocial and psychosomatic problems, basic counseling and collaboration with mental health specialists) and provides relevant information about the most common mental and psychosomatic problems and disorders. The scope of the book is intercultural-it addresses global cultures, subcultures living in a single country and strengthening the care given by physicians working abroad. This clinically useful book outlines best practices for diagnosing the most common bio psychosocial problems and mastering the most common communication challenges (e.g. doctor-patient conversation, breaking bad news, dealing with difficult patients, family and health systems communication and collaboration). Every chapter integrates basic theoretical background and practical skills and includes trans-culturally sensitive material, important for work with patients from different cultures. Psychosomatic Medicine: An International Primer for the Primary Care Setting serves as an excellent resource for clinicians hoping to gain and develop knowledge and skills in psychosomatic medicine.

The book is a compilation of guidelines from various organizations such as Society of Nuclear Medicine & Molecular Imaging, European Association of Nuclear Medicine, American College of Radiology and International Atomic Energy Agency. The description of the procedures is simple, easy to understand and current. The aim of this book is: a) Nuclear medicine professionals can use this book as a quick reference about how a procedure is to be performed. The set of instructions given to patient before, during and after the procedure have also been included in each chapter. b) To educate general physicians about nuclear medicine procedures. The procedures are explained briefly with common indications and precautions. Normal and abnormal nuclear medicine images have also been included for quick comparison. c) To educate paramedical staff or healthcare professionals so that they send patients to nuclear medicine department after proper preparation. d) To educate patients who come for nuclear medicine procedure. e) To clarify apprehensions and doubts which arise in the mind of the patients.

Becoming a Good Doctor focuses on medical ethics in basic sense: the character traits and styles of practice we look for when we seek a doctor's help. This book will appeal to doctors and medical students for its sound application of the venerable tradition of virtue ethics to modern medical practice.