The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Targeting the practical needs of clinical teachers who do not have extensive time to undergo additional training, this book provides an accessible, on-the-spot resource to bolster teaching skills and optimize the education of trainees. A massive transformation takes place every summer in the United States: thousands of trainees in graduate medical education are appointed as attending physicians responsible for effectively teaching the next generation of medical students and residents. This handbook includes only the most relevant topics for new clinical teachers, and covers the basics of clinical teaching, teaching in specific situations, teaching different audiences, and best practices for handling challenging situations. The format is conducive to "just in time" learning, perfect for quick reference before meeting with learners or engaging in specific teaching situations, such as in an ambulatory clinic or at the bedside. Key points are emphasized with frequent use of tables and boxed practical content. Applicable to all teaching attendings regardless of specialty, the Handbook of Clinical Teaching is a valuable aid for individuals who wish to improve their teaching, and serves as a practical guide for faculty development in clinical teaching.

This textbook consists of ten chapters, and is a must-read to all medical and health professionals, who already have basic knowledge of how to analyze their clinical data, but still, wonder, after having done so, why procedures were performed the way they were. The book is also a must-read to those who tend to submerge in the flood of novel statistical methodologies, as communicated in current clinical reports, and scientific meetings. In the past few years, the HOW-SO of current statistical tests has been made much more simple than it was in the past, thanks to the abundance of statistical software programs of an excellent quality. However, the WHY-SO may have been somewhat under-emphasized. For example, why do statistical tests constantly use unfamiliar terms, like probability distributions, hypothesis testing, randomness, normality, scientific rigor, and why are Gaussian curves so hard, and do they make non-mathematicians getting lost all the time? The book will cover the WHY-SOs.

The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Histopathologists all over the world have to report cytopathology during the course of their work and it is then that they find themselves facing diagnostic dilemmas. This practical, well-illustrated book, explicitly dedicated to this readership will serve their needs and meets their requirements in daily practice.

This reference book compiles the most recent developments in experimental and clinical research and practice in one comprehensive edition. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a landmark title in the field, offering a clear, detailed, and cohesive call by leading experts for coordinated care for patients with concurrent psychiatric and medical conditions. The renowned editors and authors argue that what is slowly occurring, and greatly needed at a faster pace, is nothing less than a sea change in the way that psychiatric care will be delivered. The current, mostly segregated, medical and psychiatric model of care has led to the development of competing medical and psychiatric subcultures that have resulted in a lack of dialog among health providers, administrators, and payers - and thus in less than optimal patient outcomes. To remedy this problem, the book offers a practical, insightful road map to achieving the central tenet of health reform - truly coordinated, patient-centered care where the care experience for the patient, the medical care itself, and the cost outcomes improve as the system changes from fee-for-service to population-based health. An invaluable reference for all clinicians, policy makers, payers, administrators, and others interested in the debate surrounding healthcare systems, Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a major contribution to the literature and a gold standard resource.

Since their first application in 1982, Totally Implantable Venous Access Devices (TIVADs) have become increasingly important in the clinical practice, as more intensive chemotherapy and parenteral treatments have come into use. At this time, there is objective evidence that TIVADs are a safe, effective strategy for long-term venous access; they play a significant role throughout the management of the oncology patient, as they are needed in the initial phases for active treatments as well as in the last stages for palliative measures, making possible repeated administration of chemotherapeutic vesicant agents, nutrients, antibiotics, analgesics, and blood products. According to a number of prospective studies, use of TIVADs is associated with a significant complication rate (10% to 25% of all patients). Evidence-based data support that most complications are directly related to inappropriate technique of placement and/or nursing care, sometimes leading to TIVAD loss, significant morbidity, increased duration of hospitalization, and additional medical cost. A group of world-renowned experts - both in the clinical and research fields - contributed to this volume, whose aim is to provide clinicians, nurses and medical students with a multidisciplinary, full update on these devices, as long term central venous access can no be longer considered a routine matter, and serious complications can be maintained at a very low level only if strict adherence to a well-defined protocol of surgical technique and of catheter care is maintained.

Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 2 represents a multidisciplinary approach to food fortification. This book aims to disseminate important material pertaining to the fortification of foods from strategic initiatives to public health applications. Optimal nutritional intake is an essential component of health and wellbeing. Unfortunately situations arise on a local or national scale when nutrient supply or intake is deemed to be suboptimal. As a consequence, ill health occurs affecting individual organs or causing premature death. In terms of public health, malnutrition due to micronutrient deficiency can be quite profound imposing economic and social burdens on individuals and whole communities. This comprehensive text examines the broad spectrum of food fortification in all its manifestations. Coverage includes sections on definitions of fortifications, fortified foods, beverages and nutrients, fortifications with micronutrients, biofortification, impact on individuals, public health concepts and issues, and selective methods and food chemistry. Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 2 is an indispensable text designed for nutritionists, dietitians, clinicians and health related professionals.

Diagnosing and managing type 2 diabetes presents an enormous challenge to the primary care provider confronted with multiple emerging scientific insights, therapeutic strategies and risk reduction principles. In Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition, Ronald A. Codario, M.D., FACP -- a well-known and highly respected authority on diabetes -- details the state-of-the-art in diagnosing, managing and attenuating risks in patients with this disease. Utilizing his extensive experience in private practice, medical education and clinical research for over 35 years, Dr. Codario explains in simple clinical terms, the current understanding of the pathophysiology of diabetes, the latest clinical trials, developing controversies, updates on new medications and an expanded section on Special Populations. With his unique, multiple board certifications in clinical hypertension, vascular medicine, internal medicine, vascular ultrasound and clinical lipidology, Dr. Codario provides practical guidelines for treatment with insulin and oral agents, lipid and hypertension control and comprehensive risk reduction strategies. Extensively reviewed are the metabolic syndrome, the role of exercise and nutrition, and key issues associated with herb and nutriceutical use. Illustrative case studies in diabetes management, an outstanding bibliography of suggested readings, and extensive chapter subheadings for quick reference make this book a practical, easy-to-read guide for dealing with this killer disease. Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition is the direct result of many years of listening, teaching, lecturing and empathizing with fellow primary care providers and their patients in the ongoing fight against diabetes. Like the internationally acclaimed first edition, this is a must read and invaluable guide for all primary care providers, students, caregivers and patients battling the ravages of this ever increasing epidemic.

The second edition of this concise and practical guide describes infections in geographical areas and provides information on disease risk, concomitant infections (such as co-prevalence of HIV and tuberculosis) and emerging bacterial, viral and parasitic infections in a given geographical area of the world. * Geographic approach means that it's the only book to guide the health care worker towards a diagnosis based on the location of symptoms and travel history by encouraging the question where have you been? * New content covering MERS, Ebola, Zika, and infections transmitted during air and maritime travel * Covers the major infectious disease outbreaks framed in their geographic setting such as H7N9 bird flu influenza, H1N1, Ebola, and Zika * Outstanding international editor team with vast experience on various international infectious disease and as journal editors and key leaders in infection surveillance

Based on detailed multi-disciplinary analyses of more than 800 recorded handover interactions, audits of written handover documentation, interviews and survey responses, the contributing authors identify features of effective and ineffective clinical handovers in diverse hospital contexts. The authors then translate their descriptive findings into practical protocols, communication strategies and checklists that clinicians, managers and policy makers can apply to improve the safety and quality of clinical handovers. All the contributors are affiliated with the International Research Centre for Communication in Healthcare (IRCCH), an international multidisciplinary organisation of over 90 healthcare professionals from more than 17 countries committed to improving improving communication in healthcare systems around the world. 'The authors have created a new and tightly woven systems safety net that will, if implemented, significantly reduce the occurrence of errors resulting from cumulative communication failures.' -H. Esterbrook Longmaid III, MD, FACR, President of Medical Staff, Beth Israel Deaconess-Milton Hospital, Milton, MA USA 'Uncommonly valuable for the rigorous, original communication research it reports and for the careful translation of the research findings into practical strategies that actually improve clinical handovers in the real world of practice.' -Professor Suzanne Kurtz, Washington State University 'This clear, plain English book is an outstanding resource for the training of all involved in healthcare.' -Elizabeth Trickett, (Former) Director of Safety and Quality, ACT Health, Australia

* The first single source work to deal with the two primary radiologic modalities in diagnosing and treating benign and malignant diseases of the liver, presented with clearly laid out MRI and CT correlations. Developed by an editor team led by one of the world s leading authorities in abdominal imaging, Richard C. Semelka MD. * User-friendly, atlas-style presentation, with over 1500 MRI and CT images in over 320 figures featuring state-of-the-art MR and CT imaging sequences, multidetector row CT images, 3D reformatted images, breath-hold MRI sequences, and cutting-edge MR 3T images * Highly practical approach for imaging of focal and diffuse liver lesions, complete relevant and systematic (differential) diagnostic information, the latest references to primary literature and clinical evidence, and patient management possibilities * Reflects a pattern-recognition approach to MRI and CT imaging, assisting with efficient scanning of images and assessment and diagnosis of disorders

The book presents the latest developments in clinical medicine, particularly involved with pulmonary care and diseases. Emphasis is placed on the role of childhood obesity, often a result of the ill effects of an unhealthy diet and nutritional deficits, in shaping propensity for inflammatory pathologies, allergies, immune deficiency and respiratory and cardiovascular sequelae in adult life. Oxidative damage, caused by not full well understood cellular biochemistry, when unchecked by antioxidative rescue mechanisms, takes toll on a respiratory health. The book underscores the need to consider the complexity of mutual interactions of pathophysiological processes, which calls for tailoring the management strategies depending on the subgroups which patients belong to, be it obesity, children or elderly. The chapters also tackle biological diseases with genetic underpinnings. The application of genetics to identify the molecular alterations or mutations will serve well both diagnostics and targeted optimization of treatment; the poignant exemplar being the histological subtypes of lung cancer. The book provides a source of current facts and trends in clinical research and practice.

This is a basic book on evidence-based medicine (EBM). It starts with an introduction to the topic. It outlines the relationship between EBM and research and quality of care. Then It goes on to cover the most commonly used modules of EBM, i.e. therapy, diagnosis, prognosis and meta-analysis. Each module starts with an introduction to fundamental concepts, and description of the related research process, and then follows the critical appraisal of related type of research artcle. At the end, it covers the different systems of grading of level of evidence and strength of recommendations. The book also has three examples of critical appraisal on diagnosis, therapy, and meta-analysis.

A comprehensive and practical resource for analyses of crossover designs For ethical reasons, it is vital to keep the number of patients in a clinical trial as low as possible. As evidenced by extensive research publications, crossover design can be a useful and powerful tool to reduce the number of patients needed for a parallel group design in studying treatments for non-curable chronic diseases. This book introduces commonly-used and well-established statistical tests and estimators in epidemiology that can easily be applied to hypothesis testing and estimation of the relative treatment effect for various types of data scale in crossover designs. Models with distribution-free random effects are assumed and hence most approaches considered here are semi-parametric. The book provides clinicians and biostatisticians with the exact test procedures and exact interval estimators, which are applicable even when the number of patients in a crossover trial is small. Systematic discussion on sample size determination is also included, which will be a valuable resource for researchers involved in crossover trial design. Key features: * Provides exact test procedures and interval estimators, which are especially of use in small-sample cases. * Presents most test procedures and interval estimators in closed-forms, enabling readers to calculate them by use of a pocket calculator or commonly-used statistical packages. * Each chapter is self-contained, allowing the book to be used a reference resource. * Uses real-life examples to illustrate the practical use of test procedures and estimators * Provides extensive exercises to help readers appreciate the underlying theory, learn other relevant test procedures and understand how to calculate the required sample size. Crossover Designs: Testing, Estimation and Sample Size will be a useful resource for researchers from biostatistics, as well as pharmaceutical and clinical sciences. It can also be used as a textbook or reference for graduate students studying clinical experiments.

The promotion of standards and guidelines to advance quality assurance and control is an integral part of the health care sector. Quantitative methods are needed to monitor, control and improve the quality of medical processes.

"Statistical Development of Quality in Medicine" presents the statistical concepts behind the application of industrial quality control methods. Filled with numerous case studies and worked examples, the text enables the reader to choose the relevant control chart, to critically apply it, improve it if necessary, and monitor its stability. Furthermore, the reader is provided with the necessary background to critically assess the literature on the application of control charts and risk adjustment and to apply the findings. Contains a user-friendly introduction, setting out the necessary statistical concepts used in the field. Uses numerous real-life case studies from the literature and the authors' own research as the backbone of the text. Provides a supplementary website featuring problems and answers drawn from the book, alongside examples in Statgraphics.

The accessible style of "Statistical Development of in Clinical Medicine" invites a large readership. It is primarily aimed at health care officials, and personnel responsible for developing and controlling the quality of health care services. However, it is also ideal for statisticians working with health care problems, diagnostic and pharmaceutical companies, and graduate students of quality control.

This book presents a vast collection of radiologic images of cases seen in a very busy emergency room. It encompasses common and very unusual pathology and every imaging modality. The book is divided into four parts on pathology of the vascular system, chest, abdomen and pelvis and reproductive organs. Images obtained with the modalities that best depict the abnormality in question are presented, with marking of the salient pathology and explanation of the abnormal imaging features in concise captions. Whenever possible, differential diagnosis is covered using further images and guidance is also provided on selection of additional modalities to confirm the diagnosis. The book will help residents to analyze different diseases and relate pathophysiology to imaging and assist students in appreciating what is abnormal. It will be a useful guide for the busy practicing radiologist and aid clinicians in understanding the complexity of these cases and delivering better focused treatment.p>

This chart defines temporomandibular joint (TMJ) syndrome. It illustrates the normal jaw closed and open, and the nerves of the temporomandibular region. The chart shows and explains common causes and disorders and lists symptoms, disorders sometimes mistaken for TMJ syndrome, and treatment options.

This book provides an update on recent clinical practice and an in-depth view of selected topics relevant to hospital medicine. It is divided into four sections that explore clinical, administrative, systems and ethical issues. Each section places an emphasis on the opportunities, challenges and potential directions of this bourgeoning subspecialty. This new edition expands on topics covered in the previous edition, including the COVID-19 pandemic, racial disparities in healthcare delivery and providers, and pediatric hospital medicine. Other chapters explore worldwide practice patterns and practical application of philosophical tools in daily practice. This up-to-date resource provides hospitalists, advanced nurse practitioners, medical students and administrators with the latest research, trends and issues in hospital medicine.

Are your exams coming up? Are you drowning in textbooks and lecture notes and wondering where to begin? Take the FASTtrack route to successful study for your examinations. FASTtrack is a new series of indispensable revision/study guides created especially for pharmacy students. Each book focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs, case studies, sample essay questions and worked examples. The FASTtrack series provides the ultimate lecture notes and is a must-have for all pharmacy students wanting to revise and test themselves for forthcoming exams. Therapeutics is a basic study guide in therapeutics and will cover all the main systems of the body with a summary of therapeutics in these areas. Covering all areas of the pharmacy degree, the first titles in the series include: Applied Pharmaceutical Practice (due September 2009) Complementary and Alternative Medicine Managing Symptoms in the Pharmacy Pharmaceutical Compounding and Dispensing (based on the textbook of the same name) Pharmaceutics - Dosage Form and Design Pharmaceutics - Delivery and Targeting (due August 2009) Pharmacology (due August 2009) Physical Pharmacy (based on Florence & Attwood's Physicochemical Principles of Pharmacy) Therapeutics

Our goal is to develop automated methods for the segmentation of thr- dimensional biomedical images. Here, we describe the segmentation of c- focal microscopy images of bee brains (20 individuals) by registration to one or several atlas images. Registration is performed by a highly parallel imp- mentation of an entropy-based nonrigid registration algorithm using B-spline transformations. We present and evaluate different methods to solve the cor- spondence problem in atlas based registration. An image can be segmented by registering it to an individual atlas, an average atlas, or multiple atlases. When registering to multiple atlases, combining the individual segmentations into a ?nalsegmentationcanbeachievedbyatlasselection,ormulticlassi?erdecision fusion. Wedescribeallthesemethodsandevaluatethesegmentationaccuracies that they achieve by performing experiments with electronic phantoms as well as by comparing their outputs to a manual gold standard. The present work is focused on the mathematical and computational t- ory behind a technique for deformable image registration termed Hyperelastic Warping, and demonstration of the technique via applications in image regist- tion and strain measurement. The approach combines well-established prin- ples of nonlinear continuum mechanics with forces derived directly from thr- dimensional image data to achieve registration. The general approach does not require the de?nition of landmarks, ?ducials, or surfaces, although it can - commodate these if available. Representative problems demonstrate the robust and ?exible nature of the approach. Three-dimensional registration methods are introduced for registering MRI volumes of the pelvis and prostate. The chapter ?rst reviews the applications, xi xii Preface challenges, and previous methods of image registration in the prostate.