The process of discovery of medicinal compounds has evolved over
millennia, from Neanderthal man's use of medicinal herbs to the
highly-evolved techniques of biotechnology and high-throughput
screening used by today's medicinal chemists. "Drug Discovery - A
History" reviews the full panoply of discovery of therapeutic
compounds in use today.
The book is divided into three parts. The first, the Legacy of
the Past, gives an overview of medicinal compounds in society,
ranging from the earliest use of medicinal herbs through the
ancient civilisations in Mesopotamia, Egypt, Greece, and Rome,
concluding with an overview of development of life-saving organic
compounds in the 20th century. The second part examines the
commonest source of the drug - the natural world. Prototypes from
vegetable, animal, and microbial sources are described in separate
chapters, as are the medicinal compounds prepared from them. The
problem of relying on nature as a source of drug prototypes is
confronted. Part Three considers synthetic compounds that have
served as drug prototypes, the role of serendipity in providing
these synthetic prototypes, and a review of compounds derived from
them.
"Drug Discovery - A History" is essential reading for medicinal
chemists, pharmacologists, organic chemists, physicians,
researchers and anyone with an interest in the development of
therapeutic drugs.
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